City Of Hope Medical Center

This study tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL), whose immune systems often don't respond well to standard vaccines. The new vaccine uses a modified virus to better activate T cells, which are key infection-fightin…

This study tests a vaccine designed to protect children from cytomegalovirus (CMV) after a stem cell transplant. CMV can cause serious complications in these patients. The trial will find the best dose and check if the vaccine safely reduces CMV infections. About 80 children will…

This early-phase trial tests whether combining tagraxofusp (a targeted therapy) with azacitidine (a chemotherapy-like drug) can safely prevent acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) from coming back after a donor stem cell transplant. About 43 adults aged …

This study tests whether a combination of three drugs—acalabrutinib, obinutuzumab, and glofitamab—is safe and effective for people with mantle cell lymphoma that has come back or not improved after prior treatment. About 40 adults will receive these medications to see if the canc…

This early-stage trial tests a pill called olutasidenib in people with certain blood cancers (AML, MDS, or CMML) who have an IDH1 gene change. The goal is to see if taking this drug after a donor stem cell transplant is safe and can help prevent the cancer from coming back. About…

This early-phase trial tests a combination of three drugs—pembrolizumab, decitabine, and venetoclax—in adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or not responded to prior treatment. The goal is to find the safest dose and see how well the dr…

This early-stage study tests a new treatment for children whose brain tumors have come back or are not responding to standard care. The treatment uses the child's own immune cells, which are modified in a lab to better recognize and attack the tumor. Before receiving these cells,…

This study tests a combination of three drugs—lisocabtagene maraleucel (a personalized cell therapy), nivolumab (an immunotherapy), and ibrutinib (a targeted pill)—in 20 adults with Richter's transformation, an aggressive form of leukemia. The goal is to see if this triple therap…

This study tests whether a new version of the drug asparaginase, made from a different bacterium, can be safely combined with standard chemotherapy for high-risk adults (ages 18–54) newly diagnosed with acute lymphoblastic leukemia or lymphoblastic lymphoma. The drug works by bre…

This early-phase trial tests whether combining two targeted drugs (pacritinib and a BTK inhibitor) is safe and can shrink tumors in people with mantle cell lymphoma that came back or didn't respond to prior therapy. About 10 adults will receive the drug combo. The goal is to find…

This early-phase trial tests whether adding emapalumab to standard medications can safely prevent graft-versus-host disease (GVHD) in 15 adults with acute myeloid leukemia or myelodysplastic syndrome receiving a reduced-intensity donor stem cell transplant. Emapalumab blocks an i…

This study tests whether combining a light-based blood treatment (ECP) with a targeted antibody drug (mogamulizumab) can better control erythrodermic cutaneous T-cell lymphoma (CTCL), a rare skin cancer. About 34 adults with advanced CTCL will receive both treatments to see if th…

This study tests a new robotic system that performs abdominal and pelvic surgeries through just one small cut. The goal is to see if it causes fewer complications and helps patients recover faster. About 33 adults who need these surgeries will take part.

This study tests a combination of two treatments for mantle cell lymphoma that has returned or stopped responding to standard therapy. Patients receive their own immune cells that have been modified to recognize and attack the cancer, along with a drug that blocks cancer growth. …

This phase 2 trial tests a combination of two targeted drugs, mosunetuzumab and polatuzumab vedotin, in 41 adults with follicular lymphoma that has come back or not responded to prior therapy. The goal is to see if the combo can shrink or eliminate cancer cells while monitoring s…

This study tests a treatment called CAR T cell therapy for adults with a type of blood cancer (B-cell acute lymphoblastic leukemia) that has returned or not responded to standard treatments. The therapy involves taking a patient's own immune cells, modifying them in a lab to bett…

This study tests whether adding leflunomide to two standard drugs (pomalidomide and dexamethasone) can better control multiple myeloma that has come back or is resistant to treatment. About 29 adults with this type of blood cancer will receive the three-drug combination. The goal…

