Mayo Clinic

This study tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer and possibly prevent it from coming back. The main go…

This study tests if the drug obinutuzumab can safely reduce protein in the urine of people with fibrillary glomerulonephritis, a rare kidney condition. About 20 adults with confirmed disease and significant protein leakage will receive the drug and be monitored for a year. The go…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (a type of cancer). The goal is to see which treatment provides better disease control and fewer side effects, and to measure quality of life after treatment. About 72 partici…

This study tests whether early use of midodrine, a pill that raises blood pressure, can help people with sepsis need less IV medicine and recover faster. About 308 adults with sepsis and low blood pressure will receive midodrine or a placebo. The goal is to see if it reduces time…

This early-stage study tests whether injecting donor stem cells directly into the artery of a transplanted kidney is safe and can reduce inflammation from rejection. It involves 12 adult kidney transplant recipients who have signs of rejection on biopsy. The goal is to see if thi…

This study tests whether the drug deucravacitinib can safely and effectively treat pityriasis rubra pilaris (PRP), a rare skin disease that causes red, scaly patches. About 12 adults with moderate to severe PRP will take the drug for 24 weeks. Researchers will measure changes in …

This study is testing whether a private Facebook group can help Native American women in Minnesota stay free from opioid use. Participants are women already on medication for opioid use disorder and have been abstinent for at least one month. The study will measure how well the F…

This phase 2 trial tests whether adding high-dose vitamin C to standard chemotherapy can improve outcomes for people with lymphoma that has returned or not responded to treatment, as well as for those with related blood disorders like chronic myelomonocytic leukemia. About 80 adu…

This study looks at whether increasing the dose of a stop-smoking medication or adding another drug helps people with pancreatitis quit smoking. All 45 participants start with the standard dose of varenicline. If they still smoke after 6 weeks, they are randomly assigned to a hig…

This study tests a new way of giving radiation for Ewing sarcoma, a rare bone and soft tissue cancer. The radiation dose is tailored to each patient's tumor size and features, with higher doses given over a shorter time. The goal is to better control the tumor at its original sit…

This early-phase study tests a new treatment called MC10029, which uses a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells. It is for people with certain types of blood cancers (like lymphoma or leukemia) that have returned or stopped respond…

This study tests a new way to treat stomach cancer that has spread to the lining of the abdomen. Doctors will use a robot to remove visible cancer and then deliver heated chemotherapy directly into the belly during surgery. The goal is to help patients recover faster and have few…

This early-stage study tests whether adding a drug called aldesleukin (IL-2) to standard immunotherapy and chemotherapy can better control stomach cancer that has spread to the abdomen lining. About 15 adults with this condition will receive the combination. The goal is to see if…

This study looks at whether older kidney transplant patients (55+) can safely stop taking one of their anti-rejection drugs (mycophenolate mofetil) while keeping their new kidney healthy. About 350 participants will be randomly assigned to either stop the drug or continue standar…

This study tests a special type of radiation called grid therapy combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has gotten worse despite treatment. Grid therapy delivers high doses of radiation to small parts of the tumor, which may …

This early-stage study is testing the safety and best dose of a drug called decitabine when added to standard cancer treatments like surgery and radiation. It is for adults with a specific type of head and neck cancer not linked to HPV. The goal is to see if decitabine makes the …

This early-stage study is testing a new, personalized vaccine made from a patient's own immune cells. It aims to see if the vaccine is safe and can trigger an immune response against the virus that causes recurrent, non-cancerous growths in the throat. The study will enroll 9 adu…

This study is testing a new, non-invasive capsule system that uses a detachable string to help doctors get better views of the esophagus. The goal is to detect Barrett's esophagus, a condition that can lead to cancer, without needing a traditional endoscopy. About 57 adults with …

This study compares a new type of CT scanner (PCD-CT) to standard MRI for determining how far rectal cancer has grown. About 200 adults with rectal cancer will receive both scans, and doctors will check if the CT is as accurate as MRI. If successful, this could offer a faster and…

This study tests whether artificial intelligence can make standard electrocardiograms (ECGs) better at finding two common heart conditions: aortic stenosis (a narrowed heart valve) and diastolic dysfunction (stiff heart muscle). Researchers at Mayo Clinic will enroll 2,000 adults…

This study tests whether a special type of breast imaging called molecular breast imaging (MBI) can help doctors take tissue samples (biopsies) from breast abnormalities that are hard to see on standard ultrasound or mammography. About 70 women with a known breast finding will un…

This study tests a special PET scan that uses a radioactive tracer called 68Ga-FAPI-46 to highlight pancreatic cancer cells. The goal is to see if this scan can find tumors more accurately than current methods. About 130 adults with early-stage pancreatic cancer will get the scan…

