New combo aims to stall lung Cancer's spread
NCT ID NCT06014827
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial tests whether adding two types of precisely targeted radiation (BgRT and SBRT) to the standard drug osimertinib can better control advanced EGFR-positive lung cancer that has started to grow in a few new spots. About 32 adults with this specific type of lung cancer will receive the combination. The goal is to see if the approach keeps more patients on their planned treatment without major side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Osimertinib (a targeted cancer pill) plus biologically guided radiation therapy (BgRT) and stereotactic body radiation therapy (SBRT)
What this could lead to
If it works, this combination could help control advanced lung cancer that has started to grow in a few new spots, potentially delaying the need for a different treatment.
What could go wrong
This is a small, early-phase trial with only 32 participants, so results may not apply to everyone. Radiation and osimertinib can cause side effects like fatigue, lung inflammation, and skin reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Yale University
NOT_YET_RECRUITINGNew Haven, Connecticut, 06520, United States
Contact Email: •••••@•••••
Contact