Mayo Clinic

This early-phase trial tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer. The main goals are to check for side eff…

This early-phase trial tests a genetically modified virus (VSV-hIFNβ-NIS) combined with an immunotherapy drug (cemiplimab) in adults with relapsed or refractory T-cell lymphoma. The virus is designed to kill cancer cells while leaving healthy cells alone, and the immunotherapy he…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This study tests whether a personalized care plan at hospital discharge helps people who survived acute kidney injury recover better. Depending on their risk level, patients get education, a primary care visit, or specialist monitoring. The goal is to see if this approach increas…

This study tests two drugs—retifanlimab (an immunotherapy) and DFMO (a growth blocker)—alone or together in 33 adults with progressive high-grade glioma, an aggressive brain cancer. The goal is to find the safest, most effective dose and see if the combination boosts the immune s…

This early-stage trial tests a combination of four drugs—iberdomide, daratumumab, elotuzumab, and dexamethasone—in people whose multiple myeloma has come back after treatment. The study has two phases: first, finding the safest dose of iberdomide, and second, seeing how well the …

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study tests whether a combination of two drugs, acalabrutinib and obinutuzumab, can eliminate signs of cancer in patients with early-stage chronic lymphocytic leukemia or small lymphocytic lymphoma who are at high risk of progression. About 120 participants will be randomly …

This early-stage trial tests a gene therapy for propionic acidemia, a rare genetic disorder that causes dangerous metabolic crises and organ damage. The study will enroll 9 children aged 6 months to 2 years with confirmed PCCA gene mutations. The therapy uses a harmless virus to …

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the d…

This early-stage study tests a new oral drug called onvansertib for people with chronic myelomonocytic leukemia (CMML) or related blood cancers that have returned or stopped responding to standard treatments. The drug works by blocking a protein that helps cancer cells grow. The …

This early-phase trial at Mayo Clinic is testing combinations of four drugs (dasatinib, quercetin, fisetin, and temozolomide) in 30 adults with previously treated glioma that still has residual tumor cells. The goal is to see if it's feasible to use individual patient data from b…

This study tests a procedure called rectal artery embolization (RAE) to treat bleeding from internal hemorrhoids. Doctors use imaging to guide tiny particles into the blood vessels feeding the hemorrhoids, blocking blood flow to reduce bleeding. The trial enrolls 20 adults with g…

This early-phase trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in people with metastatic breast cancer. The virus is designed to kill cancer cells and also carry an extra protein to boost the immune response. Researchers are monitoring…

This study looks at whether giving focused radiation before or after surgery works better for people with brain tumors that started elsewhere in the body. About 140 adults with one brain tumor that can be removed will be randomly assigned to get radiation either before or after s…

This early-phase trial tests a genetically modified virus (VSV-IFNβ-NIS) alone or with chemotherapy and immunotherapy drugs in people with blood cancers like multiple myeloma, acute myeloid leukemia, and lymphomas that have returned or not responded to treatment. The virus is des…

This study tests whether a lifestyle program tailored to a person's specific obesity type helps them lose more weight and keep it off. Researchers at Mayo Clinic will enroll 228 adults with obesity and give them either a standard or a personalized diet and exercise plan for 12 mo…

This study tests a new combination of drugs for people with advanced pancreatic cancer that has spread or come back. The treatment includes an experimental antibody (BMS-986340) plus immunotherapy and two chemotherapy drugs. The goal is to see if this mix is safe and shrinks tumo…

This study tests whether spironolactone, a medication that blocks aldosterone, can reduce stiffness in the aorta for people with a thoracic aortic aneurysm. About 50 adults with an enlarged aorta will receive either spironolactone or a placebo for a short time. The goal is to see…

This study tests a drug called enfortumab vedotin for people with penile cancer that has spread or cannot be removed by surgery. The drug works like a smart bomb, targeting a protein on cancer cells to deliver a toxin that kills them. About 28 adults will take part to see if the …

This early-stage trial tests a new treatment called IC19/1563 for people with certain blood cancers (like lymphoma or leukemia) that have returned or not improved after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recogn…

This study tests a new radiation method called minibeam therapy for people with skin or soft tissue tumors that have come back or spread. The treatment uses a special device to split a wide radiation beam into many tiny beams, which may reduce damage to healthy tissue. The goal i…

This phase 2 trial tests whether adding a lab-modified virus (VSV-IFNβ-NIS) to standard immunotherapy drugs (ipilimumab and nivolumab) can shrink tumors in people with advanced or metastatic clear cell kidney cancer. The virus is designed to kill cancer cells without harming norm…

This study tests a new way of giving radiation therapy for Ewing sarcoma, a rare bone and soft tissue cancer. The radiation dose is tailored to each patient's tumor size and biology, with higher doses given over a shorter time. The goal is to reduce the chance of the cancer retur…

This phase I/II trial tests whether vasodilator drugs (isosorbide mononitrate or diltiazem) can prevent blood vessel damage caused by fluoropyrimidine chemotherapy in 60 patients with gastrointestinal cancer. Researchers will monitor blood vessel reactivity using a non-invasive d…

This study tests whether a continuous glucose monitor (CGM) helps control blood sugar better than standard finger-stick checks for people with diabetes who are recovering at home through Mayo Clinic's Advanced Care at Home program. About 100 participants will use the Dexcom G6 PR…

This pilot study is testing whether the antifungal drug itraconazole is feasible and safe for people with bronchiectasis who have mold growing in their airways. Thirty participants will take itraconazole twice daily for six weeks. The study will measure how many people complete t…

This study tests whether giving the oral drug midodrine early to sepsis patients with low blood pressure can help them stop needing IV blood-pressure medications sooner. Researchers will compare standard care plus midodrine to standard care alone in 308 adults. The goal is to see…

This early-phase trial is testing whether combining a targeted radiation treatment (Y90 radioembolization) with two immunotherapy drugs (durvalumab and tremelimumab) is safe and shows promise for people with bile duct cancer that cannot be removed by surgery. The study will enrol…

This phase 2 trial tests whether giving the chemotherapy drug capecitabine in a flexible, response-based way (adaptive therapy) can better control metastatic ER-positive breast cancer. About 35 adults with advanced, hormone-resistant disease will receive doses that are adjusted b…

This study is testing whether taking three oral chemotherapy drugs together is safe and practical for patients with head and neck cancer that has returned or spread. The trial focuses on people living in rural Midwest areas, making it easier for them to participate from home. The…

This study tests whether a high-dose probiotic (De Simone formulation) can lower bile acid levels in stool and improve diarrhea in people with bile acid malabsorption. Twenty-four adults will take the probiotic or a placebo for about three weeks. Researchers will measure changes …

This phase II trial tests whether a blood test that detects HPV DNA can help doctors decide the right amount of radiation for people with HPV-positive throat cancer. About 455 participants will either have surgery or receive standard chemotherapy plus radiation, but the radiation…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This study tests whether a continuous glucose monitor (CGM) can help people with glioblastoma, a severe brain cancer, manage their blood sugar levels and potentially live longer. High blood sugar during treatment is linked to worse outcomes, often caused by steroids. The CGM devi…

This study is testing a procedure called MRI-guided cryoablation, which uses extreme cold to freeze and destroy small prostate cancer tumors. The goal is to see if this targeted approach can safely control the cancer while avoiding the side effects of surgery or radiation. About …

This study tests whether a procedure that filters a patient's blood (therapeutic plasma exchange) can help standard cancer drugs work better in people with advanced bladder or urinary tract cancer that has stopped responding to previous treatments. About 70 adults will be randoml…

This study tests whether starting plasma exchange early, rather than waiting, leads to better vision in severe optic neuritis and less disability in severe transverse myelitis. About 382 adults with these inflammatory nerve conditions will be randomly assigned to early or rescue …

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can lower vein pressure in adults with a failing Fontan circulation. About 27 participants will take the drug or a placebo for 3 months. The goal is to see if it helps the heart pump blood more ea…

This study compares two ways to perform double lung transplants: one without a heart-lung machine (off-pump) and one using a machine called VA ECMO. The goal is to see which method leads to fewer lung complications after surgery. About 228 people receiving double lung transplants…

This study tests whether a combination eye drop (Rocklatan) works better than a standard drop (Latanoprost) at lowering eye pressure over a full 24-hour period in adults with open-angle glaucoma or ocular hypertension. About 30 participants will use one drop in each eye nightly. …

This Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …

This early study tests whether a liquid form of the drug avacopan can be safely given through a feeding tube to critically ill patients with ANCA vasculitis who have severe lung bleeding and need a ventilator. The main goal is to measure how the drug levels change in the blood ov…

This study compares a reduced radiation dose (3 treatments) against the standard 12 treatments for people with indolent (slow-growing) non-Hodgkin lymphoma. The goal is to see if the shorter course is safer and still works well at controlling the cancer. About 112 adults with cer…

This early-phase trial tests a drug called WSD0628, which blocks a DNA repair protein, given together with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after previous treatment. The study aims to find the safest dose and see if the co…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor (meningioma) that cannot be removed by surgery and has continued to grow after radiation therapy. The drug is given through a vein and targets tumor cells to stop them from growing. The tri…

This early-phase trial at Mayo Clinic is testing whether it is possible to transplant a bladder along with a kidney in people who have kidney failure due to bladder problems. Up to 30 participants will receive both organs from a deceased donor. The goal is to see if the bladder w…

This phase I trial is testing whether giving a single, high dose of radiation (radiosurgery) before surgery can help control high grade glioma, a fast-growing brain tumor. About 28 adults with newly diagnosed or previously biopsied high grade glioma will receive radiosurgery foll…

This study is for people with stage I to III esophageal or gastroesophageal junction cancer. It tests whether giving a shorter, higher-dose radiation treatment along with chemotherapy (FOLFOX) before surgery can kill more cancer cells. The goal is to see if this approach leads to…

This study looks at the best timing for combining targeted radiation (SBRT) with hormone therapy in men whose prostate cancer has returned and spread. It also tests if radiation to the pelvis can stop cancer from spreading further. About 532 men with recurrent, hormone-sensitive …

This study tests a new approach for people with advanced liver cancer that cannot be surgically removed. Participants receive radiation followed by an injection of their own specially trained immune cells (dendritic cells), a pneumonia vaccine to boost immunity, and immunotherapy…

This study looks at whether having a specially trained community paramedic visit people with heart failure at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. The goal is to see if this app…

This study looks at how drinking whole-fat milk changes heart disease risk factors in adults with metabolic syndrome. Researchers will measure cholesterol, blood sugar, and blood vessel function in 40 participants. The goal is to see if whole-fat dairy is helpful or harmful for p…

This study tests whether adding high-dose vitamin C (ascorbic acid) to standard chemotherapy can help kill cancer cells better in people with certain blood cancers that have returned or not responded to treatment. It includes adults with relapsed or refractory lymphoma, clonal cy…

This study tests whether giving radiation in one session or several sessions works better for people whose cancer has spread to the brain. About 90 adults with brain tumors between 2 and 4 cm will be randomly assigned to one of two radiation approaches. The goal is to see which m…

This study tests whether obinutuzumab, a drug used for certain blood cancers, can help people with fibrillary glomerulonephritis (FGN), a rare kidney condition that causes protein leakage and can lead to kidney failure. Twenty adults with confirmed FGN will receive the drug intra…

This phase II trial at Mayo Clinic is testing a special type of radiation called grid therapy combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has stopped responding to treatment. Grid therapy delivers high doses of radiation to small …

This study tests a new way to treat stomach cancer that has spread to the lining of the belly. Doctors will use a robot to remove visible cancer and then deliver heated chemotherapy directly into the abdomen during surgery. The goal is to help patients recover faster and have few…

