SOLID TUMOR, ADULT

This early-stage trial is testing a new oral drug called OK-1 in adults with advanced solid tumors that have returned or spread despite other treatments. The main goal is to find a safe dose and understand the drug's side effects. Participants will take capsules twice daily in re…

This study is testing a new personalized treatment for adults with advanced solid tumors that have returned or stopped responding to standard therapies. Doctors take a patient's own immune cells, modify them in a lab to better target their cancer, and then infuse them back. The t…

This early-stage study is testing whether a probiotic pill called R-5780 is safe and tolerable for people with advanced solid tumors who are already receiving a standard immunotherapy. The goal is to see if adding this probiotic can help control the cancer and improve quality of …

This study is testing the safety of a new two-drug combination (avutometinib and defactinib) for children and young adults (ages 3-30) whose solid tumors have come back or stopped responding to standard treatments. The main goal is to find the highest dose that is safe and causes…

This early-stage trial is testing a new drug called BBO-11818 in people with advanced cancers that have specific KRAS gene mutations. The study aims to find a safe dose and see if the drug can shrink tumors in cancers like lung, pancreatic, and colorectal cancer. Participants wil…

This study is testing a new oral drug called LNS8801 to see if it is safe and can help control advanced solid tumors. It is for adults whose cancer has progressed despite standard treatments. The drug will be tested both by itself and in combination with an existing immunotherapy…

This is the first study in people testing a new drug called DB-1419 for adults with advanced or spreading solid tumors that have not responded to standard treatments. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs that it ca…

This is the first time researchers are testing an experimental drug called ATTR-01 in people. The treatment uses a modified common cold virus designed to infect only cancer cells and deliver an immune-boosting drug directly to the tumor. The trial aims to find a safe dose and see…

This study is testing a combination of three treatments—an immunotherapy drug (atezolizumab), a new immune-stimulating drug (BDB001), and targeted radiation—to see if they can better control advanced solid tumors. It is enrolling 247 adults with specific advanced cancers, includi…

This study is testing whether adding an immunotherapy drug called TSR-042 before standard chemoradiation and surgery works better for advanced solid tumors with specific genetic features. Researchers want to see if this combination helps eliminate cancer cells more effectively. T…

This early-stage study is testing a new drug called VT3989, both alone and in combination with other cancer therapies. It aims to find a safe dose and see if it can help control advanced solid tumors and mesothelioma that have stopped responding to standard treatments. The trial …

This early-stage trial is testing a new oral medication called NST-628 for adults with advanced solid tumors that have specific genetic changes in a key cancer growth pathway. The study aims to find a safe and effective dose and see if the drug can shrink tumors in patients who h…

This study is testing an inhaled therapy called KB707 for adults with advanced solid tumors in the lungs that have stopped responding to standard treatments. The therapy uses a modified, harmless virus designed to stimulate the immune system to fight the cancer directly in the lu…

This study is testing an experimental drug called patritumab deruxtecan for adults with advanced solid tumors that have a specific, rare genetic change called an NRG1 fusion. The goal is to see if the drug can shrink these tumors and control the cancer. About 30 participants will…

This study is testing whether a drug called nivolumab can be safely given after a half-matched bone marrow transplant to help prevent cancer from coming back. It involves children and young adults up to age 50 who have high-risk, recurrent, or hard-to-treat sarcomas and have alre…

This is the first study in people to test a new drug called RLY-2608, which is designed to target a specific genetic mutation (PIK3CA) found in many advanced solid tumors and breast cancers. The main goals are to find the safest and most effective dose, check for side effects, an…

This early-stage trial is testing whether combining up to five existing oral medications is safe and can help control advanced solid tumors or prostate cancer that has returned after treatment. The study will first determine the safest combination of drugs, then see if that combi…

This study is testing if adding a drug called ATRA to a precise form of radiation (SBRT) is safe and can protect a patient's immune cells from damage. The goal is to see if protecting these cells helps the body's own immune system better fight cancer that has spread to a few loca…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack canc…

This study is testing the safety and early effectiveness of a new two-drug combination (AK119 and AK112) for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the treatment can shrink tumors. I…

This is the first time a new drug called IMA401 is being tested in people. The main goal is to find a safe dose and see if it can help control advanced solid tumors that have come back or stopped responding to other treatments. The study will test IMA401 by itself and combined wi…

This study is testing an oral drug called HMPL-453 for people with advanced bile duct cancer inside the liver that has a specific genetic change (FGFR2 fusion/rearrangement) and has worsened after at least one prior treatment. The main goal is to see how well the drug shrinks tum…

This early-stage study is testing a new oral drug called VS-7375, which is designed to block a specific cancer-driving mutation known as KRAS G12D. Researchers will give the drug alone and in combination with other cancer therapies to adults with advanced solid tumors, including …

