Can Pre-Surgery chemotherapy outsmart aggressive bladder cancer?

This phase 2 trial is testing whether giving chemotherapy before surgery to remove the bladder improves outcomes for people with a specific type of muscle-invasive bladder cancer called luminal subtype. Half the participants will receive standard neoadjuvant chemotherapy followed by cystectomy, while the other half will have surgery right away. The study will compare how often the cancer is found to have spread at the time of surgery, as well as changes in quality of life.