COLORECTAL NEOPLASMS

This early-stage study is testing a new radioactive cancer drug called LY4337713 in adults with advanced solid tumors that have spread. The drug is designed to seek out and deliver radiation directly to cancer cells that have a specific protein marker called FAP. Researchers will…

This study is testing whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy works better than current standard treatments for people with advanced HER2-positive colorectal cancer that has spread. About 400 participants with this specific cancer ty…

This study is testing whether a combination of targeted cancer drugs, with or without immunotherapy, can control advanced colorectal cancer without using traditional chemotherapy. It's for patients with a specific genetic profile (RAS/BRAF wild-type) whose cancer has spread and c…

This UK trial is testing if a drug combination already approved for breast cancer can help control other cancers with a specific genetic feature. It aims to treat adults and children (12+) with rare cancers or common cancers that have a rare genetic change called HER2. The goal i…

This study is testing whether a computer system (AI) can help doctors spot more dangerous growths during a routine colonoscopy. About 600 people getting a screening colonoscopy will be randomly assigned to have it done with or without the AI assistant. The main goal is to see if …

This trial is testing if an existing immunotherapy drug called atezolizumab can help control rare cancers or common cancers with rare genetic features. It will involve about 30 adults and children whose cancers have specific genetic markers. The goal is to see if this approved dr…

This trial is testing if a combination of two drugs, already approved for a type of skin cancer, can help control other rare cancers that share the same genetic change (a BRAF V600 mutation). It aims to enroll 30 adult patients with various rare or uncommon cancers to see if the …

This study is testing whether adding a new immune-stimulating drug called PDS01ADC to a specialized liver cancer treatment can better control advanced cancers that have spread to the liver. The treatment involves surgically placing a pump that delivers chemotherapy directly to th…

This study compares an immunotherapy drug called pembrolizumab against standard chemotherapy for Chinese patients with advanced colorectal cancer that has specific genetic features. The trial aims to see which treatment better controls cancer growth and extends survival. About 10…

This study is testing whether adding a newer drug called amivantamab to standard chemotherapy works better than the current standard treatment (cetuximab plus chemotherapy) for people with advanced left-sided colon or rectal cancer that has spread and cannot be removed by surgery…

This study is testing a new targeted radiation treatment called LY4257496 for people with advanced cancers that have a specific protein (GRPR). The main goals are to find a safe dose and see if the treatment helps shrink tumors. It is for adults with certain advanced breast, pros…

This study aims to make a common chemotherapy treatment safer by using a genetic test. It will check if adjusting the drug dose based on a patient's specific gene (DPYD) reduces severe side effects compared to the standard dose. The trial includes 100 adults with cancers like col…

This is a first-in-human study to test the safety and find the right dose of a new oral medicine, PF-07934040. It is being tested alone and in combination with other cancer drugs in people with advanced lung, colorectal, or pancreatic cancer that has a specific genetic change cal…

This study is testing an experimental pill called LY3537982 for people with advanced cancers that have a specific genetic change called KRAS G12C. The research aims to find the safest and most effective dose, both alone and combined with other cancer drugs, for patients with lung…

This is the first-ever study in people of an experimental drug called metarrestin. The main goals are to find a safe dose and see if it can shrink tumors. It is for adults and teenagers (12+) with advanced solid tumors that have spread and have not been cured by standard treatmen…

This study is comparing two methods for monitoring older adults who have had colon polyps in the past. Researchers want to see if an annual at-home stool test works as well as a colonoscopy at finding serious colon problems. The goal is to offer older adults a safer, less invasiv…

This early-stage trial is testing a new experimental drug called JNJ-95437446 in people with advanced solid tumors, including colorectal, lung, and head/neck cancers. The study aims to find safe doses and check for side effects in 380 participants. Researchers will also gather in…

This study is testing whether a personalized virtual support hub can help people recover better from colorectal cancer surgery. The hub provides education, exercise guidance, nutritional advice, psychological support, and peer groups before and after the operation. Researchers wi…

This is the first study in people of an experimental drug called JNJ-89402638 for advanced colorectal and stomach cancers that have spread and stopped responding to standard treatments. The main goals are to find a safe dose and see how the body handles the drug, both alone and w…

This early-stage trial is testing the safety and dosing of an experimental drug called PF-08046050 in adults with advanced solid tumors that have returned or stopped responding to standard treatments. The drug is designed to attach to cancer cells and deliver a toxic payload dire…

This is the first study in humans testing a new cancer drug called AZD9592. Researchers want to find safe doses and see if it helps control advanced cancers like lung, head/neck, and colorectal tumors. The study will test AZD9592 alone and combined with other cancer treatments in…

This is the first study in people to test a new targeted cancer drug called LY4170156. It aims to find a safe dose and see if it can help control advanced cancers, including ovarian, lung, breast, and pancreatic cancers. The study will also test the drug in combination with other…

This study aims to find the best time for patients to start eating after having a colon polyp removed with a special endoscopic procedure. Researchers will compare starting to eat within 24 hours to waiting more than 24 hours. They want to see if eating sooner is just as safe and…

This study is comparing a new drug combination to the current standard treatment for advanced colorectal cancer that has returned or spread after initial chemotherapy. It aims to see if adding the drug amivantamab to a common chemotherapy regimen helps patients live longer withou…

This is the first human study of an experimental cancer drug called DM002 for people with advanced solid tumors including ovarian, prostate, endometrial, and colorectal cancers. The study has two parts: first finding the safest dose, then testing that dose to see how well it work…

This study is testing whether a new drug called PF-08634404, when combined with standard chemotherapy, works better than the current standard treatment (bevacizumab plus chemotherapy) for people with advanced colorectal cancer that has spread. The trial will involve 800 adults wh…

This study aims to create and validate a new, non-invasive blood test to detect early-onset colorectal cancer in adults under 50. Researchers will analyze tiny genetic signals in the blood using advanced computer models to build a highly accurate test. The goal is to provide a si…

This study is testing a new microwave-based device designed to be used during a standard colonoscopy. The goal is to see if it can safely help doctors find more colorectal polyps, which are growths that can sometimes turn into cancer. The device is being tested in 50 patients who…

This study is testing a new blood test to see if it can better predict which colon cancer patients are at high risk of their cancer returning after surgery. The test looks for tiny pieces of cancer DNA left in the blood. Researchers will enroll 1,600 patients to see if this test …

This study is testing whether a simple at-home stool test (FIT) works as well as colonoscopy for monitoring people who have had polyps removed. Researchers want to see if the home test can detect cancer risk while reducing the need for invasive colonoscopies. The trial involves 4…

This study is testing whether a 12-week support program can help people at high risk for colorectal cancer adopt healthier habits to lower their risk. 80 participants will be randomly assigned to either receive the special program or general health information. The program includ…

This study is testing whether adding a medication called dexmedetomidine to standard anesthesia (desflurane) helps patients recover better after laparoscopic colon surgery. Researchers will compare the combination to anesthesia alone in 40 patients. They want to see if the mix us…

This study aims to understand how chemotherapy and radiation treatments affect the ability to have children and sexual health in younger adults with colorectal cancer. Researchers will track hormone levels and ask participants about their reproductive and sexual health over time.…

This study collects tumor and normal tissue samples from patients who are already scheduled for a biopsy or surgery for a solid tumor. The goal is to use these samples in research to discover new targets for future cancer therapies. No experimental treatments are given as part of…