University Of California, Irvine

This phase 2 trial is testing a combination of three drugs (cabozantinib, ipilimumab, and nivolumab) plus a procedure called TACE in 35 people with liver cancer that cannot be cured by surgery or transplant. The goal is to see if this approach can stop the cancer from growing for…

This study tests whether adding appetite-suppressant drugs (topiramate or phentermine) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained at le…

This study is for people with colon cancer who still have signs of cancer in their blood (ctDNA positive) after surgery and standard chemotherapy. It tests whether switching to a combination of two drugs (trifluridine/tipiracil and irinotecan) can clear those remaining cancer cel…

This study is testing whether a reduced dose of radiation can safely treat HPV-positive oropharyngeal (throat) cancer. About 111 patients will receive a lower total radiation dose than usual, with some also getting chemotherapy if needed. The goal is to see if this approach keeps…

This early-phase trial tests adding the cholesterol-lowering drug pitavastatin to standard chemotherapy (gemcitabine and nab-paclitaxel) as maintenance therapy for people with advanced pancreatic cancer that cannot be removed by surgery. About 18 adults whose disease is stable af…

This study tests whether nelfinavir, a drug originally used for HIV, can help people with myelofibrosis who have anemia (low red blood cells). The drug aims to restore iron delivery to the bone marrow. Ten adults with myelofibrosis and low hemoglobin will take nelfinavir twice da…

This phase 2 trial tests whether combining two drugs—sacituzumab govitecan and nivolumab—after surgery can keep high-risk bladder cancer from coming back. About 23 adults who had their bladder or part of their urinary tract removed will receive the drugs intravenously. The main g…

This study tests a modified version of sleeve gastrectomy, a common weight-loss surgery, to see if it can reduce or prevent acid reflux (GERD) that often occurs after the standard procedure. About 44 adults with obesity and GERD will be randomly assigned to receive either the sta…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with a common type of advanced breast cancer (hormone receptor positive, HER2-negative). About 20 participants whose cancer has spread or retur…

This study tests whether adding a low-dose chemotherapy drug (cyclophosphamide) to an immunotherapy (pembrolizumab) can shrink tumors in people with advanced melanoma that has stopped responding to standard immunotherapy. About 14 adults with stage III or IV melanoma that cannot …

This early-phase trial is testing whether adjusting chemotherapy based on how a patient's tumor responds can improve outcomes for people with stomach or gastroesophageal junction cancer. About 20 participants with stage IB to III disease will receive standard chemo combinations (…

This study compares a 48-hour course of antibiotics to a standard 7-day course for people with severe, life-threatening skin infections called necrotizing soft tissue infections. Researchers want to see if the shorter treatment is just as safe and effective. The trial will enroll…

This phase 2 trial tests a personalized approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Instead of a one-size-fits-all chemotherapy and radiation regimen, doctors adjust the doses based on each patient's risk. The goal is to improve the…

This study tests whether taking the blood thinner Lovenox three times a day works better than the standard twice-a-day schedule for pregnant women at high risk of blood clots. Pregnancy increases clot risk fivefold, and many women on the standard schedule don't get enough protect…

This study tests whether giving a thyroid hormone supplement (levothyroxine) to dialysis patients with mild hypothyroidism can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for up to two years. The go…

This study is testing whether a special MRI scan (mpMRI) can accurately diagnose muscle-invasive bladder cancer without needing an invasive biopsy (TURBT). Researchers will compare the MRI results to the biopsy results in 30 adults with suspected muscle-invasive bladder cancer. I…

This study tests a new device that uses special lights to look at the eardrum and detect fluid behind it, which is a sign of middle ear infection. The goal is to make diagnosis more accurate than current methods. The study will include 150 people of all ages who are scheduled for…

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests a therapy called Positive Affect Treatment (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more adverse childhood events. The therapy involves 15 weekly sessions focused on building positive emotions and coping skills…

This study tests a program called GRIT, where community health workers coach teens (ages 11-14) and their families over six weekly sessions. The goal is to help teens who have experienced four or more adverse childhood events build self-regulation skills and avoid starting regula…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests whether core shamanism—sessions with drumming, rattling, and discussion—can help reduce pain and other symptoms in women with fibromyalgia. Twenty-five participants will attend up to five sessions while researchers measure pain, heart rate, breathing, and brain a…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study tests whether acupuncture can make opioid painkillers more effective for people with fibromyalgia. About 45 adults who already take daily opioids will receive either real acupuncture or a sham (fake) version. Researchers will measure pain changes after an opioid dose t…

This study tests whether combining sound therapy with mild electrical stimulation inside the ear can reduce or temporarily stop tinnitus (ringing in the ears). Researchers will enroll 100 adults who have had tinnitus for at least 6 months. Participants will listen to sounds and r…

This study tests whether Reiki, a gentle hands-on relaxation therapy, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions right away or after a waiting period. Researchers will measure changes in fa…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their parents prepare for surgery. The app provides culturally tailored information and coping skills to reduce anxiety and pain. Researchers will compare the app to standard care in 120…

This study is testing whether a single dose of nicotine gum can reverse age-related hearing problems. Researchers will give 48 healthy non-smokers aged 18-85 either nicotine gum or a placebo and measure their hearing and brain responses. The goal is to see if nicotine can improve…