This study tests whether a new type of CT scanner, called Photon Counting Detector CT (PCD-CT), can provide clearer images of heart artery disease when used with a drug that makes the heart work harder. About 450 adults with suspected coronary artery disease will get both a stand…

This study looks at whether a special ultrasound-guided needle biopsy can accurately determine the stage of bladder cancer. Researchers will compare the biopsy results with the final results from standard surgery. The goal is to see if this less invasive method could be a reliabl…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help reduce depression in people with bipolar disorder. Researchers will track mood changes and heart health in 30 adults aged 18-50. Participants must be willing to change their diet completely for…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study tests if a personalized exercise program before surgery helps people with soft tissue sarcoma recover faster and with less disability. About 30 adults with lower-limb sarcoma will either receive standard care or a tailored prehabilitation plan during radiotherapy. The …

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study tests if a device called Bioboosti, which uses pulsed electromagnetic waves, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow and exercise ability in 120 adults who cannot have standard heart procedures. Th…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes who use automated insulin delivery systems. The app helps manage blood sugar levels during and after exercise. Researchers will check if the app improves glucose control and other heart health fact…

This study looks at why people with indigestion and diabetes often have stomach issues, like pain or fullness. Researchers are testing if ondansetron, a drug used for nausea, can reduce these symptoms. About 150 adults will take part to see if the drug helps with daily discomfort…

This study looks at whether a skin care program can improve skin quality and self-esteem in breast cancer survivors who are starting a type of hormone therapy called aromatase inhibitors. The study will include 25 women with early-stage breast cancer. Researchers will use special…

This study tests a new surgical method to prevent thick, painful scars after trigger finger surgery in people who also have Dupuytren's contracture. About 50 adults who need surgery will be randomly assigned to receive either the standard surgery or the new technique. Researchers…

This study tests whether a single dose of intravenous ketamine can rapidly reduce depression symptoms in 30 adults with treatment-resistant depression. Researchers will measure changes in key brain chemicals (GABA and glutamate) using brain scans and blood tests. The goal is to u…

This study tests whether up to 12 phone-based health coaching sessions over 12-16 weeks can improve emotional health and self-management in adults waiting for a lung transplant. 230 participants will be compared to a group receiving usual care. The goal is to see if coaching help…

This study tests whether a home-based, digitally guided breathing and respiratory muscle training program, supported by a health coach, can improve exercise ability and lung function in people with non-cystic fibrosis bronchiectasis. Researchers will enroll 50 adults with this ch…

This study tests whether training the muscles used for breathing can help midlife women (ages 45-60) who have hot flashes. Researchers will measure changes in hot flash frequency, sleep quality, and blood pressure. The goal is to find a simple, time-efficient way to ease common m…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce coughing in adults with refractory chronic cough—a cough that persists despite standard treatment. About 50 participants will receive either a low or high dose of one of the drugs or a placebo. The main …

This study tests whether two common nerve pain medications, duloxetine and amitriptyline, can reduce coughing in people with interstitial lung disease (ILD). About 25 adults with a chronic cough lasting at least 3 months will receive either a low or high dose of one drug or a pla…

This study tests whether tamsulosin, a drug often used for prostate problems, can prevent or shorten trouble urinating after spine surgery. About 20 adults having certain types of spine surgery will take the drug and be monitored. The goal is to reduce the need for catheters and …

This study tests a special tissue wrap placed on the nerves during prostate removal surgery for men with localized prostate cancer. The wrap aims to reduce common side effects like erectile dysfunction and urine leakage. About 25 men will take part to see if the wrap is safe and …

This study is testing if adding the medication mirtazapine to a special low-FODMAP diet helps people with IBS-D feel better than using the diet alone. It will involve about 20 adults with IBS-D to see if the combination reduces symptoms like abdominal pain, diarrhea, and bloating…

This study looks at whether ovarian hormones are linked to aging and Alzheimer's disease in women. Researchers will use brain scans to measure markers of aging and Alzheimer's in 614 women aged 60 and older. No treatment is given—the goal is to better understand how hormones may …

This study aims to improve how doctors and families discuss scoliosis treatment options. Researchers will record and analyze video conversations between healthcare providers, patients, and their families. The goal is to create a shared decision-making tool that helps patients wit…

This study looks at whether blood flow in fat tissue changes as we age. Healthy adults aged 18-35 or 65-80 will have their fat blood flow measured, provide two small fat samples, and drink a sugary drink. The goal is to understand basic aging processes, not to treat any disease.

