Rutgers, The State University Of New Jersey

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests a simple, safe way to help babies' guts recover after antibiotics. Researchers will collect a stool sample from healthy infants before they start antibiotics, then give it back to them mixed in milk or formula after treatment. The goal is to restore their unique …

This study tests a two-drug combination (gemcitabine and Jelmyto) given in sequence to treat a high-risk type of upper urinary tract cancer. The goal is to destroy the tumor without removing the kidney, which is the usual treatment. About 28 adults with non-invasive, high-grade c…

This study is testing a new way to give chemotherapy and immunotherapy for people with advanced lung or head and neck cancers. Instead of giving both treatments together every time, the plan alternates cycles of chemo plus immunotherapy with immunotherapy alone. The goal is to se…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study is testing two counseling approaches—Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE)—to help people on methadone treatment reduce their use of tobacco, opioids, and other drugs. Researchers will enroll 420 adults who are currently on…

This study tests a new way to personalize treatment for people with HER2-positive early-stage breast cancer. A special test (HARPS) analyzes tumor proteins to see if the cancer is likely to respond to certain drugs. The goal is to improve the chance of eliminating all cancer befo…

This study tests whether a single daily dose of long-acting insulin can control blood sugar as well as the usual regimen of long-acting insulin plus mealtime insulin in pregnant women with diabetes. About 176 participants will be randomly assigned to one of the two approaches and…

This study looks at whether a liver transplant can help people with a certain type of advanced bile duct cancer that hasn't spread. Participants will first receive chemotherapy to control the cancer, then undergo a liver transplant. The goal is to see if this approach helps them …

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with bevacizumab to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this approach can control the cancer and…

This phase 2 trial is testing whether adding the immunotherapy drug tislelizumab after standard liver-directed treatments (like radiation) can help control inoperable liver cancer. About 35 adults with hepatocellular carcinoma who have not had systemic therapy will receive tislel…

This study tests whether tirzepatide, a drug used for weight loss, can help patients with early-stage hormone receptor-positive, HER2-negative breast cancer lose at least 5% of their body weight during adjuvant treatment. The trial will enroll 40 adults and also check safety, sid…

This phase II trial is testing a rotating schedule of two chemotherapy regimens (FOLFOX and FOLFIRI), with or without the immunotherapy nivolumab, in 38 people with advanced HER2-negative gastric or esophageal cancer. The goal is to see if this approach improves tumor shrinkage a…

This study tests whether taking a daily statin (atorvastatin) can prevent heart damage caused by HER2-targeted therapy in women with early-stage breast cancer. About 60 participants will take the statin alongside their cancer treatment. The goal is to reduce treatment delays or e…

This study tests whether adjusting the dose of chemotherapy drugs (fluorouracil or capecitabine) based on a person's DPYD gene test can lower the risk of severe side effects. About 100 cancer patients with a specific gene variant will receive either a reduced starting dose or sta…

This study tests whether giving a higher-than-standard dose of buprenorphine (a medication for opioid use disorder) in the emergency department is safe and helps more people start addiction treatment within a week. About 140 adults with moderate to severe opioid use disorder who …

This study tests whether melatonin, a common sleep aid, can prevent kidney damage in hospitalized patients who need a strong antibiotic called vancomycin. About 300 adults aged 18 to 75 will receive either melatonin or a placebo alongside their antibiotic. The goal is to see if m…

This study tests a mobile health app that sends WhatsApp messages to encourage sun protection and skin self-exams among Hispanics at risk for skin cancer. About 114 participants will be randomly assigned to receive either the skin cancer messages or general health information. Th…

This study tests whether sulfasalazine, a drug used for arthritis, can lower a stress hormone called CRH and prevent recurrent preterm birth. Fifty pregnant women with a history of preterm birth will receive either sulfasalazine or no drug between 24 and 36 weeks of pregnancy. Re…

This early-phase study tests a 4-week training program that uses mixed reality to guide precise movements, like stacking virtual objects. The goal is to see if this can improve walking speed, balance, and thinking in people with multiple sclerosis. Thirty adults with MS will part…

This study tests whether a numbing injection called Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after surgery will receive either the Twin Block or a placebo. Researchers w…

This study tests a special gel called RADA-16 that is applied to the throat after tonsil removal. The goal is to see if it reduces bleeding and pain compared to standard care. About 134 adults having tonsillectomy will take part and report their symptoms via online surveys for 15…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests whether home-based video games can improve speech clarity and arm movement in children with cerebral palsy. Fifteen children aged 8-17 will play specially designed computer games for 30 minutes a day, 5 days a week, for 8 weeks. Researchers will measure changes i…

This study tests whether applying RADA16 hydrogel to the surgical site during tonsillectomy reduces pain and bleeding in children aged 3-17. Half the children will get the gel, half will not. Families will track symptoms via online surveys for 30 days after surgery.

