COLORECTAL NEOPLASMS

This study tested whether a chemotherapy drug called FTD/TPI can prevent colorectal cancer from coming back in patients who had surgery to remove their tumors but still have cancer DNA in their blood. 243 patients were randomly assigned to receive either the drug or a placebo. Th…

This study tested a treatment for people with colorectal cancer that spread to the liver and didn't respond to earlier therapies. The approach combines chemotherapy delivered directly to the liver with a targeted drug called fuquintinib. The goal was to shrink liver tumors and co…

This study tested a new drug called E7386 combined with the immunotherapy pembrolizumab (and sometimes lenvatinib) in 89 people with advanced melanoma, colorectal cancer, or liver cancer that had stopped responding to prior treatments. The goal was to check safety and find the ri…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in people with advanced colorectal cancer that had spread and stopped responding to earlier treatments. The goal was to see if this new combination helped people live longer compared to standard treatment…

This study tested a two-step treatment for advanced colorectal cancer that hasn't responded to standard therapies. First, some patients received a chemotherapy drug (temozolomide) to make their cancer cells more genetically unstable. Then, they received an immunotherapy drug (pem…

This study tested whether using a non-invasive device (ClearSight) to monitor blood flow and guide fluid management during colorectal surgery could lower the chance of complications. 160 adults having colorectal surgery for polyps, cancer, or Crohn's disease took part. The approa…

This study tested an artificial intelligence system called EndoBRAIN that helps doctors instantly tell whether a colon polyp is cancerous or harmless during a colonoscopy. 680 adults with colorectal lesions took part. The goal was to see if the AI could accurately diagnose polyps…

This study tested three different colonoscopy techniques to see which one best predicts whether colorectal growths are cancerous. Over 500 patients with at least one growth larger than 6mm took part. The results showed that narrow band imaging (a special light filter) works as we…

This study tested whether artificial intelligence (AI) can help doctors spot precancerous polyps during colonoscopy. Over 334,000 veterans participated across multiple VA medical centers. Some centers used AI devices during the procedure, while others did not. The goal was to see…

This study tested an artificial intelligence (AI) system that helps doctors see whether colon growths (polyps) are cancerous or harmless during a colonoscopy. The AI works with a special microscope that magnifies the lining of the colon. The goal is to improve accuracy and reduce…

This study tested a remote monitoring system called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Participants used the system at home, with or without nursing support, while others received standard care. The goal was to see if th…

This study looked at the gut bacteria of nearly 1,800 people who had colon polyps or colorectal cancer. The goal was to find bacterial patterns that could predict who is at high risk for cancer returning. Researchers hope this will lead to a simple stool test to catch colorectal …

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which better predicts if the cancer will come back within …

This study tested a computer tool that helps doctors and cancer survivors discuss heart health during follow-up visits. 645 survivors of breast, prostate, colorectal, endometrial, or lymphoma cancers took part. The tool aimed to increase conversations about heart risks and referr…

This study examined colon cancer cells from 60 patients to find out why some cells are better at spreading and resisting chemotherapy. Researchers collected samples from tumors, blood, and metastases to study these 'cancer stem cells.' The goal was to learn more about how colon c…

This study tested whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) affects pain and how long the procedure takes. 198 adults having a colonoscopy were randomly assigned to one of the two positions. The goal was to s…

This study looked at whether a short educational session on Blink features can improve medical students' and non-GI trainees' ability to detect colorectal cancer in pictures of colon polyps. 65 participants without prior endoscopy experience completed an online survey before and …

This study looked at 500 adults aged 50 or younger diagnosed with colorectal cancer or a precancerous condition. Researchers reviewed medical records to find out which patients had more advanced cancer at the time of diagnosis. The goal is to help doctors catch the disease earlie…

This study tested whether using an artificial intelligence system (ENDOAID) together with a small attachment called Endocuff helps doctors find more abnormal growths (polyps) in the colon during a colonoscopy. Over 1,700 adults aged 45-85 who needed a colonoscopy for screening or…