MELANOMA

This early-stage study is testing whether a probiotic pill called R-5780 is safe and tolerable for people with advanced solid tumors who are already receiving a standard immunotherapy. The goal is to see if adding this probiotic can help control the cancer and improve quality of …

This study is testing whether giving immunotherapy drugs before surgery can lead to better outcomes for people with advanced melanoma that has spread to nearby lymph nodes or tissue. The treatment aims to help the patient's own immune system attack the cancer to shrink tumors pri…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This study is testing a combination of three treatments—an immunotherapy drug (atezolizumab), a new immune-stimulating drug (BDB001), and targeted radiation—to see if they can better control advanced solid tumors. It is enrolling 247 adults with specific advanced cancers, includi…

This study is testing whether adding a low-dose chemotherapy drug (cyclophosphamide) to an existing immunotherapy (pembrolizumab) can help patients with advanced melanoma that has stopped responding to standard treatments. The trial will enroll 14 adults with stage III or IV mela…

This early-stage study is testing a new drug called TRK-950 in people with advanced solid tumors that have not responded to standard treatments. The trial has three parts: testing TRK-950 alone, testing it combined with an existing immunotherapy (nivolumab), and specifically test…

This early-stage study aims to find a safe and effective dose of a new drug called AZD6750, which is designed to boost the immune system to fight cancer. It will test the drug alone and combined with other cancer treatments in about 60 adults with advanced or spreading solid tumo…

This study is testing a more precise way to deliver radiation therapy to people whose lung cancer, melanoma, or kidney cancer has spread to a few new spots. It uses PET scans to guide the radiation beams to the most active parts of the tumors. The goal is to see if this targeted …

This is a very early-stage study to test the safety of a new drug called GV20-0251 in adults with advanced solid tumors that have progressed despite standard treatments. The main goal is to find a safe dose by giving the drug to small groups of patients at different levels. It is…

This study is testing whether adding a drug called sarilumab to a combination of three other immunotherapy drugs works better for people with advanced melanoma that cannot be removed by surgery. The main goals are to see if this four-drug combination is safe, tolerable, and more …

This study is testing if a new drug called HLX17 works similarly to the established cancer drug Keytruda. It aims to prevent cancer from returning in people who have had surgery for certain lung, skin, or kidney cancers. Researchers will compare how the two drugs are processed by…

This study is testing whether combining two existing drugs, axitinib and ipilimumab, can help control advanced melanoma in patients whose cancer didn't respond to previous immunotherapy. The trial will enroll 25 adults with advanced melanoma who have already tried anti-PD-1/PD-L1…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study aims to find out if adding a precise, targeted form of radiation to the brain (called stereotactic radiosurgery) to standard drug treatments works better than drugs alone for people whose melanoma or non-small cell lung cancer has spread to the brain. It will enroll 18…

This study is testing a new type of personalized cell therapy called OBX-115 in adults with advanced melanoma or non-small cell lung cancer that has progressed after standard treatments. Doctors take a patient's own immune cells from a tumor, genetically engineer them to be more …

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This early-stage trial is testing a new oral medication called NST-628 for adults with advanced solid tumors that have specific genetic changes in a key cancer growth pathway. The study aims to find a safe and effective dose and see if the drug can shrink tumors in patients who h…

This study is testing a new oral medication called Alintegimod, given alongside the immunotherapy drugs ipilimumab and nivolumab. It aims to see if this combination is safe and can help control advanced cancers that have spread or returned after other treatments. The study will e…

This early-stage trial is testing a personalized cell therapy for people with advanced melanoma that hasn't responded to standard treatments. Doctors take immune cells from a patient's own tumor, boost them in the lab with a protein called CD40L, and then infuse them back into th…

This early-stage study is testing a personalized treatment called lifileucel for patients with advanced uveal melanoma (a rare eye cancer) or certain aggressive soft-tissue sarcomas. Doctors take a patient's own immune cells from their tumor, grow large numbers of them in a lab, …

This study is testing if changing the bacteria in a patient's gut, using a treatment called a fecal microbiota transplant (FMT), can make standard immunotherapy work better against advanced melanoma. About 128 patients will be randomly assigned to receive either the standard immu…

This study is testing a precise, high-dose radiation treatment for liver tumors that cannot be surgically removed. It is designed for patients whose tumors are too large or located too close to major blood vessels or sensitive organs for standard heat-based treatments. The goal i…

