University Of California, Irvine

This study tests whether adjusting chemotherapy based on how a patient's tumor responds can improve treatment for stomach or gastroesophageal junction cancer. About 20 adults with stage IB to III cancer will receive a personalized chemo plan before surgery. The goal is to see if …

This study tests whether adding weight-loss medications (topiramate, phentermine, or both) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and have regai…

This early-phase trial tests whether adding the cholesterol-lowering drug pitavastatin to standard chemotherapy (gemcitabine and nab-paclitaxel) can safely help control advanced pancreatic cancer. About 18 adults whose cancer has not worsened on initial chemo will receive the com…

This study tests a combination of drugs (cabozantinib, ipilimumab, nivolumab) and a procedure called TACE in 35 adults with liver cancer that cannot be removed by surgery or treated with a transplant. The goal is to see if this approach can stop the cancer from growing for at lea…

This study tests a modified version of sleeve gastrectomy (a common weight-loss surgery) to see if it can reduce acid reflux, a frequent side effect. About 44 adults with obesity and GERD will be randomly assigned to the standard or modified surgery. Researchers will measure chan…

This study is testing whether a lower dose of radiation can work just as well for people with HPV-positive throat cancer, while causing fewer side effects. Researchers will track 111 participants over two years to see if the cancer stays away. The goal is to make treatment easier…

This study tests whether adding a low-dose chemotherapy drug (cyclophosphamide) to an immunotherapy (pembrolizumab) can shrink tumors in people with advanced melanoma that no longer responds to standard immunotherapy. About 14 adults with stage III or IV melanoma will receive the…

This early-phase trial tests whether nelfinavir, a drug originally used for HIV, can improve anemia in people with myelofibrosis — a rare bone marrow cancer. The study aims to see if the drug helps the body deliver iron to the bone marrow to make more red blood cells. About 10 ad…

This study looks at whether giving thyroid hormone (levothyroxine) to people on dialysis who have slightly high TSH levels can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo. The goal is to see if this…

This study looks at whether taking the blood thinner Lovenox three times a day works better than the usual twice-a-day schedule for pregnant women at high risk of blood clots. Pregnancy increases clot risk fivefold, and many women on the standard schedule don't get enough protect…

This early-phase study tests whether a combination of two chemotherapy drugs (trifluridine/tipiracil and irinotecan) can clear leftover cancer cells in people with colon cancer whose blood still shows cancer DNA after standard treatment. About 22 adults with stage II–IV colon can…

This study compares a short course of antibiotics (48 hours after infection control) to the usual 7-day course for people with severe, life-threatening skin infections called necrotizing soft tissue infections (NSTI). The goal is to see if the shorter treatment is just as safe an…

This study tests whether a combination of two drugs (sacituzumab govitecan and nivolumab) given after surgery can keep bladder cancer from returning in patients at high risk. About 23 adults who have had their bladder or part of their urinary tract removed will receive the treatm…

This study tests a personalized approach to stem cell transplants for adults with blood cancers like leukemia and lymphoma. The intensity of chemotherapy and radiation is adjusted based on each patient's risk level to try to improve survival and reduce side effects. About 60 part…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 20 participants will receive the treatment, and researchers will me…

This pilot study is testing whether a special MRI scan (mpMRI) can accurately detect muscle-invasive bladder cancer without needing a surgical biopsy (TURBT). About 30 adults with suspected muscle-invasive bladder cancer will get both tests, and researchers will compare the resul…

This study tests a new, non-invasive device that uses LED lights to measure how light scatters off the eardrum. The goal is to see if this can accurately detect fluid behind the eardrum, a sign of middle ear infection. Researchers will enroll 150 people of all ages who are alread…

This study tests a program that combines cervical cancer screening, nutrition education, protein supplements, and emotional support for women in India who have both HIV and HPV. The goal is to see if this approach can reduce persistent HPV infections, a key risk factor for cervic…

This study tests a therapy called Positive Affect Therapy (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more difficult childhood events (like abuse or neglect). The therapy focuses on increasing positive emotions and reward sensitiv…

This study tests a coaching program called GRIT for teens aged 11-14 who have had four or more adverse childhood experiences (ACEs) and do not yet regularly use alcohol or cannabis. The program, delivered by community health workers over six video sessions, teaches self-regulatio…

This study tests whether energy healing can reduce pain and change brain activity in women with fibromyalgia. Twenty-five participants will receive either real or sham energy healing while their brains are scanned with fMRI. The goal is to see if real energy healing improves pain…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study is testing whether using a special dye called indocyanine green (ICG) during robot-assisted prostate removal surgery can help men recover bladder control and sexual function better. About 400 men with prostate cancer who are good candidates for nerve-sparing surgery wi…

This study tests whether a vaginal laser can help relieve symptoms of menopause like dryness, burning, and pain during sex. About 50 postmenopausal women will either receive the laser treatment or a sham (fake) procedure. Researchers will use a special camera to measure changes i…

This study compares two medications, Sugammadex and Neostigmine with Glycopyrrolate, to see which one helps bowel function return faster after colorectal surgery. About 128 adults having laparoscopic bowel resection will be randomly assigned to receive one of the drugs. The main …

This study tests whether a stepwise regimen of two medications, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. The trial will enroll 40 adults aged 25 to 85 who have active or frequent symptoms. Participants will be randomly …

This study tests a mobile health app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started a new oral therapy…

