OBESITY

This study tests whether partially replacing animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to se…

This study tests an experimental drug called ALN-2232, alone or together with an approved weight-loss medication (tirzepatide), in adults with obesity. The goal is to see if the combination is safe and helps people lose more weight. About 156 participants with a BMI between 30 an…

This study tests whether inviting friends, family, or coworkers to join a weight loss program helps Black or Hispanic adults with obesity lose more weight. Participants will attend coaching sessions and use a food tracking app. The goal is to see if social support makes it easier…

This study tests a new weekly injection called KAI-9531 for weight loss in 1,200 adults with obesity (BMI 35 or higher) who do not have diabetes. Participants will receive either KAI-9531, semaglutide (the drug in Wegovy), or a placebo for 76 weeks. The main goal is to see how mu…

This study tests a new drug called brenipatide in healthy adults who are overweight or have obesity. Participants receive different doses as injections under the skin to see how much weight they lose and if the drug is safe. The study lasts about 42 weeks and involves 150 people.

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) disappear without worsening liver scarring. It includes 100 obese adults with advanced liver fibrosis. Participants are randomly assigned to either sur…

This study looks at the best way to maintain weight loss after initial success with a weight-loss drug called mazdutide. It will test whether a year of intensive lifestyle changes, a lower dose of the drug, or both together can help people with obesity keep the weight off. The st…

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women in low-resource areas increase their physical activity. About 325 women aged 21-75 from specific neighborhoods near Washington, DC wi…

This study tests whether a simple saliva test can predict who will lose the most weight with the drug semaglutide. About 135 adults with obesity will receive either semaglutide or a placebo. The goal is to see if a biomarker in saliva helps personalize obesity treatment.

This early-stage study is testing a new drug called LY4167586 in 84 people with obesity or overweight who are otherwise healthy. The main goal is to see if the drug is safe and how the body processes it after a single dose. Participants will be monitored for about 7 months, and t…

This study tests a new medicine called MET097, given as a weekly shot under the skin, to help adults with overweight or obesity and type 2 diabetes lose weight. About 1,000 people will take part, with most receiving the real medicine and some receiving a placebo. The study lasts …

This early-stage study tests a new drug called DA-1726 in 139 people with obesity but otherwise healthy. The main goal is to check if the drug is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor side effects, drug levels…

This study tests if doing many short, one-minute exercises throughout the day can improve fitness and health in adults with obesity. Researchers will enroll 80 inactive adults aged 35-64 with a BMI of 30-45. Participants will follow a 12-week program using technology and behavior…

This study tests whether a structured lifestyle program can help Malaysian adults with early type 2 diabetes achieve remission—meaning blood sugar stays normal without diabetes medication. About 92 participants will either follow the intensive lifestyle plan or receive usual care…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and control their blood sugar better than standard care. Over 6 months, 30 participants will weigh themselves every morning and check their blood glucose before and after …

This study tests whether a new medication, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have both heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a pl…

This study tests a weight loss program for 522 low-income adults with obesity in Louisiana. Participants receive health coaching, digital self-monitoring tools, and group support, or standard educational materials. The goal is to see if the program leads to significant weight los…

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and heart health in adults with low socioeconomic status, type 2 diabetes, and obesity. Participants will be randomly assi…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study tests whether a virtual weight management program, including a weight-loss drug, can help people with obesity and advanced kidney disease lose enough weight to qualify for a kidney transplant. About 60 adults will be randomly assigned to the program or their usual care…

This study is testing a new procedure called PSAM that uses a scope to cut stomach muscles, slowing how fast food leaves the stomach. The goal is to help people with obesity lose weight. About 30 adults with a BMI over 35 will take part and be followed for a year.

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The goal is to check the drug's safety, how the body processes it, and its potential to help with weight and blood sugar control. About 564 part…

This study looks at whether a daily dose of milk polar lipids (a type of fat found in milk) can improve cholesterol levels, reduce inflammation, and support gut health in adults with high cholesterol and abdominal obesity. About 130 participants will take the supplement for 8 wee…

This study tests a once-weekly medicine called tirzepatide in adults with obesity who do not have diabetes. The goal is to see if it helps with weight loss and prevents type 2 diabetes compared to standard care. About 3000 people will take part for up to 5 years.

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive either the balloon pl…

This study tests whether a type of counseling called acceptance and commitment therapy (ACT) can help people who have had weight-loss surgery stay physically active and avoid regaining weight. About 164 adults who had surgery 6 to 20 months ago will either receive ACT or standard…

This study tests a new medicine called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The goal is to see if the drug is safe and helps with weight loss, either alone or with another weight-loss drug. Participants receive injections and are closely m…

This study looks at people who had a sleeve gastrectomy but didn't lose enough weight or regained it. It compares two follow-up surgeries: a newer, simpler one called SADI-S and a standard one called DS. The goal is to see if SADI-S works just as well for weight loss but with few…

This study compares three weight loss approaches in 492 adults with obesity: a new stepped-care program called SMARTer, the standard Diabetes Prevention Program (DPP), and a self-guided control. The SMARTer program starts with minimal support and adds more help only for those who…

This early-stage study is checking whether two different versions of the experimental drug survodutide are absorbed the same way in the body. It involves 80 healthy adults who are overweight or have obesity. The goal is to make sure both forms work equally well before moving to l…

This study tests a mobile health program designed to help young adult cancer survivors (ages 18-39) who are overweight or obese lose weight and keep it off. Participants will either get a full mHealth weight management program or self-guided digital tools plus health education an…

This study looks at whether losing weight while following the Dietary Guidelines for Americans (DGA) is better for heart health than just eating a healthy diet without losing weight. Researchers will compare a DGA-style diet with a typical American diet in 70 adults who are overw…

This early-stage study tests a new drug called MBX 4291 in 124 adults with obesity (BMI 30 to under 50). The main goal is to see if the drug is safe and how well people tolerate it. Participants receive either the drug or a placebo as an injection under the skin. The study is cur…

This study tests whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning improves gum health in people who have both gum disease and obesity. Twenty-four adults with obesity and moderate to severe gum disease will receive either stand…

This study looks at whether losing weight and exercising can improve walking ability and emotional well-being in veterans who are overweight and have had a stroke. About 130 participants will be assigned to a diet program, a diet-plus-exercise program, or a waitlist. The goal is …

This study tests an experimental drug called CS060380 in adults with both fatty liver disease (MASH) and obesity. About 120 participants will receive either the drug or a placebo, plus a weight-loss medication, for 36 weeks. The goal is to see if the drug reduces liver fat and bo…

This early-stage study is testing a new drug called HM17321 to see if it is safe and how the body processes it. About 90 healthy and obese adults will receive either the drug or a placebo. The main goal is to check for side effects, not to treat obesity yet.

