COLORECTAL NEOPLASMS

This trial tests two approved drugs, dabrafenib and trametinib, in people with rare cancers that have a BRAF V600 mutation. The drugs are already used for melanoma and lung cancer. About 30 adults, children, and teens will take part. The goal is to see if the drugs shrink tumors …

This study tests whether a new treatment sequence—radiation followed by a mix of drugs (bevacizumab and TAS-102)—can slow the growth of advanced colorectal cancer that has not responded to earlier treatments. About 58 adults aged 18-75 will be randomly assigned to either the new …

This study tests whether an artificial intelligence system can help doctors spot more precancerous polyps and early colorectal cancers during colonoscopy. Over 3,300 adults will be randomly assigned to either AI-assisted or standard colonoscopy. The goal is to see if AI can reduc…

This study tests a smarter way to prevent colon cancer in people who have had multiple advanced polyps removed. Instead of waiting three years for a standard colonoscopy, some participants will do a simple stool test every year. If the stool test finds hidden blood, they get a co…

This study tests a new health education program using the metaverse to help colorectal cancer survivors improve their quality of life and adopt healthier lifestyles. The program includes virtual classes, immersive interactions, and group support. Researchers will compare this app…

This study tests whether electroacupuncture (using mild electrical pulses on acupuncture needles) can help bowel function return faster after minimally invasive colorectal cancer surgery. About 240 adults will be randomly assigned to receive real acupuncture, a sham (placebo) ver…

This study looks at whether a special ultrasound can tell doctors earlier if chemotherapy is working for people with colorectal cancer that has spread to the liver. Currently, it takes about 2 months with CT or MRI scans to see if the tumor is shrinking. The new method uses contr…

This study looks at 1,280 adults aged 18 to 75 who had colon polyps removed. Researchers want to create a tool that predicts if polyps will come back. They will use past medical records and follow new patients over time, collecting lifestyle details and blood samples. The goal is…

This study compares two surgical methods for removing right-sided colon cancer: laparoscopic (keyhole) surgery and open surgery. Researchers want to see if the keyhole approach leads to less blood loss, fewer complications, and a shorter hospital stay. About 22 adults with right …

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can tell which growths are cancerous and which have spread to lymph nodes. Current methods often lead to unnecessary surgery because they can't accurately predict risk. The …

This study tests whether artificial intelligence can help more high-risk adults in China get a colonoscopy, the gold standard for detecting colorectal cancer. About 400 people aged 40 to 64 will be split into two groups: one gets usual care, the other gets AI-assisted support fro…

This study looks at two ways to examine the colon during routine cancer screening in people with inflammatory bowel disease (IBD). One method uses a special dye sprayed inside the colon, while the other uses advanced camera technology to enhance images without dye. About 480 adul…