Morbid obesity

This study tests an experimental drug called mibavademab in people with a rare form of obesity caused by a faulty leptin gene. The drug aims to help control hunger and body weight. Only 4 participants will be enrolled to see how well it works and if it is safe.

Researchers compare two bariatric surgeries, Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass (RYGB), in adults with morbid obesity. Participants wear a continuous glucose monitor for 7 days before surgery and again 6 and 12 months after. The study measu…

Researchers are studying whether a digital app called Get-Ready can improve remote monitoring for people with obesity who are preparing for or recovering from bariatric surgery. The trial enrolls 500 patients aged 18 to 65 who are eligible for weight-loss surgery. The app aims to…

This study compares two different doses of the blood thinner bemiparin to see which works better at preventing dangerous blood clots in people with severe obesity after surgery. About 2,400 participants will be enrolled. The goal is to find the safest and most effective dose for …

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study tests whether restarting semaglutide (Wegovy) just two weeks after sleeve gastrectomy helps teens with severe obesity lose more weight than surgery alone. About 150 teens aged 12–18 who were already on semaglutide before surgery will be randomly assigned to restart the…

This trial compares two surgical techniques used during one-anastomosis gastric bypass for severe obesity. One method sets the length of the bypassed intestine based on the patient's measured total small bowel length, while the other uses standard lengths based on body mass index…

This study compares two approaches for adults with severe obesity: an intensive non-surgical program (meal replacements, behavior support, and weight-loss medication) versus bariatric surgery. Researchers will track 500 participants to see which method better improves health and …

This study tests whether taking daily protein supplements and doing resistance exercises (like lifting weights) can prevent too much muscle loss after bariatric surgery. About 400 patients will be randomly assigned to either standard care or standard care plus the protein and exe…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…

About 20% of severely obese patients need their breathing tube reinserted after it's removed, which raises risks of pneumonia and longer hospital stays. This study tests whether using noninvasive breathing support (alternating between two devices) for 24 hours after tube removal …

This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after me…

This trial tests whether a 50 microgram dose of misoprostol works better than a 25 microgram dose for starting labor in pregnant women with a BMI over 40. The goal is to see if the higher dose can lead to more vaginal deliveries and fewer cesarean sections. Participants will rece…

This study tests whether semaglutide, a drug used for weight loss, can reduce markers of heart disease risk in adolescents aged 12 to 15 with severe obesity (class 2 or 3). Participants receive semaglutide and undergo heart scans, body composition tests, and blood work over about…

This study uses MRI scans to measure how weight loss treatments affect fat in the liver, pancreas, and other organs of adolescents aged 12 to 18 with severe obesity. Researchers compare two approaches: GLP-1 receptor agonist drugs combined with lifestyle changes versus lifestyle …

This study is testing whether bariatric surgery (like gastric bypass) can safely reduce the risk of major heart problems—such as heart attacks, strokes, and heart failure—in people with severe obesity and high heart risk. About 700 participants will be randomly assigned to either…

This study compares two weight-loss surgeries—SASI bypass and sleeve gastrectomy—in 220 adults with severe obesity. The goal is to see which one leads to more weight loss and fewer problems like acid reflux. Participants will be randomly assigned to one of the two procedures and …

This study tests two types of distal gastric bypass surgery for people who regained weight or didn't lose enough after an initial Roux-en-Y gastric bypass. About 150 participants will be randomly assigned to one of the two procedures and followed for three years. The main goals a…

This study looks at whether adding a GLP-1 drug (semaglutide) to bariatric surgery helps people with severe obesity lose more weight and keep it off. About 200 adults aged 18-60 with a BMI of 35 or higher and related health issues will be followed for a year. The goal is to see i…

This study tests whether adding an essential amino acid supplement (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose weight while keeping muscle mass. Sixty participants aged 45-65 with a BMI over 35 will be randomly assigned to receive either the …