This early-stage study tests a new drug called HRS-5817, given as an injection, to see if it is safe and how the body processes it. The study involves 92 healthy adults, some with obesity and some without. Researchers will monitor side effects and measure drug levels in the blood…

This study tests a new once-weekly injection called eloralintide for adults who are still obese or overweight despite taking a weekly incretin drug (like Ozempic or Wegovy). About 900 participants will receive either eloralintide or a placebo for 80 weeks to see if it helps them …

This study tests a new once-weekly injection called eloralintide for weight loss in adults with obesity or overweight who do not have type 2 diabetes. About 1,980 participants will receive either the drug or a placebo for up to 75 weeks, with some continuing for 2 more years. The…

This study tests whether adding weight-loss medications (topiramate, phentermine, or both) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained a…

This study tests a telehealth program for cancer survivors who smoke, are inactive, or have overweight. Participants either get 12 coaching sessions or just health information. The goal is to see which approach helps more people adopt healthier behaviors. About 1500 adults from N…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study looks at whether semaglutide, a drug already used for weight loss, can help people with HIV who are obese lose more weight than just diet and exercise. About 80 adults with well-controlled HIV will take semaglutide or follow standard lifestyle advice for 28 weeks. Rese…

This study looks at whether a specific probiotic (Lactobacillus paracasei) can help overweight or obese people lose weight and improve their metabolism. About 140 participants will follow a reduced-calorie diet and lifestyle plan, and some will also take the probiotic, a weight-l…

This study looks at whether a daily capsule made from fermented fruits and vegetables (Rutazyme® lemon fermented product) can help improve metabolic health in adults with obesity. Forty adults aged 18 to 65 with a BMI of 27 or higher will take either the active capsule or a place…

This study compares an intensive lifestyle program to standard weight loss advice in 32 women aged 18-25 with a BMI of 25-50. The goal is to see if the intensive program leads to greater reductions in weight, waist size, and body fat, and also improves markers of inflammation and…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to learn if this drug can improv…

This study tests a once-weekly injection called eloralintide to help adults with obesity or overweight and type 2 diabetes lose weight. About 1035 participants will receive either the drug or a placebo for 75 weeks. The main goal is to see how much body weight changes, along with…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis who are obese and need colon removal surgery. About 12 participants will be enrolled. The goal is to help them lose weight befo…

This study tests a new weekly injection called retatrutide (LY3437943) to help people with obesity or overweight who also have weight-related health problems like high blood pressure or heart disease. About 300 adults will receive either the drug or a placebo, along with diet and…

This study tests two new drugs, CagriSema and cagrilintide, to help children and adolescents with overweight or obesity lose weight. About 460 participants will receive either the study drugs, an existing drug (semaglutide), or a placebo for up to 4 years and 10 months. The goal …

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program and be monitored for weight and A1c changes. The goal …

This study tests whether metformin, a diabetes medication, can help adults with intellectual disabilities who have gained weight from antipsychotic drugs. About 100 participants will receive either metformin or a placebo for several months. The goal is to see if metformin leads t…

This study looks at whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older Veterans who have obesity and signs of muscle loss (sarcopenia). About 50 Veterans aged 55 and older will take part. The goal is…

This study looks at whether limiting food intake to a 9-hour window each day can improve how the body uses insulin and manages blood sugar in people with obesity and prediabetes. Researchers will measure changes in insulin sensitivity, daily glucose control, and fat and muscle bi…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30 or higher) lose weight and improve their fertility. About 98 men aged 22-40, whose partners are also in the study, will follow the program while undergoing assisted…

This study tests whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. Participants will weigh themselves daily and check blood glucose before and after meals for 6 months.…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. The goal is to see if it helps control blood sugar and reduce weight.

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in adolescents and young adults (ages 18-25) with obesity and a fatty liver condition called MASLD. Participants will be randomly assigned to drink either a ketone ester or a …

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat better and control blood pressure. The goal is to see if th…

This study tests whether empagliflozin, a diabetes medication, can improve artery stiffness in 50 veterans with obesity but without diabetes. Participants will take either the drug or a placebo for 12 weeks, and researchers will measure changes in arterial health. The goal is to …

This study tests whether an online weight management program for child care teachers can improve the diet and physical activity of the 2-to-5-year-old children in their care. About 84 child care centers and over 900 participants (directors, teachers, and children) will take part.…

This study looks at whether a special cardiometabolic clinic can help obese adults with heart disease lose weight and improve their health. About 60 participants will be followed for 12 months to track weight loss, body mass index, and belly fat. The goal is to see if this clinic…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. Researchers will test four different support methods, like counseling and text messages, to see which work best. About 1,785 drivers in New York City will take part. The goal is to find a low-cos…

This study tests the safety and effectiveness of new medicines to help children and teens with obesity or overweight manage their weight long-term. It includes 125 participants aged 12 to 17 who have already tried lifestyle changes like diet and exercise without enough success. T…

This study compares two approaches to weight management: an environmental control strategy (AVOID) that helps people steer clear of tempting situations, and an impulse control training strategy (RESIST) that builds willpower. About 500 adults with a BMI between 25 and 45 will tak…

This study tests several experimental treatments to help adults with obesity or overweight lose weight and keep it off. About 1,481 participants will try different combinations of medicines to see which works best and is safest. The goal is to find better long-term weight managem…

This early-stage study tests a new injection called SHR-2906 in healthy volunteers and people with obesity. The main goal is to check safety and how the body processes the drug. Up to 124 participants will receive either the drug or a placebo in increasing doses.

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural nighttime drop in blood pressure in people with obesity. Obese individuals often have high nighttime blood pressure, which raises their risk for heart problems. Res…

This study tests a new drug, maridebart cafraglutide, in people with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and improves symptoms. About 5,056 adults will take the drug or a placebo alongside their usual care. The st…

This study tests a new medicine called NNC0487-0111, given as a weekly shot, to see if it helps people with obesity lose weight safely. About 600 adults will either get the active drug or a placebo (dummy shot) for several weeks. The main goal is to measure how much body weight t…

This study tests whether adding a low dose of levothyroxine (a thyroid hormone medication) to a healthy diet and exercise program helps people with obesity lose more weight and keep it off. About 286 adults aged 25-60 with mild to moderate obesity and slightly high thyroid-stimul…

This study compares two different programs designed to reduce heart disease risk factors in Black women after pregnancy. Researchers will track changes in blood pressure and body weight at 6 weeks and 12 months after delivery. The goal is to find the best way to support heart hea…

This study is testing whether a probiotic supplement can help adults with obesity lose weight and reduce food addiction. Researchers will measure changes in gut bacteria and blood markers. The study involves 100 participants aged 18-50 with a BMI between 25 and 40. It is a placeb…

This study looks at whether eating protein and fiber bars as part of a low-calorie diet helps people with overweight or obesity lose weight and improve their heart and joint health. About 144 adults aged 18 to 65 with a BMI between 27 and 40 will eat three bars daily for 12 weeks…

This study tests different ways to increase the dose of the drug retatrutide to help people with obesity or overweight lose weight. About 600 participants who do not have type 2 diabetes will receive the drug or a placebo for nearly two years. The main goal is to see how much wei…

This study tests whether doing aerobic exercise before eating (fasted) leads to more weight loss and better heart health than exercising after a meal. Forty adults with overweight or obesity will follow a 16-week exercise program. Researchers will measure body fat, blood fats, bl…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) can help adults with obesity lose mostly fat instead of muscle and bone. About 63 participants will receive one of three treatments for 52 weeks, plus lifestyle advice. The …

