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Engineered immune cells take on childhood brain cancer

NCT ID NCT04510051

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new type of immunotherapy for children whose brain tumors have come back or are not responding to treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack the tumor. These cells are given along with chemotherapy drugs to help them work better. The main goal is to see if the combination is safe and to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CAR T cells (IL13(EQ)BBzeta/CD19t+ T cells) and chemotherapy (cyclophosphamide and fludarabine)
What this could lead to
If it works, this could point toward a new treatment option for children with hard-to-treat brain tumors that have come back or not responded to standard therapy.
What could go wrong
This is a very early (Phase 1) and small trial (18 participants). It mainly tests safety, not effectiveness. The treatment may cause serious side effects, and it is unknown if it will work for most patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT BRAIN NEOPLASM RECURRENT MALIGNANT BRAIN NEOPLASM REFRACTORY MALIGNANT BRAIN NEOPLASM

Contacts and locations

Locations

  • C.S. Mott Children's Hospital, University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

    Contact Email: •••••@•••••

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