This phase 2 trial tests a new drug called GI-102, alone or with the immunotherapy pembrolizumab, given before surgery to people with recurrent or progressive glioblastoma (a fast-growing brain cancer). The goal is to see if these drugs can increase cancer-fighting immune cells i…

This study tests a new treatment for ovarian cancer that has returned after initial therapy. It combines a personalized vaccine made from a patient's own white blood cells (FRαDC) with an immunotherapy drug (pembrolizumab) to help the immune system attack cancer cells. The trial …

This study tests two diabetes medications, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 with this type of diabetes will take one of the drugs,…

This early-stage trial tests whether stem cells taken from fat tissue can be safely injected into the brain during surgery for recurrent glioblastoma. The stem cells are meant to attack remaining tumor cells and make them more sensitive to chemotherapy. About 20 adults whose brai…

This early-stage trial tests a custom-made vaccine for recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous growths keep coming back in the throat. The vaccine is made from each patient's own immune cells and designed to target the virus that causes RR…

This study tests a cryotherapy spray (Tru-Freeze) to treat gastric antral vascular ectasia (GAVE), a condition that causes bleeding in the stomach. Researchers will measure changes in hemoglobin levels and blood transfusion needs in 50 adults over 6 months. The goal is to see if …

This phase II trial at Mayo Clinic is testing whether longer maintenance therapy with daratumumab can improve survival for people with AL amyloidosis. About 96 adults who have already responded to initial daratumumab treatment will be randomly assigned to shorter or longer mainte…

This phase 2 trial is testing whether turkey tail mushroom extract can slow or shrink estrogen receptor-positive, HER2-negative breast cancer in post-menopausal women. Forty participants will take the supplement between diagnosis and surgery, and researchers will measure changes …

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This study tests a combination of three drugs (acalabrutinib, venetoclax, and durvalumab) in people with Richter transformation, a rare and fast-growing lymphoma that develops from chronic lymphocytic leukemia (CLL). The goal is to control the disease and improve survival. About …

This study looks at whether older kidney transplant patients (55 and up) can safely stop taking one of their standard immunosuppressant drugs, mycophenolate mofetil (MMF). About 350 participants will be randomly assigned to either continue MMF or stop it, while staying on other m…

This early-stage trial is testing a new drug called MTI-301 in 42 adults with advanced solid cancers that have spread or can't be removed and haven't responded to standard treatments. The drug blocks an enzyme called SCD1, which some cancers use to grow and spread. The main goals…

This early-phase study tests a new treatment for people with ovarian cancer that has returned or is resistant to standard platinum chemotherapy. The treatment uses a patient's own immune cells (T cells), which are trained in a lab to recognize and attack a protein called MUC1 fou…

This study compares three treatments for pelvic sarcomas (cancers in the pelvic bone): carbon ion therapy, surgery (often with radiation), and proton therapy alone. Researchers want to see which approach gives patients better quality of life and controls the cancer best. About 72…

This study tests whether matching specific weight-loss medications (Wegovy, Contrave, or Qsymia) to a person's obesity type (e.g., 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. One hundred adults with bipolar or schizoaffective disor…

This program offers the drug ibudilast (MN-166) to people with ALS who cannot join other clinical trials. Participants take the drug by mouth, starting at a lower dose and increasing. The goal is to see if ibudilast can slow the progression of ALS. The program also collects blood…

This study at Mayo Clinic looks at how often high blood pressure happens in patients with certain blood cancers (like CLL or lymphoma) who are taking a type of targeted drug called a BTK inhibitor. It will track 100 patients over a year to see if managing blood pressure well can …

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure and self…

This early-phase trial is testing whether adding tumor treatment fields (TTF) — a device that delivers low-intensity electric fields to disrupt cancer cell division — to a three-drug chemotherapy regimen can safely control metastatic pancreatic cancer. About 40 adults with pancre…

This early-phase trial tests a new treatment for glioblastoma that has come back or is getting worse. The therapy combines a drug called 5-ALA with focused ultrasound waves to target and kill tumor cells without surgery. Eight adults with recurrent glioblastoma will receive the t…

This phase II trial is testing whether giving a combination of two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more tumor cells in people with stage IB to IIIB non-small cell lung cancer. About 60 participants will receive the drugs intravenously, then …

This study tests whether stimulating the vagus nerve with a magnet, while doing walking exercises, can help people who had a stroke at least 6 months ago walk better. Twenty participants will do 6 weeks of in-clinic therapy followed by 6 weeks of home exercises. The main goals ar…

This study tests whether using artificial intelligence to guide a heart pacing procedure (left bundle branch area pacing) can improve heart function more than the standard approach. Researchers will compare AI-guided pacing to conventional pacing in 224 adults with heart failure.…

This early-phase trial is testing a new type of CAR T-cell therapy called MC10029 for people with B-cell blood cancers that have returned or not responded to treatment. The therapy involves taking a patient's own immune cells, modifying them in the lab to target a protein called …

This study tests whether giving a targeted drug (enfortumab vedotin) plus an immunotherapy (pembrolizumab) before surgery to remove part or all of the bladder can improve outcomes for people with advanced bladder or urinary tract cancer. About 75 adults with cancer that has sprea…

This study tests a low dose of the drug osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and can help balance cortisol levels. Participants will take the pill and b…

This Phase II trial tests a drug called PLX038 in 43 people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum-based chemotherapy. The drug works by blocking enzymes that help cancer cells grow. Researchers will check if it shrinks tumors a…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests whether offering financial rewards to Alaska Native adults and their family members helps them quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive program or standard support. Success is measured by a saliva test…

This phase II trial at Mayo Clinic is testing whether adding dasatinib and quercetin to standard CAR-T therapy can improve outcomes for people with multiple myeloma that has returned or not responded to prior treatments. The study will enroll 44 adults who have already tried at l…

This study tests whether precisely targeted radiation (SBRT) can treat a few growing cancer spots in patients with metastatic breast cancer, allowing them to stay on their current systemic therapy instead of switching to a new drug. Researchers will also look at whether circulati…

This phase II trial is testing different doses and schedules of belantamab mafodotin, a drug that delivers chemotherapy directly to myeloma cells. The goal is to find a way to give the drug that causes fewer severe eye problems while still controlling the cancer. About 62 adults …

This study tests whether stem cells from donated bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Up to 75 participants will receive the cells through an IV or directly into the kidney arteries, with repeat doses allow…

This pilot study tests whether a mild electrical current applied to the scalp (called tDCS) can reduce seizures in people with epilepsy. Thirty adults with hard-to-control epilepsy will use a head device for 30 minutes daily over two months. Researchers will track seizure counts …

This study tests whether giving two drugs, golcadomide and rituximab, before CAR-T cell therapy can help control aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to prior treatment. The goal is to keep the disease in check so more patients can qualify for…

This early-stage trial is testing the safety and best dose of the drug decitabine when added to standard surgery, radiation, and chemotherapy for people with HPV-negative head and neck cancer that can be surgically removed. Decitabine may help make cancer cells more sensitive to …

This study tests whether a precise, short-course radiation method (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for men whose prostate cancer has come back or spread to a few spots after surgery. About 118 participants will receive o…

This study tests two immunotherapy drugs, efineptakin alfa and pembrolizumab, in people whose glioblastoma (a type of brain cancer) has returned after standard treatment. The goal is to see if this combination can help the immune system fight the tumor and improve survival. About…

This study tests whether training the muscles used to breathe in can improve exercise capacity, quality of life, and short-term outcomes in people who have had a lung transplant. Thirty participants will use a device called POWERBreathe Plus® along with standard rehab. The goal i…

This study tests whether adding low-intensity shockwave therapy to standard Xiaflex injections can better reduce penile curvature in men with Peyronie's disease. Sixty participants will receive both treatments or Xiaflex alone. The goal is to improve sexual function and reduce bo…

This study tests whether a modified Mediterranean diet can prevent weight gain, improve heart health, and reduce fatty liver disease in people who have had a liver transplant. Researchers will enroll 80 adults and track changes in weight and body fat. The diet limits salt and alc…

This early-stage trial is testing the safety of adding venetoclax to standard multiple myeloma treatments for people whose cancer cells have a specific genetic change called t(11;14). The study will enroll 100 participants and try different drug combinations to find the best dose…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This phase II trial tests a treatment called HIPEC, where heated chemotherapy drugs are placed directly into the abdomen during surgery. It is for people with pancreatic cancer that has spread to the lining of the abdomen. The study will enroll 40 participants to see if this appr…

This study compares placing one versus two small stents in the gallbladder to prevent repeat symptoms like pain and infection in people who cannot have their gallbladder removed. About 30 adults will be randomly assigned to get one or two stents during an endoscopic procedure. Re…

This phase II trial is testing whether giving a shorter, stronger course of radiation before breast surgery is safer and works better than giving it after surgery for people with non-metastatic breast cancer. The study will enroll 120 participants with different breast cancer typ…

This study offers boys aged 0-17 the chance to freeze testicular tissue before undergoing treatments like chemotherapy or radiation that could cause permanent infertility. The tissue is stored for potential future use to achieve pregnancy. Researchers will track whether transplan…

This study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blo…

This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size b…

This study looks at whether taking melatonin for 12 weeks can help lower blood pressure in women going through menopause who already have high blood pressure. Researchers will measure nighttime blood pressure and check for changes in stress markers. The goal is to find a simple, …

This study tests whether real-time video consultations with a neonatologist (a baby doctor) can improve outcomes for at-risk newborns delivered in community hospitals. About 947 newborns and their doctors will take part. The main goal is to see if this approach lowers the number …

This phase 2 trial is testing whether giving fewer hormone therapy drugs (abiraterone acetate and GnRH analogs) along with radiation can work as well as longer treatment for high-risk prostate cancer that has spread a little. The goal is to reduce side effects while still control…

This phase 3 trial tests whether tadalafil, a drug that relaxes blood vessels, can improve blood flow and protect organs in adults who had Fontan surgery for a single-ventricle heart defect. About 80 participants will receive either tadalafil or a placebo daily for a year. Resear…

This study tests whether repeatedly injecting a sterile saltwater solution into the womb can help fetuses with severe kidney problems grow their lungs. Normally, these babies have too little amniotic fluid, which prevents the lungs from developing. The goal is to see if this proc…

This trial tests whether wrapping the nerves around the prostate with a special tissue allograft during surgery can reduce erectile dysfunction and incontinence. 25 men with localized prostate cancer will receive the wrap during nerve-sparing prostate removal. The study focuses o…

This study tests a program called RETAIN that helps people who are injured or ill stay at work or return to work. The program assigns a case manager to coordinate care and connect workers with job support services. About 1,000 adults in Minnesota who are employed or recently unem…

This study looks at whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors manage diabetes more safely. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to reduce dangerous high and low bloo…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This early-stage trial is testing a new drug called Q702 in people with various blood cancers and related disorders that have not responded to standard treatments. Q702 is designed to help the immune system attack cancer cells and help the bone marrow make healthy blood cells. Th…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving a beta-lactam antibiotic. The goal is to see which combination helps patients leave the hospital sooner and reduces the need f…

This study tests whether the Mayo Clinic Diet helps people with obesity lose at least 5% of their body weight compared to standard advice. Two hundred fifty adults aged 18–64 with a BMI of 25 or higher will follow the diet using a book, an app, or both for 12 weeks. Researchers w…