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests a new weekly injection called KAI-9531 to help people with obesity lose weight. About 250 adults with a BMI of 35 or higher who have tried diet and exercise before will receive either the drug or a placebo for 48 weeks. The main goal is to see how much weight the…

This study tests a weight loss program for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or have obesity. Participants receive a weekly injection of tirzepatide plus remote, supervised resistance exercise three times a week for 28 weeks. The g…

This study looks at whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG) can help people with obesity lose more weight than lifestyle changes alone. It includes 150 adults who stopped taking GLP-1 weight-loss drugs because of side effects or not losi…

This study tests a community-based program called FEAST Perinatal Support Program for 40 pregnant adults, mostly Latino, who qualify for food assistance. The program provides nutrition education, skill-building, social support, and grocery gift cards to improve diet and health du…

This early-stage study is testing whether attapulgite, a natural clay mineral, can help people with obesity or overweight with type 2 diabetes lose weight safely. Researchers will measure changes in body mass index (BMI), waist size, and body fat. The trial aims to enroll 40 adul…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard care. About 182 Veterans will take part…

This study tests whether matching weight-loss medications to a person's specific obesity type (like 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. About 100 adults aged 18-65 will take one of three FDA-approved drugs or join a weight-…

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study tracks 200 obese adults in the EU who choose to get the Orbera365 intragastric balloon for weight loss. Researchers will monitor serious side effects and how many people lose at least 10% of their total body weight over up to 12 months. The balloon is placed in the sto…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This study looks at whether combining bariatric surgery with GLP-1 weight-loss drugs works better than surgery alone for severe obesity. About 200 adults aged 18-60 with a BMI of 35 or higher will take part. The goal is to see if the combo leads to greater weight loss and better …

This study looks at whether adding protein supplements to a weight-loss plan (diet and the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part, with some getting just diet, some diet plus…

This study looks at whether a stepped-care digital health program can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through a 16-week diet and group counseling. Those who succeed are then randomly assigned to usual care, self…

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults to see if the drug helps control disease risk. The goal is…

This study tests a modified version of sleeve gastrectomy (a common weight-loss surgery) to see if it can reduce acid reflux, a frequent side effect. About 44 adults with obesity and GERD will be randomly assigned to the standard or modified surgery. Researchers will measure chan…

This study tests whether a once-weekly injection of semaglutide can help people who quit smoking avoid gaining weight. It includes 197 adults who are overweight or have obesity. The goal is to see if the drug can control appetite and body changes during smoking cessation.

This early-stage study tests a new drug called ABBV-295 in 48 adults with obesity. The main goals are to check safety, how the drug moves through the body, and any weight changes. Participants receive multiple injections of the drug or a placebo over several weeks.

This study compares two approaches for people with severe obesity: a non-surgical program using meal replacements, behavioral support, and weight-loss medication versus bariatric surgery. Researchers will track 500 adults aged 18-60 to see which method better improves health and …

This study compares two weight-loss surgeries for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer omega gastric bypass with a shorter intestinal loop. The goal is to see if the newer surgery works just as well for weight loss and causes fewer nutriti…

This study tests whether taking glutamine, a natural amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo powder. The goal is to s…

This study tests whether a dietary supplement made from omega-3 and omega-6 fatty acids (called SPMs) can reduce inflammation and improve blood vessel function in 60 adults with obesity and high blood pressure. Participants will take the supplement or a placebo for 12 weeks. The …

This study is testing a new single-port robot system for weight loss surgery in 50 overweight or obese adults. The goal is to see if the robot makes the surgery safer and more effective, measuring weight loss, blood pressure, and sugar levels. Participants must have a BMI of 27.5…

This study tests whether a new medicine called UBT251 is safe and helps people with overweight or obesity lose weight. About 333 adults will receive either UBT251 or a placebo (dummy treatment) by chance. The main goals are to check for side effects and measure weight change over…

This study aims to find the best telehealth weight loss approach for older adults (ages 65-85) who have obesity and at least two chronic conditions. Researchers will compare different treatment combinations to see which helps participants lose the most weight over 52 weeks. The g…

This study tests a practical program that uses motivational interviewing—a supportive counseling style—to help children ages 2 to 8 with overweight or obesity lower their body mass index (BMI). About 6,600 children from Kaiser Permanente clinics will take part over two years. The…

This study tests whether a low-dose weekly injection of semaglutide can help obese adults without diabetes lose weight and improve heart health. Sixty Pakistani adults aged 18 and older with a BMI of 27.5 or higher will receive the drug for 24 weeks, along with diet and exercise …

This study tests a new medicine called KAI-9531, given as a weekly shot, to help people with obesity or overweight who also have weight-related health problems (like high blood pressure or sleep apnea) but do not have diabetes. About 1,800 adults will receive either the drug or a…

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 24 doctors and 48 patients will take part. The goal is to see if the tool is easy to use and…

This study tests a new magnetic system (MagDI) that creates a shortcut in the small intestine to help with weight loss and type 2 diabetes. It involves 60 adults with obesity (BMI 30-50) who have diabetes or regained weight after previous weight-loss surgery. The goal is to see i…

This study looks at whether resistance exercise and/or extra protein can help people with obesity keep their muscle and improve physical function while taking semaglutide or tirzepatide for weight loss. About 232 adults will be randomly assigned to one of four groups: control, ex…

This study looks at whether adding whole-body vibration sessions to a standard 3-week weight-loss program helps obese teenage boys burn more energy while resting. About 28 boys aged 13-18 will either get the vibration training plus the program or just the program alone. Researche…

This study tests whether the Mayo Clinic Diet helps people with obesity lose at least 5% of their body weight compared to standard care. Researchers will follow 250 adults for up to a year to see how well the diet works, what barriers people face, and whether weight loss lasts. T…

This study looks at whether adding extra protein to the diet can help adults with obesity keep their muscle while losing weight with GLP-1 medications. About 130 people aged 30-65 with a BMI over 30 will take part. Half will get standard medication, and the other half will also g…

This study tests an experimental daily pill called KAI-7535 to see if it helps people with obesity or overweight lose more weight than a placebo. The trial includes 320 adults who also have at least one weight-related health problem like high blood pressure or sleep apnea. Partic…

This study tests two minimally invasive procedures—EndoZip and Apollo ESG—to help obese adults lose weight. Participants (ages 21-65, BMI 30-50) who haven't succeeded with diet or exercise will get one of the two treatments, plus lifestyle coaching. The main goal is to see which …

This study tests a once-weekly medicine called tirzepatide in 300 teens with obesity and at least two weight-related health issues like high blood pressure or prediabetes. Participants receive the drug or a placebo along with healthy eating and exercise advice for about 76 weeks.…

This study tests a once-daily pill called orforglipron in 125 teens aged 12–17 who have obesity or are overweight with related health issues. Participants take either the drug or a placebo for about 18 months. The goal is to see if the pill helps lower body mass index (BMI) and i…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the drug or a placeb…

This study tests whether two approved drugs, mirabegron and tadalafil, can improve how the body handles sugar in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drugs can reverse prediabetes a…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking popular weight-loss drugs like Ozempic or Mounjaro. About 100 adults who recently started or plan t…

