Can exercise rewire your genes to fix blood vessels?
NCT ID NCT03527420
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at how 12 weeks of aerobic exercise changes DNA methylation—a chemical tag on genes—in fat tissue of 80 people with obesity who are scheduled for bariatric surgery. Researchers want to see if these changes improve blood vessel function and reduce inflammation. The goal is to understand the biological steps linking exercise to better vascular health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
aerobic exercise training
What this could lead to
If successful, this could reveal how exercise improves blood vessel health in obesity at a genetic level, pointing toward new prevention strategies.
What could go wrong
This is an early-stage observational study, not a treatment trial. Results may not lead to direct therapies, and individual responses to exercise can vary widely.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Illinois at Chicago
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••