This study tests whether the drug Entresto (sacubitril-valsartan) can improve heart structure and function in adults with congenital heart disease. 45 participants will take either Entresto or a placebo for 52 weeks. Researchers will measure heart changes, blood markers, and qual…

This phase 2 trial tests whether adding avacopan (a pill that blocks inflammation) to low-dose steroids can help people with crescentic IgA nephropathy, a severe kidney condition. Sixteen adults with high-risk features will be randomly assigned to receive either avacopan plus low…

This phase II trial tests whether a custom-made vaccine (FRαDCs) can help prevent or delay cancer from coming back in people with stage III or IV ovarian, fallopian tube, or primary peritoneal cancer. The vaccine is made from a patient's own white blood cells and trained to targe…

This study tests a drug called daratumumab in 40 people with a rare kidney condition called PGNMID, where abnormal proteins damage the kidneys. Participants receive weekly injections for 8 weeks, then every two weeks for another 8 weeks. The goal is to see if the drug can reduce …

This phase II trial is testing whether giving 5 cycles of the radioactive drug Lu-177 PSMA-617 works as well as the standard 6 cycles for men with metastatic castration-resistant prostate cancer. The goal is to see if a shorter treatment course can control the cancer just as effe…

This Mayo Clinic trial is testing a procedure called MRI-guided TULSA for men with low to intermediate grade prostate cancer. It uses high-energy sound waves guided by MRI to precisely destroy tumor cells, aiming to avoid surgery or radiation. The study will enroll 100 men aged 4…

This study compares two surgical approaches for hip dysplasia: the standard periacetabular osteotomy (PAO) alone versus PAO combined with hip arthroscopy. Researchers will enroll 106 people aged 15-55 with mild or no arthritis. The goal is to see if adding arthroscopy leads to be…

This study tests whether metformin, a diabetes drug, and wearable activity trackers can help prevent memory and thinking problems after cranial radiation for brain tumors. About 100 patients will take metformin or not, and complete remote cognitive tests and wear a device. The ma…

This study at Mayo Clinic is testing whether an artificial intelligence (AI) program can detect heart transplant rejection using standard tests like ECG and ultrasound. Researchers will enroll 500 heart transplant patients and compare the AI's findings to biopsy results. If it wo…

This study tests whether a special PET scan using GA-68 PSMA-11 can tell the difference between a returning brain tumor and changes caused by previous treatment. About 25 adults with grade 3 or 4 glioma who are already scheduled for surgery will receive the scan beforehand. If su…

This study tests whether a special PET scan (FET PET/CT) can better locate small pituitary tumors that cause Cushing disease. About 50 adults with confirmed Cushing disease who are scheduled for pituitary surgery will receive the scan before their operation. The goal is to see if…

This early study at Mayo Clinic is testing whether a new 3D ultrasound technique can better tell if lymph nodes under the arm contain cancer in people with breast cancer. About 55 adults who already need a lymph node biopsy or have a clip placed will get both standard 2D and the …

This study is testing whether an ultrasound-guided core needle biopsy can accurately determine the stage of bladder cancer. Researchers will compare the biopsy results with the final stage found during standard surgery. The goal is to see if this less invasive method can be a rel…

This study explores whether an artificial intelligence (AI) program can accurately identify endometrial cancer or precancerous changes by analyzing standard transvaginal ultrasound images. Researchers will compare the AI's predictions with results from endometrial biopsies in 300…

This study at Mayo Clinic is testing whether a special ultrasound technique called vibroelastography can better assess erectile function recovery in men after prostate cancer surgery. The technique measures tissue stiffness, which may indicate scarring. Ten men with low-risk pros…

This study tests a new 3D ultrasound imaging method to see if it can better diagnose breast masses. Researchers will compare the new 3D images to standard 2D ultrasound in 125 adult women with solid breast lesions. The goal is to improve accuracy and reduce unnecessary biopsies.

This trial is testing a new, less invasive way to detect Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a capsule attached to a string that expands into a sponge in the stomach, collecting cells as it is pulled back up. The goal is to se…

This study is testing whether new tests on blood, stool, and fluid from pancreatic cysts can detect early signs of cancer. Researchers will collect samples from 800 people with pancreatic cysts and follow them for up to 3 years. The goal is to find better ways to tell which cysts…

This study tests whether a smartphone app that analyzes voice patterns can help diagnose and monitor myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers will compare voice samples from 40 people with ME/CFS and those without to find unique voice signatures. T…

This study is testing a new stool DNA test (mt-sDNA 2.0) to see how well it detects colorectal cancer or advanced growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 950 participants and compare…

This study is testing whether combining AI-powered electrocardiograms (ECGs) with focused heart ultrasound can effectively screen for heart disease in everyday community settings. Researchers at Mayo Clinic plan to enroll 19,300 people, including teens, adults, and pregnant women…

This study at Mayo Clinic is testing a new, non-invasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare the ultrasound results with standard tests like ankle-brachial index and CT scans. The study includes 400 pe…

This study tests whether an artificial intelligence (AI) program can help doctors figure out what is causing a narrowing in the bile duct. About 100 adults who are already scheduled for a special scope procedure will take part. The AI analyzes video from the scope in real time to…

This phase 2 trial at Mayo Clinic is testing whether adding an amino acid PET/CT scan (using a radioactive tracer called FDOPA) to standard imaging can improve clinical management for people with brain tumors. The study will enroll 47 adults with brain tumors to see if the extra …

This study is testing whether a new type of CT scanner, called photon-counting detector CT (PCD-CT), can determine how far rectal cancer has grown as accurately as MRI. About 200 adults with rectal cancer will get both a standard MRI and the new CT scan, and doctors will compare …

This study aims to see if a special MRI done during exercise can help doctors better diagnose and predict outcomes in people with a type of heart failure called HFpEF. Researchers will enroll 400 adults, including those with HFpEF, those with shortness of breath from other causes…

This study aims to develop a screening test that uses a vaginal swab and blood sample to find DNA markers for endometrial, ovarian, and cervical cancers. Researchers at Mayo Clinic will enroll over 3,000 women to see if the test can accurately detect these cancers at an early sta…

This study tests whether artificial intelligence can help doctors interpret echocardiograms (heart ultrasounds) more accurately and quickly. Researchers at Mayo Clinic will deploy AI algorithms to flag signs of genetic cardiomyopathy, ischemic heart disease, and cardiac amyloidos…

This study tests whether a combined PET/MRI scan using a radioactive tracer can accurately detect if prostate cancer has spread to nearby lymph nodes. Fifty men with high-risk localized prostate cancer will receive the scan before their planned prostate removal surgery. The resul…

This study tests a new, less invasive way to look for Barrett's esophagus, a condition that can lead to cancer. Instead of a traditional endoscopy, a capsule attached to a string is swallowed to take pictures of the esophagus. The goal is to see if this method works well for dete…

This phase 3 trial tests whether a fluorescent dye called pafolacianine (Cytalux) can help surgeons see and remove solid tumors in children and teens during surgery. The dye targets cancer cells and lights up under a special near-infrared camera. Up to 20 participants aged 6 mont…

This study tests a new ultrasound method to measure bladder function without invasive procedures. Researchers at Mayo Clinic will compare the new technique to standard tests in adults with bladder issues or enlarged prostate. The goal is to see if this painless approach can accur…

This study tests a new imaging method called vibro-acoustography (VA) to find and tell apart harmless and cancerous thyroid nodules. Researchers at Mayo Clinic will compare VA images to standard ultrasound in 650 people aged 8 and older who are at risk for thyroid cancer. The goa…

This study compares a new ultrasound technique (shear-wave elastography) to standard breathing tests for measuring diaphragm muscle forces. Researchers will test 24 healthy adults during various breathing maneuvers and nerve stimulation. The goal is to see if the ultrasound metho…

This study tests whether a short course of hormone therapy (relugolix) can make PSMA PET/CT scans better at finding prostate cancer that has spread to lymph nodes. About 30 men with high-risk prostate cancer will get the hormone drug for 5, 10, or 15 days before their scan. The g…

This early study tests a special PET/MRI scan using a radioactive tracer called FET to find small pituitary tumors that don't show up on regular MRI. The goal is to improve detection of these hormone-producing tumors in 5 adults with confirmed biochemical disease. If the scan wor…

This study aims to find normal values for a new blood and urine test that might detect cancer early. Researchers at Mayo Clinic will collect samples from 10,000 adults without known cancer and review their medical records. The goal is to set a baseline for future cancer screening…

This study at Mayo Clinic is testing whether artificial intelligence can help standard electrocardiograms (ECGs) detect two common heart valve problems: aortic stenosis and diastolic dysfunction. Researchers will enroll 2000 adults aged 60 and older who are already scheduled for …

This study tests a new blood and urine test that looks for DNA markers to detect cancer early and identify where it started. Researchers at Mayo Clinic will enroll about 6,150 people, including those with and without cancer. The goal is to see if these tests can accurately find c…

This study is testing a new type of PET/CT scan (18F-TFB) to see if it can find thyroid cancer that has come back or spread better than the current standard scan. About 24 adults with papillary or follicular thyroid cancer will get both scans to compare results. The goal is to im…

This early-phase study tests whether a special PET scan tracer, Ga68-FAPI-46, can detect early fibrosis (scarring) in the small bowel of people with Crohn's disease. About 45 participants will be divided into those with known strictures and those without, to compare scan results.…

This study tests whether a dye called indocyanine green can help surgeons see if any cancer remains after removing a sarcoma. About 50 adults with bone or soft tissue sarcoma will receive the dye during surgery, and the surgeon will check for glowing areas that might indicate lef…

This study explores whether a lung ultrasound can safely detect rejection or infection in lung transplant recipients who have no symptoms. Currently, patients need an invasive bronchoscopy with biopsy to check for rejection. If ultrasound works, it could offer a faster, safer, an…

Researchers at Mayo Clinic are testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well a patient responds to treatment. The study will involve 550 adult volunteers with suspicious breast masses or biopsy-confirmed breast cancer. Pa…

This study tests a new ultrasound technique called microvessel imaging (UMI) to see if it can better detect small blood vessels in ovarian lesions, which may indicate cancer. Forty women scheduled for ovarian surgery will receive both standard and UMI ultrasounds. Doctors will co…

This study is testing a new, less invasive way to diagnose Barrett's esophagus and esophageal cancer using a sponge capsule that patients swallow. The sponge collects cells from the esophagus, which are then analyzed for signs of disease. Researchers will enroll 1,550 people aged…

This study explores whether a high-resolution ultrasound can better monitor healing in chronic wounds like diabetic foot ulcers. Ten participants will have their wounds scanned and biopsied to see if the ultrasound matches standard assessments. If it works, it could offer a painl…

This study tests a new ultrasound method to help surgeons find pituitary tumors during surgery. Researchers will compare ultrasound images with MRI scans to see if the new technique can better identify tumors in people with Cushing's disease and other pituitary tumors. About 110 …

This study tests a new MRI technique to measure how cerebrospinal fluid flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understanding of…

This study at Mayo Clinic is testing whether voice recordings can help detect pulmonary hypertension, a serious condition affecting the heart and lungs. Researchers will collect voice samples from 7,000 people already scheduled for an echocardiogram. The goal is to see if voice p…

This study at Mayo Clinic is testing whether a special MRI technique called magnetic resonance elastography (MRE) can measure stiffness in the hearts of people with cardiac amyloidosis, a condition where abnormal proteins build up and stiffen the heart. Researchers will enroll 20…