This study compares two versions of gastric bypass surgery for people with severe obesity. One method uses fixed lengths for the rerouted intestine, while the other customizes the lengths based on each patient's total small bowel length. The goal is to see if the customized appro…

This pilot study tests a new procedure called PSAM (Pylorus-Sparing Antral Myotomy) for weight loss in 30 adults with obesity. The procedure involves cutting some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight…

This study compares two types of gastric bypass surgery for people with severe obesity: the standard Roux-en-Y and a simpler omega (one-anastomosis) bypass with a shorter intestinal loop. Researchers want to see if the omega procedure is just as good at helping patients lose weig…

This study looks at how the size of the tube (bougie) used during laparoscopic sleeve gastrectomy affects outcomes like weight loss and complications. About 100 adults with obesity will be randomly assigned to receive a small (36-Fr) or extra-large (over 40-Fr) bougie. The goal i…

This study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical …

This study looks at people who had a sleeve gastrectomy but didn't lose enough weight or regained it. It compares a newer, simpler surgery (SADI-S) to a more complex one (BPD-DS) to see which works better and has fewer side effects. About 151 adults will be randomly assigned to o…

This study tests tirzepatide, a weight loss medication, in 36 young adults aged 18-26 with obesity from Prader-Willi syndrome, hypothalamic obesity, or general causes. Participants take the drug for 48 weeks to see how much weight they lose and how their health changes. The goal …

This study compares two surgical options for people with severe obesity and acid reflux (GERD). Half of the 560 participants will get a newer procedure called Nissen-Sleeve Gastrectomy, which combines stomach reduction with a reflux barrier; the other half will get the standard R…

This study looks at whether taking a daily iron supplement after sleeve gastrectomy surgery can prevent iron deficiency anemia. Researchers will compare two groups of adults who had the surgery: one group takes extra iron plus a multivitamin, the other takes only a multivitamin. …

This study tests whether a daily powder containing fiber and plant compounds (inulin, resveratrol, quercetin) can reduce brain inflammation in 120 overweight women aged 35-60 who are going through menopause. Participants take the supplement or a placebo for 6 months, and research…

This study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after surgery. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to get either standard…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, instead of the usual mouth-and-sedation approach. Researchers want to see if it improves patient experience and lowers costs for people in bariatric care. About 100 adults will try the …

This trial compares a new 'low impact' laparoscopic technique using lower gas pressure and smaller incisions to standard laparoscopy for sleeve gastrectomy in 128 obese patients. The goal is to see if it reduces post-surgery pain and improves lung function. Participants are rando…

This study tests whether a wrist-worn device called Reletex Reliefband can reduce nausea and vomiting after bariatric sleeve gastrectomy. The device uses mild electrical pulses to stimulate nerves and suppress nausea. Researchers will compare it to a sham device in 100 adults to …

This study tests if a mild electrical patch placed on the skin (called TENS) can prevent breathing problems after weight-loss surgery in people with severe obesity. About 70 participants will be randomly assigned to receive either TENS or a fake device. The main goal is to see if…

This study tests whether a synbiotic supplement (a mix of probiotics and prebiotics) can improve gut health and reduce mild stomach discomfort in adults aged 50-70 who are overweight. Participants take the supplement or a placebo daily for 8 weeks, and researchers measure changes…

This study tests whether a new device that combines a bite block, oxygen tube, and airway support can prevent dangerously low oxygen levels in severely obese patients during sedated endoscopy. About 410 adults with a BMI of 35 or higher will be randomly assigned to receive either…

This study looks at whether a special diet workshop held 15 days after bariatric surgery can help patients increase their protein intake. About 88 adults who are scheduled for weight-loss surgery will take part. The goal is to improve protein levels and overall recovery over the …

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during weight-loss surgery can reduce pain, inflammation, and cell stress afterward. About 104 adults having laparoscopic bariatric surgery will receive either the combo, one drug alone, or…

