One-Time immune boost for ARID1A-Mutant cancers?
NCT ID NCT06824363
First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times
Summary
This early-phase trial is testing whether a single dose of two immunotherapy drugs (tremelimumab and durvalumab) can increase cancer-fighting immune cells inside tumors. It includes 34 people with untreated, non-metastatic stomach or esophageal cancers that have an ARID1A gene mutation. The main goal is to see if the treatment is feasible and changes the tumor's immune environment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tremelimumab and Durvalumab (two immunotherapy drugs given as a single dose)
- What this could lead to
- If successful, this could point toward a new treatment option for people with hard-to-treat stomach and esophageal cancers that have a specific genetic mutation (ARID1A).
- What could go wrong
- This is a very early, small proof-of-principle study with only 34 people. It is designed to see if the drugs increase immune cells in the tumor, not yet to prove they shrink tumors or extend life. Immune checkpoint inhibitors can cause serious immune-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Chao Family Comprehensive Cancer Center, University of California, Irvine
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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