This study tests whether a special ultrasound technique (SHAPE) can detect high blood pressure in the liver without using a needle. Portal hypertension is a serious condition that can lead to severe liver damage and death. The standard test requires inserting a catheter into a ve…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This study tests whether molecular breast imaging (MBI) can guide biopsies for breast abnormalities that are hard to see on ultrasound or mammography. About 70 women with a prior MBI finding that turned out to be benign will undergo a new MBI-guided biopsy procedure. The goal is …

This study tests a special PET scan that uses a radioactive tracer called 68Ga-FAPI-46 to highlight pancreatic cancer cells. The goal is to see if this scan can find tumors more accurately than current methods. About 130 adults with early-stage pancreatic cancer will get the scan…

This Mayo Clinic study tests if a simple sticker (surface EMG) on the neck can measure how well people with Eosinophilic Esophagitis swallow food. Researchers will compare the sticker's readings to a standard scope exam. The study enrolls 30 adults — both healthy volunteers and E…

This study tests whether taking low-dose aspirin can lower inflammation and reduce the risk of breast cancer in women who have had a baby within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes. The…

This study tests if a nerve block called a stellate ganglion block can lower the chance of developing atrial fibrillation (a fast, irregular heartbeat) after heart surgery. About 220 adults having valve or bypass surgery will receive either the nerve block or a placebo. The goal …

This study offers free home-based fecal immunochemical tests (FIT) and education to Black and underserved communities in Phoenix. The goal is to increase colorectal cancer screening and reduce disparities. About 450 people aged 45 and older who haven't had a recent colonoscopy or…

This study tests whether a 6-week home exercise program delivered through a smartphone app can improve balance, muscle strength, and confidence in cardiac rehabilitation patients. Researchers will enroll 128 participants to see if the program reduces fall risk and improves qualit…

This study tests whether giving magnesium through a vein can prevent or reduce bladder spasms after urologic surgery. About 120 adults having bladder procedures will receive either magnesium or a placebo. Researchers will compare how many people in each group have spasms and how …

This study tests whether tamsulosin, a drug often used for prostate problems, can reduce the risk and length of time patients have trouble urinating after spine surgery. Twenty adults having certain types of spine surgery will take either tamsulosin or a placebo starting five day…

This study tests a new augmented reality system called LUMENA that helps doctors guide needles during MRI scans of the liver. Twenty adults having a liver biopsy or tumor ablation will try the device. The goal is to see if it is safe and works well enough to use in most procedure…

This study at Mayo Clinic compares a new electronic massager called EMMA to a standard massage from a licensed therapist. Twenty adults will receive both types of back massage and report which they prefer. The goal is to see if the robot is practical and satisfying enough to use …

This pilot study tests whether a virtual mindfulness-based stress reduction (MBSR) program can improve mental health in cancer patients living in underserved or rural parts of Minnesota. About 45 participants will take the online course and report changes in stress, anxiety, and …

This study tests whether a tailored exercise program before standard surgery and radiotherapy helps people with soft tissue sarcoma recover better. Thirty adults with deep soft tissue sarcoma of the lower leg will either receive the prehabilitation program or standard care. The s…

This study follows 350 people with stage III-IV melanoma during their first two years after diagnosis to understand how their quality of life and mental health change. It also tests whether cognitive behavioral therapy for cancer distress (CBT-C) can help reduce stress, improve s…

This study tests whether an AI-assisted program called 'Reflections: My Story' is practical and acceptable for adults with serious illness. The program helps patients create a personal legacy, guided by a trained clinician. Researchers will enroll 20 participants to see if they f…

This phase III trial tests whether an automated planning tool called RapidPlan can match or beat human-driven planning for prostate cancer radiation therapy. About 108 men with prostate cancer will be randomly assigned to one of two planning methods. The goal is to see if the aut…

This study tests whether Reishi mushroom extract can reduce fatigue and joint pain in breast cancer patients taking aromatase inhibitors. About 80 women with moderate to severe fatigue will receive either the mushroom extract or a placebo for 8 weeks. The goal is to see if this n…

This study tests whether numbing certain scalp nerves can stop migraine pain quickly and prevent future attacks. Researchers will compare blocking two nerves versus ten nerves in 60 people who have frequent migraines. The goal is to see if this approach can eliminate headache pai…

This study tests whether a community-based exercise program can improve memory, attention, and brain health in women who have had breast cancer. About 160 survivors, aged 50 and older, will either take part in aerobic exercise or health education sessions. The goal is to see if p…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study compares two common injection treatments for chronic mid-back pain: the erector spinae plane (ESP) block and trigger point injection (TPI). About 76 adults with pain lasting at least three months will be randomly assigned to one treatment. Researchers will track pain l…

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study tests whether group sessions that teach stress management skills can lower distress in people with cancer. About 400 adults with cancer who have moderate distress will take part. The program helps patients recognize and reduce stress in their daily lives.

This pilot study from the Mayo Clinic tests whether a simple breathing technique—diaphragmatic breathing—can reduce bloating and stomach distension. Thirty-five adults referred for breath testing will learn the technique in a 30-minute session and practice it for 5-10 minutes twi…

This pilot study tests whether tirzepatide, a medication used for diabetes and weight loss, can reduce the frequency and severity of hot flashes in postmenopausal women with obesity. Researchers will also measure markers of biological aging, like cellular senescence and epigeneti…

This study tests whether a smartphone app called Smart Symptom Tracking ALEX can help young adults (ages 18-44) track gastrointestinal symptoms better than traditional paper logs. The app uses artificial intelligence to provide reminders, coaching, and education. Researchers want…

This Mayo Clinic pilot study tests whether breathing controlled levels of oxygen or carbon dioxide can help people with Long COVID brain fog. 45 participants will try short sessions of these gas mixtures and report changes in brain fog, fatigue, and blood flow. The goal is to see…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This pilot study tests whether a wearable EEG headband (MUSE-S) that guides meditation can help breast cancer survivors who struggle with anxiety and insomnia. Twenty participants will use the headband at home, and researchers will track how often they use it and whether it impro…

This study tests whether virtual group therapy based on Acceptance and Commitment Therapy (ACT) and compassion practices can improve psychological well-being in cancer patients. Researchers at Mayo Clinic will enroll 200 adults with cancer who are experiencing stress. Participant…

This study tests whether acupressure, a non-invasive technique using finger pressure on specific body points, can reduce anxiety in cancer patients receiving chemotherapy. Researchers will compare real acupressure to a sham (placebo) version in 78 adults with cancer. The goal is …

This study tests whether a special low-calorie, plant-based diet that mimics fasting can reduce common side effects like rash, diarrhea, and fatigue in cancer patients receiving immunotherapy. Ten adults with advanced cancer will follow the diet and report their symptoms. The goa…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study looks at how a low-sodium version of the drug oxybate affects total sleep time in adults with idiopathic hypersomnia, a condition causing excessive sleepiness. About 30 participants will use sleep trackers and special earbuds to measure sleep. The goal is to see if the…

This study aims to bring pulmonary rehabilitation—a proven treatment for COPD—to people living in rural areas who currently have no access to it. Researchers will test whether a home-based program can improve breathing, fatigue, and emotional well-being. About 306 adults aged 40 …

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve pain and numbness caused by chemotherapy. About 300 participants (survivors and their caregivers) will use the app at home. The goal is to reduc…

This Mayo Clinic study tests whether using a virtual reality (VR) headset can reduce pain and the need for opioid painkillers in 100 adults hospitalized with a broken bone. Participants will use a VR program while in the hospital, and researchers will track their pain medication …

This study at Mayo Clinic tests whether using a CalmiGo device—a small inhaler-like tool that guides slow breathing and grounding—can improve blood vessel function and reduce heart disease risk in people recovering from a heart attack. One hundred adults in cardiac rehab will eit…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study compares a robotic massage device (EMMA) to a human massage therapist for relieving lower back pain. Researchers want to see if people find the robot acceptable and if it's practical to use. About 40 adults with lower back pain will take part.

This study tests whether structured breathing exercises can reduce burnout, anxiety, depression, and sleep problems in healthcare workers. Forty professionals from four Mayo Clinic sites will use a mobile app for breathing sessions of 15 to 36 minutes. The main goal is to see if …

This study compares two treatments for hand and wrist osteoarthritis pain: low-dose radiotherapy and corticosteroid injections. Researchers want to see which works better at reducing pain and improving hand function. The study involves 165 adults aged 50 and older with moderate t…

This study compares giving cancer treatment at home versus in the clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves overall experience. About 220 participants will be randomly assigned to receive their reg…

This study tests if a gentle electrical pulse to the ear (auricular transcutaneous vagus nerve stimulation) can reduce chronic dizziness in people with Persistent Postural-Perceptual Dizziness (PPPD). Sixty adults aged 18-75 with dizziness lasting at least 3 months will use the d…

This early study tests whether a weekly shot of low-dose growth hormone can improve symptoms like nausea, fullness, and belly pain in people with gastroparesis (stomach paralysis) that hasn't responded to standard treatments. Ten adults will receive the drug for 12 weeks, and res…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain control and lower the risk of opioid misuse. About 660 adults with cancer-rel…

This study tests whether a home-based mindfulness exercise program, combined with health coaching over the phone, can reduce fatigue and improve quality of life in people aged 65 and older with multiple myeloma. Participants will do gentle physical activities at home while being …

This study tests whether health coaching before a lung transplant can improve emotional health and self-management. 230 adults waiting for a lung transplant will receive up to 12 coaching phone calls over 12-16 weeks, or standard care. Researchers will measure changes in quality …

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study tests whether giving chemotherapy directly into the bladder at home is safe and acceptable for people with non-muscle invasive bladder cancer. About 40 participants will receive their usual medications—such as BCG, gemcitabine, docetaxel, or mitomycin—at home instead o…

This study tests whether eating a whole food plant-based diet for 8 weeks can reduce daytime sleepiness and improve sleep apnea severity. Researchers will measure changes using a sleepiness questionnaire and a home sleep test. The study involves 40 adults with sleep apnea who are…

This study tests whether two radiation treatments with advanced targeting cause fewer side effects than the usual five treatments for men with localized prostate cancer. About 144 participants will receive either the shorter or standard approach, and researchers will track qualit…

This study tests a virtual art therapy program for teens and young adults who have had cancer. The goal is to see if it helps with anxiety, depression, and stress. About 30 participants aged 10-25 will take part in online art sessions. The program aims to improve emotional well-b…

This study tests a two-day cognitive behavioral therapy (CBT) program to help breast cancer survivors manage joint and muscle pain caused by their hormone-blocking medication. The goal is to reduce pain, improve quality of life, and help patients stay on their prescribed treatmen…

This study tests whether training the muscles you use to breathe in can help midlife women with hot flashes, sleep problems, and blood pressure. Thirty women aged 45-60 will use a breathing device daily for 6 weeks. Researchers will measure changes in hot flash frequency, sleep q…

This study looks at whether adding a simple saltwater rinse (saline irrigation) through a chest tube can improve how well the standard medication clears a serious lung infection called empyema. About 60 adults with this infection will receive either standard treatment alone or st…

This Phase III trial tests whether American ginseng can reduce fatigue in 160 cancer patients. Fatigue is a common and tough side effect of cancer and its treatment. Participants will take either ginseng or a placebo, and researchers will measure changes in fatigue levels over ti…

This study compares giving standard prostate cancer treatment at home versus in a clinic for Black men with advanced or metastatic prostate cancer. The goal is to see if home treatment improves patient satisfaction, safety, and reduces stress. Thirty-eight participants will recei…

This study tests whether a headband that uses sound waves (acoustic resonance therapy) can improve sleep quality in people with moderate to severe chronic insomnia. It compares the headband to a standard behavioral therapy (CBT-I) over 6 weeks. About 60 adults will participate to…

