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New Virus-Based therapy offered to bladder cancer patients who failed standard care

NCT ID NCT06443944

AVAILABLE Disease control Sponsor: CG Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This program provides early access to cretostimogene grenadenorepvec, a virus-based therapy, for patients with non-muscle invasive bladder cancer that has not responded to standard BCG treatment. Eligible participants have a specific type of bladder cancer (CIS with or without high-grade Ta/T1). The goal is to offer a potential treatment option while gathering more information about its effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cretostimogene grenadenorepvec (a virus-based therapy that targets cancer cells)
What this could lead to
If successful, this could offer a new treatment option for patients with bladder cancer that hasn't responded to standard therapy, potentially delaying or avoiding bladder removal surgery.
What could go wrong
This is an expanded access program, not a formal trial, so data on effectiveness and safety are still limited. The therapy may not work for everyone and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

benign urinary system neoplasm bladder carcinoma in situ malignant urinary system neoplasm non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms transitional cell carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER NON-MUSCLE INVASIVE BLADDER CANCER UROLOGIC CANCER UROTHELIAL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Advanced Urology Institute

    AVAILABLE

    Daytona Beach, Florida, 32114, United States

  • Advanced Urology Institute

    AVAILABLE

    Largo, Florida, 33771, United States

  • Banner MD Anderson Cancer Center

    AVAILABLE

    Gilbert, Arizona, 85234, United States

  • Brigham and Women's Hospital

    AVAILABLE

    Boston, Massachusetts, 02115, United States

  • Digestive Health Research of North Texas

    AVAILABLE

    Wichita Falls, Texas, 76301, United States

  • Emory University

    AVAILABLE

    Atlanta, Georgia, 30322, United States

  • Integrated Medical Professionals, PLLC

    AVAILABLE

    New York, New York, 10016, United States

  • Lakeland Regional Medical Center - Hollis Cancer Center

    AVAILABLE

    Lakeland, Florida, 33805, United States

  • Lowcountry Urology Clinics, PA

    AVAILABLE

    North Charleston, South Carolina, 29406, United States

  • Mayo Clinic Rochester

    AVAILABLE

    Rochester, Minnesota, 55905, United States

  • McR, Llc.

    AVAILABLE

    Murrieta, California, 92563, United States

  • MedStar Washington Hospital Center

    AVAILABLE

    Washington D.C., District of Columbia, 20010, United States

  • Michael G. Oefelein Clinical Trials

    AVAILABLE

    Bakersfield, California, 93301, United States

  • Michigan Institute of Urology, PC

    AVAILABLE

    Troy, Michigan, 40484, United States

  • MidLantic Urology

    AVAILABLE

    Bala-Cynwyd, Pennsylvania, 19004, United States

  • Spokane Urology

    AVAILABLE

    Spokane, Washington, 99202, United States

  • The Urology Group, P.C.

    AVAILABLE

    Southaven, Mississippi, 38671, United States

  • University of Southern California / Norris Comprehensive Cancer Center

    AVAILABLE

    Los Angeles, California, 90033, United States

  • University of Washington Medical Center

    AVAILABLE

    Seattle, Washington, 98195, United States

  • UroPartners, LLC

    AVAILABLE

    Glenview, Illinois, 60026, United States

  • Urologic Specialists of Northwest Indiana

    AVAILABLE

    Merrillville, Indiana, 46410, United States

  • Urology Center of Iowa Research

    AVAILABLE

    Clive, Iowa, 50325, United States

  • Urology Clinics of North Texas

    AVAILABLE

    Dallas, Texas, 75231, United States

  • Urology Partners of North Texas Research Institute

    AVAILABLE

    Arlington, Texas, 76017, United States

  • Urology San Antonio, PA dba USA Clinical Trials

    AVAILABLE

    San Antonio, Texas, 78229, United States

  • Uropartners c/o Associated Urological Specialists

    AVAILABLE

    Chicago Ridge, Illinois, 60415, United States

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