City Of Hope Medical Center

This study is testing whether a new COVID-19 booster vaccine (called GEO-CM04S1) works better than the current standard mRNA boosters for people with chronic lymphocytic leukemia (CLL), a type of cancer that weakens the immune system. The trial will enroll 80 adults with CLL who …

This study is testing whether taking two oral drugs (vemurafenib and cobimetinib) before standard radioactive iodine treatment can improve outcomes for patients with high-risk thyroid cancer that has a specific genetic change (BRAFV600E mutation). The goal is to see if these drug…

This study is testing whether a two-drug combination can help control advanced pancreatic cancer that has spread and cannot be surgically removed. The treatment is given as 'maintenance therapy' to patients whose cancer has stopped growing or shrunk after their initial chemothera…

This is an early safety study for a new oral medication called AOH1996 in adults with acute myeloid leukemia (AML) that has come back or not responded to prior treatments. The main goals are to find the safest dose and understand the drug's side effects. Researchers will also che…

This study is testing a precise, high-dose radiation treatment for people with estrogen receptor-positive (ER+) breast cancer that has spread to a few new spots in the body. The goal is to see if zapping those few spots with radiation allows patients to safely continue their curr…

This early-stage study is testing a new type of stem cell transplant for adults aged 60-75 with acute leukemias or myelodysplastic syndrome (MDS). The approach combines a precise form of radiation targeting bone marrow and lymph nodes with chemotherapy, followed by an infusion of…

This study is testing a more precise way to deliver radiation therapy to people whose lung cancer, melanoma, or kidney cancer has spread to a few new spots. It uses PET scans to guide the radiation beams to the most active parts of the tumors. The goal is to see if this targeted …

This study is testing whether combining two targeted cancer drugs is safe and effective for patients with an aggressive type of lymphoma that has come back or stopped responding to other treatments. The two drugs work together: one delivers a toxin directly to cancer cells, while…

This early-stage study is testing the safety and best dose of a personalized immune therapy for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, modify them in a lab to better targe…

This study is testing the safety and best dose of a drug called venetoclax when added to a standard, intensive chemotherapy regimen for adults newly diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukemia. The goal is to see if this combination can be tol…

This early-stage study is testing a new drug called miRisten in adults with acute myeloid leukemia (AML) that has returned or not responded to previous treatments. The main goals are to find a safe dose and check for side effects. Researchers hope the drug can slow or stop cancer…

This study is testing whether a combination of three existing drugs can help preserve the body's remaining insulin-producing cells in children and young adults recently diagnosed with type 1 diabetes. The goal is to slow disease progression and reduce dependence on injected insul…

This early-stage study is testing whether drinking milk from genetically engineered goats can help prevent a dangerous complication called graft-versus-host disease (GVHD) in blood cancer patients. The milk contains a human enzyme that may promote healthy gut bacteria and reduce …

This study is testing a minimally invasive procedure called TACE for patients with advanced lung cancer or cancer that has spread to the lungs. TACE works by injecting chemotherapy directly into the artery feeding the tumor and then blocking that artery to cut off the tumor's blo…

This study is testing a new vaccine designed to protect children from serious complications of cytomegalovirus (CMV) after they receive a donor stem cell transplant. The research aims to find the safest and most effective dose of the vaccine and see if it can reduce CMV infection…

This early-stage study is testing whether adding a drug called pacritinib to a standard BTK inhibitor treatment is safe and might work better for people with mantle cell lymphoma that has come back or hasn't responded to prior therapy. The trial will enroll about 10 patients to c…

This early-stage trial is testing a new combination treatment for a rare and very aggressive form of thyroid cancer. It combines two targeted drugs (dabrafenib and trametinib) with a precise form of radiation therapy. The main goal is to find the safest dose of this combination a…

This study tests whether adding the drug ruxolitinib to two standard medications helps prevent graft-versus-host disease (GVHD) in children and young adults receiving bone marrow transplants for blood cancers. GVHD is a serious complication where donor immune cells attack the pat…

