Can pills reverse weight regain after bariatric surgery? new trial aims to find out.

NCT ID NCT05975580

Recruiting now Disease control Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether adding appetite-suppressant drugs (topiramate or phentermine) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained at least 5% of their lowest post-surgery weight will participate. The trial compares the drugs against a placebo over 12 months to see which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Topiramate and phentermine (appetite suppressant drugs)
What this could lead to: If successful, this could provide a drug-based option to help people who regain weight after bariatric surgery lose it again, without additional surgery.
What could go wrong: This is a relatively small phase 4 trial, and the drugs may cause side effects like dizziness or dry mouth. Results may not apply to everyone who has had bariatric surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

University of California Irvine Medical Center
RECRUITING

Orange, California, 92868, United States

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