Gene test could make chemo safer by tailoring doses
NCT ID NCT07158164
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adjusting the dose of chemotherapy drugs (fluorouracil or capecitabine) based on a person's DPYD gene test can lower the risk of severe side effects. About 100 cancer patients with a specific gene variant will receive either a reduced starting dose or standard dose. The goal is to find a safer, more personalized way to give chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fluorouracil or Capecitabine (chemotherapy drugs)
What this could lead to
If successful, this could make chemotherapy safer by using a genetic test to personalize doses, reducing severe side effects without lowering effectiveness.
What could go wrong
This is a small, early-phase study (100 people) and results may not apply to all patients. The genetic test is not yet standard, and dose adjustments might still lead to side effects or reduced cancer control.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cancer Center Initiative
RECRUITINGNewark, New Jersey, 07103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cooperman Barnabas Medical Center
RECRUITINGLivingston, New Jersey, 07039, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jack and Sheryl Morris Cancer Center
RECRUITINGNew Brunswick, New Jersey, 08901, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health - Community Medical Center
RECRUITINGToms River, New Jersey, 08755, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health - Robert Wood Johnson University Hospita
RECRUITINGNew Brunswick, New Jersey, 08903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health - Robert Wood Johnson University Hospital Somerset
RECRUITINGSomerville, New Jersey, 08873, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health - Robert Wood Johnson University Hospital, Hamilton
RECRUITINGHamilton, New Jersey, 08690, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health Clara Maas Medical Center
RECRUITINGBelleville, New Jersey, 07109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health Jersey City Medical Center
RECRUITINGJersey City, New Jersey, 07302, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJBarnabas Health Newark Beth Israel Medical Center
RECRUITINGNewark, New Jersey, 07112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Trinitas Hospital and Comprehensive Cancer Center
RECRUITINGElizabeth, New Jersey, 07202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital
RECRUITINGNewark, New Jersey, 07103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••