This study tests a combination of the immunotherapy drug pembrolizumab and three chemotherapy drugs (gemcitabine, brentuximab vedotin, and dacarbazine) in 23 frail patients newly diagnosed with classical Hodgkin lymphoma who cannot tolerate standard treatment. The goal is to see …

This early-stage trial tests a new treatment for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. Some participants w…

This early-phase study tests whether giving specially engineered immune cells (CAR T cells) along with a vaccine is safe and feasible for people with high-risk acute lymphoblastic leukemia who have already received a stem cell transplant from a matched related donor. The CAR T ce…

This early-stage study tests whether giving two targeted drugs together is feasible for people with certain B-cell lymphomas that have returned or stopped responding to prior therapy. The drugs, zanubrutinib and sonrotoclax, work by blocking proteins that help cancer cells surviv…

This study tests whether giving radiation to all active cancer spots before CAR T-cell therapy can help people with large B-cell lymphoma that has returned or not responded to treatment. About 9 adults will receive targeted radiation to control the disease while their own immune …

This study tests a new way to deliver radiation therapy for people with lung cancer, melanoma, or kidney cancer that has started to grow in a few new spots while on other treatments. The approach uses a PET scan to find the most active parts of the tumor and deliver a higher radi…

This early-phase study tests whether adding the drug mezigdomide after CAR T-cell therapy can help keep multiple myeloma from coming back. About 15 adults whose cancer returned after several prior treatments will receive the drug to see if it is safe and how well it works. The go…

This early-phase study tests whether adding bosentan to standard chemotherapy can help control pancreatic cancer that cannot be removed by surgery. About 21 adults will receive the combination to find the safest dose and check for side effects. The goal is to slow or stop tumor g…

This early-stage trial tests whether adding a radioactive drug (177Lu-PSMA-617) to an immune cell therapy (Sipuleucel-T) is safe and works better than the radioactive drug alone for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About…

This early-phase trial tests the safety of a drug called glofitamab, given after a pre-treatment with obinutuzumab, for people with central nervous system (CNS) lymphoma. The study enrolls 20 adults with primary or secondary CNS lymphoma. The goal is to see if this combination is…

This study looks at whether metformin, a common diabetes medicine, can help prevent or reverse insulin resistance (a step toward diabetes) in women who finished chemotherapy for early-stage breast cancer. About 200 women will either get metformin plus standard diet and exercise a…

This early-phase study tests a new treatment for multiple myeloma that has returned or not responded to standard therapy. The treatment combines a cancer-targeting antibody with a radioactive payload to deliver radiation directly to cancer cells. About 15 participants will receiv…

This study tests whether combining three drugs (glofitamab, venetoclax, and lenalidomide) can safely treat people newly diagnosed with a high-risk form of mantle cell lymphoma. About 50 adults aged 18 to 80 will receive the combination to see if it improves cancer control. The go…

This study is testing whether adding an experimental drug called venetoclax to two standard drugs (lenalidomide and rituximab) is safe and works well for people with untreated mantle cell lymphoma, a rare blood cancer. About 28 adults will take the three drugs together. The goal …

This early-phase study tests whether giving specially engineered immune cells (CAR T cells) along with a vaccine can safely treat people with intermediate or high-grade B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The CAR T cells are designed to re…

This early-phase study tests whether giving specially engineered immune cells (CAR T-cells) along with a vaccine can safely prevent B-cell lymphoma from coming back after a stem cell transplant. About 15 adults with aggressive or recurrent B-cell lymphoma will receive the treatme…

This early-phase study tests whether adding two targeted drugs (dabrafenib and trametinib) to standard radiation therapy can better control anaplastic thyroid cancer that has a specific BRAF mutation. The trial enrolls about 6 people with this rare and aggressive cancer. The main…

This study tests a type of radiation therapy called craniospinal irradiation for people whose breast or lung cancer has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the cancer in these areas. About 35 adult…