This pilot study tests whether two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes occur after an epidural needle accidentally punctures the spinal lining during labor. The study will enroll 18 postpartum women with this type of headache. The goal…

This study tests whether a 12-week home-based pulmonary rehabilitation program, combined with health coaching, can improve quality of life and physical activity in people with fibrotic interstitial lung disease. Participants will do daily breathing exercises, balance walks, and m…

This study tests whether an advanced balance perturbation training program can help warfighters with lower limb trauma—such as amputations or limb salvage—recover better. Researchers want to see if it increases weight-bearing on the injured limb and reduces stumbles and falls. Th…

This study tests whether removing a Dupuytren's cord during trigger finger surgery leads to less scarring and better hand function. Fifty adults with both conditions will be randomly assigned to have the cord removed or simply cut. Researchers will measure scar quality using two …

This early-phase trial at Mayo Clinic is testing whether eating magnesium-rich foods and applying a magnesium lotion can help keep magnesium levels healthy in people with lymphoma. The study will enroll 60 adults who have or had lymphoma. Researchers will also check for side effe…

This study tests whether a low dose of steroid injected into the knee works as well as the standard dose for reducing pain and improving function in obese people with knee arthritis. Forty participants will receive either a low or standard dose and report their pain levels and da…

This phase 2 trial tests whether pyridostigmine, a drug that affects nerve signals, can reduce symptoms of postural tachycardia syndrome (POTS) like rapid heartbeat and dizziness. Fifty adults with POTS will take either pyridostigmine or a placebo for three days. The study aims t…

This study compares two opioid pain medicines—methadone given through an IV and hydromorphone injected into the spine—for pain relief after gynecologic cancer surgery. About 140 women will take part, and researchers will measure their pain scores and side effects like itching and…

This study tests if a digital hypnotherapy program can reduce stomach and gut symptoms like pain, bloating, and nausea. Researchers will enroll 100 adults with upper GI disorders (e.g., functional dyspepsia) and measure changes using symptom questionnaires. The approach is non-in…

This study looks at whether high-frequency spinal cord stimulation can reduce chronic neuropathic pain in people who have had a brachial plexus avulsion injury. Researchers will track pain levels and daily function in 20 adults who are already scheduled to receive the implant. Th…

This study explores whether writing and playing songs with a music therapist can help teens (ages 11-18) with sickle cell disease feel less anxious and more resilient. Thirty participants will try the songwriting program and report changes in anxiety, mood, and pain-related stres…

This study tests whether fucoidan, a supplement from brown seaweed, can prevent or reduce fatigue in people with gastrointestinal or gynecologic cancers who are starting chemotherapy. About 34 participants will receive either fucoidan or a placebo daily for up to 16 weeks. Resear…

This study tests whether an NSAID injection (ketorolac) works better than a steroid injection (triamcinolone) for easing pain from moderate to advanced thumb arthritis. About 240 adults over 40 with persistent thumb pain will receive one type of injection and report their pain le…

This study tests whether using virtual reality (VR) can safely reduce abdominal pain in people with Crohn's disease who are not currently experiencing active inflammation. Researchers at Mayo Clinic will enroll 15 participants to see if VR improves pain and quality of life over 1…

This study tests whether using virtual reality (VR) can reduce symptoms of non-cardiac chest pain, which is chest pain not caused by the heart. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life. The goa…

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms and improve daily life. Participants will use the app for pain self-management and report changes in pain interference and confidence. The goal is to see i…

This study tests whether a new AI-based noise reduction feature in Phonak hearing aids helps people with hearing loss or cochlear implants hear speech more clearly in noisy settings. Researchers will measure how well 500 participants repeat words and sentences in quiet and noisy …

This study tests whether spinal cord stimulation (SCS) can reduce pain and improve quality of life in people with chemotherapy-induced peripheral neuropathy (CIPN). CIPN causes numbness, tingling, and pain, often in the hands and feet. Researchers will follow 20 adults who have h…

This study tests whether taking the steroid prednisone after ureteroscopy (a surgery for kidney stones) can help reduce pain and the need for other pain medications. Researchers will enroll 90 adults who are having this surgery with a stent placed. The goal is to see if adding a …

This study tests whether phone-based health and wellness coaching can reduce the burden and boost the confidence of people caring for a loved one awaiting a heart or lung transplant. About 30 caregivers will receive coaching sessions and complete questionnaires about their stress…

This study tests whether wearing noise-cancelling headphones with music or a movie can help people stay calm and need less sedation during knee replacement surgery done under spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal is to se…

This study looks at whether foam sclerotherapy can reduce pain and improve quality of life for people with autosomal dominant polycystic kidney or liver disease who have large, painful cysts. Researchers will treat 100 adults with 1-3 dominant cysts and follow them for 12 months.…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 with bipolar I or II will follow the diet for 8 weeks while researchers track mood changes and heart health. The goa…

This pilot study tests whether adding immersive virtual reality therapy to the standard IBS medication linaclotide can improve symptoms and quality of life more than medication alone. Researchers will enroll 65 adults with IBS-C and compare those getting real VR therapy to those …

This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 …

This study is for people with a rare and aggressive brain tumor called diffuse midline glioma. Instead of the usual six weeks of daily radiation, researchers are testing a shorter course of just two weeks. The goal is to see if the shorter treatment works just as well at controll…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce chronic coughing in people with interstitial lung disease (ILD). 25 participants will receive either a low or high dose of one drug or a placebo for 4 weeks. The main goal is to see if cough frequency de…

This study tests whether using virtual reality can help relieve stomach pain and other symptoms in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers at Mayo Clinic will enroll 30 adults who meet specific criteria. Parti…

This study tests whether a fuzzy wale compression stockinet can help wounds heal faster and lower costs after a leg amputation due to poor blood flow. About 40 adults will be enrolled. The goal is to see if this special sock reduces infections, pain, and time until a prosthetic l…

This study compares giving methadone as a pill before heart surgery versus through an IV during surgery. Researchers want to see which method reduces pain and the amount of extra opioids needed in the days after surgery. About 100 adults having planned heart surgery will take par…

This study tests whether injecting lidocaine around the sciatic nerve of the intact leg can reduce phantom or residual limb pain in people with lower-limb amputations. Twenty adults who have had pain for over six months despite other treatments will receive either the nerve block…

This study tests whether a home-based breathing and respiratory muscle training program, supported by a health coach, can help people with non-cystic fibrosis bronchiectasis improve their exercise ability and lung function. About 50 participants will use a digital program at home…

This study tests whether 12 sessions of Latin dance can improve wellbeing in people who have had a lung transplant. Researchers will measure changes in anxiety, depression, fear of movement, balance, and breathing. The study aims to enroll 52 participants who are already out of t…

This Mayo Clinic study tests a smartphone app called SleepWell24 to help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. The app connects to a smart plug and a Fitbit to track CPAP usage, sleep time, and activity. Research…

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while follow…

This study tests whether giving sevoflurane plus dexmedetomidine reduces emergence delirium (confusion and agitation) in children aged 2-7 after surgery, compared to isoflurane alone. About 400 children having ear, eye, or urology procedures will take part. The main goal is to se…

This study tests whether custom 3D-printed external breast prostheses improve comfort, fit, and emotional well-being for women who have had a mastectomy without reconstruction. Fifty participants will receive a personalized prosthesis made from 3D scans of their chest. The goal i…

This study looks at whether a nerve graft during nipple-sparing mastectomy can help restore feeling in the nipple. About 20 women with early-stage breast cancer will be randomly assigned to receive the nerve graft or not. The goal is to see if the procedure improves sensation and…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the globus pallidus externa (GPe) can help people with Parkinson's disease who have severe insomnia. Ten participants aged 40-80 will report changes in their sleep quality…

This early study at Mayo Clinic tests whether blocking a specific vein in the lower back (lumbar vein embolization) can safely reduce chronic headaches in people with Nutcracker physiology. Only 4 participants with daily pressure headaches that haven't responded to other treatmen…

This study tests whether increasing the dose of varenicline or adding bupropion helps people with recurrent acute or chronic pancreatitis quit smoking. All 45 participants start with standard varenicline; those still smoking after 6 weeks are randomly assigned to a higher dose, a…

This study at Mayo Clinic tests whether biofeedback therapy and inspiratory muscle training can help people with dyssynergic defecation—a condition where pelvic floor muscles don't relax properly during bowel movements. Two hundred adults aged 18 to 80 with chronic constipation w…

This study tests whether a special breathing exercise program, called inspiratory muscle training, can improve how well the breathing muscles work during exercise in people with heart failure. Researchers will measure blood flow to breathing and leg muscles, and how long particip…

This study tests whether a short-term therapy called accelerated resolution therapy (ART) can reduce grief in older adults caring for a family member with a life-limiting illness. About 440 caregivers will receive ART and be monitored for changes in grief symptoms. The goal is to…

This study tests whether adding inspiratory muscle training (using a device called PowerBreathe) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers will measure blood flow and oxygen use in …

This study tests whether a long-acting numbing drug called Exparel can reduce pain after rib cartilage removal for nasal surgery. About 60 adults having nasal surgery will receive either Exparel or standard lidocaine. The goal is to see if Exparel provides better pain control and…

This study tests different doses of dexmedetomidine to find the amount that stops shivering in 90% of women having planned C-sections. Forty healthy mothers with a single baby will receive the drug during spinal anesthesia. The goal is to improve comfort without causing unwanted …

This pilot study tests whether daily neck traction can reduce the need for gabapentin or pregabalin in people with neuropathic itch on the scalp, arms, or upper back. Twelve adults will use a home neck traction device for 12 weeks while their medication dose is adjusted based on …

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

This study looks at how people recover from Cushing syndrome after surgery. Researchers want to understand what affects recovery and whether using a MUSE biofeedback headband can help ease withdrawal symptoms. The study will include 700 adults who are planning to have curative su…

This Mayo Clinic study is collecting blood samples from 30 cancer patients to create personalized stem cell models. The goal is to understand why some people have severe side effects from cancer therapy while others do not. This is a non-interventional study, meaning no new treat…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This study looks at how the opioid fentanyl affects the diaphragm, the main muscle used for breathing. Researchers will give different doses of fentanyl to 69 adults having leg surgery and use ultrasound to measure diaphragm strength. The goal is to understand how opioids might w…

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This study at Mayo Clinic compares 50 people who have had SCAD (a tear in a heart artery) with healthy volunteers. Researchers measure artery stiffness, thickness, and how the 'fight or flight' nervous system responds to stress. The goal is to understand what might cause SCAD, no…

This study at Mayo Clinic looks at how changes in the blood vessels of the lungs affect people with heart valve disease. Researchers will use echocardiograms during routine heart catheterization to measure these changes in 600 adults scheduled for valve procedures. The goal is to…

This study from Mayo Clinic is looking at how T cells (a type of immune cell) change during anti-PD-1 immunotherapy in people with advanced melanoma, lung cancer, or other solid tumors. Researchers will collect blood and tissue samples from 500 participants to measure specific ma…

This study collects blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to see how the immune system reacts to these treatments. The goal is to learn more, not to test a new the…

This study at Mayo Clinic looks at how hot flashes in women may be connected to problems with blood vessels and nerves that control blood pressure. Researchers will measure nerve activity and blood vessel function in 120 women with different levels of hot flashes. The goal is to …

This study looks at whether special breathing exercises can help the brains of people with multiple sclerosis or cancer, as well as their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connection bet…

This study tests whether community health forums called WE-CARE can help more rural and low-income women get screened for breast cancer and join clinical trials. The forums include educational sessions, survivor storytelling, and patient navigation to address barriers. Researcher…

This study collects tumor tissue, blood, and cheek swabs from 50 adults with cancer to create personalized 3D models in the lab. Researchers will analyze the genetics and drug responses of these models to find new treatment targets. The goal is to improve understanding of aggress…

This study looks at DNA and protein changes in tumor samples from 50 adults with aggressive or metastatic cancer. Researchers aim to find new markers for diagnosis and potential drugs. Participants provide blood, cheek swabs, and tissue from standard biopsies or surgeries.

