MALIGNANT BRAIN NEOPLASM

This early-stage study tests a new treatment for children whose brain tumors have come back or are not responding to standard care. The treatment uses the child's own immune cells, which are modified in a lab to better recognize and attack the tumor. Before receiving these cells,…

This study tests a special dye that attaches to brain tumor cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma wi…

This study tests whether adding a special amino acid PET/CT scan to standard imaging helps doctors better manage brain tumors in over half of cases. About 47 adults with brain tumors will receive the extra scan. The goal is to see if the new scan provides clearer information to g…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors choose the right treat…

This study tests whether metformin, a common diabetes drug, along with wearable activity trackers, can reduce memory and thinking problems caused by brain radiation. About 100 adults who have had or will have cranial radiation for a brain tumor will participate remotely using onl…

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and slow wound healing. About 200 adults with certain brain tumors will be randomly assigned to either a standard steroid tape…

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This early-stage trial tests a new imaging method that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. The goal is to see if this PET scan can show where immune cells are active without needing a biopsy. About 20 adults with brain tumors schedul…

This study tests whether special breathing exercises can improve brain and mental health in people with multiple sclerosis or cancer, and their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connecti…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…