OBESITY, MORBID

This study is testing a new, less invasive procedure called PSAM that aims to help people with obesity lose weight by slowing down how fast the stomach empties. The procedure uses an endoscope (a thin tube passed through the mouth) to make cuts in the stomach muscle, without remo…

This study explores whether time-restricted eating (eating only during certain hours of the day) is safe and practical for pregnant women with severe obesity. About 60 women in their second and third trimesters will either follow this eating pattern or receive standard care. The …

This study looks at 151 people who had sleeve gastrectomy but didn't lose enough weight or regained it. It compares a newer, simpler surgery (SADI-S) with a standard, more complex one (BPD-DS) to see which works better with fewer side effects. The goal is to help patients achieve…

This study looks at 150 adults who regained weight or didn't lose enough after a previous gastric bypass. They will be randomly assigned to one of two types of revision surgery (distal gastric bypass). The goal is to see which surgery leads to more weight loss and fewer side effe…

This study looks at whether using noninvasive breathing support right after removing the breathing tube can help severely obese patients avoid needing the tube again. About 20% of these patients currently need to be re-intubated, which raises risks like pneumonia and longer hospi…

This study compares a new, gentler type of weight-loss surgery (low impact laparoscopy) to the standard method. The goal is to see if using lower gas pressure and smaller cuts reduces pain and helps patients breathe better after surgery. About 128 adults with obesity will be rand…

This study compares two methods of calculating propofol doses for obese patients during surgery to see which one works better with an automated anesthesia delivery system. About 46 obese adults having surgery will take part. The goal is to find a dosing method that avoids giving …

This study tests whether adding a special mix of essential amino acids and carboxylic acids (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose more weight and maintain muscle mass. Sixty adults aged 45-65 with a BMI over 35 will be randomly assigned…

This study looks at how full people feel after two types of weight-loss procedures: sleeve gastrectomy (stomach reduction) or a stitch procedure (OverStitch) for those who regained weight after earlier surgery. Researchers will use a water load test—where participants drink water…

This study tests a personalized method to set breathing machines for severely obese patients with acute respiratory distress syndrome (ARDS). Researchers will use a special tube to measure pressure inside the chest and adjust ventilator settings accordingly. The goal is to see if…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at how losing a lot of weight and keeping it off changes the way the body breaks down fat in response to insulin. Researchers will measure fat tissue inflammation and insulin's ability to control fat release in 30 people before and after bariatric surgery. The go…

This study looks at how inflammation in fat tissue is connected to fat buildup in the liver and insulin resistance in people with severe obesity. Researchers will measure liver stiffness and markers of inflammation in 60 adults who are having gastric bypass surgery. The goal is t…

This study is testing a new, ultra-thin endoscope that can be inserted through the nose without sedation to examine the upper digestive tract in people with obesity. The goal is to see if this approach is more comfortable, safer, and cheaper than traditional endoscopy. About 100 …