Can exercise rewire your genes to fix blood vessels?
NCT ID NCT03527420
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at how 12 weeks of aerobic exercise changes DNA methylation—a chemical tag on genes—in fat tissue of 80 people with obesity who are scheduled for bariatric surgery. Researchers want to see if these changes improve blood vessel function and reduce inflammation. The goal is to understand the biological steps linking exercise to better vascular health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aerobic exercise training
- What this could lead to
- If successful, this could reveal how exercise improves blood vessel health in obesity at a genetic level, pointing toward new prevention strategies.
- What could go wrong
- This is an early-stage observational study, not a treatment trial. Results may not lead to direct therapies, and individual responses to exercise can vary widely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Illinois at Chicago
RECRUITINGChicago, Illinois, 60612, United States
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