Could a diabetes drug shield your brain after radiation?
NCT ID NCT06377696
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study tests whether metformin, a diabetes drug, and wearable activity trackers can help prevent memory and thinking problems after cranial radiation for brain tumors. About 100 patients will take metformin or not, and complete remote cognitive tests and wear a device. The main goal is to see if remote monitoring is feasible, while also checking if metformin reduces cognitive decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin
What this could lead to
If it works, this could point toward a way to protect thinking and memory after brain radiation, using a common diabetes drug and wearable devices.
What could go wrong
This is a small, early-phase trial focused on feasibility, not proof of benefit. Metformin may not help cognition, and side effects or low compliance could limit results.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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