Can switching IBD meds heal the gut when symptoms are quiet?
NCT ID NCT05230173
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study looks at people with inflammatory bowel disease (Crohn's or ulcerative colitis) who feel fine but still have moderate to severe inflammation inside their gut. It compares two approaches: switching to a different targeted medication versus staying on the current one. The goal is to see which strategy better achieves endoscopic remission—healing of the gut lining—and reduces the risk of flares, hospitalizations, or surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Switching to an alternative targeted immunomodulator (TIM) therapy
- What this could lead to
- If switching therapies works, it could offer a better way to heal the gut lining and prevent flares, hospitalizations, or surgery in people with IBD.
- What could go wrong
- This is a real-world study, not a controlled drug trial, so results may vary. Switching meds could cause side effects or fail to improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advent Health
RECRUITINGOrlando, Florida, 32804, United States
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Cedars-Sinai
RECRUITINGLos Angeles, California, 90048, United States
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Cornell University
RECRUITINGNew York, New York, 10021, United States
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Dartmouth Hitchcock
RECRUITINGLebanon, New Hampshire, 03756, United States
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GastroOne
WITHDRAWNGermantown, Tennessee, 38138, United States
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Gastroenterology Associates
RECRUITINGProvidence, Rhode Island, 02904, United States
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Hightower Clinical
ACTIVE_NOT_RECRUITINGOklahoma City, Oklahoma, 73102, United States
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Hoag Hospital
RECRUITINGIrvine, California, 92618, United States
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Mayo Clinic Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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MedStar Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Oregon Clinic
WITHDRAWNPortland, Oregon, 97220, United States
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Saratoga Schenectady Gastroenterology Associates
RECRUITINGBurnt Hills, New York, 12027, United States
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Sutter Health
RECRUITINGPalo Alto, California, 94301, United States
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UC San Diego Health
RECRUITINGLa Jolla, California, 92037, United States
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University of Chicago Medicine
RECRUITINGChicago, Illinois, 60637, United States
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Rochester
TERMINATEDRochester, New York, 14642, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75235, United States
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University of Utah Health
RECRUITINGSalt Lake City, Utah, 84132, United States
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University of Virginia
WITHDRAWNCharlottesville, Virginia, 22908, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
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