This study is testing whether adding radiation therapy to standard immunotherapy helps prevent melanoma from coming back in the lymph nodes. It's for patients whose melanoma has spread to a nearby lymph node but hasn't traveled further. Participants are randomly assigned to recei…

This early-stage study is testing the safety and early effectiveness of an experimental cancer treatment called T3011. The treatment is injected directly into tumors and is being tested both alone and combined with an existing immunotherapy drug (pembrolizumab) in people with adv…

This study is testing whether a new combination of two immunotherapy drugs (fianlimab and cemiplimab) works better than an already approved combination (Opdualag) for treating advanced melanoma that cannot be removed by surgery. It will involve 560 adults with this type of skin c…

This study is testing a new combination of three immune-based treatments for advanced melanoma that cannot be removed by surgery. It aims to see if using CAR T cells, CTLs, and a special vaccine together is safe and can help control the cancer. The trial will also track how long …

This trial is testing if an existing immunotherapy drug called atezolizumab can help control rare cancers or common cancers with rare genetic features. It will involve about 30 adults and children whose cancers have specific genetic markers. The goal is to see if this approved dr…

This study is testing whether it is safe to combine a new targeted drug called tarlatamab with standard radiation therapy. It is for adults with advanced cancers that have a specific protein called DLL3, including certain lung cancers, melanoma, and others. The main goal is to se…

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This early-stage trial is testing a new, personalized vaccine made from a patient's own tumor. The goal is to see if this vaccine can help the patient's immune system recognize and fight their cancer, especially when standard immunotherapy has stopped working. The study will enro…

This trial is testing if a combination of two drugs, already approved for a type of skin cancer, can help control other rare cancers that share the same genetic change (a BRAF V600 mutation). It aims to enroll 30 adult patients with various rare or uncommon cancers to see if the …

This study is testing an experimental therapy called RP1 for people who have had an organ or bone marrow transplant and now have advanced skin cancer. RP1 is a modified cold sore virus that is injected directly into tumors to try to destroy them and boost the body's immune respon…

This study is testing whether a supplement called Urolithin A can improve how the immune system responds to cancer immunotherapy drugs. Researchers will compare 45 patients with newly diagnosed solid tumors who take either the supplement or a placebo while receiving standard immu…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing a new treatment called VSV-02 for people with advanced solid tumors who have few or no other treatment options left. VSV-02 is a specially engineered virus designed to both kill cancer cells directly and boost the body's immune system to fight the cancer. Th…

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This study is testing whether removing only the single cancerous lymph node, instead of many nearby nodes, is effective at preventing melanoma from returning in that area. Researchers want to see if this more targeted surgery causes fewer side effects, like painful swelling (lymp…

This study is testing a new oral drug called IPN01194 in adults with advanced solid tumors that have spread and have specific genetic changes. The main goals are to find a safe and tolerable dose and to see if the drug can help shrink tumors. The study is open to people with cert…

This study is testing a new type of personalized cell therapy called CAR-T that is engineered to attack melanoma cancer cells using two targets, NG2 and DLL3. It is for adults whose melanoma has come back or stopped responding to standard treatments. The main goals are to see if …

This study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …

This study is testing an experimental cell therapy for people with metastatic melanoma that has spread. Doctors take a patient's own immune cells from a tumor, grow billions of them in a lab, and infuse them back to attack the cancer. The trial is also testing if adding the drug …

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This study is testing a personalized treatment for advanced melanoma, a serious skin cancer. It compares a new therapy, where a patient's own immune cells are grown in a lab and reinfused, against standard chemotherapy. The goal is to see if this cell therapy can better control t…

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This study is testing a new drug called GV20-0251 for adults with advanced solid tumor cancers that have progressed despite standard treatments. The first part aims to find a safe dose, and the second part will see how well the drug works against several types of cancer, includin…

This study is testing how well immunotherapy works as a first treatment for people in Slovenia with advanced melanoma that has spread. It will follow 40 patients to see how their cancer responds and how long it stays under control. Researchers will also collect blood, stool, and …

This study is testing a new cancer vaccine made from a patient's own or donated tumor cells. The cells are modified in a lab to train the patient's immune system to attack the cancer, then injected back into the patient. The goal is to see if this approach can help people with ad…

