New pill takes on KRAS-Mutant cancers in early trial

NCT ID NCT06447662

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests a new experimental drug called PF-07934040, taken as a pill, for people with advanced solid tumors that have a KRAS gene mutation. The trial includes patients with non-small cell lung cancer, colorectal cancer, and pancreatic cancer. Researchers will give the drug alone or combined with other cancer treatments to find the safest dose and see if it helps control the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

PF-07934040 (a pan-KRAS inhibitor pill)

What this could lead to

If successful, this could lead to a new treatment option for people with advanced cancers driven by KRAS mutations, including lung, colorectal, and pancreatic cancers.

What could go wrong

This is an early Phase 1 trial focused on safety and dosing, not yet proven to work. Side effects are unknown, and the drug may not shrink tumors or improve survival.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal carcinoma colorectal neoplasm lung neoplasm neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG CARCINOMA, PANCREATIC DUCTAL COLORECTAL NEOPLASMS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Beijing Cancer hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100142, China
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITING

Duarte, California, 91010, United States
City of Hope Investigational Drug Service (IDS)
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic Taussig Cancer Center
RECRUITING

Cleveland, Ohio, 44195, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duke University Medical Center, lnvestigational Chemotherapy Service
RECRUITING

Durham, North Carolina, 27710, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Highlands Oncology Group, PA
RECRUITING

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group, PA
RECRUITING

Rogers, Arkansas, 72758, United States
Miriam Hospital
RECRUITING

Providence, Rhode Island, 02906, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States
Siteman Cancer Center - North County
RECRUITING

Florissant, Missouri, 63031, United States
Siteman Cancer Center - South County
RECRUITING

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St Peters
RECRUITING

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County
RECRUITING

Creve Coeur, Missouri, 63141, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Outpatient Pavilion
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Hospital- Anschutz Cancer Pavilion (ACP)
RECRUITING

Aurora, Colorado, 80045, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West Chester Hospital
RECRUITING

West Chester, Ohio, 45069, United States