This study tests whether adding two types of focused radiation (BgRT and SBRT) to the standard drug osimertinib can better control EGFR-positive non-small cell lung cancer that has started to grow in a few new spots. About 32 adults with advanced lung cancer will receive the comb…

This study tests a new, shorter radiation schedule for women with stage I-III breast cancer. Instead of the usual 3-4 weeks of daily radiation, this approach delivers the entire treatment in just 5 days. The goal is to see if this ultra-fast method is as effective at preventing c…

This study tests whether adding the drug ruxolitinib to the standard anti-rejection drugs tacrolimus and methotrexate can better prevent graft-versus-host disease (GVHD) in children and young adults (ages 2-22) receiving a bone marrow transplant for blood cancers like leukemia. G…

This study tests whether two targeted drugs, vemurafenib and cobimetinib, can help high-risk thyroid cancer patients respond better to standard radioactive iodine therapy. The drugs block a faulty protein that drives cancer growth, potentially making cancer cells more receptive t…

This early-phase study tests whether combining two drugs—zanubrutinib and odronextamab—is safe and effective for people with Richter's transformation, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. The trial enrolls 23 adults whose cancer has come back…

This early-phase study tests whether adding venetoclax to a standard chemotherapy regimen is safe for adults aged 18-54 with a specific, high-risk form of B-cell acute lymphoblastic leukemia (Ph-Like ALL). About 24 participants will receive the combination to find the best dose a…

This study tests a new approach for people with Hodgkin lymphoma that has returned or not responded to treatment. It combines a radioactive antibody (Y-90 anti-CD25) with standard chemotherapy (BEAM) before a stem cell transplant. The goal is to see if this combination improves h…

This early-phase trial tests whether adding leflunomide (an arthritis drug) to standard chemotherapy gemcitabine is safe and effective for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will receive the combination to find the best dose …

This study tests a daily pill called enasidenib given after a donor stem cell transplant to people with a specific genetic form of acute myeloid leukemia (IDH2 mutation). The goal is to see if the drug is safe and can help prevent the leukemia from coming back. About 35 participa…

This study tests whether adding targeted radiation to the drug talquetamab can safely and effectively treat multiple myeloma that has spread to organs or soft tissues (extramedullary disease). About 20 adults with this difficult-to-treat condition will receive radiation to one tu…

This early-phase study tests a new treatment for adults with a type of blood cancer called multiple myeloma that has returned or stopped responding to standard therapies. The treatment involves taking a patient's own immune cells, modifying them in a lab to recognize and attack m…

This study tests whether a fecal transplant from healthy donors can repair gut damage caused by antibiotics and chemotherapy in lymphoma patients receiving CAR T-cell therapy. About 56 adults with relapsed or hard-to-treat lymphoma will be randomly assigned to get either the tran…

This study tests two drugs, brentuximab vedotin and nivolumab, in people whose Hodgkin lymphoma has returned or not responded to initial treatment. The goal is to see if this combination can control the disease well enough to avoid a stem cell transplant, which is more toxic and …

This study tests whether combining two targeted drugs—loncastuximab tesirine and mosunetuzumab—can shrink or eliminate tumors in people with diffuse large B-cell lymphoma that has returned or not responded to prior treatment. About 36 adults will receive the drug combination, and…

This early-phase trial tests a new method of delivering chemotherapy directly into the abdomen as a fine mist under pressure (PIPAC) for stomach cancer that has spread to the lining of the belly. The study involves 30 people whose cancer progressed after initial treatment. The go…

This early study tests a new stem cell transplant method for people with severe aplastic anemia whose disease has not responded to treatment or has returned. The approach uses a gentle chemotherapy-like regimen and specially processed donor stem cells from a partially matched fam…

This early-stage trial tests whether combining two drugs, carfilzomib and sotorasib, is safe and effective for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. About 15 adults who have already tried a KRAS-targeting drug will re…