This study is looking at how common low vitamin D levels are among Black men with prostate cancer, and whether vitamin D supplements can improve their immune function. Researchers will measure vitamin D and immune markers in blood samples before and after supplementation. The goa…

This study collects blood or apheresis samples from 24 people with solid tumors and healthy volunteers. Researchers will analyze immune cells to see how they respond to a neoantigen vaccine, which is designed to help the immune system recognize cancer. The goal is to learn how to…

This study aims to find pancreatic cancer earlier in people who are at higher-than-average risk due to family history or genetic mutations. Researchers will collect blood samples and health data from 30,000 participants over time to build a biobank. The goal is to improve early d…

This study looks at how well patients recover after mastectomy and tissue expander placement when they stay in a special 'Care Hotel' instead of a hospital or going straight home. The Care Hotel offers a comfortable room with nursing care during the day and 24-hour video monitori…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study is looking at whether a blood test called DiviTum TKa can predict when hormone-receptor-positive, HER2-negative metastatic breast cancer stops responding to treatment. About 100 participants will give blood samples before and during their standard therapy. The goal is …

This study looks at whether a longer fasting period before an upper endoscopy can lower the risk of stomach contents entering the lungs (aspiration) in people taking GLP-1 receptor agonists (like Ozempic or Wegovy). Researchers at Mayo Clinic will check the stomachs of 150 adults…

This study from Mayo Clinic looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers will compare 13 people with MS to healthy volunteers using simple lab tests. The goal…

This study from Mayo Clinic looks at how the body manages blood pressure after a spinal cord injury and whether those changes can predict future health problems. Researchers will test 18 people with spinal cord injuries (either recent or long-term) using simple procedures like co…

This Mayo Clinic study is looking at how spinal cord stimulation affects blood pressure, heart rate, and immune function in people with spinal cord injuries. Researchers will test how the body handles changes in blood pressure using simple tasks like hand cold pressor tests and b…

This study explores the link between physical activity and thinking skills in people who survived cancer as adolescents or young adults. Researchers will use computer-based brain games to measure memory and attention. The goal is to understand how exercise might help brain health…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at why fat tissue in the belly area doesn't respond normally in people with obesity. Researchers will measure how fat cells release fatty acids in different body areas. The goal is to understand the basic biology of fat tissue, not to test a treatment. 24 adults …

This study, led by Mayo Clinic, will take leftover tumor tissue from 250 cancer patients after surgery. Researchers will treat small fragments of the live tumor with different chemotherapy and immunotherapy drugs in the lab, monitoring responses over 72 hours. The goal is to see …

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

This study looks at whether gender-affirming hormone therapy changes how the lungs work in transgender and gender diverse people. Researchers will measure lung volumes and airflow over time in about 44 participants. The goal is to understand if lung function aligns more with a pe…

This study at Mayo Clinic looks at how renin, a protein in the blood, changes when patients are on the heart-lung machine during open heart surgery. Researchers want to see if renin levels can help guide treatments for low blood pressure. The study will enroll 100 adults having e…

This study from Mayo Clinic is testing whether a 12-week progressive barbell strength training program can lower blood pressure and improve cholesterol in 200 sedentary adults. Participants will train three times a week with certified coaches. The goal is to see if this type of e…

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study aims to understand why some people continue to have symptoms like shortness of breath and fatigue long after a severe COVID-19 infection. Researchers will follow 67 adults for up to 12 months, using scans, blood tests, and other measures to look for clues in the lungs …

This study uses special PET scans to measure tau protein buildup in the brains of 332 people with Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. Researchers want to see how tau levels change over time and relate to symptoms. Partici…

This study at Mayo Clinic enrolls 50 healthy adults to provide comparison data for the Adult Congenital Heart Disease Registry. Participants undergo an MRI and a test measuring blood pressure in the lungs during exercise. The goal is to better understand heart and lung function i…

This study collects blood and tissue samples from 200 people with any degree of carotid artery narrowing who are already scheduled for a procedure. Researchers aim to learn more about the features of plaque that may increase stroke risk. No extra treatments or tests are involved …

This study compares two biopsy methods—a standard forceps and a new miniature cryoprobe—to see which better detects rejection in lung transplant recipients. About 100 participants will be randomly assigned to one method during their scheduled biopsy. The goal is to find which tec…

This study aims to understand whether blood flow in fat tissue changes as we age. Researchers will compare healthy younger adults (18-35) with older adults (65-80) by measuring blood flow and taking small fat samples. Participants will also drink a sugary drink to see how the bod…

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study tracks hair loss in 170 women with breast cancer who are taking hormone therapy. Researchers want to learn how common hair loss is, when it starts, how long it lasts, and how severe it gets. Participants will fill out questionnaires about their hair loss and quality of…

This study aims to collect and analyze pancreatic fluid from 24 healthy adults after giving them a synthetic hormone called secretin. The secretin is injected during an endoscopic ultrasound to stimulate the pancreas to release fluid, which is then collected from the duodenum. Re…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better un…

This study is testing a special PET scan that uses a tracer called 68Ga-FAPI to look for inflammation and scarring in the hearts of people with a specific type of heart failure (HFpEF). About 35 adults with this condition will get the scan to see how well it works. The goal is to…

This study is creating a repository of blood samples from 635 people with interstitial lung diseases (ILD), pneumonia, and healthy volunteers. Researchers hope these samples will help identify biomarkers to improve diagnosis and treatment. No experimental treatments are given; pa…

This study is a registry that follows up to 10,000 people who have been diagnosed with a blood clot (deep vein thrombosis or pulmonary embolism) and started blood-thinning medication within 14 days. Researchers at the Mayo Clinic will track how many patients have another clot or …

This study from Mayo Clinic aims to find biological markers (biomarkers) in blood, tissue, and saliva that can signal the presence or absence of HPV-related oropharyngeal cancer. Researchers will follow 560 participants, including patients with and without the disease, to see if …

This study records conversations between doctors, patients, and families to understand how decisions are made about scoliosis treatment. Researchers will use these videos to create a tool that helps patients choose between surgery or simply watching the curve. The study includes …

This study collects cerebrospinal fluid (CSF) from 400 adults with brain or spinal cord tumors to identify biomarkers—measurable signs of disease. Researchers hope these samples will help develop new strategies to diagnose, monitor, and treat brain tumors more effectively. Partic…

This study looks at how the hormone glucagon affects insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high blood sug…

This study at Mayo Clinic is testing whether new computer algorithms can make MRI images of the prostate clearer, both with and without contrast dye. Researchers will compare standard images to those created using the new method. The goal is to improve how doctors see blood flow …

This study from Mayo Clinic aims to understand the individual and social reasons why some patients with end-stage liver disease are not listed for or do not receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list, who receives a transpl…

This study aims to find genetic mutations that cause spontaneous coronary artery dissection (SCAD), a condition where arteries in the heart tear without warning. Researchers will analyze DNA from 2000 people diagnosed with SCAD, as well as their relatives. The goal is to identify…

This study looks at how the body's internal clock affects fat tissue in people with and without obesity. Researchers want to see if eating around the clock changes these rhythms. The goal is to better understand obesity, not to test a treatment. 40 healthy, sedentary adults are n…

This study looks at the genetics of high-risk endometrial cancer to find out why it sometimes returns after treatment. About 100 adults having surgery at Mayo Clinic will provide tissue and blood samples. Researchers will analyze these samples to build a databank for future studi…

This study looks at how people with spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) respond to different types of exercise. Researchers will measure changes in blood pressure, breathing, and symptoms during and after exercise. The goal is to better…

This study looks at why people who carry extra weight around their belly have fat cells that don't respond normally to signals that should 'turn off' fat release. Researchers at Mayo Clinic will give niacin (a B vitamin) to 32 overweight and lean adults and measure how their fat …

This study aims to find the specific genes and mutations that cause rare, inherited forms of kidney stone disease. Researchers will analyze DNA from up to 6,000 participants to understand how these genetic changes lead to stones. The goal is to use this knowledge to develop bette…

This study looks at why adults who carry extra weight around their belly don't respond to insulin the same way lean people do. Researchers will measure how fat is released from different parts of the body in 48 overweight and lean volunteers. The goal is to better understand how …

This study tests whether a video camera and artificial intelligence can accurately measure delirium severity in ICU patients over 50. Researchers will compare the camera data with standard bedside assessments. The goal is to create a passive digital marker that works automaticall…

This study looks at how short-term and long-term exercise affects the immune system in people with slow-growing blood cancers like chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (NHL). Researchers at Mayo Clinic will have 70 participants undergo a 12-week ex…

This study is an observational registry that will follow about 120 adults with pulmonary hypertension who are being treated with the drug sotatercept at the Mayo Clinic. Researchers will track changes in quality of life, exercise ability, heart function, and side effects like ble…

This Mayo Clinic study is observing 500 adults who have had or will have a multi-cancer detection (MCD) blood test. Researchers want to see how these tests affect medical decisions, patient emotions, and satisfaction in everyday practice. Participants will give blood samples and …

This study aims to find markers and causes of cancer by analyzing participants' DNA, RNA, and tissue samples. Researchers will use this information to improve cancer prevention, early detection, and treatment. The study will enroll 500 adults with cancer at Mayo Clinic.

This early study tests if a portable device that creates electric fields is safe and practical for people with breast or lung cancer that has spread to the lining of the spine. Only 5 participants will wear the device for at least 28 days. The goal is to see if the treatment is t…

This study follows 200 sinonasal cancer patients over time to understand how the disease progresses, how treatments affect survival, and how patients feel. Researchers will also analyze tumor genetics to learn more about the cancer's molecular makeup. No new treatments are being …

This study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …

This study is collecting survey responses from 1,000 people who have had or will have surgery on their esophagus. The goal is to validate new questionnaires that measure recovery and symptoms. The information will help doctors set expected recovery scores and improve treatment pl…

This study from Mayo Clinic interviews breast cancer patients who are undergoing or have recently finished radiotherapy. The goal is to learn about their physical, emotional, and social experiences with radiation dermatitis (skin irritation from radiation). By collecting these pe…

This study looks at how the esophagus changes in people with a precancerous condition called Barrett's esophagus who are getting a treatment called radiofrequency ablation (RFA). Researchers will use two special devices during routine endoscopies to measure the tightness and heal…

This study is looking at how hormone treatments for breast cancer, called aromatase inhibitors and tamoxifen, affect blood sugar control and diabetes risk in postmenopausal women. Researchers will compare blood sugar measures in women taking these drugs to healthy women not on tr…

This study looks at how chronic lymphocytic leukemia (CLL) and its early stage, monoclonal B-cell lymphocytosis (MBL), affect the bone marrow's ability to fight infections. Researchers will compare bone marrow samples from 50 participants—including people with CLL, people with MB…

This study is collecting blood and bone marrow samples from 80 adults with acute myeloid leukemia (AML) who are starting treatment with azacitidine plus venetoclax. Researchers want to understand how the immune system responds to this chemotherapy combination. The goal is to find…

