Can stomach surgery alter how painkillers work?

NCT ID NCT03538457

Recruiting now Knowledge-focused Sponsor: Norwegian University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study asks whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs paracetamol, a common painkiller. Researchers will measure paracetamol levels in the blood of 12 people before and after surgery. The goal is to understand if these procedures affect drug availability, which could guide safer medication use in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paracetamol (acetaminophen)
What this could lead to: If it works, this could help doctors adjust painkiller doses for people who have had weight-loss surgery, ensuring safer and more effective treatment.
What could go wrong: This is a very small study with only 12 participants, so results may not apply to everyone. It only looks at one drug, and findings may not change clinical practice without larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

Locations

St. Olavs University Hospital
RECRUITING

Trondheim, Norway

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