BLADDER CANCER

This study tests whether adding new investigational drugs to the standard two-drug treatment (enfortumab vedotin plus pembrolizumab) can shrink tumors more safely in people with advanced bladder cancer that has spread. About 55 adults who have not had prior treatment for their ad…

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to destroy the tumor without removing the bladder, offering an alternative to standard surgery. About 47 adults wi…

This study is testing whether combining an immunotherapy drug (atezolizumab), an immune-boosting agent (BDB001), and targeted radiation can help control advanced solid tumors. It includes people with pancreatic cancer, lung cancer, melanoma, bladder cancer, triple-negative breast…

This study is for people with metastatic urothelial cancer, a type of bladder cancer that has spread. It tests two antibody-drug conjugates (sacituzumab govitecan and enfortumab vedotin) with or without the immunotherapy pembrolizumab. The goal is to find the safest doses and see…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study is for people with bladder cancer that has spread to a small number of other body parts (up to 3 spots). It compares standard treatment (chemotherapy or immunotherapy) alone versus standard treatment plus a precise, high-dose radiation therapy called stereotactic body …

This study tests a new medicine called MK-3120 for people with high-risk bladder cancer that hasn't spread to the muscle. After standard surgery to remove the tumor, participants receive MK-3120 directly into the bladder. The main goals are to check safety and side effects, and t…

This early-stage study tests a new drug called PF-08046876 in people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. The drug is designed to stick to cancer cells and kill them directly. The main goals are to check safety, find the best dose, an…

This early-phase study tests a new drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change called p53 R175H and a certain immune type (HLA-A*02:01). The goal is to find a safe dose and see if the drug can …

This study tests a comprehensive health program (exercise, nutrition, and mental support) given before major cancer surgery. It includes 148 frail patients with pancreatic, ovarian, kidney, or bladder cancer. Some patients also receive chemotherapy before surgery. The goal is to …

This study tests a combination of a targeted drug (enfortumab vedotin) and radiation therapy given before bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard chemotherapy. The goal is to see if this approach is safe and can eliminate or…

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), combined with standard chemotherapy (carboplatin or cisplatin) in people with advanced bladder cancer that worsened after prior treatment with enfortumab vedotin and pembrolizumab. About 630 adults will be randomly a…

This study tests whether rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after surgery can reduce urinary tract infections. About 23 adults with bladder cancer having their bladder removed will receive this wash. The main goal is to see if urine …

This study is testing whether a new type of radiation therapy guided by MRI is safe and works well for people with gastric, breast, or other cancers. About 70 adults will receive this treatment along with chemotherapy. The goal is to see if the MRI guidance helps doctors target t…

This study tests a new approach to treat high-risk bladder cancer without removing the bladder. The treatment involves freezing the tumor during surgery, followed by immunotherapy and low-dose chemotherapy. The goal is to see if this combination can improve survival and quality o…

This study looks at whether a urine test for tumor DNA can help doctors decide how long to give immunotherapy to people with a severe, hard-to-treat type of bladder cancer. About 53 adults with very-high-risk non-muscle-invasive bladder cancer that cannot be fully removed by surg…

This study tests whether a precise, adaptive radiation boost can reduce side effects and maintain cancer control for people with prostate or bladder cancer. About 60 participants will receive the treatment on a special MRI-guided machine. Researchers will track side effects, qual…

This study tests whether adding an immunotherapy drug (toripalimab) to standard BCG treatment can help prevent bladder cancer from coming back after surgery. It involves 31 adults with high-risk non-muscle-invasive bladder cancer who have not had BCG before. The goal is to see if…

This early-stage trial tests a new drug, ONM-501, injected directly into tumors, either alone or with another drug (cemiplimab), for people with advanced solid tumors or lymphomas that have not responded to other treatments. The study aims to find the safest dose and check for si…

This Phase 3 trial tests a new treatment called VERITY-BCG for people with intermediate or high-risk non-muscle invasive bladder cancer who have not received BCG therapy before. The study compares VERITY-BCG to the standard BCG treatment (OncoTICE) to see if it works just as well…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of needing to go back to the hospital. About 130 adults having this surgery will be randomly assigned to either get the usual care or the usual care plus…

This study tests an experimental drug called CP-383 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if CP-383 can slow or stop cancer growth and to find the safest and most effective dose. About 150 participants will take th…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a new drug called LY4052031 in people with advanced or spreading solid tumors, including bladder, breast, lung, and other cancers. The goal is to see if the drug is safe and works against these cancers. About 420 participants will take part, and the study will la…