This study is testing whether adding a new immune-boosting drug (epcoritamab) to a standard two-drug treatment can lead to better and longer-lasting results for people with newly diagnosed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see …

This is the first human study of an experimental oral drug called AOH1996 for patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and understand how the body processes the drug. Researchers will enrol…

This study is testing a new combination of two drugs, nemtabrutinib and rituximab, for adults with mantle cell lymphoma who have not yet received any treatment. The goal is to see if this two-drug approach can effectively control the cancer by blocking a key protein in cancer cel…

This study is testing a combination treatment for breast cancer that has spread to the liver. It pairs an immunotherapy drug (cemiplimab) that helps the immune system fight cancer with a targeted radiation treatment (Y90) delivered directly to liver tumors. The main goal is to se…

This early-stage study is testing a new, less intense bone marrow transplant procedure for adults with severe aplastic anemia whose disease has returned or hasn't responded to standard treatments. The goal is to see if using a partially matched family donor and a special cell pre…

This early-stage study is testing a two-part treatment to prevent aggressive B-cell lymphoma from coming back after a stem cell transplant. Doctors take a patient's own immune cells, modify them to target cancer, and infuse them back. They then give a vaccine designed to boost th…

This study tests whether combining two treatments works better against mantle cell lymphoma that has returned or resisted previous therapies. Researchers modify patients' own immune cells to target cancer and give them with the drug acalabrutinib. The trial aims to see if this co…

This study is testing if a new combination treatment is safe and effective for people with a hard-to-treat form of multiple myeloma that has spread to soft tissues. It combines a targeted cancer drug (talquetamab) with a short course of focused radiation aimed at one of the cance…

This study is testing a new oral drug called revumenib to see if it can safely help prevent certain aggressive types of leukemia from coming back after a patient has received a stem cell transplant. The trial will enroll about 27 patients, including children as young as 2, who ha…

This study is testing a two-part treatment for a severe, widespread red rash caused by a rare skin cancer called cutaneous T-cell lymphoma (CTCL). It combines a drug (mogamulizumab) that targets cancer cells with a blood treatment (ECP) that aims to boost the immune system. The g…

This is an early safety study testing a new type of cell therapy for people living with HIV. Researchers are modifying a person's own immune cells to help them find and potentially eliminate cells hiding the HIV virus, even while on standard medication. The main goal is to see if…

This study is testing whether combining three drugs—venetoclax, lenalidomide, and rituximab—is safe and effective for people newly diagnosed with mantle cell lymphoma, a type of blood cancer. The main goals are to find the highest safe dose of the combination and to see how well …

This early-stage study is testing if combining two different treatments is safe and works better than one alone for advanced prostate cancer. One treatment is a targeted radiation drug that seeks out and kills cancer cells. The other is a personalized vaccine designed to train th…

This early-stage trial is testing a new combination of three drugs for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or not responded to other treatments. The goal is to find the safest and most effective dose by combining an immunot…

This early study is testing a two-part immune therapy for adults with high-risk acute lymphoblastic leukemia (ALL) who have just received a stem cell transplant from a matched relative. The goal is to see if giving specially engineered immune cells (CAR T-cells) followed by a vac…

This early-stage study is testing the safety and feasibility of a two-part treatment for aggressive B-cell lymphoma that has come back or is not responding to other therapies. Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and then infuse…

This early-stage study is testing the safety and side effects of a new two-part drug treatment for lymphoma that has spread to the brain or spinal cord. The treatment involves an antibody called glofitamab, which is designed to help the body's own immune cells find and attack the…

This study is testing a new combination of three cancer drugs for patients with Richter's transformation, a rare and aggressive form of blood cancer that develops from chronic lymphocytic leukemia (CLL). The treatment combines a personalized cell therapy (made from the patient's …

This is a first-in-human study to find a safe dose of a new experimental treatment for advanced cancers that produce a protein called CEA. The treatment is an antibody attached to a radioactive particle (Actinium-225) designed to seek out cancer cells and deliver radiation direct…

