New hope for gut disease: experimental drugs enter human trials

NCT ID NCT07483073

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. The study lasts at least 62 weeks and is currently recruiting participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mirikizumab (given by IV or injection) and LY4395089 (taken by mouth)
What this could lead to: If successful, this could point toward new treatment options that help control symptoms and reduce disease activity for people with ulcerative colitis or Crohn's disease.
What could go wrong: This is an early phase 2 trial with only 60 participants, so results may not apply to everyone. The drugs may not work better than existing treatments or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLITIS, ULCERATIVE CROHN DISEASE

Contacts and locations

Locations

AZ Delta vzw
NOT_YET_RECRUITING

Roeselare, 8800, Belgium
AZ Maria Middelares
NOT_YET_RECRUITING

Ghent, 9000, Belgium
Affiliated Hospital of Jiangsu University
RECRUITING

Zhenjiang, 212000, China
Assuta Ashdod Medical Center
NOT_YET_RECRUITING

Ashdod, 7747629, Israel
Atlanta Gastroenterology Associates - Peachtree Dunwoody
RECRUITING

Atlanta, Georgia, 30342, United States
Azienda Ospedaliera Universitaria Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
BR Trials - Ensaios Clinicos e Consultoria
NOT_YET_RECRUITING

São Paulo, 01236030, Brazil
Biopharma Informatic, LLC
RECRUITING

Los Angeles, California, 90035, United States
CEDOES
NOT_YET_RECRUITING

Vitória, 29055450, Brazil
CPCLIN
NOT_YET_RECRUITING

São Paulo, 01228-200, Brazil
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
NOT_YET_RECRUITING

São Paulo, 01228-000, Brazil
Centro Digestivo de Curitiba
NOT_YET_RECRUITING

Curitiba, 80430-180, Brazil
Centro de Pesquisa Clínica de Marília - CPCLIM
NOT_YET_RECRUITING

Marília, 17504-072, Brazil
Centrum Medyczne Oslomed
NOT_YET_RECRUITING

Krakow, 31-228, Poland
Changzhou Second People's Hospital
RECRUITING

Changzhou, 213000, China
Charité Universitaetsmedizin Berlin - Campus Mitte
NOT_YET_RECRUITING

Berlin, 10117, Germany
Clínica Hepatogastro JK
NOT_YET_RECRUITING

São Paulo, 04077-020, Brazil
Cotton O'Neil Digestive Health Center
RECRUITING

Topeka, Kansas, 66606, United States
ETG Siedlce
NOT_YET_RECRUITING

Siedlce, 08-110, Poland
ETG Zamość
NOT_YET_RECRUITING

Zamość, 22-400, Poland
Ezy Medical Research
RECRUITING

Miami Lakes, Florida, 33015, United States
Fondazione IRCCS San Gerardo dei Tintori
NOT_YET_RECRUITING

Monza, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli
NOT_YET_RECRUITING

Roma, 00168, Italy
Fundação Universidade de Caxias do Sul (FUCS)
NOT_YET_RECRUITING

Caxias do Sul, 95070-560, Brazil
Gastro Health Research - Miami
RECRUITING

Miami, Florida, 33176, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
RECRUITING

Wyoming, Michigan, 49519, United States
Geomedical Egészségügyi Központ
NOT_YET_RECRUITING

Budapest, 1066, Hungary
Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero
NOT_YET_RECRUITING

Katowice, 40-600, Poland
Hadassah Medical Center
RECRUITING

Jerusalem, 9112001, Israel
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
Humanitas
NOT_YET_RECRUITING

Rozzano, 20089, Italy
KAD Clinical Research
RECRUITING

St Louis, Missouri, 63123, United States
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
NOT_YET_RECRUITING

Tatabánya, 2800, Hungary
Loema Instituto de Pesquisa Clinica
NOT_YET_RECRUITING

Campinas, 13092-133, Brazil
London Digestive Disease Institute
SUSPENDED

London, N6K 1M6, Canada
Mayo Clinic in Arizona - Scottsdale
NOT_YET_RECRUITING

Scottsdale, Arizona, 85259, United States
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
NOT_YET_RECRUITING

Warsaw, 04-501, Poland
Medrise Sp. z o.o.
NOT_YET_RECRUITING

Lublin, 20-582, Poland
Om Research LLC
RECRUITING

Oxnard, California, 93030, United States
One of a Kind Clinical Research Center - Kingwood
NOT_YET_RECRUITING

Kingwood, Texas, 77339, United States
Ospedale Sacro Cuore Don G. Calabria
NOT_YET_RECRUITING

Negrar, 37024, Italy
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Prairie Institute of Liver and Luminal Advanced Research Ltd (PILLAR)
NOT_YET_RECRUITING

Lethbridge, T1J 4G9, Canada
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
Rush University Medical Center
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
Semmelweis Egyetem
NOT_YET_RECRUITING

Budapest, 1082, Hungary
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 5262100, Israel
Sonomed Sp. z o. o.
NOT_YET_RECRUITING

Szczecin, 71-685, Poland
South Denver Gastroenterology
RECRUITING

Englewood, Colorado, 80113, United States
Southern Star Research Institute
RECRUITING

San Antonio, Texas, 78229, United States
St. Marien- und St. Annastiftskrankenhaus
NOT_YET_RECRUITING

Ludwigshafen, 67067, Germany
Studiengesellschaft Mitteldeutschland GmbH
NOT_YET_RECRUITING

Halle, 06108, Germany
Studienzentrum MVZ Dachau
NOT_YET_RECRUITING

Dachau, 85221, Germany
Tdda Inc.
RECRUITING

Vaughan, L4L 4Y7, Canada
The First Affiliated Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, 510080, China
The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
RECRUITING

Wenzhou, 325000, China
The Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215004, China
The Second Affiliated hospital of Zhejiang University school of medicine
RECRUITING

Hangzhou, 310052, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, 410011, China
Twoja Przychodnia PCM
NOT_YET_RECRUITING

Poznan, 60-324, Poland
Twoja Przychodnia SCM
NOT_YET_RECRUITING

Szczecin, 71-434, Poland
UZ Gent
NOT_YET_RECRUITING

Ghent, 9000, Belgium
UZ Leuven
NOT_YET_RECRUITING

Leuven, 3000, Belgium
Universitaetsklinikum Ulm
NOT_YET_RECRUITING

Ulm, 89081, Germany
Vector Clinical Trials
RECRUITING

Las Vegas, Nevada, 89128, United States
WSD MEDI
NOT_YET_RECRUITING

Warsaw, 02-786, Poland
Yitzhak Shamir Medical Center
RECRUITING

Ẕerifin, 7033001, Israel
Zhongshan Hospital Affiliated to Xiamen University
RECRUITING

Xiamen, 361000, China

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