This study compares two types of light used during bladder cancer surgery to see which better removes tumors and prevents return of the disease. About 200 adults with high-risk non-muscle invasive bladder cancer will be randomly assigned to standard white-light or enhanced blue-l…

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study tests a combination of two cancer drugs, enfortumab vedotin and pembrolizumab, in 20 people with high-grade upper tract urothelial cancer (a rare cancer of the kidney and ureter). Participants are those who cannot or choose not to have standard surgery to remove the ki…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, lung, or ovarian cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors, either alone or combined with ot…

This study tests whether giving a combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (etoposide and cisplatin) before bladder removal surgery can completely eliminate a rare and aggressive type of bladder cancer (neuroendocrine carcinoma). About 22 adu…

This study tests whether growing a patient's tumor cells in the lab (organoids) can help doctors choose the best anti-HER2 drug for advanced bladder cancer. About 224 adults who have failed platinum chemotherapy will be enrolled. The goal is to see if this personalized approach i…

This study is for people with a type of bladder cancer that hasn't spread into the muscle. It tests a drug called durvalumab, either alone or with other treatments like BCG, radiation, or chemotherapy. The goal is to find safe doses and see how well these combinations work at mak…

This study tests whether a special nutritional drink taken before bladder removal surgery (cystectomy) can lower the risk of infections and other complications. About 232 adults with various bladder conditions will be randomly assigned to receive the drink or standard care. The m…

This study tests a new drug, sacituzumab tirumotecan, against standard chemotherapy for people with advanced bladder cancer that has gotten worse after prior treatments. About 590 participants will be randomly assigned to receive either the new drug or a chemotherapy chosen by th…

This program provides access to an experimental treatment called cretostimogene for people with a type of bladder cancer that has not responded to standard BCG therapy. It is for patients with non-muscle invasive bladder cancer, specifically carcinoma in situ with or without high…

This early-stage trial tests a new treatment made from donor immune cells (CAR-NK cells) designed to attack two targets on bladder cancer cells. It is for adults with advanced bladder cancer that has not responded to standard therapies. The main goals are to check safety and see …

This study tests a new treatment using specially engineered immune cells (4SCAR-T cells) in people with advanced bladder cancer that has spread and has no other treatment options. About 20 participants will receive the cells to see if they can shrink tumors and improve survival. …

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This early-phase study tests two drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination helps the immune system fight cancer better. About…

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery reduces the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to receive a stent or not. Researchers will track infections …

This study tests whether adding a drug called tarlatamab to standard radiation therapy is safe and effective for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and bladder cancers. About 30 adults with advanced or returning cancers will receive …

This early-phase study tests a new drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell cancers (lung, esophagus, skin, and others) that have not responded to standard treatments. About 160 participants will receive the drug to see if it …

This study tests a two-drug combination (mitomycin-C and gemcitabine) given directly into the bladder for people with high-risk non-muscle invasive bladder cancer that did not respond to BCG therapy. The goal is to see if this treatment can prevent the cancer from coming back or …

This study tests whether a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder can prevent low-grade bladder cancer from returning. About 34 adults with intermediate-risk, non-invasive bladder cancer will receive this treatment. The g…

This study compares two approaches for choosing chemotherapy drugs in people with muscle-invasive bladder cancer. One group receives drugs selected by testing on lab-grown tumor organoids, while the other gets standard treatment. The goal is to see if the organoid-guided approach…

This study tests whether using MRI to guide brachytherapy (internal radiation) can better target tumors and reduce radiation exposure to nearby organs like the bladder and rectum. About 54 adults with cervical, uterine, vaginal, vulvar, or bladder cancer will receive treatment in…

This study tests whether a combination of two chemotherapy drugs, gemcitabine and docetaxel, can treat high-risk bladder cancer that did not respond to standard BCG therapy. About 174 adults will receive the drugs directly into the bladder weekly for 6 weeks, then monthly for up …

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder. Adults with localized bladder cancer will receive treatment and be closely monitored. If t…

This early-stage study is testing a new drug, IDE892, both alone and in combination with another drug called IDE397. It is for adults with advanced solid tumors that have a specific genetic change called MTAP deletion and have stopped responding to standard treatments. The main g…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study tests a new urine test called BCDx that aims to find bladder cancer early in people who have had it before. Researchers will check how accurate the test is compared to the standard scope exam. About 500 adults with a recent bladder cancer diagnosis will provide urine s…

This study is testing whether a simple urine test can detect leftover cancer after initial surgery for high-risk bladder cancer. Currently, many patients need a second surgery to check for remaining tumor, but this procedure has risks and costs. The study will enroll 60 adults to…