This early-stage trial is testing a new immune therapy drug called ADU-1805, both alone and combined with an existing cancer drug (pembrolizumab). It aims to find safe doses and see if the treatment helps control advanced solid tumors that haven't responded to standard treatments…

This is the first study in people to test a new oral drug called NKT3964. It aims to see if the drug is safe and can help control advanced cancers that have spread and stopped responding to standard treatments. The study will enroll adults with specific advanced solid tumors, inc…

This is the first human study testing a new experimental drug called BBO-10203 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goal is to find safe doses and see how the body processes the drug, both alone and when combined with oth…

This is the first study in people testing a new oral medication called TRE-515 for advanced solid tumors that have stopped responding to standard treatments. The main goal is to find the highest safe daily dose and understand how the drug moves through the body. Researchers will …

This study is testing a new oral drug called ACE-86225106 to see if it is safe and can help control advanced solid tumors in adults. It is for people with cancers like ovarian, breast, or prostate cancer that have not responded well to standard treatments. The main goals are to f…

This is the first human study of an experimental cancer drug called CX-801. Researchers are testing it alone and combined with an existing immunotherapy drug (pembrolizumab) in 121 adults with advanced solid tumors that have stopped responding to standard treatments. The main goa…

This study is testing a new personalized cell therapy called GT307 for adults with advanced solid tumors that have not responded to standard treatments. Doctors take a patient's own immune cells from a tumor, grow large numbers of them in a lab, and then infuse them back into the…

This is the first study in people testing an experimental pill called TYRA-430. It aims to find a safe dose and see if it can help control advanced liver cancer and other solid tumors that have specific genetic changes in the FGF/FGFR pathway. The study will enroll about 100 adul…

This early-stage trial is testing a new drug called CRB-701 for people with advanced solid tumors that have a specific protein called nectin-4. Researchers want to find the safest and most effective dose and see which types of cancer respond to the treatment. Participants will re…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This early-stage study is testing a new cancer drug called INV-1120, both by itself and combined with an existing immunotherapy (pembrolizumab), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe dose levels a…

This trial is testing a new, first-of-its-kind drug called IMA402 in adults with advanced solid tumors that have come back or stopped responding to all standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. The study will enroll about 1…

This early-stage study is testing a new cancer drug called KQB198 in adults with advanced solid tumors that have spread or cannot be surgically removed. Researchers want to find the safest dose of KQB198 when taken alone or combined with other cancer drugs, and see if it helps sh…

This early-stage trial is testing personalized radiation therapy approaches for small cell lung cancer and brain tumors. The study aims to make radiation treatment safer and more effective by adjusting it based on how each patient's tumors respond during therapy. Researchers will…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This is the first study in humans testing a new cancer drug called CX-2051. Researchers want to find the safest dose and see if it helps control advanced solid tumors, either by itself or combined with another cancer drug (bevacizumab). The study will enroll about 160 adults whos…

This study is testing a new drug called FMC-376 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find a safe and effective dose and to see if the drug can shrink or control tumors. It is for patients whose cancer ha…

This study is testing a new drug, BI-1206, given alongside the immunotherapy pembrolizumab. It aims to see if this combination is safe and can help control advanced solid tumors, particularly in adults with non-small cell lung cancer or uveal melanoma who have not responded well …

This study is adapting and testing a program called CONVO for Latinx cancer patients. In the program, oncology nurses have a special conversation with patients about their personal values and goals for care. The goal is to see if these talks help improve communication and the ove…

This study is adapting a counseling approach called Meaning-Centered Psychotherapy to better serve Latino patients with advanced cancer. Researchers will work with about 285 participants to make the therapy culturally relevant and test if it improves spiritual well-being, reduces…

This study is testing whether a Spanish-language telehealth program called DESCANSO/REST is practical and helpful for Latino cancer patients struggling with depression, fatigue, and insomnia. Researchers want to see if patients complete the sessions and find them useful. The prog…

This study is adapting a counseling program called Meaning Centered Psychotherapy to be more culturally relevant for Latino adults with advanced solid tumors. Researchers want to understand what affects quality of life for these patients and test if this adapted therapy can help …

This study is testing a new type of PET scan that uses a special tracer called 64Cu-GRIP B. The goal is to see if this scan can safely detect a marker of immune system activity (granzyme B) in tumors of patients with advanced cancers, including prostate, kidney, and bladder cance…

This study is collecting blood samples from adults with solid tumors and healthy volunteers, including some with COVID-19. The goal is to gather immune and tumor cells to develop better lab devices for growing and studying these cells. Researchers will test if specific immune cel…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This study aims to collect tumor tissue and blood cells from people with advanced solid tumors to prepare for future CAR T-cell therapy. Researchers will analyze the cancer tissue to understand how tumors hide from the immune system and collect participants' own immune cells thro…

This study aims to create a detailed database and biobank of 500 adults with solid tumors who are starting immunotherapy. The goal is to observe how well the treatments work and what side effects occur in real-world patients over five years. Researchers will collect health data a…