Morbid obesity

This study tests whether the drug lisdexamfetamine (Vyvanse), usually used for ADHD, can help children aged 6 to 12 with severe obesity lose weight. About 44 children will receive either the drug or a placebo, plus lifestyle therapy, for 24 weeks. The main goal is to see if their…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested a new, non-surgical weight loss technique called Gastric Mucosal Ablation (GMA) in 13 people with class III obesity. The procedure uses a device to carefully burn the stomach lining, aiming to mimic the hormonal effects of weight-loss surgery. The main goal was …

This study looked at whether a supervised exercise program, started 3 months after bariatric surgery, helps improve body composition, muscle strength, and insulin resistance. 61 adults with severe obesity took part. Participants were randomly assigned to either an exercise group …

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study compared two weight loss surgeries for people with severe obesity: SASI and SAPI. Researchers looked at costs, weight loss, and safety in 68 adults aged 18-65. The goal was to see which surgery is more affordable and effective for long-term weight control.

This study tested whether a combination of two weight-loss drugs, phentermine and topiramate, could help 100 teens with severe obesity keep weight off after losing it through a meal replacement program. The goal was to see if the medication could counteract the body's natural ten…

This study tested a new surgical technique called FundoRing, where the surgeon wraps the unused part of the stomach around the new stomach pouch during gastric bypass. The goal is to improve weight loss and reduce bile reflux compared to the standard bypass. One thousand adults w…

This study tested whether adding a crural repair and gastropexy to standard sleeve gastrectomy reduces acid reflux in people with severe obesity. Fifty patients were randomly assigned to either the standard surgery or the enhanced version. After one year, the group with the extra…

This study tested a device that uses self-forming magnets to create new connections in the gut. It was done in 28 adults with severe obesity who had already had weight-loss surgery but did not lose enough weight. The goal was to see if the device is safe and works as intended. Th…

This study tested a 100-day weight management program in 140 overweight adults. The program included meal replacements, protein and fiber supplements, probiotics, diet plans, exercise, and counseling. Researchers measured weight loss and health changes to see if the program is sa…

This study looked at whether giving a single dose of gabapentin before laparoscopic sleeve gastrectomy (weight-loss surgery) helps protect kidney function in people with severe obesity. 90 patients with normal kidney function were enrolled. Researchers measured kidney markers lik…

This study compared two types of weight loss surgery in 80 adults with severe obesity. The goal was to see which surgery leads to better weight loss, improves health problems like diabetes and high blood pressure, and has fewer complications. Participants were followed after surg…

This early study tested a new medicine, NNC0519-0130, in 161 people to see if it is safe and how it works in the body. The medicine aims to lower blood sugar and reduce appetite, which could help people with type 2 diabetes and overweight. Participants received either the medicin…

This study compared two types of weight-loss surgery in 256 adults with severe obesity. The goal was to see if a newer, simpler surgery (Omega Loop bypass) works as well as the standard Roux-en-Y gastric bypass, with fewer side effects. Participants were followed for two years to…

This study tested whether topiramate, a drug usually used for seizures, can help severely obese children and teenagers lose weight. 18 participants aged 9 to 17 took either topiramate or a placebo for 9 months. The main goal was to see if the drug could lower their Body Mass Inde…

This study looked at whether adding dapagliflozin to metformin helps people with prediabetes or type 2 diabetes and severe obesity lose more weight than metformin alone. About 160 participants took either both drugs or just metformin for up to 12 months. The main goal was to see …

This study compares a newer weight-loss surgery called SADI-S to an older, more complex one called BPD-DS in 62 adults with severe obesity. The goal is to see if SADI-S is safer and just as effective for long-term weight loss and managing related health problems like diabetes. Re…

This study looked at whether having a partner or support figure attend clinic visits before and after bariatric surgery helps patients lose more weight and make healthier choices. 63 adults seeking weight-loss surgery were randomly assigned to bring a support person or not. Resea…

This study tested whether giving tranexamic acid (TXA) during weight-loss surgery reduces bleeding. 132 adults having sleeve gastrectomy received either TXA or a placebo right after anesthesia. The results showed that TXA lowered blood loss during and after surgery, without incre…

This study tested whether sleeve gastrectomy, a type of weight-loss surgery, improves walking ability in people with severe obesity. About 99 participants completed a 6-minute walk test before and 6 months after surgery. Researchers also measured quality of life and overall healt…

This study compared two types of weight-loss surgery: the newer SADI-S and the standard RYGB. Researchers wanted to see which one leads to more weight loss after two years. The trial involved 382 adults with severe obesity and measured safety and nutritional effects as well.