This phase 2 trial tests whether a higher dose of radiation (40-50 Gy over 10 sessions) can better relieve pain from cancer that has spread to bones or other areas. Researchers hope to double the complete pain response rate at one month compared to standard doses. The study invol…

This early trial is testing whether loratadine, better known as the allergy medicine Claritin, can reduce bone pain caused by a drug called G-CSF in people with multiple myeloma who are having their stem cells collected. The study will compare pain levels between those taking lor…

This study compares a new wound dressing, Pelashield PainGuard, to the standard Restrata dressing for people with severe hidradenitis suppurativa (HS) who need surgery. The new dressing contains silver to fight bacteria and lidocaine to numb pain. Researchers will track healing t…

This study looks at whether a culturally tailored Latin dance program can help Hispanic cancer survivors sleep better. Researchers will enroll 40 adults who have finished their main cancer treatment but still have trouble sleeping. Participants will either take dance classes or c…

This study tests a manualized behavioral therapy called Functional Communication Training (FCT) for children aged 3-17 with severe challenging behaviors like aggression and self-injury. The therapy teaches children to communicate their needs instead of acting out. Researchers wil…

This study is testing a new smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. About 50 adults who have been diagnosed with cancer and smoke at least one cigarette a day will try the app. The goal is to see if the app is easy to use and if peopl…

This study tests whether a mindfulness program delivered through a smartphone app can help reduce anxiety in older adults (60+) with serious illnesses like cancer or heart disease, and their caregivers. Participants will use the app to practice mindfulness exercises. The goal is …

This study tests a behavioral therapy for children aged 3 to 17 who have frequent problem behavior like aggression or self-injury. The therapy uses a schedule where children sometimes get what they want and sometimes don't, to teach them that the alternative behavior works but no…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help older African Americans sleep better and think more clearly. Twenty participants will receive 8 weekly sleep training sessions via Zoom or a single education session. Researchers will measure slee…

This study tests whether a virtual reality headset, combined with focus feedback, can help 252 young adults aged 18-25 with ADHD concentrate better on homework and studying. Participants use a Meta Quest 3 VR headset that blocks distractions, and some also get feedback on their f…

This study compares two methods for controlling pain after same-day orthopedic surgeries like ACL repair or rotator cuff surgery. One group gets a continuous pain pump that delivers numbing medicine for days, while the other gets a single injection nerve block before surgery. Res…

This study tests whether a numbing injection (nerve block) given during vocal cord surgery can reduce pain, coughing, and improve voice recovery afterward. About 28 adults with benign vocal cord growths will receive either the numbing medicine or a saltwater placebo. Researchers …

This study tests whether an AI-powered therapy program can help older adults (50+) living with HIV who are at risk for suicide. Participants watch short videos teaching coping skills and can chat with a coach. The goal is to see if this approach is practical and helps people mana…

This study tests whether a smartphone app called Sleepio, which teaches better sleep habits, can help teens ages 14-18 who were recently hospitalized for suicide risk and also have insomnia. Half the teens will use the app plus get their usual care, while the other half gets usua…

This study tests whether a special numbing injection called a temporo-masseteric nerve block (TMNB) can reduce pain after wisdom tooth removal. About 20 adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels an…

This study tests whether a condensed form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help people who are also being treated for substance use disorders. About 168 adults will either receive M-PE alongside their usual substance use program or continue with stand…

This study tests whether adding visual signals and gradually introducing real-life materials can help children with severe aggression or self-injury maintain progress after communication training. The 24 participants, ages 3 to 17, will be observed in different settings to see if…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at whether charcoal-filtered cigarettes change how people smoke and how much harmful chemicals they breathe in. About 252 adult smokers who smoke at least 5 cigarettes a day will be randomly assigned to smoke either charcoal-filtered or regular cigarettes for 4 w…

This study looks at how strong desires (cravings) change the way people make decisions. Researchers will use brain scans and decision-making tasks to see how craving for opioids or a specific snack affects what people are willing to pay for items. The study involves 160 adults, i…

This observational study from Rutgers University aims to learn how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even without a cancer diagnosis. Participants fill out online health surveys and provide a saliva sample by mail. The study will an…

This study aims to learn more about the medical and behavioral effects of two rare genetic conditions: 3q29 deletion and 3q29 duplication syndromes. Researchers will collect health and behavior data from 800 participants, including those with the syndromes and healthy siblings. T…

This study tests a new training program called EMIT that helps young autistic children learn to imitate others. Imitation is a key skill for learning and social interaction. The program uses play-based exercises to teach children how to copy actions, sounds, and object use. The s…

This study monitors lung function continuously in 35 preterm infants to classify the causes of their oxygen drops into four types: breathing pauses, lung volume loss, both, or unknown. By better understanding these mechanisms, researchers hope to guide future treatments to reduce…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study looks at how pancreatic cancer cells get and use nutrients to grow. Researchers will give a special sugar to 16 patients during surgery to trace the cancer's energy use in the lab. The goal is to find weaknesses in the cancer's fuel system that could lead to new treatm…

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This study collects oral history interviews from doctors, nurses, and other professionals who have worked in Neonatal Intensive Care Units (NICUs). The goal is to document how neonatology has evolved in the United States since the 1960s, especially how treatment decisions were ma…

