COLORECTAL NEOPLASMS

This study tests a new drug (GV20-0251) combined with an immunotherapy (anti-PD-1) in people with advanced solid tumors that have not responded to or cannot tolerate standard treatments. About 227 adults with various cancers, including lung, breast, and colorectal, will participa…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This study will test a new robotic device called the Triton 1.5 System for performing colonoscopies, which are exams to look for colon cancer. About 40 adults who need a routine colonoscopy will take part. The main goal is to see if the robot is safe and can successfully complete…

This phase 2 trial tests whether adding targeted radiation (SBRT) and an immunotherapy drug (sintilimab) to standard chemotherapy (TAS-102) and bevacizumab can help people with recurrent metastatic colorectal cancer live longer without their cancer growing. The study will enroll …

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This study tests a special ultrasound technique called contrast-enhanced subharmonic ultrasound to see if it can predict whether chemotherapy is working for colorectal cancer that has spread to the liver. Currently, doctors wait about 2 months for CT or MRI scans to see if tumors…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

This study tests whether a multilevel screening program can increase colorectal cancer screening rates among Veterans aged 45-49, an age group now recommended for screening due to rising early-onset cases. Participants are randomly assigned to receive a patient education letter a…

This study tests whether an AI-powered chatbot and smart reminders can encourage more high-risk adults aged 45 to 74 to get a colonoscopy, the best way to detect colorectal cancer early. About 1,680 participants will be split into two groups: one gets usual care, the other also g…

This study compares two ways to prevent colon cancer in people who have had multiple advanced polyps removed. One group gets a standard colonoscopy after three years, while the other group does a simple stool test every year for two years, and only gets a colonoscopy if the test …

This study tests whether electroacupuncture can help bowel function return faster after minimally invasive colorectal cancer surgery. 240 adults will be randomly assigned to receive real acupuncture, sham acupuncture, or standard care. The main goal is to see how quickly patients…

This study tests a new health education program using a virtual 'metaverse' to help colorectal cancer survivors improve their quality of life and adopt healthier lifestyles. The program includes online lessons, immersive virtual interactions, and group support via WeChat. Researc…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…

This study will look at 1,280 people who had colon polyps removed to find better ways to predict if polyps will come back. Researchers will combine lifestyle information, blood markers, and past medical records to build a risk prediction model. The goal is to improve follow-up sc…

People with inflammatory bowel disease (IBD) have a higher risk of colon cancer and need regular colonoscopies. This study compares two advanced methods: one uses a dye spray to highlight abnormal areas, and the other uses built-in camera filters to enhance the view without dye. …

This study compares two types of surgery for right-sided colon cancer: laparoscopic (keyhole) surgery and open surgery. The goal is to see which approach leads to less blood loss, fewer complications, and a shorter hospital stay. The study will include 22 adults with right colon …

This study tests whether artificial intelligence (AI) can help more high-risk adults aged 40 to 64 get colonoscopies to screen for colorectal cancer. About 400 participants will be split into two groups: one gets usual care, the other gets AI-assisted support from doctors and nur…