This pilot study looks at whether changes in gut bacteria are linked to fatigue and nausea in women with early-stage breast cancer undergoing chemotherapy. Researchers will collect stool and blood samples and have participants fill out questionnaires before and after treatment. T…

This study is collecting medical data and biological samples from 15,000 people receiving radiation therapy for solid tumors or blood cancers. Researchers aim to understand how radiation affects quality of life, side effects, and survival. The goal is to learn from real-world out…

This study tests a new screening program for people aged 50 to 85 who have recently developed diabetes and are at high risk for pancreatic cancer. Participants will receive repeated AI-enhanced CT scans and blood draws over time to see if these tools can spot cancer earlier than …

This study tests whether a mobile app can help people with glioma (a type of brain tumor) receive care at home instead of traveling to a specialist center. About 120 adults with glioma who need ongoing treatment will use the app to stay in touch with their care team. The main goa…

This study is building a registry of up to 600 people with or suspected of having 24-hydroxylase deficiency, a rare genetic condition that causes high calcium levels and related problems like kidney stones. Researchers will collect health information over time to better understan…

This study tests whether a deep brain stimulation (DBS) system already implanted in the brain can accurately detect seizures in 5 adults with drug-resistant epilepsy. Researchers will compare the device's recordings to standard video-EEG monitoring in a hospital setting. The goal…

This study tests whether a tiny device placed under the scalp can predict seizures in people with epilepsy that doesn't respond to medication. Twelve adults with focal epilepsy will wear the device and a smartwatch to track brain activity and other signals. The goal is to see if …

This study at Mayo Clinic is testing whether a simple blood test can measure organ damage and immune system changes in people with sepsis. Researchers will take one extra blood sample from 1,000 patients in the emergency department and use advanced DNA analysis to look for signal…

This study equips hospital rooms with cameras, microphones, and temperature sensors to monitor cancer patients for early signs of delirium, falls, sleep trouble, or mood changes. Researchers hope this technology helps nurses and doctors spot problems sooner and improve patient sa…

This study looks at whether analyzing stomach fluid from newborns can predict if they will need breathing support for more than 6 hours after birth. Researchers will enroll 500 babies born at 32 weeks or later in a lower-level NICU. The goal is to see if a new algorithm can accur…

This study from Mayo Clinic is collecting blood and urine samples from 1,500 people with bladder cancer. The goal is to use these samples to develop simple, non-invasive tests that could detect bladder cancer earlier. Participants provide samples once, and no experimental treatme…

This study from Mayo Clinic is looking at how the bacteria in your gut (the microbiome) might influence how well cancer treatments work. Researchers will collect blood and stool samples from 3,000 cancer patients undergoing therapy or stem cell transplants. The goal is to find li…

This Mayo Clinic study is recruiting 4,500 women who had a benign breast biopsy between 2002 and 2022. Researchers will examine tissue samples, mammograms, and genetic data to find clues about why some women later develop breast cancer. The goal is to improve risk prediction and …

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study tests a communication tool that helps doctors and patients with non-small cell lung cancer work together on treatment decisions. About 100 patients and their doctors will use the tool during appointments to see if it improves how decisions are made and how satisfied pa…

This study collects blood, tissue, and health information from 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or cysts. The goal is to create a large database and sample bank that researchers can use to better understand these conditions and develop be…

This study enrolls 5,000 people at high risk for pancreatic cancer to donate blood, pancreatic juice, and medical images over 10 years. Researchers will use this information to develop and validate tests that can detect pancreatic cancer earlier, when it may be more treatable. Pa…

This study looks at how bladder cancer surgery affects quality of life and urinary function. Researchers will compare patients who had partial bladder removal with those who had full bladder removal. The goal is to understand which approach leads to better daily living and urinar…

This study looks at how common stomach symptoms like pain and nausea are in people with Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed. Researchers will use a simple breath test done at home to check how well the stomach empt…

This study looks at how the heart works in healthy adults of different ages, both at rest and during exercise. Researchers will use a thin tube inserted into the heart to measure pressures and blood flow. The goal is to understand what is normal, which can help doctors better dia…

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3000 people referred for catheterization. The goal is to see if ultrasound can accurately measure heart function and blood flow during exercise. Participant…

This study looks at how well the heart works during exercise compared to at rest in people with congenital heart disease. Researchers will use a special test during a routine heart catheterization to measure blood flow and pressures. The goal is to find out if exercise can uncove…

This study is testing whether a device called EndoFLIP can predict who will develop acid reflux after sleeve gastrectomy, a common weight-loss surgery. Researchers will measure the flexibility and function of the valve between the stomach and esophagus in 200 adults before surger…

This study aims to create personalized tumor models from breast cancer patients who still have cancer after initial treatment. By growing these tumors in mice, researchers hope to understand why some cancers resist therapy and test new drug combinations. The study enrolls adults …

This pilot study at Mayo Clinic will use cardiac MRI scans to examine how the heart's main pumping chamber changes in people with severe mitral regurgitation before and after valve repair surgery. The goal is to see if this approach can help identify patients at risk of developin…

This study from the Mayo Clinic looks at how major, lasting weight loss from bariatric surgery changes the way insulin controls fat breakdown. Researchers will measure inflammation and fat cell activity in 30 people with severe obesity before and after surgery. The goal is to bet…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy allows doctors to safely collect fluid samples from the brain over time. Researchers want to see if this method works better than repeated spinal taps for tra…

This study is trying to understand why some people who get chemotherapy for cancer later develop heart issues, while others don't. Researchers will collect blood samples from 1,000 adults who have had chemotherapy, including those who had heart problems and those who didn't. By s…

This study uses a special heart MRI to see if a device called a coronary sinus reducer can improve blood flow in patients with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (small vessel disease). The device is implanted to reroute …

This study looks at how well robotic biopsies can collect enough tissue to find genetic changes linked to lung cancer. About 40 adults at high risk for lung cancer or with suspected spread to the lungs will take part. The goal is to create a databank of genetic and medical inform…

This study is collecting information from 150 people who need open surgery for complex aortic aneurysms (a bulge in the main artery). The goal is to see how their quality of life changes after the operation. Researchers will use surveys to measure physical and mental well-being o…

This pilot study aims to see if a new method can measure how healthy bone marrow plasma cells use glutamine, an important nutrient. Twenty healthy adults will receive an intravenous infusion of a special labeled glutamine, followed by a bone marrow aspiration. The goal is to comp…

This study collects tumor samples and medical information from 2000 people with breast cancer that has spread or come back. The goal is to create a resource for researchers to learn more about how the disease progresses and responds to treatments. No new treatments are tested her…

This study looks at the gut microbiome (the bacteria living in the digestive system) of people with POEMS syndrome, multiple myeloma, MGUS, AL amyloidosis, and healthy household members. Participants provide stool samples at home using a collection kit. The goal is to understand …

This study is looking at 2,000 people who have early warning signs of blood cancers or bone marrow failure. Researchers use a special genetic test (next generation sequencing) to find changes in cancer-related genes. The goal is to better understand who is at risk and to catch th…

This study is checking how often women who have HPV-positive throat cancer, or whose partner has it, also have HPV infections in their genital or anal areas. Researchers will compare these rates to similar women without cancer. The goal is to learn more about how HPV spreads and …

This study tests whether a virtual community health educator (vCHE) can increase referrals to cancer clinical trials among diverse populations. Researchers will enroll 2,000 cancer patients and their caregivers across Florida. Participants interact with a computer-based agent tha…

This study compares two methods of collecting bone graft material: from the pelvic bone (iliac crest) and from the shin bone (proximal tibia) using a product called Avitus. Researchers want to see if the cells and bone-growth factors from the shin are as good as those from the pe…

This study is for people with a low-risk type of uterine cancer (endometrial cancer). Researchers want to see if finding very small groups of cancer cells (called isolated tumor cells) in the first lymph nodes near the tumor changes the chance of the cancer coming back. About 212…

This study collects bile and bile duct cells from people with Primary Sclerosing Cholangitis (PSC) and healthy volunteers to grow mini-livers called organoids. The goal is to understand how PSC progresses and leads to liver cancer. No treatment is given; it is purely for research…

This study at Mayo Clinic is testing new AI-based image processing techniques (AIR Recon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic abnormalities like endometrial and prostate cancer. Researchers will compare the new methods to stan…

This study looks at whether fat around the kidney (called PRAT) affects kidney function and blood pressure in living kidney donors. Researchers will compare donors with more or less of this fat by taking blood, urine, and fat samples during surgery. The goal is to better manage b…

This study is creating a large collection of blood, urine, stool, bile, and bile duct cells from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis, as well as from healthy volunteers. The samples and medical dat…

This early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the lymph node to help doctors find and remove the right node during surgery. The goal is to see if this mark…

This study looks at how sleep apnea changes fat tissue in adults. Researchers will take small fat samples from the belly and thigh to check for signs of cell damage. They hope to understand why sleep apnea raises the risk of heart disease. The study is currently recruiting 120 pa…

This study looks at how the chemotherapy drug calaspargase pegol (Cal-PEG) affects blood clotting in children with acute lymphoblastic leukemia (ALL). Researchers will take blood samples before and after treatment to measure changes in coagulation. The goal is to better understan…

Researchers at Mayo Clinic are recruiting 5,000 adults to study how the trillions of microbes living in and on our bodies influence health and disease. Participants will provide samples so scientists can compare the types and amounts of different microorganisms. This observationa…

This study tests the safety of placing a small device called an Ommaya reservoir under the scalp during brain tumor surgery. The device allows doctors to collect spinal fluid samples over time to study biomarkers. Researchers at Mayo Clinic will enroll 100 adults with brain tumor…

This study is testing whether a small probe called a microdialysis catheter can be safely used during brain surgery to collect fluid samples from tumors. The goal is to measure biomarkers that could help doctors better understand and treat brain cancers like gliomas and metastati…

This study is looking at whether people who take proton pump inhibitors (PPIs) for heartburn or acid reflux develop an overgrowth of bacteria in the small intestine. Researchers will use a simple breath test to check for this condition. The goal is to learn how common this proble…

This study is testing a decision aid tool to help older adults (age 60+) and their doctors have better conversations about goals of care in the emergency department. The tool is designed for patients at high risk of critical illness. Researchers will collect feedback from patient…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study is testing whether a mobile app called Vigilant can help monitor side effects in 100 people with skin cancer or melanoma who are starting a specific type of immunotherapy. Participants will use the app to report any symptoms they experience, and researchers will track …

This study at Mayo Clinic looks at how tiny organisms in your gut might influence the growth of brain tumors. Researchers will collect stool, blood, urine, saliva, and tissue samples from 100 people with brain tumors to build a special biobank. The goal is to understand the conne…

This study aims to understand why people with tetralogy of Fallot and other congenital heart diseases experience shortness of breath, palpitations, and changes in heart structure. Researchers will use remote heart rhythm monitors and imaging to track 300 participants over two yea…

This study tracks how often patients being treated with recombinant Erwinia asparaginase (Rylaze) for blood cancers develop high ammonia levels, a condition called hyperammonemia. Researchers will measure ammonia in the blood of 10 children and teens during their first two treatm…

This study from Mayo Clinic looks at whether recording messages of wisdom and hope can help patients with serious illnesses and their caregivers feel more dignified and supported. About 40 patients and their caregivers will make recordings and answer surveys before and after. The…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This Mayo Clinic study uses special MRI scans to map electrical activity in the brain. Researchers will compare healthy volunteers and people with a type of brain tumor called glioma. The goal is to improve how doctors diagnose and understand brain conditions.

