Can Weight-Loss surgery change how medications work?

NCT ID NCT03497143

Recruiting now Knowledge-focused Sponsor: Norwegian University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs lamotrigine, a medication used for epilepsy and bipolar disorder. Researchers will measure the drug's concentration in the blood of 12 patients before and after surgery to see if the procedure changes its availability. The goal is to understand if dose adjustments are needed after surgery to maintain the drug's effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lamotrigine, a medication used for epilepsy and bipolar disorder, tested to see how bariatric surgery affects its absorption.
What this could lead to: If successful, this could help doctors adjust lamotrigine doses for patients who have had bariatric surgery, ensuring the drug works effectively.
What could go wrong: This is a small study with only 12 participants, so results may not apply to everyone. The findings will only show how the body processes the drug, not whether it improves health outcomes.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

Locations

St. Olavs University Hospital
RECRUITING

Trondheim, Norway

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