This early-stage study is testing a new combination of two drugs, zanubrutinib and odronextamab, for patients with Richter's transformation, a fast-growing lymphoma. The main goal is to find a safe dose and understand the side effects. Researchers will also check if the treatment…

This study is testing a new drug combination for adults with high-risk, newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma. It aims to see if adding a specific enzyme drug (asparaginase Erwinia chrysanthemi) to standard chemotherapy is safe and effective at co…

This early-stage study is testing the safety of a new, minimally invasive procedure called PIPAC. It delivers chemotherapy as a fine mist directly into the abdomen for people with advanced ovarian, uterine, stomach, colon, or appendix cancers that have spread to the abdominal lin…

This study is testing whether adding a hormone called gastrin to an islet cell transplant can help people with difficult-to-control type 1 diabetes. Islet cells from a donor pancreas are transplanted to help the body make insulin again. Researchers hope gastrin injections will he…

This study is testing a much shorter radiation schedule for people with early-stage breast cancer. Instead of treatments over several weeks, participants receive radiation to the whole breast and the surgical area at the same time, completed in just 5 daily sessions. The main goa…

This early-stage study is testing whether a two-drug combination is safe and can help prevent cancer from coming back in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after they receive a stem cell transplant from a donor. The treatment involves tag…

This early-stage study is testing whether adding a specific gut bacteria supplement, called EXL01, makes standard immunotherapy drugs (nivolumab and ipilimumab) safer and more effective for people with advanced kidney cancer that has spread. The goal is to see if changing the gut…

This study is testing a new combination of three drugs (glofitamab, venetoclax, and lenalidomide) for people newly diagnosed with a high-risk form of mantle cell lymphoma, a type of blood cancer. The goal is to see if this three-drug approach is safe and can keep the cancer from …

This study is testing a new two-part treatment for Hodgkin lymphoma that has not responded to or has returned after initial therapy. First, a radioactive antibody is given to seek out and kill cancer cells. Then, high-dose chemotherapy and a patient's own stem cells are used to t…

This study is testing whether taking capsules containing healthy donor stool (fecal microbiome transplant) can improve gut health and treatment outcomes for adults with hard-to-treat lymphoma. All participants receive standard CAR-T cell therapy, a powerful cancer treatment, but …

This early-stage trial is testing a new combination treatment for multiple myeloma that has come back or stopped responding to standard therapies. It combines a standard antibody drug with a radioactive version designed to deliver radiation directly to cancer cells. The main goal…

This early study is testing if giving targeted radiation to all visible cancer sites is a safe and practical 'bridge' treatment for patients waiting for a powerful cell therapy called CAR T-cells. It is for adults with a fast-growing type of lymphoma that has returned or hasn't r…

This early-stage trial is testing a new version of CAR T-cell therapy for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL) that has come back or not responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab t…

This study is testing a new combination of three drugs for people with mantle cell lymphoma that has come back or hasn't responded to previous treatments. The goal is to see if the combination is safe and effective at putting the cancer into remission. The treatment involves taki…

This study is testing whether two drugs, brentuximab vedotin and nivolumab, can effectively control classical Hodgkin lymphoma that has returned or not responded to initial treatment. The goal is to see if this combination can keep the cancer in check long-term, potentially allow…

This study is testing whether a personalized support plan helps older adults recover their physical strength and daily function faster after receiving CAR-T cell therapy for blood cancers like lymphoma or multiple myeloma. The plan is based on a detailed health assessment and inc…

This early-stage study is testing a new type of personalized cell therapy for adults with acute myeloid leukemia (AML) that has come back or stopped responding to standard treatments. Doctors take immune cells from a donor, genetically modify them in a lab to better recognize and…

This study is testing whether a remote support program can improve care for older adults with cancer. Researchers will use video calls to conduct detailed health assessments and connect patients to a support team. They want to see if this approach helps patients better manage tre…

