OBESITY, MORBID

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss surgery or cancer surgery on the stomach or esophagus. About 180 adults who develop such leaks will be randomly assigned to get either the new stent, …

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program on Zoom and has team meetings with their doctor and a coach. Researchers will see which met…

This study looks at whether weight-loss surgery (gastric bypass) is safer and more effective than standard treatments for teenagers aged 13 to 18 with severe obesity. About 120 teens will be followed for up to 10 years to measure weight loss, quality of life, and mental health. T…

This study compares a newer, simpler weight-loss surgery (SADI) with the standard more complex bypass in people who already had a partial stomach removal. The goal is to see if the simpler method causes fewer digestive and nutritional problems while still helping with weight loss…

This early study tests whether a brain implant that sends small electrical pulses can safely reduce episodes of loss-of-control eating in people with severe obesity. Six adults who have not been helped by other treatments will receive the device. The main goal is to check safety,…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) in 10 obese adolescents aged 12-17. Instead of surgery, doctors use a flexible tube to reduce stomach size, helping with weight loss. The goal is to see if it's safe and works long-term to lower weight and i…

This study tests a remote, 8-week positive psychology program for people who had bariatric surgery 1-3 years ago and their romantic partners. The goal is to see if the program improves mood, resilience, relationship satisfaction, and healthy behaviors. About 80 couples will be ra…

This study looks at how two different types of gastric bypass surgery change the body's metabolism and inflammation. Researchers will compare 50 people with severe obesity who had surgery to 15 healthy people who did not. The goal is to understand which surgical approach works be…

This study looks at how weight loss surgery (bariatric surgery) affects memory and thinking skills in people with obesity who also have memory problems or dementia. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to unde…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This early-phase study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-protective protein called BDNF in people with multiple sclerosis, long-COVID, or acute leukemia (in remission) who also have obesity and memory or thinking problems. …

This study reviews medical records from 8,000 people who had weight-loss surgery at one hospital. Researchers want to learn how different surgeries affect weight loss, safety, and health problems like diabetes. The goal is to use this information to help future patients get bette…

This study tests whether a green dye, injected during gastric bypass surgery, helps surgeons see blood flow at the new stomach connection. About 300 adults having this weight-loss surgery will take part. The goal is to see if better blood flow checks can reduce problems like ulce…

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol over 10 years. The goal is to learn how well these procedures wor…