This study looks at whether eating solid food before a WALANT procedure (a type of hand surgery using only local anesthesia) can reduce anxiety and nausea compared to fasting. Researchers will randomly assign 134 participants to either eat or fast before their surgery and then co…

This study tests N-Acetylcysteine (N-AC), an antioxidant, in 27 adults with myeloproliferative neoplasms (MPN) like essential thrombocythemia, polycythemia vera, or myelofibrosis. The goal is to find the best dose that safely reduces symptom burden, measured by a symptom score. P…

This study tests if using a special dye (ICG) during robot-assisted prostate removal helps preserve nerves and improve recovery of bladder control and sexual function. About 400 men with prostate cancer will take part. The goal is to see if the dye leads to better outcomes 12 mon…

This study tests a non-hormonal laser treatment for vaginal dryness, burning, and pain during sex caused by menopause. About 50 postmenopausal women will either receive the real laser or a sham (fake) treatment. Researchers will use a special camera to measure changes in vaginal …

This pilot study will test a brief cognitive-behavioral resilience training program for 60 adults who have been on parole for two years or less and are having trouble adjusting. The goal is to see if the program is practical and helpful in reducing stress and improving well-being…

This study is testing whether music therapy can help improve quality of life for people with sickle cell disease. About 90 teens and adults will be split into three groups: in-person music therapy, a mix of in-person and virtual music therapy, or health education sessions. The ma…

This study compares two medications used to reverse muscle relaxants after bowel surgery: Sugammadex versus Neostigmine with Glycopyrrolate. The goal is to see which one helps patients have their first bowel movement and tolerate solid food sooner. About 128 adults undergoing lap…

This study tests whether energy healing (a hands-off therapy that aims to balance the body's energy) can reduce pain in women with fibromyalgia. Twenty-five participants will receive both real and fake (sham) energy healing while their brain activity is scanned with fMRI. The goa…

This early study tests whether a new oxygen-delivery system using micro/nanobubbles can safely help heal different types of wounds. About 40 adults with acute or chronic wounds will receive either the oxygen bubbles or a standard saline treatment. Researchers will measure changes…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity…

This study tests whether telemedicine can effectively educate and counsel people considering living kidney donation. Researchers will compare standard in-person care with live video visits. The goal is to see if telemedicine is practical and helps donors make better decisions.

This study looks at how abnormal blood vessel growth (angiogenesis) contributes to various skin diseases like rosacea, psoriasis, and certain tumors. Researchers will collect skin samples from 85 volunteers aged 16 and older to analyze markers of angiogenesis. The goal is to bett…

This study looks at whether teens who have experienced maltreatment remember stressful events better than other teens. Researchers will compare memory for personal activities and images between 400 maltreated and non-maltreated adolescents aged 12-18. The goal is to understand ho…

This study is working to create better exercise tests for children with cystic fibrosis, sickle cell disease, or long COVID. Current tests are designed for healthy athletes and may not be safe or useful for these kids. Researchers will track 240 children over 3-4 years, measuring…

This study explores whether a person's personality traits influence how well they take their daily leukemia pills. Researchers will interview 75 adults with chronic myeloid leukemia and use questionnaires to measure medication adherence, personality, and quality of life. The goal…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX™) can make cancer cells glow during surgery for gastrointestinal cancer that has spread in the abdomen. About 10 adults will receive the dye before surgery, and surgeons will check if glowing areas m…

This pilot study compares two ways of collecting blood to detect circulating tumor DNA (ctDNA) in people with liver or pancreatic cancers. Researchers will take blood from a standard arm vein and also from the vein that drains directly from the tumor during a biopsy. The goal is …

This pilot study is looking at the gut microbiome—the collection of bacteria in your digestive system—in people with advanced non-small cell lung cancer. Researchers will collect stool and saliva samples before and during standard cancer treatment to see if the diversity of gut b…

This study is testing whether a simple finger device called EndoPAT can measure blood vessel function in men aged 30–50 with erectile dysfunction or low testosterone. About 120 men will use the device before and after taking daily low-dose ED medication or testosterone therapy. T…

This study looks at why some people's thinking and memory get worse as they get older. Researchers will use brain scans and memory tests in 300 healthy adults aged 60 and older to find early signs of Alzheimer's disease. The goal is to better understand how the brain changes over…

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study aims to develop a better way to measure oral health using photographs and imaging software, rather than traditional dental exams. About 275 adults will use different toothpastes or mouthwashes for up to 6 months, and researchers will track plaque levels, gum health, an…

This study looks at how two over-the-counter mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three common viruses in the mouth and gut. Two hundred healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for about six months.…

This study tests two noninvasive imaging methods to assess burn wound severity and predict healing. Researchers will enroll 200 burn patients to see if these cameras can accurately determine which burns will heal on their own and which need surgery. The goal is to improve treatme…

This pilot study is testing three non-invasive imaging devices that can see changes in skin blood flow and cell metabolism. Researchers will use a pressure cuff to briefly stop blood flow in the arm and then watch how the skin responds. The goal is simply to see if these devices …