This study looks at whether giving a nerve block (TAP block) early during laparoscopic sleeve gastrectomy reduces pain more than giving it later. About 200 adults having this weight-loss surgery will receive the same numbing medicine, but at different times. Researchers will comp…

This study compares two types of stitches used during robotic gastric bypass surgery for weight loss. About 150 adults with severe obesity will be randomly assigned to receive either a special barbed suture or a standard one. The main goal is to see which stitch is faster to use …

This study tested a new video laryngeal mask airway (SaCoVLM™) in 57 morbidly obese patients undergoing bariatric surgery. The device helped doctors place a breathing tube on the first try in most cases. The goal was to see if it is safe and effective for this group of patients.…

This study aimed to find the right dose of a spinal anesthesia drug (bupivacaine) for women with a BMI over 50 undergoing a planned C-section. Researchers tested different doses in 45 women to see which dose worked best without needing extra pain relief. The goal is to improve sa…

This study looked at whether adding TECAR therapy or shock wave therapy to standard treatment (complex decongestive therapy) could better reduce leg swelling in severely obese women with lymphedema. Forty-five women took part, receiving one of three treatments over four weeks. Re…

This study tested whether a short educational video watched before bariatric surgery could lower patients' fear and improve their recovery. Fifty-one adults having weight-loss surgery were randomly assigned to either watch the video or receive standard care. Researchers measured …

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested whether adding a drug called dexmedetomidine to a standard numbing medicine (bupivacaine) could improve pain control after weight loss surgery in severely obese patients. 78 adults having laparoscopic bariatric surgery received an ultrasound-guided nerve block w…

This study tested whether a mobile app (Care4Today®) helps people with severe obesity lose weight before gastric bypass surgery. 142 adults used either the app or standard care. The goal was to see if the app leads to more weight loss and better patient knowledge and satisfaction…

This study tested whether using ultrasound to guide the needle for spinal anesthesia works better than the traditional method of feeling for landmarks in super obese women (BMI 50 or higher) having a planned C-section. Sixty women participated, and the main goal was to see if the…

This study tested whether avoiding opioids during weight-loss surgery leads to less pain and fewer side effects like nausea. Sixty adults having laparoscopic bariatric surgery were randomly assigned to receive either opioid-free anesthesia (using other drugs) or standard opioid-b…

This study tested whether giving lidocaine through a vein during weight-loss surgery helps patients recover faster and need less strong pain medicine. 180 adults scheduled for bariatric surgery received either lidocaine or a placebo (salt water). Researchers measured how much pai…

This study compared two ultrasound-guided nerve block techniques—erector spinae plane block and modified thoracoabdominal nerve block—for pain control in 40 obese patients undergoing laparoscopic sleeve gastrectomy. The goal was to see which method delays the need for rescue pain…

This study tested whether a specific nerve block, called a rectointercostal fascial plane block, could reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy. Fifty-six adults undergoing weight-loss surgery were randomly assigned to receive either t…

This study looked at whether a specific nerve block (external oblique intercostal block) can reduce pain after laparoscopic sleeve gastrectomy, a weight-loss surgery. Twenty patients aged 18-65 participated. Researchers measured how much the block numbed the belly area and how mu…

This study tested whether giving a medicated mist (dexmedetomidine) before surgery could prevent dangerous spikes in heart rate and blood pressure when placing a breathing tube in 90 obese patients undergoing laparoscopic bariatric surgery. The approach aims to make the procedure…

This study tested whether using virtual reality glasses for discharge education helps patients better care for themselves after bariatric surgery. Sixty adults who had laparoscopic weight-loss surgery were split into two groups: one received standard care, the other watched a 15-…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This completed trial tested whether a nerve block called erector spinae plane block (ESPB) can reduce pain and opioid use in super obese patients (BMI over 50) after laparoscopic bariatric surgery. Sixty participants received either the ESPB or standard local anesthetic at the in…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 participated. The goal was to understand why some people are more resistant to gai…

This study used ultrasound to measure the optic nerve sheath (the lining around the eye nerve) in 56 adults having laparoscopic bariatric surgery. The goal was to see how brain pressure changes during surgery due to gas inflation and body positioning. No drug or treatment was tes…

This study looked at 40 adults who had sleeve gastrectomy surgery for obesity. Researchers measured blood levels of fractalkine, a protein involved in inflammation, before and three months after surgery. The goal was to see how fractalkine levels change and whether those changes …

This study looks at whether gastric bypass surgery can protect the kidneys of people who are severely obese and have chronic kidney disease. Researchers measured kidney function before and one year after surgery in 14 patients. The goal is to see if the surgery improves the balan…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study looked at whether placing patients in a specific position (head up, feet down) before starting laparoscopic weight-loss surgery could reduce pressure on the brain. Researchers measured the optic nerve sheath diameter, an indicator of brain pressure, in 90 patients. The…

This completed study followed 687 people who had bariatric surgery (gastric bypass or sleeve gastrectomy) in Norwegian public hospitals between 2010 and 2015. Researchers aimed to see how long weight loss lasts and whether related health problems like diabetes, high blood pressur…

