Mayo Clinic

This study tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer and possibly prevent it from coming back. The main go…

This study tests if the drug obinutuzumab can safely reduce protein in the urine of people with fibrillary glomerulonephritis, a rare kidney condition. About 20 adults with confirmed disease and significant protein leakage will receive the drug and be monitored for a year. The go…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (a type of cancer). The goal is to see which treatment provides better disease control and fewer side effects, and to measure quality of life after treatment. About 72 partici…

This study tests whether early use of midodrine, a pill that raises blood pressure, can help people with sepsis need less IV medicine and recover faster. About 308 adults with sepsis and low blood pressure will receive midodrine or a placebo. The goal is to see if it reduces time…

This early-stage study tests whether injecting donor stem cells directly into the artery of a transplanted kidney is safe and can reduce inflammation from rejection. It involves 12 adult kidney transplant recipients who have signs of rejection on biopsy. The goal is to see if thi…

This study is testing whether a private Facebook group can help Native American women in Minnesota stay free from opioid use. Participants are women already on medication for opioid use disorder and have been abstinent for at least one month. The study will measure how well the F…

This study looks at whether increasing the dose of a stop-smoking medication or adding another drug helps people with pancreatitis quit smoking. All 45 participants start with the standard dose of varenicline. If they still smoke after 6 weeks, they are randomly assigned to a hig…

This early-phase study tests a new treatment called MC10029, which uses a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells. It is for people with certain types of blood cancers (like lymphoma or leukemia) that have returned or stopped respond…

This study tests a new way to treat stomach cancer that has spread to the lining of the abdomen. Doctors will use a robot to remove visible cancer and then deliver heated chemotherapy directly into the belly during surgery. The goal is to help patients recover faster and have few…

This early-stage study tests whether adding a drug called aldesleukin (IL-2) to standard immunotherapy and chemotherapy can better control stomach cancer that has spread to the abdomen lining. About 15 adults with this condition will receive the combination. The goal is to see if…

This study looks at whether older kidney transplant patients (55+) can safely stop taking one of their anti-rejection drugs (mycophenolate mofetil) while keeping their new kidney healthy. About 350 participants will be randomly assigned to either stop the drug or continue standar…

This early-stage study is testing the safety and best dose of a drug called decitabine when added to standard cancer treatments like surgery and radiation. It is for adults with a specific type of head and neck cancer not linked to HPV. The goal is to see if decitabine makes the …

This study is testing a new, non-invasive capsule system that uses a detachable string to help doctors get better views of the esophagus. The goal is to detect Barrett's esophagus, a condition that can lead to cancer, without needing a traditional endoscopy. About 57 adults with …

This study compares a new type of CT scanner (PCD-CT) to standard MRI for determining how far rectal cancer has grown. About 200 adults with rectal cancer will receive both scans, and doctors will check if the CT is as accurate as MRI. If successful, this could offer a faster and…

This study tests whether a special type of breast imaging called molecular breast imaging (MBI) can help doctors take tissue samples (biopsies) from breast abnormalities that are hard to see on standard ultrasound or mammography. About 70 women with a known breast finding will un…

This study tests whether a new type of CT scanner, called Photon Counting Detector CT (PCD-CT), can provide clearer images of heart artery disease when used with a drug that makes the heart work harder. About 450 adults with suspected coronary artery disease will get both a stand…

This study looks at whether a special ultrasound-guided needle biopsy can accurately determine the stage of bladder cancer. Researchers will compare the biopsy results with the final results from standard surgery. The goal is to see if this less invasive method could be a reliabl…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help reduce depression in people with bipolar disorder. Researchers will track mood changes and heart health in 30 adults aged 18-50. Participants must be willing to change their diet completely for…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study looks at why people with indigestion and diabetes often have stomach issues, like pain or fullness. Researchers are testing if ondansetron, a drug used for nausea, can reduce these symptoms. About 150 adults will take part to see if the drug helps with daily discomfort…

This study looks at whether a skin care program can improve skin quality and self-esteem in breast cancer survivors who are starting a type of hormone therapy called aromatase inhibitors. The study will include 25 women with early-stage breast cancer. Researchers will use special…

This study tests a new surgical method to prevent thick, painful scars after trigger finger surgery in people who also have Dupuytren's contracture. About 50 adults who need surgery will be randomly assigned to receive either the standard surgery or the new technique. Researchers…

This study tests whether a single dose of intravenous ketamine can rapidly reduce depression symptoms in 30 adults with treatment-resistant depression. Researchers will measure changes in key brain chemicals (GABA and glutamate) using brain scans and blood tests. The goal is to u…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce coughing in adults with refractory chronic cough—a cough that persists despite standard treatment. About 50 participants will receive either a low or high dose of one of the drugs or a placebo. The main …

This study looks at whether ovarian hormones are linked to aging and Alzheimer's disease in women. Researchers will use brain scans to measure markers of aging and Alzheimer's in 614 women aged 60 and older. No treatment is given—the goal is to better understand how hormones may …

This study aims to improve how doctors and families discuss scoliosis treatment options. Researchers will record and analyze video conversations between healthcare providers, patients, and their families. The goal is to create a shared decision-making tool that helps patients wit…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study looks at 100 living kidney donors to see if the amount of fat around the kidney (called PRAT) is linked to worse blood pressure and kidney function after donation. Researchers will compare donors with high and low PRAT by testing blood, urine, and fat samples. The goal…

This study tests whether a probiotic called Saccharomyces boulardii can improve the gut's ability to control what passes into the body. Researchers will give the probiotic or a placebo to 56 healthy adults and measure changes in gut permeability, inflammation, and digestive sympt…

This study is creating a registry of 100 women diagnosed with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect information on treatments, outcomes, and long-term survival, as well as tissue and swab samples to better understand the disea…

This study is a registry that will track 200 people with spontaneous intracranial hypotension (low spinal fluid pressure) caused by CSF-venous fistulas. The goal is to see how well a procedure called paraspinal vein embolization works to stop the leak and improve headaches. The i…

This study from Mayo Clinic looks at why some people on a ketogenic diet develop very high LDL cholesterol ("hyper-responders"). Researchers will test the DNA of 100 adults with LDL over 170 mg/dL to see if certain gene mutations are linked to this extreme response. The goal is t…

This study looks at why some families have more blood cancers like lymphoma, leukemia, and myeloma. Researchers will study the genes and environment of 3000 people who have at least two living relatives with these cancers. The goal is to find inherited factors that raise risk, no…

This study collects blood and tumor tissue from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to learn how the immune system responds to these treatments. The goal is to better understand the connecti…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block the hormone's action to see how it affects insulin and glucagon release. The goal is to learn why some people develop type 2 diabetes…

This study looks at whether changes in gut bacteria are connected to fatigue and nausea in women receiving chemotherapy for early-stage breast cancer. Researchers will collect stool samples and questionnaires from 70 participants before and after treatment. The goal is to better …

This study looks at why people with certain congenital heart conditions, like tetralogy of Fallot, experience symptoms such as shortness of breath and palpitations. Researchers will use heart imaging and exercise tests in 300 participants to understand changes in heart structure …

This study compares bone marrow collected from the hip bone versus the shin bone using a special device. Researchers want to see if the cells and growth factors are similar between the two sites. About 12 adults needing bone graft for foot or ankle surgery will take part. The goa…

This study uses a surface electromyography (EMG) machine—like sticky patches on the neck—to measure how people with Eosinophilic Esophagitis (EoE) swallow food. Researchers will compare the timing of swallowing preparation and initiation between EoE patients and healthy controls.…

This study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…