This early-stage trial is testing whether combining a new drug called 8-chloroadenosine with an existing cancer drug (venetoclax) is safe and tolerable for adults with acute myeloid leukemia that has come back or stopped responding to other treatments. The main goal is to find th…

This is a first-in-human safety study for children whose aggressive brain tumors have come back or stopped responding to standard treatments. Doctors are testing a new type of treatment where a child's own immune cells are collected, genetically reprogrammed in a lab to hunt for …

This study is testing how well older adults tolerate a breast cancer drug called abemaciclib. It is for people aged 70 and older whose hormone-positive breast cancer has spread and worsened after previous treatments. The main goal is to understand the side effects and safety of t…

This study is testing whether a lower dose of a common chemotherapy combination (docetaxel and cyclophosphamide) works as well as the standard dose for women aged 65 and older with early-stage breast cancer. The main goal is to see if the reduced dose is easier to tolerate, cause…

This early-stage study is testing whether combining a precise form of radiation therapy with an immunotherapy drug is safe for people with advanced skin cancer that is difficult or impossible to remove with surgery. The goal is to see if using these two treatments together can be…

This early-stage trial is testing a new way to deliver chemotherapy for advanced stomach cancer that has spread to the abdominal lining. Researchers are combining a standard second-line treatment with a new method that sprays chemotherapy as a fine mist directly into the abdomen …

This early-stage trial is testing whether a drug called olutasidenib can safely prevent certain blood cancers from returning after a patient has received a donor bone marrow transplant. The study will enroll about 15 adults with acute myeloid leukemia, myelodysplastic syndrome, o…

This study is testing a combination of two targeted drugs, mosunetuzumab and polatuzumab vedotin, for people with follicular lymphoma that has come back or not responded to previous treatments. The goal is to see if using these two drugs together is safe and can eliminate detecta…

This study is testing whether adding a new targeted drug called talazoparib to standard hormone-blocking treatments can better control advanced prostate cancer that has spread. It aims to see if this combination helps stop cancer growth for longer by preventing cancer cells from …

This study is testing a specialized radiation treatment for patients whose breast or lung cancer has spread to the fluid surrounding the brain and spinal cord. The treatment aims to target all areas where this type of cancer spread might occur. Researchers want to see if this app…

This study compares two approaches to protect heart and metabolic health in prostate cancer patients undergoing hormone therapy. Researchers will test whether time-restricted eating (a form of intermittent fasting) or specific weight-loss medications work better than standard hea…

This study aims to develop a simple blood test to detect six different gastrointestinal cancers earlier than current methods. Researchers will analyze blood samples from 1,000 people, including those with cancer and healthy controls, to find tiny genetic signals that indicate can…

This study is developing a simple blood test to find esophageal cancer early, when it's most treatable. Researchers will analyze tiny genetic markers in the blood of 600 people, comparing those with and without cancer. The goal is to create a test that is less invasive and more a…

This study aims to create and validate a new, non-invasive blood test to detect early-onset colorectal cancer in adults under 50. Researchers will analyze tiny genetic signals in the blood using advanced computer models to build a highly accurate test. The goal is to provide a si…

This study is testing a new lab test to better diagnose thyroid cancer from needle biopsies. The goal is to create a more accurate test so that patients with suspicious but benign nodules can avoid unnecessary surgery. Researchers will analyze tissue samples from about 1,450 adul…

This study is testing whether a convenient at-home blood test can help more high-risk smokers get screened for lung cancer. Currently, many people avoid the standard CT scan. Researchers want to see if a positive result from this easier test makes people more willing to get the f…

This study is developing a blood test to find tiny, hidden traces of stomach cancer that might remain after surgery. The test looks for special genetic signals released by cancer cells. If successful, it could help doctors predict which patients are at high risk of the cancer ret…

This study is testing a new type of PET/MRI scan to see if it can help doctors better understand and predict how well a standard breast cancer treatment will work when the cancer has spread to the brain. Researchers will give the scan to 10 women with this specific type of advanc…

