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Could a probiotic help fight cancer? early trial launches

NCT ID NCT06398418

Recruiting now Disease control Sponsor: Rise Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-stage trial is testing whether an oral probiotic called R-5780 is safe and tolerable when taken alongside a standard PD-1 checkpoint inhibitor in people with advanced solid tumors (like melanoma or certain skin cancers). About 33 adults whose cancer has not responded to prior immunotherapy will take the probiotic and be monitored for side effects and quality of life. The goal is to see if this combination can be given safely, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
R-5780 (a probiotic taken by mouth)
What this could lead to
If it works, this could point toward a way to boost the immune system's ability to fight tumors using a simple probiotic.
What could go wrong
This is a very early (Phase 1) and small (33 people) study focused on safety, not effectiveness. The probiotic may not improve cancer control and could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoma basal cell carcinoma basal cell neoplasm melanoma squamous cell carcinoma squamous cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOMA BASAL CELL CANCER MELANOMA SOLID TUMOR SOLID TUMOR, ADULT SQUAMOUS CELL CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sarah Cannon Research Institute

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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