This early-phase study tests the safety and best dose of revumenib, a drug that blocks a protein fueling leukemia growth, in 27 adults and children with specific genetic types of acute leukemia. Participants take revumenib after a stem cell transplant to help keep the cancer from…

This early-phase study tests whether adding a live bacteria product (EXL01) to standard immunotherapy (nivolumab + ipilimumab) is safe and helps control metastatic kidney cancer. About 33 adults with advanced renal cell carcinoma will receive either the standard drugs alone or wi…

This study tests whether a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to 21 who were recently diagnosed with type 1 diabetes. The goal is to slow the loss of insulin-pr…

This study looks at whether time-restricted eating (intermittent fasting) or GLP-1 medications (semaglutide and tirzepatide) can better protect the heart and metabolism of prostate cancer patients on hormone therapy compared to a standard heart-healthy diet. About 60 men aged 30-…

This early-stage trial tests a new treatment for people with high-grade gliomas that have returned or worsened. The therapy uses the patient's own immune cells, modified in a lab to recognize and attack tumor cells, and delivers them directly into the brain. The main goals are to…

This early-phase study tests whether combining precise radiation (SBRT) with an immunotherapy drug (atezolizumab) is safe and effective for people with advanced skin squamous cell carcinoma that can or cannot be removed by surgery. About 12 participants will receive both treatmen…

This early-phase trial tests a combination of three drugs (asparaginase, venetoclax, and blinatumomab) in adults aged 12-55 whose B-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. The goal is to find a safe dose and see if the combo can help th…

This early-stage trial tests a new drug called miRisten in 12 adults whose acute myeloid leukemia (AML) has returned or not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. Researchers hope miRisten can block cancer cell growth…

This study tests whether adding a natural gut hormone called gastrin to islet cell transplants can help people with hard-to-control type 1 diabetes produce their own insulin and improve blood sugar. About 20 adults aged 18-68 with unstable blood sugar will receive donor islet cel…

This early-phase study tests a new stem cell treatment called Orca-T, combined with targeted radiation and chemotherapy, for people aged 60-75 with acute leukemias or myelodysplastic syndrome (MDS). The goal is to find the safest dose and see how well the body tolerates the treat…

This early-stage study is testing a new method called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. The goal is to see if this approach is safe and can reduce side effects compared to standard chemotherapy. Abou…

This early-stage study is testing a new drug, AOH1996, in adults with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and understand side effects. The drug works by blocking certai…

This study tests whether a precise type of radiation (SBRT) can allow people with estrogen receptor-positive (ER+) breast cancer that has spread and is starting to grow again to keep using their current medication instead of switching to a new one. About 18 participants will rece…

This study tests a procedure called TACE (chemoembolization) for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps t…

This study tests whether adding a newer drug, epcoritamab, to a standard two-drug combination can make cancer disappear more completely and for longer in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 33 adults who have not had…

This early study tests whether a precise form of total body radiation, given with chemotherapy before a patient's own stem cell transplant, is safe and feasible for people with severe systemic sclerosis (scleroderma). The goal is to reduce radiation exposure to the lungs and kidn…

This early-phase trial tests a new treatment for adults with acute myeloid leukemia that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack leukemia cells. The main goals are to…

This study tests a new treatment for people living with HIV. It uses specially designed immune cells (CMV-HIV CAR T cells) to target and control the virus. The goal is to see if this approach is safe and possible, while participants continue their regular HIV medications. About 1…

This study tests whether combining an immunotherapy drug (cemiplimab) with a targeted radiation treatment (Y90 radioembolization) can help control breast cancer that has spread to the liver. About 11 adults with stage IV breast cancer and liver tumors will receive both treatments…

This study tests whether a new targeted drug (nemtabrutinib) combined with an immune-boosting antibody (rituximab) can shrink or eliminate mantle cell lymphoma in people who haven't had treatment yet. About 27 adults will receive the drug combination, and doctors will measure how…