This study is testing a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) for people with melanoma that has spread to the brain. It aims to see if this combo can shrink or control brain tumors and improve survival. The trial will enroll 60 adults, i…

This study is testing a new drug called tegavivint in children, teens, and young adults whose solid tumors or lymphomas have come back or haven't responded to other treatments. The main goals are to find the safest dose, understand the side effects, and see if the drug can help s…

This study is testing if adding a very low dose of radiation to the liver can make standard immunotherapy work better for people with lung cancer or melanoma that has spread to the liver. It is for patients already planning to receive immunotherapy. The goal is to see if this com…

This is a first-in-human study testing a new type of personalized cell therapy for children and young adults (up to age 21) whose solid tumors have come back or haven't responded to standard treatments. Doctors will collect a patient's own immune cells (T cells), genetically modi…

This study is testing whether combining two drugs, enfortumab vedotin and pembrolizumab, can help control advanced melanoma that has continued to grow despite standard immunotherapy. It will enroll about 60 adults whose cancer has worsened after prior treatment. The main goal is …

This early-stage trial is testing the safety and best dose of a new two-drug combination (ulixertinib and palbociclib) for people with advanced solid tumors that have stopped responding to standard treatments. It will enroll up to 45 adults, with a specific focus on metastatic pa…

This study is testing whether adding a special prebiotic-rich diet to standard immunotherapy helps patients with melanoma that can be surgically removed. Researchers want to see if the diet is easy for patients to follow and if it improves the body's response to the cancer drugs.…

This is a first-in-human study to test the safety and find the right dose of a new drug called PF-08046054/SGN-PDL1V for people with advanced solid tumors. It will be tested alone and in combination with another cancer drug, pembrolizumab. The study is recruiting 714 participants…

This study continues to monitor patients who have already completed previous cancer treatment studies with dabrafenib and/or trametinib. It tracks 100 patients with various cancers including melanoma and lung cancer to understand the long-term safety of these medications. The goa…

This is an early-stage trial testing a new drug called BI-1808 for people with advanced cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates the drug, both by itself and when combined with an exist…

This is an early-stage safety study testing a new personalized cell therapy for adults with advanced sarcoma, lung cancer, or melanoma. Doctors take a patient's own immune cells, modify them in a lab to better target a specific protein found on their cancer cells, and then infuse…

This study is testing a new drug called BMS-986340 to see if it is safe and can help control advanced cancers. It will be given alone or combined with two other cancer drugs to about 950 people whose cancers have grown despite standard treatments. The main goal is to find the rig…

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if giving smaller radiation doses over several days causes fewer side effects than the standard single-day treatment. The trial…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This early-stage study is testing a new oral medicine called PF-07799933, both alone and combined with other drugs, for people with advanced solid tumors that have a specific BRAF gene change and have stopped responding to standard treatments. The main goals are to find a safe do…

This study is testing if giving two immunotherapy drugs (ipilimumab and nivolumab) before surgery can help control melanoma that has come back after a patient's initial treatment. About 25 adults with high-risk, operable melanoma that returned during or shortly after their last t…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This early-stage study is testing a new drug called NUC-7738 in adults with advanced cancers that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors, either by itself or combined with another immunotherapy drug.…

This study is testing a new type of personalized cancer treatment called CAR-T cell therapy. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer cells that have a specific marker called CD70, and then infuse them back …

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This early-stage study is testing a new, experimental immunotherapy drug called REGN10597, both by itself and combined with an existing drug (cemiplimab), in people with advanced solid tumors like melanoma and kidney cancer. The main goals are to find a safe dose and see if the t…

This study is testing a new diagnostic platform called IT-TCP that analyzes tumor samples from patients with high-risk cancers. Researchers will collect samples from 300 patients with various cancers including leukemia, pancreatic cancer, and melanoma to see if this detailed anal…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing a new, non-radioactive method to find the first lymph nodes where cancer might spread. It compares a special contrast-enhanced ultrasound to the current standard method that uses a radioactive dye. The goal is to see if the ultrasound method works just as we…

This study is testing a digital tool called mySmartSkin, designed to help people who have had melanoma perform more thorough skin self-exams. Researchers will compare the app's effectiveness against a basic educational webpage to see if it leads to better exam habits and earlier …

This study is testing whether performing a special surgical connection, called a lymphovenous bypass, at the same time as standard underarm lymph node removal can prevent a painful and chronic side effect called lymphedema (arm swelling). The research involves 252 adults with adv…

