OBESITY, MORBID

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study follows 120 teenagers aged 13 to 18 with severe obesity to see if weight-loss surgery (gastric bypass) leads to better health than standard treatments like diet and exercise. Participants are tracked for up to 10 years, measuring weight loss, quality of life, and menta…

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This pilot study is testing whether a procedure called endoscopic sleeve gastroplasty (ESG) is safe and helpful for weight loss in 10 obese adolescents aged 12-17. Instead of traditional weight-loss surgery, doctors use a device inserted through the mouth to stitch the stomach sm…

This study compares two types of weight-loss surgery for people who have already had a sleeve gastrectomy but still have obesity. One surgery is the standard duodenal switch, and the other is a simpler single-loop version. Researchers want to see if the simpler surgery causes few…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study tests an 8-week mindfulness program (MB-EAT) for people who had bariatric surgery at least six months ago and struggle with eating guidelines. About 85 participants will be split into two groups: one gets the mindfulness training, the other does not. Researchers will t…

This study tests a remote program called ReConnect for people who had bariatric surgery about 2 years ago and their romantic partners. The program uses weekly handouts and videos with positive psychology activities to improve mood, resilience, and relationship satisfaction. 82 co…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study tests whether a safe green dye, injected during gastric bypass surgery, can help surgeons see blood flow to the new stomach connection. Poor blood flow can lead to ulcers, leaks, or narrowing. The trial involves 300 adults and will follow them for two years to see if u…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

Researchers are analyzing data from 8,000 patients who had bariatric surgery for severe obesity. The goal is to learn which procedures lead to the best weight loss and health improvements, while also tracking risks like complications and death. This study does not test a new trea…