This study is testing whether a urine DNA test can help decide when patients with high-risk bladder cancer need a cystoscopy (a camera exam inside the bladder). The goal is to safely reduce the number of uncomfortable and invasive cystoscopies without missing cancer recurrences. …

This study involves 30 people with bladder cancer who are scheduled to have their bladder removed. Right before surgery, while the patient is asleep, doctors will use a special ultrasound to look for any remaining cancer in the bladder. The results will be compared with standard …

This study is testing whether a new PET imaging tracer called [18F]FAPI-74 can find tumors as well as or better than the standard tracer in adults with certain cancers (like pancreatic, ovarian, or lung cancer). Participants will get both types of scans to compare how many tumors…

This study aims to see if a new urine test can accurately detect bladder cancer recurrence in 300 people with a history of the disease. Currently, patients need a camera inserted into the bladder (cystoscopy) to check for cancer return. If successful, this simple urine test could…

This study is testing whether routine urine tests every 6 months for 2 years can find bladder cancer at an earlier stage in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to see …

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study is testing a new urine test that looks for signs of bladder cancer in people who have tiny amounts of blood in their urine (microscopic hematuria). The goal is to see if the test can accurately detect bladder cancer without needing a cystoscopy, which is an invasive pr…

This study is testing a new urine test to see if it can predict which bladder cancer patients will respond well to a standard treatment called BCG. Currently, about half of patients do not respond to BCG, leading to more treatments or surgery. The goal is to use this test to help…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests whether a shorter, dye-free MRI scan (called bp-MRI) can accurately diagnose bladder cancer and tell if it has spread into the muscle. Researchers will compare this simpler scan to the standard contrast MRI in 58 adults suspected of having bladder cancer. If succ…

This study is testing whether a special PET scan called 68Ga PSMA-PET/CT can find cancer spots in people with advanced bladder cancer or melanoma that has spread. About 20 participants will get both the new scan and the standard scan to compare. The goal is to see if the new scan…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study is testing a new, non-invasive urine test that looks for a protein called CREPT in cells shed from the bladder. The goal is to see if this test can accurately detect bladder cancer early and monitor for its return after treatment, without needing a painful scope proced…

This study is testing a new platform that uses advanced testing to better understand different types of cancer, including leukemia, myeloma, and solid tumors. The goal is to see if this platform can change the recommended treatment for patients, making it more personalized. About…

This study looks at whether taking PET scans later (2.5 hours after injection) finds lymph node spread in muscle-invasive bladder cancer more accurately than standard scans (1 hour after). About 66 adults with this cancer will get both scans, and results will be compared to surgi…

This study compares two ways to diagnose muscle-invasive bladder cancer: the standard procedure (TURBT) versus an MRI followed by a same-day biopsy. About 360 adults with suspected muscle-invasive bladder cancer will take part. The goal is to see if the MRI approach leads to fast…

This study tests whether dutasteride, a pill currently used for prostate issues, can stop low-grade bladder cancer from coming back. About 95 adults with this type of bladder cancer will take the drug daily. The goal is to see if it reduces the need for repeated surgeries and imp…

This study is testing whether a personalized home exercise program, delivered through a smartphone app, can improve physical function and recovery in people scheduled for bladder or upper tract cancer surgery. About 128 participants will either receive the exercise program plus s…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps immune cells attack…

This study tests whether watching educational videos can help people aged 65 and older who are having bladder cancer surgery (cystectomy) avoid problems like trouble moving, medication issues, and lower quality of life. Participants watch videos with tips and fill out questionnai…

This study looks at two common practices after bladder cancer surgery: using a ureteral stent (a tube to drain urine) and giving a drug called alvimopan to help the bowels work again. The goal is to see if avoiding stents reduces urinary tract infections and if alvimopan shortens…

This study compares two surgical techniques for bladder cancer: prostate capsule-sparing and nerve-sparing radical cystectomy. The goal is to see which approach better preserves erectile function and urinary control. 70 men with bladder cancer will be randomly assigned to one of …

This study looks at how women with bladder cancer cope, focusing on emotional distress and sexual health. About 80 participants will either receive standard care or extra educational support. They will fill out surveys about their mood and sexual function. The goal is to see if e…

This study looks at two treatment options for people aged 65 and older with advanced bladder cancer who cannot take the chemotherapy drug cisplatin. Researchers want to see which treatment better maintains quality of life and causes fewer side effects. Participants will receive e…

This study tests a telehealth program to help people with colorectal or bladder cancer who have an ostomy (a surgically created opening for waste). Participants and their caregivers will join seven group video sessions before and after surgery to learn self-management skills. The…