This study tests whether a diet rich in plant-based protein can help adults aged 55 and older with obesity lose weight while preserving muscle. Two hundred participants will follow a calorie-restricted diet for six months, with either mostly plant or mostly animal protein. Resear…

This study looks at whether adding different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease (NAFLD). About 90 participants will be assigned to diet only, diet plus one…

This study tests whether a daily dose of nicotinamide (a form of vitamin B3) can stop or reverse liver scarring (fibrosis) in people with fatty liver disease. Thirty overweight or obese adults with liver scarring will take either nicotinamide or a placebo for one year. Researcher…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. Sixty adults aged 21-65 with a BMI of 25 or higher and signs of insulin resistance will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. Re…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who do not use a breathing machine (CPAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants will receive either the drug or a p…

This study tests a drug called ACM-001.1 in 120 obese adults who are taking semaglutide (a weight-loss medication). The goal is to see if ACM-001.1 can reduce the muscle loss that often happens with weight loss. The study has two parts: one where participants take both drugs toge…

This study tests a new drug called BGM0504 against an existing weight-loss medication, tirzepatide, in adults with obesity. The goal is to see which works better for weight loss and safety over 26 weeks. About 90 people will participate, and they must have a BMI between 35 and 45…

This study explores whether changing gut bacteria with antibiotics can prevent weight regain after losing at least 10% of body weight. Researchers will give antibiotics or a placebo to 200 adults with obesity (BMI 28-35) and track weight and microbiome changes. The goal is to fin…

This study tests whether a time-efficient breathing muscle training can lower blood pressure in adults with obesity. About 44 participants with a BMI between 30 and 40 will do the training at home and have their blood pressure measured in the lab and at home. The goal is to see i…

This study tests whether giving an iron infusion before weight-loss surgery can prevent anemia and improve quality of life. About 200 obese adults with low iron will receive either the iron supplement or a placebo. The goal is to see if their hemoglobin levels stay healthier afte…

This study tests if the drug efsubaglutide alfa can help people who are still obese 6 months after metabolic surgery lose more weight. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they los…

This study is testing a new device that uses magnets to create a shortcut in the digestive system, helping people with obesity and type 2 diabetes lose weight and control blood sugar. About 35 adults aged 18-65 with a BMI between 30 and 50 will receive the procedure. The goal is …

This study tests a new medicine called NNC0487-0111, given as a weekly shot, to see if it helps people with obesity lose weight safely. About 1,150 adults will receive either the active drug or a placebo (dummy shot) for several months. The main goal is to measure how much body w…

This study tests whether the weight-loss medication tirzepatide can improve control of atrial fibrillation (an irregular heartbeat) in people with obesity. About 100 adults with a BMI of 27 or higher and symptomatic AFib will receive either tirzepatide or a placebo. The main goal…

This study looks at whether time-restricted eating (eating all meals within 8 hours or less) can help people with obesity maintain weight loss after a calorie-restricted diet. About 212 participants will follow a diet to lose 8-10% of their weight, then be split into two groups: …

This study compares an intensive weight loss program—including meal replacements, behavioral support, and weight-loss medication—to standard care for 600 adults aged 18-60 with severe obesity and related health issues. The goal is to see if the intensive approach leads to better …

This pilot study is testing a smartphone app with telephone coaching to help teens and young adults (ages 13-30) who are overweight or obese after a stem cell transplant. The goal is to see if the app can help them lose weight and improve their health. The study will enroll 20 pa…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or obese and have type 2 diabetes. About 630 adults will receive either the active drug or a placebo to see if it safely helps reduce body weight and improve blood sugar control. The go…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests a once-weekly injection called tirzepatide in adults who have obesity or are overweight with related health problems, but do not have type 2 diabetes. Participants receive either the drug or a placebo, along with diet and exercise advice. The main goal is to see …

This early-stage study tests a new drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight and blood sugar. Participants receive either the drug or a placebo, and some may also tak…

This study tests a remote behavioral program for people who have regained at least 5% of their weight after bariatric surgery. 200 participants will either receive the program or standard advice. The goal is to see if the program helps reverse weight regain and improve eating hab…

This study is testing a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults who smoke and are preparing for weight-loss surgery lose weight and quit smoking. About 20 participants will try the program to see if it is feasible and accepta…

This study looks at whether whole milk or nonfat milk is better for body composition and heart health in children ages 9 to 12 who have a higher BMI. Researchers will measure body fat, lean muscle, and other health markers over one year. The goal is to help guide healthy milk cho…

This study tests an experimental drug called HDM1005 to help obese adults who do not have diabetes lose weight. About 240 people will receive either the drug or a placebo injection. The main goal is to see how much weight they lose after 22 weeks, and whether the drug is safe.

This study tests a new drug called HDM1005 against an existing weight-loss medication, tirzepatide, in 372 adults with obesity but without diabetes. Participants receive weekly injections for 52 weeks, plus diet and exercise counseling. The main goal is to see how much weight is …

This study tests whether adding a stitch (omentopexy) during sleeve gastrectomy reduces new or worsening heartburn two years after surgery. About 526 adults with obesity will be randomly assigned to get sleeve surgery alone or with omentopexy. Researchers will measure heartburn s…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in obese patients with endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor samples taken before and a…

This study aims to help African American adults who don't get enough sleep and have overweight or obesity. Researchers will first talk with community members to understand their sleep habits and then test a program designed to help them sleep longer and be more active. The goal i…

This study tests whether simple home-based strategies and wearable devices can reduce the negative health effects of evening screen time. Researchers will enroll 30 adults who are overweight, inactive, and spend at least 3 hours of recreational screen time after 5pm. Participants…

This study tests different doses of a green dye (indocyanine green) to find the smallest amount needed to see blood flow during repeat weight loss surgery. About 108 people with obesity will take part. The goal is to improve safety by ensuring surgeons can clearly see blood vesse…

This study is testing a family-centered program to help Hispanic families lose weight and prevent obesity. Parents and their children ages 8-12 will work together to build healthy habits. The goal is to find the best way to support families using text messages and other tools.

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study tests whether a program of online classes for couples expecting their first child can help prevent obesity in both parents and their baby. 825 military families will take part, with half receiving the 10-session program and half getting standard care. The goal is to se…

This study looks at whether using a sit-stand desk can help prevent type 2 diabetes in people who are overweight and sit a lot at work. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to a con…

This study tests a six-month virtual dietary education program (PEDALL) to prevent overweight and obesity in children and teens (ages 5-21) with acute lymphoblastic leukemia (ALL) during maintenance chemotherapy. The program is offered in English and Spanish to 376 participants. …

This study looks at whether taking a daily iron supplement (60 mg) after sleeve gastrectomy surgery can prevent iron deficiency anemia better than a standard multivitamin alone. About 66 adults having weight loss surgery will be split into two groups based on their hospital unit.…

This study looks at whether changing when you eat can lower disease risk for night-shift nurses and nursing assistants who are overweight. About 180 participants will be split into three groups: one just tracks their diet, another eats only during a 10-hour daytime window, and th…

This study tests whether using a special lung-monitoring device (EIT) to set the ventilator during surgery can reduce lung complications like pneumonia or respiratory failure in people having laparoscopic gastric sleeve surgery. About 118 obese adults will be randomly assigned to…