This study looks at how often insomnia occurs in people with metastatic non-small cell lung cancer. Researchers will ask 60 patients to fill out a sleep questionnaire. The goal is simply to measure the problem, not to test a treatment.

This study tests a special MRI method to see how muscles and connective tissues move and respond to pressure. Researchers will compare healthy people and those with myofascial pain, and see if hands-on therapy (Tuina) changes tissue movement. Participants with pain will be random…

This study looks at how social factors, like transportation problems, affect medical care for people with liver and bile duct cancers. Researchers will ask 400 patients about barriers they face. The goal is to understand risks and improve access to care.

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. About 60 participants will join group sessions led by social workers. The goal is to see if the program improves quality of …

This pilot study at Mayo Clinic is testing whether a dietary supplement called resistant potato starch can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take 20 grams of potato starch twice daily…

This study uses focused ultrasound to temporarily open the blood-brain barrier during brain tumor surgery. Researchers will place tiny catheters to sample fluid from different brain areas to see how the barrier affects the tumor environment. Only 6 adults with large brain tumors …

This early-phase study at Mayo Clinic is looking at why insulin doesn't properly control fat breakdown in people with upper-body obesity. Researchers will test the diabetes drug pioglitazone and weight loss programs in 64 adults to see how fat cells respond. The goal is to unders…

This study from Mayo Clinic looks at how inflammation in fat tissue may affect the liver in people with severe obesity. Researchers will measure liver stiffness and fat tissue markers in 60 adults before they have weight-loss surgery. The goal is to better understand why some peo…

This study looks at genetic changes in cancer cells from Indigenous American participants in the Southwest. The goal is to learn more about these cancers to improve screening and treatment. Researchers will enroll 300 adults who have or had cancer and identify as Indigenous Ameri…

This study is creating a registry of 100 women with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect health information, tissue samples, and skin swabs to learn more about the disease and the bacteria living on affected skin. The goal is…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study is testing a new type of adjustable skin disk for feeding tubes, called a Constant Pressure Skin Disk (CPSD). The goal is to see if it can safely help the skin heal better and reduce problems. About 20 adults getting a new feeding tube will take part at Mayo Clinic.

This study is creating a large registry of people who have had a spontaneous coronary artery dissection (SCAD), a type of heart attack. Researchers will collect medical history and follow participants over time to learn more about risk factors, treatments, and long-term outcomes.…

This study sets up Community Living Labs at American Legion posts to help Black men access prostate health services and education. Researchers will see if these labs improve knowledge, screening, and trust. About 250 people, including community health workers and advisors, will t…

This study from Mayo Clinic looks at why older adults' muscles don't respond as well to exercise as younger people's. Researchers will measure how muscles build protein after a single workout session in 120 healthy young and older adults. The goal is to understand if chronic infl…

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will ask about 50 participants to use the app and give feedback on how easy and helpful it is. The goal is to se…

This study tests whether teaching mindfulness and meditation to mothers with babies in the neonatal ICU can increase breastmilk volume and reduce stress. Forty mothers will be split into two groups: one gets standard care, the other adds mindfulness training. Researchers will mea…

This study tracks how adults with curved spines move and stay stable before and after surgery. About 50 participants will wear motion sensors and undergo lab tests to measure walking, balance, and trunk control. The goal is to understand how surgery affects everyday function, not…

This study looks at whether providing cancer care at home is a good option for Black men with advanced prostate cancer. Researchers want to see if this approach can reduce healthcare disparities and improve quality of life. Participants will fill out questionnaires about their pr…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study looks at how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County, Minnesota. Researchers will follow 800 adults over time to better diagnose these conditions and see how they affect long-term health, including risks f…

This study aims to understand how oxidative stress and the body's antioxidant defenses work in early stages of autosomal dominant polycystic kidney disease (ADPKD). Researchers will measure various biomarkers in blood and urine, and use MRI to measure kidney size. The goal is to …

This study looks at how different types of fat affect how muscles respond to insulin. Healthy adults will receive infusions of palm oil or a fat emulsion through a tube into the intestine overnight. Researchers will then take small muscle samples to see how the fats are stored an…

This study is looking for markers in urine and blood that can show how severe autosomal dominant polycystic kidney disease (ADPKD) is in its early stages. Researchers will measure NOX4, mitochondrial DNA, and other substances in 60 people aged 15-40 with early ADPKD. The goal is …

This Mayo Clinic study looks at how doctors' actions and other factors during radiation treatment affect distress levels in cancer patients. Researchers will survey 5,000 adults with cancer to find out which physician behaviors increase or lessen distress. The goal is to improve …

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (found in Culturelle) can prevent or reverse changes in gut bacteria caused by the acid reflux drug omeprazole. Researchers will give 30 healthy adults omeprazole plus either the probiotic or a placebo for s…

This study looks at gene changes that might cause low blood cell counts (cytopenia) in people with multiple myeloma or certain lymphomas after CAR-T therapy. About one-third of patients have low blood counts lasting more than 30 days after treatment. Researchers will test blood a…

This study looks at whether taking prescription opioids for chronic pain changes the brain structure of adults aged 65 and older. Researchers will use MRI scans to measure brain changes over time. The goal is to understand the risks of long-term opioid use on brain health.

This study looks at whether men and women with untreated obstructive sleep apnea (OSA) have different blood pressure control systems. Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to understand sex-specific risk…

This study tests new MRI software to see if it can make image-guided tumor ablation procedures more precise. Researchers will compare the new sequences to standard ones in 100 healthy volunteers and patients already scheduled for ablation. The goal is to improve targeting, treatm…

This study uses a special ultrasound (stress echocardiography with contrast) to measure blood flow and blood pressure changes in people who have had a spontaneous coronary artery dissection (SCAD). Researchers want to understand how small blood vessels in the heart work after SCA…

This study surveys up to 5000 people who have been treated for adolescent idiopathic scoliosis, along with their families. The goal is to learn what influences treatment choices—observation, bracing, or surgery—and use that information to build a decision aid for future families.…

This study tests a new, non-invasive heart scan called magnetocardiography (MCG) to see if it can detect and track amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers at Mayo Clinic will compare MCG with standard ECG in 500 adults. This is an obser…

This study tests whether educational tools can help adolescents and young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start advance care planning early. Participants watch an educational video and attend a special appointment to discuss their care go…

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders. The samples are stored for future research to find biomarkers that could help understand or diagnose these diseases. Participants include patients and their spouses…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will give a drug that blocks GLP-1 to see how it changes insulin and glucagon release. The goal is to understand why some people with prediabete…

This study looks at how ovarian hormones might influence aging and Alzheimer's disease in women aged 60 and older. Researchers will use special PET scans to measure brain changes related to Alzheimer's. The goal is to better understand why women are more likely to develop the dis…

This study looks for genetic reasons why some people on a ketogenic diet develop very high LDL cholesterol ("hyper-responders"). Researchers will test blood from 100 adults whose LDL rose above 170 mg/dL after starting keto, checking for mutations in cholesterol-related genes. Th…

This study is building a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops having periods due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how common FHA is…

This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these …

This study from Mayo Clinic looks at how gender-affirming hormone therapy (GAHT) changes muscle metabolism and function in transgender and gender diverse people. Researchers will measure muscle energy use and overall physical health in 24 adults aged 18-40 who have been on GAHT f…

This study looks at how well African American and rural White men understand genetic testing for prostate cancer. Researchers will use educational videos and surveys to measure genetic literacy and knowledge. The goal is to help men make more informed decisions about their prosta…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This early phase trial at Mayo Clinic is studying how two drugs, DFMO and AMXT 1501, change the metabolism of brain tumors (gliomas) in 18 adult patients. The goal is to measure molecules in the tumor's fluid to understand how these drugs affect tumor growth and survival. Partici…

This study tests a new, non-invasive way to measure blood flow in the legs of people who may have deep vein thrombosis (a blood clot). Researchers will use an air-filled bladder under a compression cuff to see how well blood moves. The goal is to improve detection of clots withou…

This study tests a new neck strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if using the device can improve neck strength and measures of brain function, like reaction time and brain wave activity. The goal is to learn more about how ne…

This study from Mayo Clinic is looking at whether quitting opioids can reverse a condition called opioid-induced esophageal dysfunction, which causes trouble swallowing and chest pain. Researchers will follow 26 people who are already planning to stop taking opioids through a pai…

This study tests whether a smartwatch combined with artificial intelligence can reliably detect early signs of heart damage in people who have been treated for lymphoma or sarcoma. Researchers will enroll 250 survivors and use mobile ECGs to monitor heart function over time. The …

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way the pancreas works in people with type 1 or type 2 diabetes. Researchers will measure hormone levels before and after treatment. The goal is to understand how these treatments aff…

This study looks at families where at least two living blood relatives have a blood cancer like lymphoma, leukemia, or multiple myeloma. Researchers want to understand how genetics and environmental factors contribute to these cancers. The goal is to identify inherited risks that…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) affects stomach emptying and digestion. Researchers will compare stomach function in 16 people who already have the device to healthy controls. The goal is to understand the connect…

This study aims to find the most effective stimulation frequency for people with epilepsy who already have a brain implant. Researchers will compare low and high frequency settings to see which reduces seizures better. About 30 participants will track their seizures and report an…

This study uses mild electrical stimulation on the skin of the lower back to measure how well nerves and muscles work in 30 children and teens with spina bifida. Researchers will test muscle strength, spasticity, walking speed, and coordination. The goal is to better understand s…

This study tests how a single dose of intravenous ketamine changes brain chemicals like GABA and glutamate in people with treatment-resistant depression. Thirty adults will receive either ketamine or a placebo, and researchers will measure brain activity and depression symptoms. …

This study tests whether a genetic test can help doctors choose safer drugs and doses for 39 common medications. 66 adults getting a new prescription will receive the test, and researchers will track side effects like muscle aches, fainting, or mood changes for 48 weeks. The goal…

This study looks at how insulin and glucagon work together to control blood sugar levels when people are not eating. Researchers will give insulin and a fat emulsion to 60 volunteers with normal or impaired fasting glucose to see how their bodies respond. The goal is to better un…

This study looks at whether drinking beetroot juice, which is high in natural nitrate, before bed can change sleep patterns and how the brain controls blood flow. Researchers will give 60 healthy adults either active beetroot juice or a placebo and measure sleep stages, blood pre…

This study looks at why older adults respond differently to strength training. Researchers will enroll 300 people aged 65 and older who are at risk for mobility problems. Participants will either do progressive resistance training three times a week or attend weekly health educat…

This study looks at how your gut and brain work together to control appetite. Researchers will place a temporary balloon in the stomach and give participants tasteless and tasty meals while scanning their brains with MRI. The goal is to understand the signals that make us feel fu…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study looks at sleep problems in healthy Somali Americans and how they might raise the risk of high blood pressure. Researchers will use sleep studies and 24-hour blood pressure monitors on 240 adults. The goal is to find hidden sleep issues and understand their link to bloo…

This Mayo Clinic study is testing two new imaging techniques to measure the strength and flexibility of the aorta in people with and without aneurysms. Researchers will use ultrasound and MRI to find areas of high stress in the vessel wall. The goal is to see if these methods are…

This study from Mayo Clinic looks for genetic heart conditions in people with epilepsy that might raise the risk of sudden unexpected death (SUDEP). Researchers will analyze DNA from 600 adults aged 18-50 with epilepsy or related symptoms, plus their blood relatives. The goal is …

This study at Mayo Clinic will collect medical histories and blood, fluid, or tissue samples from 500 people with histiocytic disorders. Researchers will analyze these samples for molecular markers like BRAF V600E and PD-L1 to better understand the diseases. The goal is to gather…