This study trains high school students (ages 15-18) to become health advocates and talk with adults in their community about cancer screening. The goal is to see if these youth-led conversations can increase screening rates among adults who are overdue. About 84 pairs of students…

This study looks at a common problem in behavior therapy for children with severe aggression or self-injury: sometimes, when therapists stop rewarding problem behaviors (called extinction), the child's behavior briefly gets worse before improving. This 'extinction burst' can be d…

This study looks at how genes influence the risk of kidney disease. Anyone 18 or older living in the US can join, even without kidney disease. Participation is online: you fill out health surveys and mail in a saliva sample. You may get free genetic ancestry information in return…

This research study is looking at the genetic makeup of tumors from 1,100 people with rare or hard-to-treat cancers. By analyzing blood and tissue samples, scientists hope to find specific gene changes that could lead to better diagnosis and more effective treatments. The goal is…

This study looks at how attention and thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to healthy volunteers. Participants will use a positive thinking strategy during a gambling task while having t…

This study tests whether a digital tool called MySmartSkin can help melanoma survivors do better skin self-exams. About 385 survivors will use either the enhanced app or a standard educational webpage. The goal is to see if the app leads to more thorough skin checks and earlier d…

This study looks at whether a 6-month cardio-dance fitness program can improve brain health and lower Alzheimer's risk in 280 older African Americans (age 60+). Participants will do either dance fitness or strength/flexibility exercises three times a week. Researchers will measur…

This study looks at whether using the word 'death' when asking patients about CPR affects their decisions. Researchers will invite 118 hospitalized adults over 65 to fill out electronic surveys about their code status. The goal is to see if different wording leads to different ch…

This study looks at how tiny particles called extracellular vesicles affect blood flow in people with type 2 diabetes. Researchers will test whether 16 weeks of supervised treadmill exercise can change these particles and improve vascular function. The goal is to understand how e…

This pilot study looks at how hormone receptor positive/HER2 negative breast cancer uses glucose and other nutrients for energy. Sixteen participants with early-stage breast cancer will receive a special labeled sugar infusion before surgery. Researchers will then analyze tumor a…

This study looks at how breathing in ozone, a common air pollutant, affects immune cells in the lungs. Healthy volunteers will breathe clean air and low-level ozone on separate days, then provide sputum samples to measure cell activity. The goal is to better understand lung injur…

This study looks at how the choices we make affect what we remember. Researchers will record brain activity from 50 epilepsy patients while they perform decision-making and memory tasks. The goal is to understand the brain processes that link decision-making to memory, which coul…

This study tests whether playing a complex online game (the Breakfast Game) can improve thinking and multitasking skills in healthy adults aged 60-75. Participants will complete 10 one-hour training sessions over a month, plus cognitive tests and a blood exam. The goal is to see …

This study looks at how a person's body composition (fat and muscle) affects the way immunoglobulin G (IgG) moves through the body after being given through a vein or under the skin. Researchers will enroll 20 adults with a nerve condition called CIDP who already receive IgG ther…

This study tests whether a remote decision coaching program helps people at high risk for lung cancer make better-informed choices about screening. About 594 participants aged 50-77 who smoke or recently quit will receive either coaching or usual care. The goal is to see if coach…

This pilot study aims to understand how a nerve block injection affects jaw muscle activity and bite force in 20 healthy adults. Participants receive one injection, and measurements are taken before and after. The goal is to gather information, not to treat any disease.

This study tests a telehealth coaching program called TELESCOPE, designed to help Hispanic adults at high risk for lung cancer decide whether to get screened. The program includes a decision aid, smoking cessation support, and help navigating the screening process. Researchers wi…

This study tests whether a non-invasive brain stimulation technique called TMS can change how the brain processes rewards in smokers. Researchers will compare different targeting methods to see which best boosts brain signals related to reward and decision-making. The goal is to …

This study tests whether magnetic pulses to the brain can change how we process space and remember locations during virtual navigation. Sixty healthy adults will receive either real or fake stimulation while performing memory tasks in a virtual maze. The goal is to see if brain w…

This study tests different patterns of transcranial magnetic stimulation (TMS) on the brain's reward center in 42 nicotine-dependent smokers. Researchers measure changes in brain waves and decision-making to find which pulse protocol works best. The goal is to identify the most e…

This study tests whether a non-invasive brain stimulation technique called TMS can alter brain signals related to reward processing. Researchers will apply TMS to the frontal cortex of 28 healthy adults while they perform decision-making tasks. The goal is to see if TMS can incre…

This study tests a training program called DECIDE for MOM, designed to help healthcare providers better support pregnant and postpartum individuals with mental health concerns. The training teaches skills like shared decision-making and understanding patients' perspectives. Resea…

This study looks at how genes may increase the risk of pulmonary hypertension (high blood pressure in the lungs). Researchers will collect health surveys and saliva samples from 10,000 adults in the US, both with and without the condition. The goal is to find genetic links that c…

This study compares a chatbot to standard care to see which better helps Black cancer survivors learn about and request genetic testing for hereditary cancer. About 428 participants will be randomly assigned to either group. The goal is to reduce disparities in genetic testing an…