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Genetic roadmaps for advanced cancer: study tests whether expert navigation boosts targeted therapy use

NCT ID NCT06896162

Recruiting now Knowledge-focused Sponsor: UNC Lineberger Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or blood genetically sequenced, and an expert will provide recommendations for matching therapies or clinical trials. The goal is to see if this personalized approach leads to more patients receiving genome-informed treatment and potentially improves survival over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Expert review of genetic test results and precision oncology navigation
What this could lead to
If successful, this approach could help more people with advanced cancer receive treatments tailored to their tumor's genetic profile, potentially improving survival.
What could go wrong
This is a single-arm study comparing against historical data, so results may not prove the intervention is better than standard care. The benefit depends on available targeted therapies, which may not exist for all genetic changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm cancer colorectal cancer colorectal neoplasm lung cancer lung neoplasm metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma stage IVb bladder cancer urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER BREAST CANCER COLORECTAL CANCER LUNG CANCER METASTATIC CANCER SOLID TUMOR MALIGNANCIES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Lineberger Comprehensive Cancer Center, University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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