SOLID TUMOR MALIGNANCIES

This is the first study in humans of an experimental tablet called SWA1211 for people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose, understand how the body processes the drug, and look for early signs that it mi…

This is the first study in people testing KQB168, a new cancer drug, for adults with advanced solid tumors that have stopped responding to standard treatments. Researchers want to find the safest dose of KQB168 when taken alone or combined with another cancer drug (pembrolizumab)…

This early-stage study is testing a new oral drug called CP-383 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see if the drug can slow or stop cancer growth. It is for patients who have run out of standard treatment …

This is the first study in people to test a new experimental drug called AO-252. The main goal is to find a safe dose and check for side effects in adults with advanced solid tumors that have stopped responding to standard treatments, including cancers that may have spread to the…

This is the first human study of a new experimental drug called VIR-5525 for people with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will test VIR-5525 alone and combined with an existing immunotherapy drug (pembrolizumab) in 450 participan…

This Florida-based study is testing a new AI-powered approach to find personalized treatments for cancer patients whose disease has returned or stopped responding to standard therapies. It aims to serve 210 patients, with a special focus on reaching children and underserved commu…

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This study is comparing two different dosing schedules for common cancer immunotherapies (pembrolizumab and nivolumab) to see if one causes fewer severe side effects. Researchers want to know if giving higher doses less frequently causes more problems than giving lower doses more…

This is an early safety study testing an experimental drug called SH009 injection in adults with advanced solid tumors who have run out of standard treatment options. The study aims to find a safe dose, see how the body processes the drug, and check for early signs that it might …

This is an early-stage study testing the safety of a new treatment called GO306, a genetically modified virus designed to infect and kill cancer cells. It is being given as an injection directly into tumors or into body cavities for adults with advanced solid tumors that have not…

This is the first study in people to test KQB548, an oral pill designed to target a specific genetic change (KRAS G12D) found in some advanced solid tumors like pancreatic, colorectal, and lung cancers. The main goals are to find a safe dose, see how the body processes the drug, …

This study is testing a new, personalized approach to treat advanced cancers that are no longer responding to standard therapies. Doctors will take a small sample of a patient's tumor and grow it in a lab to create a 'mini-tumor' model. They will then test many different cancer d…

This is an early-stage study to check the safety and find the right dose of an experimental injection called SXRN. It is for adults with advanced cancer who are experiencing severe, unintentional weight loss and loss of appetite, known as cachexia. The study will first test SXRN …

This study aims to understand how the cancer drug olutasidenib affects how the body processes other medications. Researchers will measure blood levels of several test drugs in 16 adult patients with specific genetic mutations in their cancers. The goal is to learn about potential…

This study is exploring whether testing spinal fluid can better detect cancer that has spread to the brain or its lining compared to standard blood tests. Researchers will collect spinal fluid and blood from 60 patients with solid tumors, including those with and without brain me…