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New imaging agent may help doctors see which lung tumors are still growing during immunotherapy

NCT ID NCT07619599

Recruiting now Knowledge-focused Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This early-phase trial will test a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. The goal is to see if the imaging agent can safely tell the difference between tumors that are still growing and those that are stable. Participants will also receive low-dose radiation to some tumors to see how that affects the imaging results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
64Cu-DOTA-pembrolizumab (a radioactive imaging agent)
What this could lead to
If successful, this could give doctors a better way to see which tumors are still growing during immunotherapy, helping guide treatment decisions.
What could go wrong
This is a very early, small pilot study with only 6 people. It is designed to test safety and imaging ability, not to change treatment yet. The imaging agent may not clearly distinguish tumor types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer lung cancer lung neoplasm metastatic malignant neoplasm in the brain non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC MALIGNANT NEOPLASM IN THE BRAIN OLIGOPROGRESSIVE LUNG NON-SMALL CELL CARCINOMA STAGE IV LUNG CANCER AJCC V8

Contacts and locations

Locations

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

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