This study tests whether eating a Mediterranean diet during pregnancy can prevent allergies in children. Researchers will enroll 276 healthy pregnant women who are at risk of having a baby with allergies. Half will follow a Mediterranean diet, and the other half will eat as usual…

This study tests a web and mobile program called Healthy Together ("Juntos") designed for Hispanic teens and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will take part, with teens aged 12-15 who are not cu…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can improve the quality of embryos in overweight or obese women. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive semaglutide…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study is testing an experimental medicine called cagrilintide to see if it can reduce how much people eat and their appetite. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The main goal is to measure changes in tot…

This study tests a once-weekly medicine called eloralintide in 800 adults with moderate-to-severe sleep apnea who are also overweight or have obesity. The goal is to see if it improves breathing during sleep and reduces body weight. Participants either cannot use or already use a…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This study tests whether tradipitant can reduce nausea and vomiting caused by GLP-1 weight-loss medications. About 280 healthy overweight or obese adults will receive either tradipitant or a placebo. The goal is to help people stay on their weight-loss treatment without unpleasan…

This study tests a weight loss program using a smartphone app and coaching for teens and young adults who are overweight after a stem cell transplant. The goal is to see if the app helps them lose weight and build healthy eating habits. About 20 participants will join this early-…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and weight loss, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks and be monitored for side …

This early-stage study tests an experimental injection called LY3971297 in healthy volunteers and people with obesity and high blood pressure. The main goal is to check for side effects and see how the drug moves through the body. About 225 participants will be involved, with stu…

This study looks at whether minocycline, an antibiotic that reduces inflammation, can help treat depression in people who also have obesity and high inflammation levels. About 35 adults with treatment-resistant depression and a CRP level of 3 mg/L or higher will take minocycline …

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for it. The app uses proven strategies to improve self-control and eating habits. About 50 teens will use the app for 16 weeks and give feedback on how helpf…

This study tests a once-weekly injection called NNC0487-0111 in 400 adults with overweight or obesity and knee osteoarthritis. Half get the drug, half get a placebo. Researchers will measure weight loss and changes in knee pain and function over time. The goal is to see if the dr…

This study tests a new home-based program that uses a virtual reality treadmill to help children aged 6 to 17 with conditions like cerebral palsy, neuromuscular diseases, or obesity improve their walking. The program involves at least three 30-minute sessions per week combining w…

This study looks at whether lifestyle changes can improve dry eyes in obese women with polycystic ovary syndrome (PCOS). Researchers will measure eye dryness using tests and questionnaires. The goal is to see if simple lifestyle adjustments can ease both conditions.

This study tests whether applying special elastic tape (kinesio tape) to the chest can improve lung function, breathing muscle strength, and sleep quality in people who are overweight or obese. Researchers will measure breathing tests and sleep quality in 36 adults before and aft…

This early-stage study tests a new medicine called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in different parts of the study …

This study compares two types of nerve blocks for shoulder surgery in adults with obesity. The goal is to see if a phrenic-sparing block reduces early breathing problems like shortness of breath or need for oxygen, compared to the standard block. Participants will take a simple b…

This early-stage study tests whether a new medicine, NNC6989-0001, is safe for healthy people who are overweight or have obesity. About 96 participants will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through t…

This study looks at whether lifestyle changes can lower eye pressure in people who have both glaucoma and obstructive sleep apnea. About 40 obese adults with these conditions will be followed. Researchers will measure eye pressure, sleep quality, and body measurements to see if l…

This study tests a new medicine (NNC0487-0111) given as a weekly injection under the skin. It looks at whether the drug can lower how much people eat, reduce appetite, and change how the body processes food after meals. The study includes 120 adults with obesity, and some will re…

This study tests whether training the muscles used for breathing can improve exercise tolerance in obese women who have finished treatment for early-stage breast cancer. Researchers will measure how long participants can exercise before getting tired. The goal is to find a simple…

This study tests if special workshops can help people with obesity cope with hurtful stereotypes and feel more confident. About 210 adults with a BMI over 30 will join a 12-month program with exercise and social support groups. Researchers will check if these workshops improve ho…

This study tests a new once-weekly injection (NNC0487-0111) to see if it helps people with excess weight and knee osteoarthritis lose weight and feel less knee pain. About 400 adults will receive either the study drug or a placebo for comparison. The main goals are to measure wei…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant lose weight. The program includes education on healthy eating and tools to make better lifestyle choices. About 30 adults will take part to see if the program improves their qua…

This study tests a once-weekly injection called retatrutide to see if it can relieve chronic low back pain in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The main goals are to measure changes in pain …

This study looks at whether a special vacuum dressing (negative pressure wound therapy) helps heal the belly incision better than standard bandages in obese women having breast reconstruction surgery. About 80 participants will be randomly assigned to one of two dressing types. T…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This study tests whether a gentle brain stimulation technique called tDCS can boost the effects of cognitive training to help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will receive either real or fake tDCS during training sessions. The go…

This study tests whether a special ultrasound-guided nerve block (M-TAPA) can reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy, a common weight-loss surgery. About 60 adults having this surgery will either receive the block or standard care. T…

This early-stage study tests a new nasal spray form of semaglutide (a drug used for weight loss) in 60 overweight or obese adults. The main goal is to check safety and how the drug moves through the body, not yet to prove weight loss. Participants receive a single dose and are mo…

This study looks at whether taking N-acetylcysteine (NAC), an antioxidant supplement, can improve the effects of high-intensity interval training in adults with overweight or obesity. Researchers will measure changes in body composition, fitness, and markers of inflammation and o…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults aged 18-60 will receive either real or fake TDCS sessions three times a week for four weeks, while also following a reduced-calo…

This early-stage study is testing a new drug called RT-114 in 60 healthy volunteers to see if it is safe and how the body processes it. The drug is given as a shot or an oral pill, and some participants will receive a placebo. The goal is to gather initial safety data before test…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study compares two types of weight-loss surgery—robotic and laparoscopic sleeve gastrectomy—to see which causes less pain the day after surgery. About 91 adults who qualify for weight-loss surgery will be randomly assigned to one of the two procedures. The main goal is to me…

This study tests whether avoiding opioids during and after obesity surgery can improve recovery and reduce side effects. About 220 adults having laparoscopic obesity surgery will be randomly assigned to opioid-free care (with or without personalized support) or standard opioid-ba…

This study is looking at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study will enroll 150 healthy girls ages 8-14 who have so…

This study looks at how eating different types of food (like high-carb vs. high-protein) affects what you want to eat later. Researchers want to see if this 'food memory' is different for people with normal weight, overweight, or obesity. 45 adults aged 18-45 will take part.

