Engineered immune cells take on childhood brain cancer
NCT ID NCT04510051
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a new type of immunotherapy for children whose brain tumors have come back or are not responding to treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack the tumor. These cells are given along with chemotherapy drugs to help them work better. The main goal is to see if the combination is safe and to find the best dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CAR T cells (IL13(EQ)BBzeta/CD19t+ T cells) and chemotherapy (cyclophosphamide and fludarabine)
What this could lead to
If it works, this could point toward a new treatment option for children with hard-to-treat brain tumors that have come back or not responded to standard therapy.
What could go wrong
This is a very early (Phase 1) and small trial (18 participants). It mainly tests safety, not effectiveness. The treatment may cause serious side effects, and it is unknown if it will work for most patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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C.S. Mott Children's Hospital, University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact