Coffee grounds probiotic could reshape gut health and fight inflammation

NCT ID NCT06912100

Ongoing Disease control Sponsor: University of Connecticut Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This pilot study tests whether a daily probiotic supplement containing L. acidophilus (strain TW01), originally isolated from fermented coffee grounds, can improve gut health, body composition, and markers of inflammation. Overweight or obese adults aged 18-60 will take either the probiotic or a placebo for a period, while researchers measure stool butyrate (a gut health marker), blood inflammation levels, and body fat percentage. The goal is to see if this probiotic can positively influence overall health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Probiotic L. acidophilus (strain TW01) plus a fiber source (Fibersol-2), taken as capsules daily
What this could lead to: If it works, this probiotic could support gut health, reduce inflammation, and improve body composition in people who are overweight or obese.
What could go wrong: This is a very small early-stage pilot study, so results may not apply broadly. The probiotic may have no significant effect, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESE, OTHERWISE HEALTHY VOLUNTEERS OVERWEIGHT (BMI &GT; 25)

Contacts and locations

Locations

University of Connecticut, Department of Nutritional Sciences

Storrs, Connecticut, 06269, United States

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