This study is testing how full people feel after two types of weight-loss procedures: sleeve gastrectomy (removing part of the stomach) and a stitch procedure (OverStitch™) for those who regained weight after earlier surgery. Sixty adults will drink water until comfortably full t…

Researchers are studying whether gastric bypass or sleeve gastrectomy changes the way the body processes venlafaxine, a common antidepressant. The trial enrolls 12 adults in Central Norway who are preparing for one of these weight-loss operations. Participants take venlafaxine an…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants. The goal is to better understa…

Researchers want to know whether weight loss from laparoscopic sleeve gastrectomy changes neck pain, posture, and neck function. The study follows about 25 adults scheduled for this weight-loss operation at one hospital. Participants complete neck questionnaires, strength and mot…

This study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…

This study links two Swedish national registries to examine how often adults experience nausea, vomiting, and pain right after weight-loss (bariatric) surgery. Researchers will look at data from about 30,000 operations to see which patient, anesthesia, and surgical factors are li…

This study tests whether spinal cord stimulation (SCS), a treatment for chronic back and leg pain, can also activate brown adipose tissue (BAT) — a type of fat that burns calories. Researchers will place an extra research electrode during a standard SCS implant in about 10 adults…

This study looks at whether people who leave the hospital 24 hours after bariatric (weight-loss) surgery and receive follow-up care at home have lower healthcare costs than those who stay in the hospital for the usual 48 hours. Researchers will compare costs, safety, and patient …

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study follows 70 adults with severe obesity for three years after bariatric surgery, checking in before the operation and again at several points afterward. Researchers will measure psychological distress, perceived stress, and impulsivity, along with weight changes and the …

This study investigates why people with overweight or obesity often have a reduced muscle-building response to resistance exercise and protein intake compared to lean individuals. Researchers will compare muscle tissue samples from lean and overweight/obese participants before an…

This study investigates whether bariatric surgery, such as gastric bypass or sleeve gastrectomy, changes how the body absorbs the common blood-pressure medication metoprolol. Researchers will measure drug levels in the blood of 12 patients before and after surgery. The goal is to…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs lamotrigine, a medication used for epilepsy and bipolar disorder. Researchers will measure the drug's concentration in the blood of 12 patients before and aft…

This study asks whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs paracetamol, a common painkiller. Researchers will measure paracetamol levels in the blood of 12 people before and after surgery. The goal is to understand if these…

This study looks at whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs and processes the blood pressure medication losartan. Researchers will measure losartan levels in the blood of 12 people before and after surgery. The goal is t…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs the blood pressure medication valsartan. Researchers will measure drug levels in the blood of 12 patients before and after surgery to see if the operation cha…

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study investigates how gastric bypass or sleeve gastrectomy changes the way the body processes ramipril, a drug used to treat high blood pressure. Researchers will measure ramipril levels in the blood of 12 patients before and after surgery. The goal is to understand whether…

This study looks at how gastric bypass or sleeve gastrectomy affects the way the body handles hydrochlorothiazide, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people before and after surgery. The goal is to understand whether weight…

This study investigates how gastric bypass or sleeve gastrectomy alters the absorption of irbesartan, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with morbid obesity before and after surgery. The goal is to understand whether…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — change the way the body processes the antidepressant fluoxetine (Prozac). Researchers will measure drug levels in the blood of 12 participants before and after surgery. The goal is …

This study looks at how gastric bypass and sleeve gastrectomy — two types of weight-loss surgery — change the way the body absorbs enalapril, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after su…

This study investigates how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—change the way the body absorbs the blood thinner apixaban. Researchers will measure apixaban levels in the blood of 12 participants before and after surgery. The goal is to underst…

This study looks at how gastric bypass or sleeve gastrectomy changes the way the body processes the antipsychotic medication chlorprothixene. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after surgery. The goal is to understand whe…