This study tests how well older adults (70+) with a certain type of advanced breast cancer tolerate a drug called abemaciclib combined with hormone therapy. Participants have already tried a similar drug that stopped working. The main goal is to track side effects and see if this…

This study tests whether adding the drug epcoritamab to standard chemotherapy can improve outcomes for people with diffuse large B-cell lymphoma (DLBCL) that has come back or not responded to prior treatment. About 43 adults will receive the combination before an autologous stem …

This study tests whether adding a targeted drug called talazoparib to standard hormone therapy can better control prostate cancer that has spread but still responds to hormones. About 70 men with metastatic castration-sensitive prostate cancer will receive the combination. The go…

This early-stage study is testing the safety of a new method to deliver chemotherapy directly into the abdomen for patients with advanced bile duct or gallbladder cancer that has spread there. The method, called PIPAC, uses a special device to spray chemotherapy as a fine mist du…

This study aims to create a tool that uses genetic information from tumor tissue to predict whether a stomach cancer patient will respond well to chemotherapy after surgery. By analyzing RNA splicing patterns with machine learning, researchers hope to identify patients who are le…

This study is testing a new blood test that looks for circular RNA to find colorectal cancer early. Researchers will collect blood samples from 600 adults with stage I-III colorectal cancer to see how accurate the test is. If successful, this could offer a non-invasive way to det…

This early study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to highlight rectal cancer cells. The goal is to see if this scan can show tumor extent and response better than standard scans in 15 adults with locally advanced rectal cancer before and after ch…

This study is working on a new blood test to find esophageal cancer at an early, more treatable stage. Current methods like endoscopy are invasive and often miss early signs. The test looks for tiny genetic particles in the blood that are released by cancer cells. Researchers wil…

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. Researchers will study 2,000 people, including those with and without the disease, to see how accurate the test is. If successful, it could lead to earlier diagno…

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will enroll 400 participants—half with early-onset …

This study tests a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. Researchers want to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…

This study aims to develop a blood test that uses tiny particles called exosomes and machine learning to help doctors accurately tell apart two common types of liver cancer—hepatocellular carcinoma and cholangiocarcinoma—before surgery. Researchers will collect blood samples from…

This study is developing a simple blood test to find small cancer spread that standard scans might miss in people with colorectal cancer that has reached the liver. Researchers will analyze tiny particles called exosomes in the blood of 500 adults to create a computer model that …

This study aims to create a blood test that can detect several types of gastrointestinal cancers—like liver, pancreatic, and colon cancer—at an early stage. Current screening methods are often invasive or not sensitive enough. The test looks for tiny molecules called miRNAs in th…

This study looks at whether a DNA-based test can accurately detect thyroid cancer in people with thyroid nodules. Researchers will compare the test results to the final diagnosis to see how well it works. The goal is to find a less invasive way to check for thyroid cancer.

This study is testing a new DNA-based method to determine whether thyroid nodules found during a needle biopsy are cancerous or harmless. Researchers will collect samples from 1,450 adults undergoing thyroid biopsies to see if the test can accurately tell the difference. If succe…

This study aims to develop a blood test that can detect liver cancer (hepatocellular carcinoma) at an early stage, when treatment is more likely to work. Researchers will analyze tiny genetic molecules in the blood of 600 people already diagnosed with liver cancer to see if they …

This study looks at whether a simple at-home blood test (liquid biopsy) can make lung cancer screening easier and more appealing for high-risk smokers and former smokers aged 50-80. Currently, only a few people get the recommended CT scan. The blood test looks for tiny bits of ca…

This early-stage trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV), a common and dangerous infection after transplant. About 46 people with various blood cancers or disorders will take part. The g…

This early-phase trial tests whether the drug ruxolitinib can prevent chronic graft-versus-host disease (cGVHD) in people who have had a stem cell transplant for blood cancer. About 42 participants will have their blood checked for certain markers that predict high risk of cGVHD.…

