Can a simple blood test predict who responds to immunotherapy?
NCT ID NCT06075524
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study from Mayo Clinic is looking at how T cells (a type of immune cell) change during anti-PD-1 immunotherapy in people with advanced melanoma, lung cancer, or other solid tumors. Researchers will collect blood and tissue samples from 500 participants to measure specific markers like Bim and sPD-L1. The goal is to understand why some patients respond to treatment and others don't, and to find early signs of resistance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors predict which patients will benefit from anti-PD-1 therapy and identify resistance early.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly improve outcomes for participants and may not lead to changes in clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
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