New drug combo shows promise for Tough-to-Treat cancers
NCT ID NCT05091346
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new drug called E7386 combined with the immunotherapy pembrolizumab (Keytruda) in 89 people with advanced melanoma, colorectal cancer, or liver cancer. The goal was to see if the combination is safe and can shrink tumors. Some participants with liver cancer also received a third drug, lenvatinib. The trial has been completed, and researchers are analyzing the results.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
E7386 (a drug taken as a tablet) combined with pembrolizumab (an immunotherapy given by IV), and in some cases lenvatinib (a drug taken as a capsule)
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced melanoma, colorectal, or liver cancer who have not responded to prior therapies.
What could go wrong
This is an early-phase trial (Phase 1b/2) with only 89 participants, so results may not apply to everyone. The combination may cause side effects or not work better than existing treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barbara Ann Karmanos Cancer Center
Detroit, Michigan, 48201, United States
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Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
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Chiba University Hospital
Chiba, Japan
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Clínica Universidad de Navarra
Pamplona, Navarre, Spain
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Consorcio Hospital General Universitario de Valencia
Valencia, Spain
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Florida Cancer Specialists
Fort Myers, Florida, 33916, United States
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Hospital Clinic de Barcelona
Barcelona, Spain
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Hospital Clínico San Carlos
Madrid, Calle Profesor Martín Lagos, Spain
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Hospital General Universitario Gregorio Maranon
Madrid, Spain
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Hospital Regional Universitario de Malaga
Málaga, Avenida Carolos Haya S/n, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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Hospital Universitario de Badajoz
Badajoz, Spain
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Hospital Universitario de la Paz
Madrid, Spain
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Imperial College London - Hammersmith Hospital
London, United Kingdom
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Kindai University Hospital
Ōsaka-sayama, Japan
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Kurume University Hospital
Fukuoka, Japan
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National Cancer Center Hospital
Chūōku, Japan
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National Cancer Center Hospital East
Kashiwa, Japan
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Osaka Metropolitan University Hospital
Osaka, Japan
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Providence Medical Center Institute Franz Clinic
Portland, Oregon, 97213, United States
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Royal Free Hospital NHS Foundation Trust
London, United Kingdom
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Rutgers cancer Institute of NJ
New Brunswick, New Jersey, 08901, United States
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SCRI Florida Cancer Specialists East
West Palm Beach, Florida, 33401, United States
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Sapporo-Kosei General Hospital
Sapporo, Japan
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Shizuoka Cancer Center Hospital
Shizouka, Japan
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Tennessee Oncology PPLC
Nashville, Tennessee, 37203, United States
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The Christie NHS Foundation Trust
Manchester, United Kingdom
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Toranomon Hospital
Tokyo, Japan
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University of California, Irvine Health
Orange, California, 92868, United States
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University of California, Los Angeles
Los Angeles, California, 90095, United States
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Winship Cancer Institute
Atlanta, Georgia, 30322, United States