Bariatric surgery study to unlock secrets of insulin and fat metabolism

NCT ID NCT03868592

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study from the Mayo Clinic looks at how major, lasting weight loss from bariatric surgery changes the way insulin controls fat breakdown. Researchers will measure inflammation and fat cell activity in 30 people with severe obesity before and after surgery. The goal is to better understand the link between weight loss and improved insulin function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gastric sleeve/bariatric surgery
What this could lead to: If successful, this could clarify how weight loss improves insulin's ability to control fat breakdown, potentially guiding better treatments for obesity-related metabolic issues.
What could go wrong: This is a small, early-stage observational study with only 30 participants. It aims to understand mechanisms, not test a new treatment, so direct patient benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 559055, United States

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