This early-stage study tests a new medicine, BI 456906, in 30 adults with obesity. It uses special scans to see how the drug attaches to receptors in the liver and pancreas that control appetite and weight. Participants receive either BI 456906 or the approved weight-loss drug se…

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-reducing procedure called endoscopic sleeve gastroplasty. Researchers will track 205 adults with obesity (BMI 30-35 with complications, or BMI over 35) for 12 months after …

This study looks at how the body fights to keep its weight stable. Researchers will have 12 people—some with low body weight and some with obesity—fast for 2 days and then eat freely for 2 days while staying in special metabolic chambers. The goal is to measure how much the body …

This study looks at fat tissue from older adults to see how cells change with age and obesity. Researchers will take small fat samples and use advanced techniques to map different cell types. Some older participants will also try lifestyle changes or a drug that targets aging cel…

This study explores whether tiny particles released from fat cells can serve as early warning signs for blood vessel damage in people with obesity. Researchers will compare these particles in normal-weight and obese adults, then see if weight loss reduces the particles and improv…

This study looks at how GLP-1 weight loss medications change muscle and bone in people with obesity. About 50 adults will take the drug and either follow a diet and exercise program or just standard advice. Researchers will measure muscle mass, bone health, and related blood mark…

This study looks at how blocking certain nerve signals (sympathetic blockade) for two weeks changes the way the body produces and uses sugar in people with both obesity and high blood pressure. Twelve adults will receive a placebo, a blood pressure drug (amlodipine), or the study…

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is …

This study looks at whether a ketogenic diet can increase the number of calories your body burns each day and help control appetite after you've lost weight. Researchers will enroll 20 adults with obesity who are otherwise healthy. Participants will follow a keto diet, and their …

This study uses a new device called a 'drinkometer' to precisely measure how people drink and eat after weight-loss surgery, instead of relying on self-reports. Researchers will study 420 adults with obesity to see how gut hormones and biological sex affect eating behaviors. The …

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans, physical tests, and blood draws. The goal is to understand how the drug affects muscle health, especially in people at ri…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to healthy-weight individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns. Up to 2,000 adults over 18 who are reasona…

This study looks at how beta-cells (which make insulin) respond to growth hormone in women who had gestational diabetes. Researchers want to understand why some women develop high blood sugar during pregnancy. The study involves 30 women and uses tests to measure insulin producti…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1200 adults for one year, checking kidney function and looking at conditions like diabetes, high blood pressure, and…

This study looks at how moderate wine drinking affects tiny particles called extracellular vesicles, which help cells communicate. Researchers will give healthy adults aged 35-65 a single serving of red wine, white wine, or water, then analyze blood samples for changes. The goal …

This study looks at whether starting with a low-carbohydrate diet and then switching to a low-fat diet leads to more body fat loss than the opposite order. Overweight adults aged 18-50 will follow each diet for 4 weeks at home, with all meals provided. Researchers will measure bo…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide for eight days to temporarily stop the pancreas from making insulin. Researchers will measure their…

This study looks at why having excess body fat in midlife (ages 40-60) might raise the risk of Alzheimer's disease. Researchers will use brain scans and blood tests in 240 healthy adults to compare brain inflammation and Alzheimer's-related changes among people with different obe…

This study follows up on people who already received the experimental obesity drug INV-347 in an earlier study. Participants do not receive any new treatment. The goal is to track any long-term side effects and measure how much of the drug remains in the blood. About 91 adults ag…

This study looks at how a substance called lactate helps control blood flow to the brain, especially in people with obesity. Researchers will compare 24 healthy adults with and without obesity, and test whether short-term exercise training can improve lactate levels and brain blo…

This study looks at 2,000 healthy African American men and women to understand how body size and sex affect heart disease risk. Researchers will measure body fat, blood fats, and insulin function to see if obesity plays a different role in this population than in white women. The…

This study looks at why people with lower incomes often have a harder time losing weight in behavioral programs. Researchers will track daily experiences and decision-making patterns in 230 adults with obesity. The goal is to understand what stands in the way of successful weight…

This study is a registry that gathers information from medical records and patient visits about endoscopic bariatric therapies (EBTs), which are non-surgical procedures to help with weight loss. It includes adults who have had or plan to have an EBT within six months. The goal is…

This study looks at two different training programs for doctors, nurses, and other health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth o…

This study looks at how a new drug (NNC0662-0419) affects the way the body processes birth control pills and a common painkiller. It involves 45 women who are overweight or obese and cannot become pregnant. The goal is to check for safety and drug interactions, not to treat the c…

This study aims to understand how a person's weight and blood sugar levels affect gene activity in tissues that control sugar and fat processing. Researchers will collect biological samples from up to 20,000 adults undergoing abdominal surgery. No new treatments are tested; the g…

This study compares bone health over 2 years in 120 teens and young adults (ages 12-21) with obesity. One group takes GLP-1 weight-loss drugs, the other uses lifestyle changes. Researchers measure bone density and strength to see if the drugs affect bones differently. Participant…

This study tests a web and mobile program to help Hispanic women who survived breast, uterine, or ovarian cancer, along with their adult daughters, eat better and move more. About 60 pairs (survivor and daughter) will use the program for 8 weeks. The goal is to see if the program…

This study looks at how fat tissue and gut bacteria may influence memory and thinking in people with obesity. Researchers will analyze tissue, blood, and gut samples from 100 adults scheduled for surgery. The goal is to find new ways to diagnose and treat brain problems linked to…

This study looks at how a mother's weight before pregnancy and certain hormones in her blood and breast milk might affect her baby's growth, body fat, and eating behavior. Researchers will compare mothers who were normal weight with those who were overweight or obese before pregn…

This study looks at how weight loss affects the fat stored inside your muscles, which can cause inflammation and make it harder for your body to use insulin. Researchers will measure muscle fat, strength, and insulin sensitivity before and after a 12-week diet program. The goal i…

This study aims to understand how obesity and aging interact by analyzing blood samples from 650 adults of different ages and weights. Researchers will measure biological age using DNA markers to see if obesity makes people age faster. The goal is to lay the groundwork for future…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that could explain why some groups face higher risks for metabolic problems. No…

This study looks at how high-intensity interval training (HIIT) changes brain activity and appetite in people who regained weight after bariatric surgery. Researchers will use brain scans and questionnaires to understand the connection between exercise, brain function, and weight…

This study looks at brown fat, a special type of fat that burns energy and may help control metabolism. Researchers will collect small fat samples from 40 healthy adults during planned surgeries. The goal is to learn how brown and white fat differ, which could lead to new ways to…

This study looks at why adults who carry extra weight in their belly area process insulin differently than lean people. Researchers will measure how fat is released from different parts of the body in 48 overweight or obese volunteers. The goal is to better understand the link be…

This study looks at how a new drug called maridebart cafraglutide (AMG 133) affects the way the body processes birth control pills. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the weight-loss drug changes the levels of the …

This study looks at whether whole milk or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will follow 625 children ages 1-2 for one year, measuring changes in waist size and body mass index. Families will be randomly assigned to give their child only w…

This study looks at 8,000 young Chinese adults with obesity (BMI 30 or higher) to find genetic factors that may cause or contribute to obesity and related metabolic problems. Participants provide health information and samples for analysis. The goal is to better understand why so…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study looks at how a low-carb (ketogenic) diet and a supplement called nicotinamide riboside (NR) change the way the body burns fat and uses energy. About 100 healthy overweight adults and some with a specific type of diabetes will eat a standard diet, then switch to a low-c…

This study tests a special care program for people with obesity. The program helps patients learn skills and feel more confident managing their health. Researchers will measure if patients' self-belief improves after 3 and 6 months. The study involves 133 adults in France.