This study collects medical histories and blood or tissue samples from 500 people with histiocytic disorders to identify genetic markers and understand how the disease works. Researchers will look for specific molecules in biopsies and track immune changes after radiation therapy…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study looks at 100 living kidney donors to see if the amount of fat around the kidney (called PRAT) is linked to worse blood pressure and kidney function after donation. Researchers will compare donors with high and low PRAT by testing blood, urine, and fat samples. The goal…

This study tests whether a probiotic called Saccharomyces boulardii can improve the gut's ability to control what passes into the body. Researchers will give the probiotic or a placebo to 56 healthy adults and measure changes in gut permeability, inflammation, and digestive sympt…

This study is looking for 1,000 people with a genetic heart condition called arrhythmogenic cardiomyopathy (AVC) or their family members. The goal is to discover new genes and blood markers that can predict who will get the disease, how it will progress, and who is at risk for da…

This study looks at whether taking prescription opioids for chronic pain causes changes in the brain structure of adults aged 65 and older. Researchers will use MRI scans to compare brain health in people who take opioids versus those who do not. The goal is to understand the ris…

This study is creating a registry of 100 women diagnosed with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect information on treatments, outcomes, and long-term survival, as well as tissue and swab samples to better understand the disea…

This study looks at how well blood flows through tiny heart vessels in people who have had a spontaneous coronary artery dissection (SCAD). Researchers will use a special ultrasound with contrast dye to measure blood flow and blood pressure changes during stress. The goal is to l…

This study is a registry that will track 200 people with spontaneous intracranial hypotension (low spinal fluid pressure) caused by CSF-venous fistulas. The goal is to see how well a procedure called paraspinal vein embolization works to stop the leak and improve headaches. The i…

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend weekly group meetings led by social workers and complete surveys about their quality of life and me…

This study from Mayo Clinic looks at why some people on a ketogenic diet develop very high LDL cholesterol ("hyper-responders"). Researchers will test the DNA of 100 adults with LDL over 170 mg/dL to see if certain gene mutations are linked to this extreme response. The goal is t…

This study looks at why some families have more blood cancers like lymphoma, leukemia, and myeloma. Researchers will study the genes and environment of 3000 people who have at least two living relatives with these cancers. The goal is to find inherited factors that raise risk, no…

This study collects blood and tumor tissue from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to learn how the immune system responds to these treatments. The goal is to better understand the connecti…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block the hormone's action to see how it affects insulin and glucagon release. The goal is to learn why some people develop type 2 diabetes…

This study looks at whether changes in gut bacteria are connected to fatigue and nausea in women receiving chemotherapy for early-stage breast cancer. Researchers will collect stool samples and questionnaires from 70 participants before and after treatment. The goal is to better …

This study collects blood and bone marrow samples from 80 adults with newly diagnosed acute myeloid leukemia (AML) who are receiving standard treatment with azacitidine and venetoclax. Researchers will analyze the immune profile of these samples to understand how the body respond…

This study looks at why fat cells in the belly area don't respond normally to signals that should stop them from releasing fat. Researchers will give niacin to overweight adults and measure how fat tissue from different body areas reacts. The goal is to better understand the biol…

This study looks at why people with certain congenital heart conditions, like tetralogy of Fallot, experience symptoms such as shortness of breath and palpitations. Researchers will use heart imaging and exercise tests in 300 participants to understand changes in heart structure …

This study compares two ways to perform double lung transplants: without a heart-lung machine (off-pump) or using a special heart-lung support called VA ECMO. The goal is to see which method leads to fewer serious lung complications and better survival. About 228 adults getting d…

This research study collects bile, bile duct brushings, and medical information from people with Primary Sclerosing Cholangitis (PSC) and healthy volunteers. The goal is to learn more about changes in the liver that may lead to disease. No treatments or drugs are tested.

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders, as well as their spouses or partners. The samples are stored in a biobank for future research to find biomarkers that could help understand or diagnose these diseas…

This study compares bone marrow collected from the hip bone versus the shin bone using a special device. Researchers want to see if the cells and growth factors are similar between the two sites. About 12 adults needing bone graft for foot or ankle surgery will take part. The goa…

This study is looking for genetic heart problems in people with epilepsy that might raise their risk of sudden unexpected death. Researchers will test DNA from 600 adults and their relatives to find known heart-related gene changes. The goal is to better understand why some epile…

This study aims to find the specific genes and mutations that cause rare, inherited forms of kidney stone disease. Researchers will study up to 6,000 people with a history of kidney stones or related conditions, especially those with family history or unusual symptoms. By linking…

This study uses a surface electromyography (EMG) machine—like sticky patches on the neck—to measure how people with Eosinophilic Esophagitis (EoE) swallow food. Researchers will compare the timing of swallowing preparation and initiation between EoE patients and healthy controls.…

This study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…

This study is testing whether a special communication tool helps doctors and lung cancer patients make treatment decisions together more effectively. The tool guides conversations about treatment options, benefits, and risks while considering each patient's personal situation and…