This study tests a vaccine (CMV-MVA Triplex) given to stem cell donors to help prevent CMV infection in patients receiving a stem cell transplant. The vaccine boosts the donor's immunity against CMV, which is then passed to the patient through the transplant. About 216 donor-reci…

This study looks at whether sucking on popsicles during chemotherapy can reduce taste changes in prostate cancer patients. Taste changes are a common side effect of taxane chemo, and cooling the mouth may help by reducing blood flow to taste buds. The study will enroll 60 patient…

This study tests whether a thorough health check (geriatric assessment) before CAR-T therapy can guide personalized support—like physical therapy, nutrition advice, and mental exercises—to help adults aged 60 and older recover faster. Participants have B-cell non-Hodgkin lymphoma…

This study tests whether using a 3D virtual reality (VR) mindfulness program can help head and neck cancer patients and their caregivers feel less depressed, anxious, or in pain during radiation treatment. About 40 patients and their caregivers will try VR or a 2D activity and re…

This study looks at whether different types of massage can help lower anxiety in cancer patients while they receive chemotherapy. Many patients feel anxious during infusions, and massage has shown promise in reducing stress and other side effects. The trial will enroll 50 adults …

This study tests whether cannabis-based compounds (CBD and THC) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 participants will receive different types of phytocannabinoids and report their symptoms ov…

This early-stage study tests a new type of radiation called biology-guided radiation therapy (BgRT) for people with cancer that has spread to the bone and causes pain. The treatment uses live imaging to target only the active tumor, aiming to provide pain relief with a single dos…

This study tests whether telephone-based physical activity coaching can improve physical function in older adults (65+) undergoing lung cancer surgery, compared to self-monitored activity. Both patients and their family caregivers will participate. The goal is to see if remote co…

This early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with testicular cancer that has spread. About 80% of patients develop hearing problems from cisplatin. Pedmark works by neutralizing harmful molecules that damag…

This study looks at whether a special geriatric assessment can help manage side effects and improve quality of life for older adults (60+) getting radiation for head and neck cancer, and their family caregivers. About 36 participants will either get standard care or extra support…

This study is for women aged 65 and older with early-stage HER2-negative breast cancer. It tests whether a lower dose of the chemotherapy drugs docetaxel and cyclophosphamide can still be effective while causing fewer side effects and improving quality of life. About 174 particip…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or wait a fe…

This study tests whether telehealth self-management coaching sessions can improve quality of life for people with metastatic pancreatic cancer and their family caregivers. The program focuses on managing physical symptoms, emotional well-being, social health, and spiritual needs.…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study tests whether light therapy and occupational therapy can help reduce cancer-related fatigue in people with bladder, kidney, or prostate cancer. About 224 participants who are on active treatment will be assigned to receive light therapy, occupational therapy, both, or …

This study tests whether L-theanine, a natural substance found in green tea, can help cancer survivors feel more relaxed and improve their mood. About 50 adults who have finished cancer treatment and are under surveillance will take L-theanine and report their stress and anxiety …

This study tests whether a digital health app with remote monitoring can help 190 people receiving CAR-T therapy for blood cancers better manage their symptoms and reduce distress for their family caregivers. Participants use the app to report symptoms and receive support during …

This study tests a telehealth program to help people with colorectal or bladder cancer who have an ostomy (a surgically created opening for waste). Participants and their caregivers will join seven group video sessions before and after surgery to learn self-management skills. The…

This study looks at whether a blood test can find tiny traces of gastric cancer left behind after surgery, before it grows back. Researchers will analyze particles called exosomal microRNAs in blood samples from 500 people who had their stomach cancer removed. The goal is to catc…

This study looks at stored tumor samples from 400 people with appendiceal cancer to analyze DNA and RNA patterns. The goal is to find new ways to classify the cancer and predict how it will behave, beyond standard lab tests. Participants are not given any new treatment; instead, …