This study follows 1,500 children ages 8-17 over several years to understand how genes, sleep, mood, and thinking skills affect eating behavior and health. Participants wear a wrist monitor, answer smartphone questions, and have yearly check-ups including body measurements, blood…

This study looks at how body composition (like weight and body shape) relates to airway tightness and reactivity in people with breathing issues or asthma. Researchers will use a simple breathing test called oscillometry to measure airway resistance. The goal is to better underst…

This study follows 930 young people aged 12 to 25 for up to 25 years to understand how type 2 diabetes and obesity affect heart and blood vessel health. Participants include those with diabetes, overweight but not diabetic, and healthy lean individuals. They undergo yearly tests …

This study aims to find out how often muscle loss (sarcopenia) occurs in 300 adults with obesity. Researchers will also explore factors like age, diet, and activity that may increase risk. The goal is to help doctors better identify and manage this condition in routine obesity ca…

This study looks at stomach tissue from 100 obese adults undergoing weight-loss surgery to understand how immune cells and blood vessels change. Researchers compare these samples to normal tissue to see if early signs of stomach cancer can be detected. The goal is to learn more a…

This study looks at how a new medicine called CagriSema changes the way your body uses energy (metabolism) compared to a low-calorie diet. About 80 adults with obesity will be randomly assigned to either CagriSema or a diet for the first part, then everyone gets CagriSema. The go…

This study is testing a new, ultra-thin endoscope that can be used without sedation to examine the upper digestive tract in people with obesity. Researchers want to see if this approach is more comfortable, safer, and cheaper than traditional endoscopy. About 100 adults from a ba…

This study follows up to 150 people with MEHMO syndrome or related disorders to learn how the disease progresses over time. Researchers will collect blood, urine, spinal fluid, and skin samples, along with imaging and health assessments. The goal is to find biological markers tha…

This study aims to find rare genetic changes that cause severe obesity starting in early childhood. Researchers will enroll 500 children and adults who had a very high BMI before age 6. Participants will provide a saliva or blood sample for genetic testing, answer health question…

This study follows up on 301 mothers and their 14-year-old children who were part of a earlier trial. The original trial tested if a low-calorie diet and exercise during pregnancy could improve health. Now researchers want to see if those lifestyle changes helped prevent obesity …

This study looks at how well young South African women with and without overweight or obesity absorb iron from their diet over a long period. Researchers want to understand why women with obesity are more likely to have iron deficiency. The study will track iron absorption and lo…

This study looks at why blood flow to muscles is often poor in people with obesity, and whether exercise can improve it. Researchers will use tiny probes to measure harmful molecules and blood flow in the muscles of 25 participants before and after an 8-week exercise program. The…

This early-stage study tests an experimental drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check the drug's safety and how it interacts with two common statins (pitavastatin and rosuvastatin). Participants will receive multiple doses of the…

This study looks at how 12 weeks of endurance exercise affects fat tissue quality and insulin sensitivity in 70 men and women with obesity aged 18-45. Participants will either exercise or act as controls, and small fat samples will be taken before and after to measure new fat cel…

This study aims to better understand heart and blood vessel diseases by examining people who have or are at risk for them, as well as their relatives and healthy volunteers. Participants, aged 1 to 100, may undergo various tests like imaging, blood draws, and physical exams. The …

This study is following 2,800 pregnant women and their children in Weifang, China, from early pregnancy until the children turn 18. Researchers are collecting information on diet, lifestyle, and environment, along with blood, urine, and other samples. The goal is to learn how fac…

This study aims to understand why fat tissue in the belly area doesn't respond the same way as fat in other parts of the body in people with obesity. Researchers will measure how fat cells release fatty acids in response to certain hormones. The study involves 24 adults and is co…

This study collects tissue samples (fat, muscle, liver, blood) from 270 adults with severe obesity during planned weight-loss surgery. Researchers compare samples from people with type 2 diabetes, insulin resistance, or normal insulin sensitivity to find new biological clues abou…

This study aims to find out why some people succeed at losing weight and keeping it off while others struggle. Researchers will look at factors like blood sugar, metabolism, genetics, and body composition in 3,200 volunteers. The goal is to move away from a one-size-fits-all appr…

This study looks at whether using a robot for weight-loss surgery is worth the extra cost compared to standard laparoscopic surgery. About 482 adults with obesity will be randomly assigned to one of the two methods. Researchers will track complications, quality of life, and overa…

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study looks at whether a single dose of apple cider vinegar can change levels of malondialdehyde, a marker of oxidative stress, in adults with obesity. Researchers will compare two groups: one that eats a standard meal with apple cider vinegar and one that eats the same meal…

This study aims to improve how drugs are dosed for people with obesity by looking at acyclovir as an example. Researchers will measure lean body mass using a special scan (DEXA) in 20 healthy volunteers with different body sizes. The goal is to see if lean mass can better predict…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. The goal is to measure changes in insulin sensitivity, fitness, and overall he…

This study is for teens and young adults aged 12 to 24 who are planning to have weight loss surgery (sleeve gastrectomy). Researchers want to understand how the body changes after surgery and why some people lose more weight than others. For those who haven't lost enough weight 1…

This study looks at two ways of giving a test meal to healthy adults: one where everyone gets the same number of calories, and one where the calories are adjusted based on a person's body size. Researchers want to find out which method leads to more consistent blood sugar results…

This study is testing whether a program of eating walnuts and doing moderate exercise before cancer treatment is practical and acceptable for American Indian patients. Researchers will also measure markers of inflammation in blood and tumor tissue to see if the program has an eff…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study looks at how problems with thinking skills (called executive dysfunction) affect physical performance and overall well-being in 100 adults with obesity. Participants will take thinking tests and physical tests like walking speed and grip strength. The goal is to unders…

This study looks at how tiny particles released by cells, called extracellular vesicles, affect blood flow in people with type 2 diabetes. Researchers want to understand if exercise can change these particles to improve blood vessel health. The study involves 60 adults aged 30-80…

This study looks at how two different anesthesia methods affect stress during weight-loss surgery. 70 adults having sleeve gastrectomy or gastric bypass will receive opioid-free anesthesia, either with or without the gas desflurane. Researchers will measure stress hormones in the…

This study looks at how a heart hormone called natriuretic peptide affects metabolism and exercise in people with different genetic makeups. Researchers will study 200 adults to see how their bodies respond to sugar and exercise based on their genes. The goal is to understand why…

This early-stage study tests a single dose of an experimental medicine (PF-08653944) in 54 overweight or obese adults. Researchers want to see how the drug is absorbed when injected into the thigh, upper arm, or abdomen. The goal is to gather safety and blood-level data, not to t…

This study looks at whether breathing limitations make it harder for people with heart failure (HFpEF) and obesity to exercise. Researchers will measure how much oxygen breathing takes and if special gas mixtures can reduce shortness of breath and improve exercise capacity. The g…

This study follows 320 people who had omega gastric bypass surgery 8 to 12 years ago to compare long-term side effects of two different loop lengths. Researchers will track serious complications, nutritional problems, weight loss, and quality of life. The goal is to find out whic…

This study looks at whether eating oil rich in oleic acid (a healthy fat in olive and sunflower oil) changes how fat cells process cholesterol in women with obesity. About 40 women scheduled for weight-loss surgery will take either regular sunflower oil or an oleic-acid-rich vers…

This study compares two ways of using a breathing machine during weight-loss surgery in 40 adults with obesity. The goal is to see which method keeps oxygen levels higher and puts less pressure on the lungs. Results may help doctors choose safer ventilation for future surgeries.

