MALIGNANT BRAIN NEOPLASM

This early-stage trial tests a new type of immunotherapy for children whose brain tumors have come back or are not responding to treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack the tumor. These cells are given along …

This study tests whether metformin, a diabetes drug, and wearable activity trackers can help prevent memory and thinking problems after cranial radiation for brain tumors. About 100 patients will take metformin or not, and complete remote cognitive tests and wear a device. The ma…

This study tests a special dye that makes brain tumor cells glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma will receive the dye be…

This phase 2 trial at Mayo Clinic is testing whether adding an amino acid PET/CT scan (using a radioactive tracer called FDOPA) to standard imaging can improve clinical management for people with brain tumors. The study will enroll 47 adults with brain tumors to see if the extra …

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors make more accurate tre…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study looks at whether special breathing exercises can help the brains of people with multiple sclerosis or cancer, as well as their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connection bet…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…

This study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …

This early-phase study tests a special PET imaging agent that highlights immune cells (CD8+ T-cells) in brain tumors. About 20 adults with brain tumors scheduled for surgery will receive an injection of the imaging agent before their PET scan. The goal is to see if this non-invas…

This study tests whether educational tools can help adolescents and young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start advance care planning early. Participants watch an educational video and attend a special appointment to discuss their care go…