CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Clinical trials for CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 explained in plain language.
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Custom-Made vaccine targets tough cancers in early trial
⭐️ VACCINE ⭐️ Recruiting nowThis early-phase study is testing a personalized vaccine made from each patient's unique tumor mutations. The goal is to see if it is safe and can help the immune system fight advanced breast cancer, melanoma, and non-small cell lung cancer. About 25 adults whose cancers have spr…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: Fred Hutchinson Cancer Center • Aim: ⭐️ VACCINE ⭐️
Last updated May 11, 2026 20:52 UTC
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New combo therapy targets tough cancers using biomarker clues
Disease control Recruiting nowThis study tests two drugs, cabozantinib and nivolumab, in 150 people with advanced melanoma or head and neck cancer that hasn't responded to prior immunotherapy. The goal is to see if the combination shrinks tumors and how quickly doctors can use tumor biomarkers to sort patient…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 16, 2026 23:51 UTC
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Could a flu vaccine fight melanoma? new trial injects it directly into tumors
Disease control Recruiting nowThis early-phase trial tests whether injecting a flu vaccine directly into melanoma tumors can shrink them or slow the cancer's spread. About 36 adults with stage I-IV melanoma will receive the injections. The main goals are to check safety and find the best dose.
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: Carlo Contreras • Aim: Disease control
Last updated May 16, 2026 23:51 UTC
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Could a High-Fat diet boost cancer immunotherapy?
Disease control Recruiting nowThis study tests whether a ketogenic (low-carb, high-fat) diet can make immunotherapy more effective for people with advanced melanoma or kidney cancer. About 60 adults will follow the diet while receiving standard immunotherapy drugs. The main goals are to see if the diet is saf…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated May 16, 2026 23:50 UTC
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Spinal immunotherapy injection shows promise for tough brain cancers
Disease control Recruiting nowThis early-phase study tests a combination of two ways to give the immunotherapy drug nivolumab: through a vein and directly into the fluid around the spine. It is for people with melanoma or lung cancer that has spread to the lining of the brain or spinal cord (leptomeningeal di…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Tailor-Made cancer vaccine shows promise in advanced tumors
Disease control Recruiting nowThis study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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Donor immune cells take on brain melanoma in new trial
Disease control Recruiting nowThis study tests a new treatment for advanced melanoma that has spread to the brain. It combines chemotherapy (temozolomide) with specially grown immune cells from a healthy donor (called NK cells). The goal is to see if this combination is safe and can shrink brain tumors. About…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Kari Kendra • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New hope for kidney transplant patients with advanced skin cancer
Disease control Recruiting nowThis study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with two anti-rejection medications (sirolimus and prednisone) in kidney transplant recipients who have advanced skin cancer that cannot be surgically removed or has spread. The goal is to …
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New drug combo trial hopes to tame tough cancers
Disease control Recruiting nowThis early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like certain melanomas, ovarian, and uterine cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will t…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 13, 2026 16:03 UTC
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Morning may matter: new trial tests timing of melanoma treatment
Disease control Recruiting nowThis study is testing whether giving immunotherapy drugs (ipilimumab and nivolumab) in the morning works better than giving them later in the day for people with advanced melanoma that cannot be removed by surgery. About 99 adults with stage IV melanoma will be randomly assigned …
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New hope for brain metastases: Two-Drug combo vs Three-Drug combo in melanoma trial
Disease control Recruiting nowThis study tests two different drug combinations in people with BRAF-V600 mutant melanoma that has spread to the brain. One group gets a three-drug mix (encorafenib, binimetinib, and nivolumab), the other gets two immunotherapy drugs (ipilimumab and nivolumab). The goal is to see…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New drug combo targets melanoma brain metastases in early trial
Disease control Recruiting nowThis study tests two drugs, binimetinib and encorafenib, in people with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The goal is to see if this combination can control the disease and improve survival. About 35 adults with a…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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Cancer patients may soon get immunotherapy at home – no more long clinic trips!
Symptom relief Recruiting nowThis study looks at whether giving the cancer drug nivolumab as a shot at home is as good as getting it at the clinic. About 50 adults with various cancers will try both ways to see which they prefer and how it affects their quality of life. The goal is to reduce the time, cost, …
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated May 16, 2026 23:54 UTC
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Blood tests may reveal why some cancers resist immunotherapy
Knowledge-focused Recruiting nowThis study looks at how immune cells called T cells change in people with advanced melanoma, lung, or other cancers during anti-PD-1 therapy. Researchers will measure specific markers in blood samples to see if they can predict treatment response or resistance. The goal is to und…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 16, 2026 23:56 UTC
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Poop pills could soothe cancer drug side effects
Knowledge-focused Recruiting nowThis study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung, or genitour…
Matched conditions: CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC