OBESITY, MORBID

About 20% of severely obese patients need their breathing tube reinserted after it's removed, which raises risks of pneumonia and longer hospital stays. This study tests whether using noninvasive breathing support (alternating between two devices) for 24 hours after tube removal …

This study compares two weight-loss surgeries—SASI bypass and sleeve gastrectomy—in 220 adults with severe obesity. The goal is to see which one leads to more weight loss and fewer problems like acid reflux. Participants will be randomly assigned to one of the two procedures and …

This study tests two types of distal gastric bypass surgery for people who regained weight or didn't lose enough after an initial Roux-en-Y gastric bypass. About 150 participants will be randomly assigned to one of the two procedures and followed for three years. The main goals a…

This study tests whether adding an essential amino acid supplement (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose weight while keeping muscle mass. Sixty participants aged 45-65 with a BMI over 35 will be randomly assigned to receive either the …

This pilot study tests a new procedure called PSAM (Pylorus-Sparing Antral Myotomy) for weight loss in 30 adults with obesity. The procedure involves cutting some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight…

This pilot study will test whether time-restricted eating (eating only during an 8-10 hour window each day) is safe and feasible for pregnant women with severe obesity. Sixty women in their second or third trimester will either follow this eating pattern or receive standard care.…

This study looks at people who had a sleeve gastrectomy but didn't lose enough weight or regained it. It compares a newer, simpler surgery (SADI-S) to a more complex one (BPD-DS) to see which works better and has fewer side effects. About 151 adults will be randomly assigned to o…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, instead of the usual mouth-and-sedation approach. Researchers want to see if it improves patient experience and lowers costs for people in bariatric care. About 100 adults will try the …

This trial compares a new 'low impact' laparoscopic technique using lower gas pressure and smaller incisions to standard laparoscopy for sleeve gastrectomy in 128 obese patients. The goal is to see if it reduces post-surgery pain and improves lung function. Participants are rando…

This study is testing how full people feel after two types of weight-loss procedures: sleeve gastrectomy (removing part of the stomach) and a stitch procedure (OverStitch™) for those who regained weight after earlier surgery. Sixty adults will drink water until comfortably full t…

This study investigates whether bariatric surgery, such as gastric bypass or sleeve gastrectomy, changes how the body absorbs the common blood-pressure medication metoprolol. Researchers will measure drug levels in the blood of 12 patients before and after surgery. The goal is to…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs lamotrigine, a medication used for epilepsy and bipolar disorder. Researchers will measure the drug's concentration in the blood of 12 patients before and aft…

This study asks whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs paracetamol, a common painkiller. Researchers will measure paracetamol levels in the blood of 12 people before and after surgery. The goal is to understand if these…

This study looks at whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs and processes the blood pressure medication losartan. Researchers will measure losartan levels in the blood of 12 people before and after surgery. The goal is t…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs the blood pressure medication valsartan. Researchers will measure drug levels in the blood of 12 patients before and after surgery to see if the operation cha…

This study investigates how gastric bypass or sleeve gastrectomy changes the way the body processes ramipril, a drug used to treat high blood pressure. Researchers will measure ramipril levels in the blood of 12 patients before and after surgery. The goal is to understand whether…

This study investigates how gastric bypass or sleeve gastrectomy alters the absorption of irbesartan, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with morbid obesity before and after surgery. The goal is to understand whether…

This study looks at how gastric bypass or sleeve gastrectomy affects the way the body handles hydrochlorothiazide, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people before and after surgery. The goal is to understand whether weight…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — change the way the body processes the antidepressant fluoxetine (Prozac). Researchers will measure drug levels in the blood of 12 participants before and after surgery. The goal is …

This study looks at how gastric bypass and sleeve gastrectomy — two types of weight-loss surgery — change the way the body absorbs enalapril, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after su…

This study looks at how gastric bypass or sleeve gastrectomy changes the way the body processes the antipsychotic medication chlorprothixene. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after surgery. The goal is to understand whe…

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—affect the absorption of gabapentin, a drug used for nerve pain and seizures. Researchers measure gabapentin levels in the blood of 12 participants before and after surgery. The goa…

This study investigates how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—change the way the body absorbs the blood thinner apixaban. Researchers will measure apixaban levels in the blood of 12 participants before and after surgery. The goal is to underst…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — affect the way the body absorbs the medication quetiapine. Quetiapine is a prescription drug used for mental health conditions. Researchers will measure quetiapine levels in the blo…

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—alter the way the body processes ibuprofen. Researchers will measure ibuprofen levels in the blood of 12 participants before and after surgery. The goal is to understand whether the…

This study looks at how bariatric surgery (gastric bypass or sleeve gastrectomy) affects the levels of the blood pressure drug lercanidipine in the blood. Researchers will measure drug concentrations before and after surgery in 12 people with severe obesity. The goal is to unders…

This study investigates how bariatric surgery (gastric bypass or sleeve gastrectomy) changes the way the body absorbs candesartan, a drug used to treat high blood pressure. Researchers will measure candesartan levels in the blood of 12 people with severe obesity before and after …

This study follows 750 severely or morbidly obese patients who have undergone bariatric surgery at a single hospital in France. Researchers aim to track long-term weight loss and improvements in related health issues such as diabetes and high blood pressure. By observing real-wor…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study tests whether dosing the anesthetic propofol based on adjusted body weight is better than total body weight for obese patients. Using a computer-controlled system, researchers will monitor brain activity to maintain the right depth of anesthesia. The goal is to avoid o…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study from the Mayo Clinic looks at how major, lasting weight loss from bariatric surgery changes the way insulin controls fat breakdown. Researchers will measure inflammation and fat cell activity in 30 people with severe obesity before and after surgery. The goal is to bet…

This study from Mayo Clinic looks at how inflammation in fat tissue may affect the liver in people with severe obesity. Researchers will measure liver stiffness and fat tissue markers in 60 adults before they have weight-loss surgery. The goal is to better understand why some peo…