This study is developing a new blood test that uses artificial intelligence to analyze tiny genetic signals from tumors. The goal is to more accurately identify patients with high-risk colon cancer before they have surgery, which could help doctors decide who might benefit from r…

This small, early study is testing a new type of imaging scan to see if it can provide a clearer picture of rectal cancer tumors. The scan uses a radioactive tracer that attaches to a protein common in these cancers. Researchers want to see if this scan, given before and after st…

This study aims to create a new test to help doctors predict which colon cancer patients will benefit from chemotherapy after surgery. Researchers will use artificial intelligence to analyze tumor samples from 200 patients who have already completed treatment. The goal is to deve…

This study aims to create a blood test that can detect when colorectal cancer has spread beyond the liver to other body parts. Researchers will analyze tiny particles in the blood using advanced computer analysis to identify hidden cancer spread that current scans might miss. The…

This study aims to develop a more accurate blood test to detect liver cancer (hepatocellular carcinoma) at its earliest stages. It will enroll 600 people with a confirmed liver cancer diagnosis to test a new method that looks for specific genetic signals in the blood. Finding can…

This study aims to confirm if a new blood test can find pancreatic cancer at its earliest, most treatable stages. Researchers will test the method in 2,000 people, including those with and without pancreatic cancer. The test looks for tiny genetic signals in the blood that may in…

This study is testing a new DNA-based test to see if it can better detect thyroid cancer in people with thyroid nodules. The test analyzes cells collected from a standard needle biopsy. The goal is to provide a more accurate and less invasive way to determine if a nodule is cance…

This study is testing a new blood test that looks for special RNA markers to detect colorectal cancer early. Researchers want to see if this simple test can find cancer as effectively as current methods like colonoscopies. The study involves 600 adults with and without colorectal…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing a new vaccine approach to prevent a common and serious viral infection called CMV in patients receiving a stem cell transplant for blood cancers. Researchers are giving the vaccine to the healthy stem cell donors, hoping the donor's boosted immunity will be …

This study is testing whether adding the diabetes medication metformin to standard healthy lifestyle advice can better prevent or reverse insulin resistance in women who have finished chemotherapy for early-stage breast cancer. Researchers want to see if metformin helps normalize…

This study is testing if telephone coaching to encourage physical activity helps older adults recover better from lung cancer surgery. It will compare a coaching program to just giving out educational materials. The goal is to see if the coaching improves patients' walking abilit…

This early-stage study is testing whether L-Theanine, a natural compound found in green tea, can help cancer survivors feel more relaxed and improve their mood. Researchers will enroll 50 adults who have finished cancer treatment and are now in the monitoring phase. Participants …

This study is testing if two non-drug approaches can help reduce the severe tiredness (fatigue) that often comes with cancer and its treatment. Researchers are enrolling 224 adults with bladder, kidney, or prostate cancer who are experiencing significant fatigue. Participants wil…

This study is testing if sucking on popsicles before, during, and after a specific type of chemotherapy can help reduce taste changes, a common and bothersome side effect. It will involve 60 men with prostate cancer who are about to start their first round of taxane chemotherapy.…

This study is testing whether wearing bright white light therapy glasses can help reduce severe tiredness and low mood in men with advanced prostate cancer who are receiving powerful hormone-based treatments. The main goal is to see if starting the light glasses right away is bet…

This study is testing whether two cannabis-based treatments (CBD alone or a THC:CBD mix) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy. It will involve 120 breast and colon cancer survivors who have finished treatment but still suffer from these sid…

This early-stage trial is testing whether adding a drug called Pedmark to standard chemotherapy can reduce hearing damage in men with metastatic testicular cancer. The study will compare hearing outcomes between two groups: one receiving chemotherapy alone and one receiving chemo…

This study is testing whether telehealth coaching sessions can help improve quality of life for people with metastatic pancreatic cancer and their family caregivers. The program offers support for managing physical symptoms, emotional well-being, and the challenges of caregiving …

