Could a diet and drug combo replace the knife for severe obesity?

NCT ID NCT06309238

Recruiting now Disease control Sponsor: Carsten Dirksen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two approaches for adults with severe obesity: an intensive non-surgical program (meal replacements, behavior support, and weight-loss medication) versus bariatric surgery. Researchers will track 500 participants to see which method better improves health and quality of life. The goal is to offer more effective, non-surgical options for people who currently only have surgery as a treatment.

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Department of Surgery, Viborg Regional Hospital
RECRUITING

Viborg, 8800, Denmark
Hartlands Hospital, University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, B9 5SS, United Kingdom
Musgrove Park Hospital, Somerset Foundation NHS Trust
RECRUITING

Taunton, TA1 5DA, United Kingdom
Southmead Hospital, North Bristol NHS Trust
RECRUITING

Bristol, BS10 5NB, United Kingdom
St Richard's Hospital
RECRUITING

Chichester, Sussex, PO19 6SE, United Kingdom
Steno Diabetes Center Aarhus, Aarhus Universitets Hospital
RECRUITING

Aarhus, 8200, Denmark
Sunderland Royal Hospital
RECRUITING

Sunderland, SR4 7TP, United Kingdom
The Department of Medicine and Department of Surgery, University Hospital of South West Jutland
RECRUITING

Esbjerg, 6700, Denmark
The Department of Medicine and the Gastro Unit, Copenhagen University Hospital - Amager and Hvidovre
RECRUITING

Hvidovre, 2650, Denmark
The Whittington Hospital
RECRUITING

London, N19 5NF, United Kingdom

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