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—affect the absorption of gabapentin, a drug used for nerve pain and seizures. Researchers measure gabapentin levels in the blood of 12 participants before and after surgery. The goa…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — affect the way the body absorbs the medication quetiapine. Quetiapine is a prescription drug used for mental health conditions. Researchers will measure quetiapine levels in the blo…

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—alter the way the body processes ibuprofen. Researchers will measure ibuprofen levels in the blood of 12 participants before and after surgery. The goal is to understand whether the…

This study investigates how bariatric surgery (gastric bypass or sleeve gastrectomy) changes the way the body absorbs candesartan, a drug used to treat high blood pressure. Researchers will measure candesartan levels in the blood of 12 people with severe obesity before and after …

This study looks at how bariatric surgery (gastric bypass or sleeve gastrectomy) affects the levels of the blood pressure drug lercanidipine in the blood. Researchers will measure drug concentrations before and after surgery in 12 people with severe obesity. The goal is to unders…

This study follows 750 severely or morbidly obese patients who have undergone bariatric surgery at a single hospital in France. Researchers aim to track long-term weight loss and improvements in related health issues such as diabetes and high blood pressure. By observing real-wor…

This study will enroll 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give a clearer picture of health changes than just measuring weight or waist size. Participants will be followed fo…

This study follows 40 women with severe obesity who are scheduled for weight loss surgery. Researchers will measure changes in sexual function, sex hormone levels, mood, and quality of life before surgery and 6 months after. Partners will also report on their own sexual health. T…

This study follows 1,000 people who had bariatric surgery 5 years ago to learn why some maintain significant weight loss while others do not. Researchers will track weight, type of surgery, and other factors to improve patient counseling and tailor surgical choices. The goal is t…

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study looks at 50 adults having either sleeve gastrectomy or gastric bypass to see if routine stool tests can reveal differences in gut function after surgery. Participants provide stool and blood samples before and 6 months after their operation. Researchers will check for …

This study looks at whether the amount of lean (fat-free) body mass before surgery can predict how much weight people lose in the two years after Roux-en-Y gastric bypass. Researchers will follow 91 adults with severe obesity who are scheduled for the procedure, measuring body co…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This trial tests two types of opioid-free anesthesia in 70 people having weight-loss surgery. One method uses a gas called desflurane, the other uses intravenous drugs. Researchers will measure stress hormones in the blood to see which approach causes less stress on the body. The…

This study tests whether dosing the anesthetic propofol based on adjusted body weight is better than total body weight for obese patients. Using a computer-controlled system, researchers will monitor brain activity to maintain the right depth of anesthesia. The goal is to avoid o…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures and track changes in body fat and appetite. The goa…

This study from the Mayo Clinic looks at how major, lasting weight loss from bariatric surgery changes the way insulin controls fat breakdown. Researchers will measure inflammation and fat cell activity in 30 people with severe obesity before and after surgery. The goal is to bet…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at how severe obesity and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery and some healthy-weight controls—to see if hair chemistry can signal poor metabolic hea…

This study from Mayo Clinic looks at how inflammation in fat tissue may affect the liver in people with severe obesity. Researchers will measure liver stiffness and fat tissue markers in 60 adults before they have weight-loss surgery. The goal is to better understand why some peo…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This study will test if weight-loss surgery can improve thinking skills like memory and attention. Researchers will use a virtual reality game and standard tests to measure brain function in 42 adults with severe obesity before and after surgery. The goal is to see if losing weig…

This study follows 300 people who are having weight-loss (metabolic) surgery to see how their gut bacteria change over time and how those changes relate to heart health, diabetes, and cholesterol. Participants provide blood and stool samples before surgery and at several follow-u…

This study looks at children with ROHHAD syndrome, a rare condition that causes rapid weight gain and breathing problems. Researchers will take blood samples to create special cells in the lab and study their genetic activity. The goal is to understand what goes wrong in the body…