SOLID TUMOR MALIGNANCIES

This early-stage study tests a new drug called SH009 in about 150 people with advanced solid tumors (like liver, lung, or breast cancer) that have not responded to standard treatments. The main goal is to see if the drug is safe and can shrink tumors. Researchers will also measur…

This early-stage trial tests a new drug called KQB548 in people with advanced solid tumors (like pancreatic, colorectal, or lung cancer) that have a specific genetic change called KRAS G12D. The main goals are to find a safe dose and see if the drug can shrink tumors. About 78 pa…

This early-phase study tests a new drug called KQB365 in adults with advanced solid tumors (like colorectal cancer) that have specific KRAS mutations (G12C or G12S). The main goals are to find a safe dose and see if the drug can shrink tumors when given alone or with other cancer…

This study tests an experimental drug called CP-383 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if CP-383 can slow or stop cancer growth and to find the safest and most effective dose. About 150 participants will take th…

This early-phase study tests a specially designed virus (GO306) that targets and kills cancer cells. It is for people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and understand side effects. The virus is inject…

This early-phase study tests an experimental tablet called SWA1211 in 60 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants will be clos…

This study tests a drug called valemetostat in people with advanced solid tumors that have certain gene changes (like SMARCB1 or ARID1A). The drug aims to reactivate protective genes to slow or stop cancer growth. About 900 adults will take the drug daily for up to 2 years, with …

This early-stage study tests a new daily pill, KQB168, alone or with another drug (pembrolizumab) in adults with advanced solid tumors that have stopped responding to immunotherapy. The main goals are to find a safe dose and see if the drug can shrink tumors. About 84 participant…

This early-stage study tests an experimental drug called AO-252 in people with advanced solid tumors (cancers) that have spread to the brain or other parts of the body. The main goals are to check the drug's safety and find the best dose. About 86 adults whose cancer has not resp…

This early-phase trial tests TJ101, an experimental antibody-drug conjugate, in adults with advanced solid tumors (lung, prostate, esophageal, and others) who have no standard treatment options left. The main goals are to find a safe dose and see if the drug can shrink tumors. Ab…

This early-phase study tests a new drug called VIR-5525, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have a protein called EGFR. The goal is to find safe doses and see if the drug shrinks tumors. About 450 adults with cancers that cannot …

This early-stage study tests a new injection called SXRN in 54 adults with advanced cancer who are losing weight and appetite. The main goal is to check safety and find the best dose. Researchers will also see if it helps improve appetite and weight when used alone or with standa…

This study looks at whether a lower dose of common immunotherapy drugs (pembrolizumab or nivolumab) causes fewer serious side effects than a higher dose. About 192 adults with solid tumors will be randomly assigned to receive either a higher or lower dose. The goal is to find the…

This study looks at how olutasidenib, a drug for certain cancers with an IDH1 mutation, changes the way the body processes other medications. Researchers will give participants a mix of test drugs before and during olutasidenib treatment to measure differences in drug levels. The…

This study looks at whether a sample of spinal fluid can find cancer DNA in people whose solid tumors have spread to the brain or spinal lining. Researchers will test 60 adults with different types of cancer spread. The goal is to see if this liquid biopsy method works, not to tr…

This study is testing whether a new lab platform can quickly suggest personalized cancer treatments for 210 patients in Florida whose cancer has come back or not responded to standard therapy. The platform combines drug sensitivity testing and genetic profiling to recommend optio…

This study enrolls 35 people with advanced cancers that no longer respond to standard treatments. Doctors take a small sample of the tumor, grow it in the lab, and test many drugs on it to see which ones kill the cancer cells. The goal is to see if this lab test can reliably pick…