This study looks at how two common weight loss methods—newer medications like semaglutide and gastric bypass surgery—affect muscle, metabolism, and side effects. Researchers will follow 60 adults with severe obesity for one year, using body scans and surveys to track changes. The…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study looks at how the body processes cortisol (a stress hormone) and bile acids (digestive fluids) in obese women before and after gastric bypass surgery. Researchers want to understand why these changes happen and how they might help with weight loss and metabolic health. …

This study looks at how what children eat affects their growth and development in remote farming communities in Swat, Pakistan. Researchers will follow 832 children from birth to age 5, measuring their height, weight, head size, and developmental skills. The goal is to understand…

This study looks at how being obese changes your DNA and harms blood vessels. Researchers want to see if 12 weeks of aerobic exercise can reverse these changes. 80 adults scheduled for weight-loss surgery will take part. The goal is to understand the body's inner workings, not to…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study looks at how changing what you eat—like the amount of protein, fat, carbs, and total calories—affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 24-hour periods…

This study looks at why some ultra-processed foods (like those high in fat or sugar) make people want to eat more. Researchers will measure cravings, mood, and calorie intake in 50 adults with obesity after they eat different snack foods. The goal is to understand which ingredien…

This study looks at whether resistance training (like lifting weights) can improve how fat is broken down in obese postmenopausal women who have prediabetes. Researchers will measure fat metabolism before and after 12 weeks of training. The goal is to find a practical way to prev…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and immune function in healthy women aged 18 to 50. Participants will stay in the clinic for 5 days, follow the eating schedule, and undergo tests like blood draws and …

This study tests whether adding beans to the diet can improve gut health and metabolism in overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie daily for two weeks, and researchers will measure changes in gut bacteria, blood ma…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to learn how a part of the brain called the cerebellum helps control feelings of fullness after eating. 150 partic…

This study looks at how popular weight-loss drugs (GLP-1 receptor agonists) affect muscle mass and physical function in people with obesity, and whether adding exercise helps. Researchers will follow 40 participants for 2 years, measuring muscle, strength, and metabolism. They al…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at how eating and sleeping at mismatched times (like shift workers or jet lag) affects body weight. Researchers will measure energy use, body composition, and brain responses in 42 adults. The goal is to understand how timing, not just what you eat, impacts weigh…

This study tests an experimental drug called MKP10241 in healthy adults and people with obesity, with or without type 2 diabetes. The main goals are to see if food changes how the drug works, how safe it is, and how the body processes it. About 68 participants will take either th…

This study looks at whether certain fats made from dietary fatty acids are linked to breast cancer and body weight in postmenopausal women. Researchers will compare four groups of women (healthy or with breast cancer, and with normal weight or overweight/obesity) to measure these…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at whether people with obesity who also have binge eating or food addiction experience taste differently than those without these behaviors. Researchers will measure sweet and salty taste thresholds in 300 participants. The goal is to understand why some people o…

This study aims to understand the heart health of adults in Black church communities in Washington D.C. Researchers will measure things like blood pressure, cholesterol, and weight, and ask about lifestyle habits. Participants will also wear activity monitors for a month. The inf…

This study looks at how the bacteria in your gut might talk to your brain, affecting your ability to control eating. Researchers will compare 116 adults with and without obesity using brain scans, memory tests, and gut bacteria analysis. The goal is to understand why some people …

This study looks at why insulin fails to properly control fat breakdown in people with upper body obesity. Researchers will test how the diabetes drug pioglitazone affects fat cell proteins compared to a placebo. The study involves 64 adults, both non-obese and obese, to understa…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study looks at whether taking a daily supplement called SPM Active® for 12 weeks can increase certain omega-3-related substances in the blood and improve well-being in adults with obesity. About 33 people aged 45-60 with a BMI between 30 and 40 will take two soft-gel capsule…

This study looks at how GLP-1 medications (like Ozempic) change fat tissue in people having weight-loss surgery. Researchers will measure oxytocin levels and fat quality in 40 patients, comparing those who took GLP-1 drugs for at least 3 months to those who did not. The goal is t…

This study looks at how long you need to fast and whether temporarily stopping GLP-1 medications (like liraglutide or semaglutide) affects how much food stays in your stomach. Researchers will study 75 adults with obesity who already take these drugs. The goal is to improve safet…

This study looks at tiny particles released from fat tissue, called extracellular vesicles, to understand how obesity leads to insulin resistance in muscles. Researchers will compare these particles in lean and obese people, and also check for differences between men and women. T…

This study works with clinics in Massachusetts to offer proven programs for weight management, cancer screening, and mental health to adults in underserved areas. Researchers will track changes in body mass index, cancer screening rates, and mental health scores. The goal is to r…

This study looks at how people with obesity feel about their quality of life after a less invasive stomach procedure called endoscopic vertical gastroplasty (GVE). Researchers will interview 20 Italian adults who had the procedure at least six months ago. The goal is to understan…

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food or drink left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal is …

This study aims to see if a specially designed education module helps people with spinal cord injuries learn about their increased risk for heart disease, obesity, and related conditions. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure their kn…

This study looks at how a park-based fitness program affects the health of adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, strength, and mobility in 1,000 participants. The goal is to see if community park programs can he…

This study looks at how diet affects gum health in 200 adults with obesity but no other health problems. Researchers will calculate each person's dietary inflammatory index (DII) score and measure markers of inflammation in their gum fluid and blood. The goal is to see if a pro-i…

This study looks at how a type of diabetes medicine (GLP-1 receptor agonists) affects fat tissue function in people with chronic kidney disease. Researchers want to see if improving fat health can slow kidney damage. About 250 adults with early-to-moderate kidney disease, obesity…

This study looks at whether bariatric surgery can slow or reverse biological aging in people with obesity. Researchers will measure changes in blood markers, fat cells, and gut bacteria before and after surgery. The goal is to understand how weight-loss surgery affects the body's…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study is testing an experimental drug called angiotensin-(1-7) to see if it can improve how blood vessels and nerves work in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery size during a short infusion of the drug comp…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study tests whether a simple, home-based breathing exercise program can improve brain function and reduce inflammation in adults with obesity. Researchers will measure changes in blood flow to the brain and immune system activity before and after 8 weeks of training. The goa…

This study aims to understand why night shift workers are more likely to become obese. Researchers will compare 1,000 shift and day workers from five European countries. They will look at diet, sleep, and body samples to find the biological and behavioral reasons behind weight ga…

This study looks at how body weight relates to women's bathroom habits, genital hygiene, and bladder symptoms. Researchers will compare normal-weight and overweight/obese women aged 18-45 using questionnaires. The goal is to understand these connections and improve quality of lif…

This study aims to understand how the brains and metabolisms of people with obesity react differently to sugar, fat, and protein compared to people without obesity. Researchers will give 60 participants liquid meals and use brain scans and blood tests to measure their responses. …