This study looks at how bladder cancer treatment affects patients' energy needs and muscle function. Researchers will measure resting energy use before and after chemotherapy and surgery in 30 adults. The goal is to learn how to better support patients during treatment, not to te…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study is observing 600 adults in Russia with bladder cancer to see what treatments they receive and how often their tumors have HER2 or PD-L1 markers. It does not test a new drug but collects real-world data to understand current care patterns. Participants must have confirm…

This study looks at what makes it hard for people with non-muscle invasive bladder cancer to stick to their treatment plan. It also tests a program that lets patients receive BCG therapy at home, using a chatbot to track symptoms and boost confidence. About 50 adults who are pres…

This study looks at how hospitals across the country handle patients who are admitted with blood in their urine (hematuria). Researchers will track over 1,000 patients to see what tests and treatments they receive, how long they stay in the hospital, and their outcomes. The goal …

This study collects videos and data from 500 adults undergoing blue light cystoscopy for bladder cancer. The goal is to train an AI system to help doctors spot suspicious lesions more accurately during the procedure. No new treatments are tested; the focus is on gathering high-qu…

This study looks at whether DNA fragments in blood or urine (ctDNA) can help doctors better understand T1G3 bladder cancer, a type that is hard to predict. Researchers will collect samples from 35 adults before and after standard treatments to see if ctDNA levels change and if th…

This study tests whether growing a patient's bladder cancer cells in the lab (called organoids) can help doctors choose the most effective chemotherapy after surgery. About 266 adults with muscle-invasive bladder cancer will have their tumor cells tested against different drugs. …

This study compares two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine put directly into the bladder) versus surgery to remove the bladder. Researchers want to see which option is better for patients' finance…

This study tests a redesigned surgical tool to remove bladder tumors more completely. Researchers want to see if the modified device provides better information about the tumor's edges and layers. The study involves 25 adults who need their bladder removed. The goal is to improve…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study is a registry that collects information on how urologists use Blue Light Cystoscopy with Cysview (BLCC) in their daily practice. It involves 4,400 adults with suspected or known non-muscle invasive bladder cancer. The goal is to compare how well BLCC detects bladder tu…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study is collecting information from 2000 bladder cancer patients who have had their bladder removed (radical cystectomy). Researchers want to understand how patients recover after surgery by tracking symptoms and quality of life. The goal is to use this information to impro…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study looks at 300 women aged 50 and older who have blood in their urine along with a bladder infection. Researchers want to see if these women need the full set of cancer tests (like a camera in the bladder and CT scans) or if they can safely skip them. The goal is to find …

This study is testing whether a new, simple method of collecting rectal mucus can find DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and analyze them for genetic and epigenetic mark…

This study aims to collect and store blood, urine, stool, and tumor samples from 1,000 adults with suspected or diagnosed urothelial carcinoma (a type of bladder cancer). The samples will be kept in a secure lab for future research to better understand the disease. No new treatme…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study aims to understand the sexual health challenges faced by bladder cancer patients and develop a support program. Researchers will interview 30 patients to learn about their needs and preferences. The goal is to create a tailored intervention to improve sexual well-being…

This study looks at whether a comprehensive geriatric assessment (CGA) before bladder cancer surgery helps older, frail patients recover better. About 140 patients aged 65 and older with muscle-invasive bladder cancer will receive either standard care or a CGA with tailored inter…

This study looks at how drugs that interact with the body's natural cannabis-like system affect bladder muscle contractions. Researchers will collect a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. In the lab, they will test whether t…

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2000 adults admitted to a hospital in Poland, focusing on those who have major cancer surgeries or stone procedures. Participants will report their job status and …

This study is creating a registry—a bank of information and samples (blood, urine, tissue) from 1,000 people with bladder cancer. Researchers will use this data to learn more about how bladder cancer develops, comes back, and affects long-term survival. The goal is to support fut…

This study follows 1,100 adults with common and rare urinary tract cancers (like bladder, kidney, or testicular cancer) over their lifetime. Researchers collect medical records, blood, urine, and tumor samples to understand how these cancers behave and respond to treatments. The …

This study looks at whether a urine test that detects tumor DNA can help doctors decide which bladder cancer patients truly need a second surgery. About 196 adults with non-muscle-invasive bladder cancer will be randomly assigned to have their repeat surgery decision guided by th…

This study aims to create a new, affordable test that detects important gene mutations in bladder cancer. Researchers will analyze tumor tissue from 400 patients to see if these mutations are linked to cancer recurrence, progression, and survival. The goal is to help doctors pers…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study collects blood, urine, saliva, and tumor tissue from people with or at risk for urothelial cancer, as well as from healthy volunteers. The goal is to analyze DNA and other molecular changes to learn what causes this cancer and how it responds to treatment. Participants…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…