This study is looking for 600 people with metastatic colorectal cancer to help develop a blood test that could predict whether standard chemotherapy (FOLFOX or FOLFIRI) will be effective. Researchers will analyze DNA markers in the blood to tell apart patients who respond well fr…

This study is developing a blood test that looks at tiny particles called exosomes to predict how well pancreatic cancer will respond to chemotherapy given before surgery. Researchers will analyze blood samples from 200 patients who have already had chemotherapy and surgery. The …

This study is developing a computer model that uses genetic information from tumors to predict which colorectal cancer patients will benefit from chemotherapy after surgery. The goal is to avoid giving chemo to those who won't respond, while ensuring those who need it get the rig…

This study looks at a common side effect—rash—from the drug mogamulizumab in people with mycosis fungoides or Sezary syndrome, two rare types of skin lymphoma. The rash can look like the cancer itself, leading doctors to stop treatment too early. Researchers will study 100 adults…

This study looks at how bone marrow changes in people with acute leukemia after they receive total body irradiation and chemotherapy. Researchers will use special scans and collect blood and bone marrow samples to track these changes over time. The goal is to learn more, not to t…

This study is looking for 500 people with advanced colorectal cancer who are about to start targeted therapy. Researchers want to see if a blood test that looks at DNA changes can tell who will benefit from the treatment. The goal is to develop a tool to help doctors choose the r…

This study looks at a new way to help family members of cancer patients learn about their own inherited cancer risk. Instead of relying on the patient to share genetic test results, doctors will directly contact at-risk relatives to offer genetic counseling and testing. The goal …

This study follows 700 people with multiple myeloma who are on chemotherapy to see how cannabis (marijuana) use affects their quality of life, symptoms, and side effects. Researchers will compare cannabis users to non-users over time using surveys and medical reports. The goal is…

This study looks at how bacteria in the gut and urine change in 30 men with prostate cancer during hormone therapy and radiation. Researchers want to see if these bacteria affect healing from radiation side effects. The goal is to find new ways to improve quality of life for pati…

This study looks at how cutaneous lymphoma, a rare skin cancer, affects patients' quality of life. Researchers will use a questionnaire called Skindex29 to measure symptoms, emotions, and daily function. Up to 1,250 participants will share their experiences to help doctors better…

This study tests whether a special PET scan (PSMA-PET) and a blood test for tumor DNA can detect prostate cancer progression earlier than the usual PSA blood test. About 50 men with prostate cancer that has spread to a few spots will get targeted radiotherapy. Researchers will th…

This study looks at whether a special health check-up for older adults with cancer, done over video, can find their weak spots and guide their care. It involves 216 people aged 65 and older starting new cancer treatment. The goal is to see if this approach helps patients complete…

This study looks at how biomarkers (like DNA from tumors in the blood) can help doctors predict which patients with advanced non-small cell lung cancer will respond to immunotherapy. It involves 535 participants and aims to use these markers to personalize treatment, especially w…

This study tests whether a wearable smart wristband can accurately measure medication levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 people with chronic or infectious diseases who are taking specific medication…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. By comparing people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers, researchers hope to better understand how diabetes starts and get…

This study looks at whether eating white button mushrooms can reduce chronic inflammation and improve immune cell function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammatory markers in the blood. …

This study aims to improve how doctors determine the stage of colon cancer before surgery and decide who should receive chemotherapy beforehand. Researchers are analyzing blood samples from 400 colon cancer patients to find specific molecules (exosomal microRNAs) that can be comb…

This study tests whether a combination of breath tests for H. pylori bacteria, questionnaires, and endoscopies can identify people at high risk for stomach cancer. Researchers will enroll 240 adults aged 40-80 who are Asian, Hispanic, or Black American. The goal is to see if this…

This study tests a new PET scan that tracks immune cells called CD8+ T cells, which help fight cancer. Ten adults with lymphoma or metastatic solid tumors will get the scan before and after radiation therapy. The goal is to see if radiation brings more immune cells to tumors, not…