COLORECTAL NEOPLASMS

This early-stage study tests the safety of a new drug, PF-08046049/SGN-BB228, in people with advanced melanoma and other solid tumors that have spread or are hard to treat. The study involves 41 participants and will look at side effects and the right dose. It is not expected to …

This early-stage study tests a new oral medication, PF-07985045, alone or with other cancer drugs, in people with advanced solid tumors that have a KRAS gene mutation. The cancers studied include non-small cell lung, colorectal, and pancreatic cancers. The main goals are to check…

This early-stage study tests an experimental drug called SGN-MesoC2 in 19 adults with advanced solid tumors (like lung, ovarian, or pancreatic cancer) that have not responded to standard treatments. The drug is designed to stick to cancer cells and kill them. The main goals are t…

This study tests three drugs—durvalumab, olaparib, and cediranib—in different combinations for people with advanced solid tumors, including ovarian, breast, lung, prostate, and colorectal cancers. The goal is to see if these combinations can shrink tumors or slow their growth. Pa…

This study tested a drug called tisotumab vedotin, alone or with other cancer drugs, in 350 people with advanced colorectal, lung, pancreatic, or head and neck cancers that had stopped responding to standard treatments. The goal was to see if the drug could shrink tumors and to t…

This early-stage study tests a new drug called E7386 in people with advanced solid tumors, including colorectal cancer, who have no other treatment options. The main goal is to check the drug's safety and find the right dose. About 70 participants will take part, and the study is…

This study tests a new drug called JDQ443, given alone or with other treatments, for people with advanced solid tumors that have a specific change in the KRAS gene (G12C). The goal is to find safe doses and see if the drug can shrink tumors. About 74 adults with lung or colorecta…

This study tests a new drug, E7386, combined with other anticancer drugs for people with advanced solid tumors, including endometrial, liver, and colorectal cancers. The goal is to find the safest and most effective dose. About 301 participants will be involved, and the study foc…

This study tests whether a software called ColoMaia II can help doctors find polyps (growths) in the colon during a colonoscopy. About 600 adults aged 40 to 80 having a routine colonoscopy will be randomly assigned to have the procedure with or without the software's assistance. …

This study tests whether taking two drugs, eflornithine and sulindac, together can prevent new high-risk polyps or second colon cancers in people who have already been treated for stage 0 to III colon or rectal cancer. About 354 participants will take the drug combination or a pl…

This study looks at three different eating plans to see which one helps overweight adults at risk for colorectal cancer eat healthier and lose weight. About 240 people with a family or personal history of colorectal cancer or polyps will follow one of the plans for 12 months. The…

This study tests whether a personalized home exercise program can improve physical function and quality of life in people aged 75 and older with colorectal cancer who are having surgery. Participants receive weekly phone coaching on strength, balance, and breathing exercises. The…

This study tests whether a specially designed physical activity program can help African American colorectal cancer survivors become more active. About 21 participants will use a Fitbit tracker and watch exercise videos to increase their daily steps and reduce sitting time. The g…

This study looks at how a plant-based Mediterranean diet affects the gut microbiome and inflammation in people who have had colon polyps removed. Researchers will analyze stool and blood samples from 30 participants over 8 weeks to see if diet changes gut bacteria and reduces inf…

This study looks at tissue samples from 64 people who had surgery to remove colorectal cancer that spread to the liver. Researchers are analyzing the immune cells around the tumors and how the tumors grow, to see if these patterns relate to how long patients live or if the cancer…