OBESITY, MORBID

This study is testing whether adding a special amino acid supplement to a low-calorie diet helps people with severe obesity lose weight while keeping their muscle mass. Researchers will compare two groups: one gets the supplement with their diet, and the other gets a placebo. The…

This study is testing if a simple eating schedule, called time-restricted eating, can help pregnant women with severe obesity manage their weight and improve health outcomes for themselves and their babies. Researchers will compare 60 participants who follow a specific daily eati…

This study is testing if a new, less invasive endoscopic stitching procedure can help people who regained weight after obesity surgery feel full again. Researchers will compare this procedure to a standard weight loss surgery by measuring how much water participants can drink bef…

This study compares two surgical approaches for people whose initial sleeve gastrectomy weight loss surgery didn't work well enough. Researchers are testing whether a newer, simpler procedure (SADI-S) works as well as the standard revision surgery (DS) but with fewer complication…

This study tests whether using noninvasive breathing support right after removing a ventilator tube helps severely obese patients avoid needing the tube reinserted. Researchers will compare two different breathing support methods in 250 patients who have been on ventilators. The …

This study is testing a new, less invasive endoscopic procedure called Pylorus Sparing Antral Myotomy (PSAM) for weight loss. It involves making a small cut in the stomach muscle to slow down how quickly food leaves the stomach, which may help people feel full longer and lose wei…

This study is testing a new, very thin endoscope that goes through the nose instead of the mouth and doesn't require sedation. It aims to see if this method is a good, cheaper, and faster way to check for stomach and esophagus problems in people enrolled in a weight management pr…

This study is testing a gentler version of 'keyhole' surgery for weight loss to see if it causes less pain and helps patients breathe better after the operation. Researchers will compare this new method, which uses lower air pressure and smaller cuts, to the standard surgical tec…

This study aims to understand how inflammation in body fat is connected to liver damage and insulin resistance in people with severe obesity. Researchers will examine tissue samples from 60 participants who are already scheduled for gastric bypass surgery. The goal is to gather k…

This study is testing whether a weight loss medication called liraglutide (Saxenda) affects brain health markers in people with multiple sclerosis, long COVID, or leukemia in remission who also have obesity and cognitive problems. Researchers will measure changes in a protein cal…

This study aims to understand how substantial, long-term weight loss after bariatric surgery improves the body's ability to regulate fat breakdown with insulin. Researchers will measure inflammation and fat cell function in 30 adults with severe obesity before and one year after …