This study is testing whether using virtual reality (VR) headsets can help improve the mental and emotional well-being of people with head and neck cancer and their caregivers during difficult radiation or chemotherapy treatments. It will compare a more immersive 3D mindfulness p…

This study is testing a new, single-dose radiation treatment for people with painful cancer that has spread to their bones. The new method, called biology-guided radiation therapy (BgRT), uses a PET scan signal to guide the radiation beam in real-time to the most active parts of …

This study is testing whether different types of massage can help reduce anxiety for cancer patients while they receive chemotherapy. Researchers will enroll 50 patients to try massages on areas like the feet, head, or hands during their infusion sessions. The main goal is to see…

This study is testing a digital health program designed to help patients and their family caregivers during and after outpatient CAR-T cell therapy, a treatment for blood cancers. The program uses remote monitoring to track patient symptoms and caregiver stress, aiming to improve…

This study aims to find biological markers in blood that could indicate how diabetes develops and worsens. Researchers are recruiting 165 people, including those with type 1 or type 2 diabetes, people with early blood sugar changes, and healthy volunteers. Participants will provi…

This study aims to understand if using cannabis (marijuana) affects the quality of life and symptoms of people with multiple myeloma who are receiving chemotherapy. Researchers will follow 700 newly diagnosed patients, comparing those who use cannabis to those who do not, by havi…

This early-phase study is testing a new type of PET scan to see if it can detect changes in the body's cancer-fighting immune cells after radiation therapy. It will enroll about 10 adults with metastatic solid tumors or lymphoma who are scheduled to receive a precise form of radi…

This study aims to develop a simple blood test that can predict whether a patient's advanced colon cancer will respond to standard chemotherapy. Researchers will analyze chemical markers in DNA from the blood of 600 patients who have already received treatment. The goal is to cre…

This study is looking at whether taking a daily white button mushroom powder supplement for three months can change certain markers of inflammation and immune cells in the body. It involves 26 obese, postmenopausal women who are at high risk for developing breast cancer. The goal…

This study aims to better understand a common rash that occurs in patients with two types of skin lymphoma (mycosis fungoides and Sézary syndrome) who are taking the drug mogamulizumab. Researchers will observe 100 patients to learn how often this rash happens and to find ways to…

This study aims to understand how a rare skin cancer called cutaneous lymphoma affects patients' quality of life, including symptoms, emotions, and daily activities. About 1,250 participants will complete questionnaires about their experience with the disease. The goal is to gath…

This study aims to create a blood test that can predict which pancreatic cancer patients will respond well to chemotherapy given before surgery. Researchers will analyze archived blood samples from 200 patients who already received standard chemotherapy and surgery. The goal is t…

This study aims to develop a blood test that can predict which patients with advanced colorectal cancer will respond to specific targeted therapies. Researchers will analyze DNA fragments in the blood of 500 patients to find patterns linked to treatment success. The goal is to cr…

This study tests whether having healthcare providers contact family members directly about inherited cancer risk leads to more genetic testing than when patients share this information themselves. Researchers are comparing two approaches: one where patients share results with rel…

This study is testing whether a smart wristband can accurately measure medication levels in a person's sweat. Researchers will compare sweat and saliva samples from 100 participants to the standard blood test. The goal is to see if this easier, home-based method could one day hel…

This study aims to learn how radiation and chemotherapy affect the bone marrow of people with acute leukemia. Researchers will use special scans and collect blood and bone marrow samples from about 74 adult participants at different times during their treatment. The goal is to ga…

This study is testing whether two new tools—a special PET scan and a blood test that looks for tumor DNA—can detect if prostate cancer is getting worse earlier than the standard PSA blood test. It will involve 50 men with prostate cancer that has spread to a few spots, who are ge…

This study aims to understand how the bacteria in the gut and urine change when men with prostate cancer receive hormone-blocking therapy and radiation. Researchers will collect stool and urine samples from 30 participants before, during, and after their standard treatment to see…