This study is testing whether an existing melanoma treatment (anti-PD1 immunotherapy) might help prevent new melanomas from developing. Researchers will give this approved treatment to 30 people who have had melanoma and also have unusual moles that could turn into cancer. They'l…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether a virtual mind-body wellness program can help cancer patients feel better during treatments like chemotherapy or radiation. The program offers online classes in things like meditation and yoga to help manage common side effects like severe fatigue. R…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This study aims to understand if using cannabis or related products helps people manage symptoms like pain and nausea during cancer treatment. It will follow 2,000 adults newly diagnosed with certain cancers who are starting chemotherapy or immunotherapy. Researchers will track p…

This study aims to understand the daily life and emotional well-being of people in the first two years after treatment for advanced melanoma. It will also test if a specific type of talk therapy (CBT-C) can help reduce cancer-related stress and improve quality of life. The resear…

This study aims to understand how modern melanoma treatments might affect fertility in young men and women. Researchers will track 80 participants aged 18-45, measuring ovarian reserve and sperm quality before treatment, right after, and one year later. The goal is to gather info…

This study is testing whether a large-scale educational campaign across Oregon helps people learn the early signs of melanoma, a serious skin cancer. The program provides information to the public, high school students, and healthcare providers. Researchers will compare melanoma …

This study aims to learn more about melanoma in children and adolescents by analyzing leftover tumor tissue and blood samples. Researchers will look for genetic changes in the cancer cells to understand how these tumors develop and respond to treatment. The study does not test ne…

This study is testing a mobile app called Vigilant to see if it can help patients track side effects from their melanoma immunotherapy at home. The goal is to understand if remote monitoring helps catch serious side effects earlier. About 100 patients starting a specific two-drug…

This study aims to improve how young adult cancer patients report their symptoms and quality of life. Researchers are testing whether letting patients choose which survey topics matter most to them leads to better participation than using standard surveys. The goal is to gather m…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study is monitoring patients for five years after they received an experimental cancer immunotherapy from Replimune. The goal is to check for any delayed side effects or safety issues that might appear long after treatment. About 50 patients with cancers like melanoma or liv…

This study analyzes cancer patients' tumor tissue and blood samples to identify specific genetic changes in their cancer. The goal is to create a detailed database of cancer mutations and use that information to match patients with the most relevant treatment options and clinical…

This study aims to understand if newer, effective drugs for preventing melanoma from returning can harm a woman's ability to have children. It will follow 270 young women under 40 who have had melanoma surgery and are taking these preventive drugs. Researchers will measure hormon…

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study is testing a new predictive tool to see if it can accurately forecast which patients with melanoma and other cancers will respond to immunotherapy drugs. It will involve 1,000 patients who are eligible for standard immunotherapy treatment. The goal is to see if this to…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to collect and analyze leftover tissue samples from 3,000 melanoma patients to better understand the disease's biology. The goal is to identify molecular changes in the cancer that could help doctors and patients make more informed treatment decisions in the futur…

This study is testing a new laboratory method to see if it can predict which cancer treatments will work best for a patient. Researchers will take a sample of a patient's tumor cells from a fluid or tissue biopsy and test how the cells react to different drugs in the lab. The goa…

This study aims to better understand melanoma by collecting and storing blood and tumor samples from patients and healthy individuals. Researchers will analyze these samples to learn how melanoma develops and behaves, hoping to discover new ways to diagnose or treat the disease i…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to learn if a special scan (PET/CT) and a blood test for tumor DNA can help doctors predict, very early on, which patients with advanced melanoma will respond well to immunotherapy and which might experience side effects. It will enroll 24 patients who are startin…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to understand how the COVID-19 pandemic affected melanoma patients' quality of life, stress levels, and access to healthcare. Researchers will survey over 1,100 patients who previously participated in a lifestyle study to learn about their pandemic experiences. Th…

This study aims to understand how a local treatment called electrochemotherapy changes the environment inside and around melanoma skin tumors. Researchers will treat patients who have melanoma that has spread to the skin and take small tissue samples before and after treatment. B…

This study aims to understand why some families are at high risk for melanoma, a serious skin cancer. Researchers will observe 3,000 people with a personal or family history of melanoma or unusual moles. Participants will provide health information, blood or cheek cell samples, a…