This study explores whether nicotine gum can improve how well older adults process sounds. Researchers will give nicotine gum to 48 non-smokers aged 18-85 and measure hearing sensitivity and brain responses. The goal is to see if nicotine can reverse some age-related hearing decl…

This study looks at whether eating solid food before a hand surgery (called WALANT) helps patients feel less anxious and nauseous. About 134 people will be randomly told to either eat or fast before their procedure. Researchers will compare anxiety, nausea, and satisfaction betwe…

This study looks at whether a relaxing therapy called Reiki can help adults with cancer who feel very tired from immunotherapy. Twelve people will either get six weekly Reiki sessions right away or wait six weeks before starting. Researchers will track changes in fatigue, pain, a…

This study tests whether acupuncture can make opioid painkillers work better for people with fibromyalgia. About 45 adults who already take daily opioids will receive either real or fake (sham) acupuncture, then their pain response to an opioid will be measured. The goal is to se…

This study looks at whether music therapy is a practical way to help teens and adults (ages 14+) with sickle cell disease feel better. Ninety people will be split into three groups: in-person music therapy, a mix of in-person and virtual music therapy, or health education. The ma…

This study is testing a mobile app called L-WebTIPS, which was culturally adapted for Latinx families, to see if it can reduce anxiety and pain in children ages 2-7 having outpatient surgery. The app provides information, modeling, and coping skills to prepare children and their …

This study tests a short cognitive-behavioral training program for adults who have been on parole for two years or less and are having trouble adjusting. The goal is to see if the program is practical and helpful for reducing stress and improving well-being. Around 60 participant…

This early-stage study is testing whether a new oxygen-delivery system using micro/nanobubbles can safely help heal both new and long-lasting wounds. Researchers will compare the bubbles to a standard saline solution in 40 adults with various wound types, including surgical cuts,…

This study explores whether core shamanism, a traditional healing practice, can reduce pain and other symptoms in people with fibromyalgia. Researchers will track attendance, pain levels, and changes in heart rate, breathing, and brain activity. The goal is to see if this approac…

This study tests N-Acetylcysteine (N-AC), a supplement, to find the best dose for reducing symptoms in people with certain blood cancers called myeloproliferative neoplasms (MPN). About 27 adults with essential thrombocythemia, polycythemia vera, or myelofibrosis will take N-AC f…

This study looks at how abnormal blood vessel growth contributes to skin diseases like rosacea, psoriasis, and certain birthmarks. Researchers will analyze skin samples from 85 volunteers aged 16 and older to find markers of blood vessel formation. The goal is to better understan…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can make cancer cells glow during surgery for gastrointestinal cancers that have spread inside the abdomen. About 10 adults will receive the dye before surgery, and surgeons will use a special camer…

This study looks at whether telemedicine (video visits) can effectively educate and counsel people considering living kidney donation. About 70 participants will either get standard care or telemedicine support. Researchers want to see if this approach helps donors make better de…

This pilot study aims to see if taking a blood sample from the vein that drains directly from a liver or pancreatic tumor can detect more cancer DNA than a standard blood draw from the arm. Fifteen adults scheduled for a tumor biopsy will provide both types of blood samples. The …

This study tests whether two noninvasive imaging techniques can accurately assess burn wound severity and predict healing potential. Researchers will enroll 200 burn patients of all ages. The goal is to help doctors decide sooner whether a burn will heal with standard care or nee…

This study is creating new, kid-friendly exercise tests for children with cystic fibrosis, sickle cell disease, or long-term effects of COVID-19. Current tests are designed for healthy athletes and don't work well for these children. Researchers will track 240 kids over 3-4 years…

This study looks at how two common mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three viruses in your mouth and gut. About 200 healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for 180 days. Researchers will collect …

This study looks at how stress changes memory in teenagers who have experienced maltreatment compared to those who haven't. Researchers will have 400 teens (ages 12-18) do activities that are either stressful or not, then test their memory for images and events over a month. The …

This study explores whether a person's personality traits influence how consistently they take their daily oral medication for chronic myeloid leukemia (CML). Researchers will observe 75 adults with CML who are already on standard therapy. The goal is to better understand barrier…

This study aims to develop a better way to measure oral health using photographs and imaging software instead of traditional exams. About 275 healthy adults will use a toothpaste or mouthwash for up to 6 months while researchers track plaque, gum health, and saliva. The goal is t…

This study looks at how ibogaine, a plant-based compound, affects brain activity and reduces cravings in people with moderate to severe opioid use disorder. Twenty adults who are already scheduled to receive ibogaine treatment at a licensed clinic in Mexico will undergo brain sca…

This study aims to understand why some people experience memory and thinking problems as they get older. Researchers will use brain scans and memory tests to detect early signs of Alzheimer's disease in 300 healthy adults aged 60 and older. Participants will undergo MRI and PET s…

This study looks at blood vessel health in men aged 30–50 with erectile dysfunction or low testosterone. Researchers use a device called EndoPAT to measure how well blood vessels respond to changes in blood flow. They will check again 3 to 6 months after starting daily low-dose E…

This study tests three non-invasive imaging devices to see how well they measure skin blood flow. About 150 adults will have a blood pressure cuff on their arm to temporarily stop blood flow while the devices take pictures. The goal is to see if these tools can detect changes in …

This study looks at the variety of bacteria in the gut of people with advanced non-small cell lung cancer. Researchers want to see if the types of gut bacteria are linked to how well treatment works or what side effects occur. About 82 participants will provide stool samples befo…