This study tested a technique to help doctors insert a breathing tube in very obese patients having weight-loss surgery. The method uses a laryngeal mask airway as a temporary helper to keep oxygen flowing while the doctor prepares for the main tube. Thirty-six patients took part…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This study looked at 78 people with severe obesity who had sleeve gastrectomy surgery. Researchers wanted to see if the balance of two hormones, adiponectin and leptin, in the blood could predict how much weight they would lose. The goal is to help doctors decide who will benefit…

This study looked at 80 people with severe obesity who had sleeve gastrectomy surgery. Researchers measured a blood protein called resistin before surgery to see if it could predict how much harmful internal belly fat patients would lose. The goal is to find a simple blood test t…

This study looked at how physical activity relates to quality of life and mental health in 38 adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track sitting, standing, and movement. The goal was to see if simply monitoring activity coul…

This study looked at how the drug topiramate works in teenagers with severe obesity. Researchers wanted to understand why some teens lose weight while others don't, by measuring drug levels in the blood. The goal is to eventually personalize dosing for better results.

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This study looked at over 21,000 people in Switzerland who had gastric bypass surgery for severe obesity. It compared two ways of connecting the stomach to the small intestine: using a linear stapler or a circular stapler. The goal was to see which method leads to fewer complicat…

This study looked at whether using a face mask to help obese patients breathe during a short pause in anesthesia makes intubation safer. Over 700 patients with a BMI of 35 or higher took part. The goal was to see which method leads to fewer complications like low oxygen levels or…

This study looked at how stress influences eating and physical activity in African-American, Hispanic, and white teen girls aged 13-17. Researchers measured food intake after stress and non-stress sessions, along with BMI and activity levels. The goal was to understand why obesit…

This study followed 80 people with severe obesity who were scheduled for weight-loss surgery to see how well their heart medications were managed and taken. Researchers used blood tests and patient reports to check if blood pressure medicines were being taken as prescribed. The g…

This study tested a special stitch device (STRATAFIX Spiral PDS Plus) used in robot-assisted surgeries for weight loss (sleeve gastrectomy) and hysterectomy. 161 adults took part. The main goal was to see how well it controlled bleeding after stitching. Doctors also rated how eas…

This completed study looked at how tirzepatide, a weight-loss drug, works in real-world settings for two groups: people who regained weight after gastric sleeve surgery, and those preparing for obesity surgery. Researchers tracked weight and metabolic changes over 6 months in 254…

This study looked at how safe and effective the easyEndo™ powered stapler is when used in weight-loss surgery. Researchers checked if the stapler worked correctly during and after surgery in 60 patients. The goal was to see if the device is reliable for cutting and sealing tissue…

This study looked at 80 severely obese adults having laparoscopic sleeve gastrectomy (weight-loss surgery). Researchers measured heart electrical activity and blood pressure as patients were moved into different positions during the operation. The goal was to understand how posit…

This study looked at 36 adults with severe obesity who had laparoscopic sleeve gastrectomy, a type of weight-loss surgery. Researchers measured blood levels of a hormone called Phoenixin-14, which is thought to influence appetite, before and after the procedure. The goal was to s…

This study looked at 40 people with severe obesity who had laparoscopic sleeve gastrectomy, a type of weight-loss surgery. Researchers measured levels of a protein called isthmin in the blood before surgery and three months after. The goal was to see if isthmin, which is linked t…

This completed study looked at how the number of meals per day and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese adults. Researchers analyzed baseline data from 34 participants (11 non-obese, 23 morbidly obese) to compare th…

This study looked at how gastric bypass surgery changes the bacteria in the small intestine. Researchers measured hydrogen in the breath of 51 severely obese patients before surgery and at several points up to 2 years after. The goal was to find out how often bacterial overgrowth…

This study looked at nearly 20,000 people in Sweden who had sleeve gastrectomy surgery for severe obesity. Researchers analyzed registry data to see how much weight patients lost, how long they kept it off, and whether related health problems like diabetes improved or went away. …

This study looked at how the blood thinner rivaroxaban behaves in people with severe obesity or after bariatric surgery (gastric bypass or sleeve gastrectomy). Researchers gave 67 participants rivaroxaban daily for 8 days and measured drug levels and blood clotting. The goal is t…

This study measured amino acid levels in the blood of 50 people before and after bariatric surgery, comparing them to 50 healthy individuals. The goal was to see how surgery affects metabolism over three months. It is an observational study, not testing a new treatment.

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This completed study looked at how the body digests and uses food during weight loss from bariatric surgery. Researchers used advanced 'omics' techniques to track nutrients in 7 participants. The goal was to understand why weight loss varies between people and to generate ideas f…

This completed study observed 563 patients who had weight-loss (bariatric) surgery and received extra oxygen during their first night in the hospital. Researchers tracked how often oxygen levels fell below 90% and what actions nurses took, like adjusting the oxygen flow or reposi…

This study tracked 46 people with severe obesity who had gastric bypass or sleeve gastrectomy. Researchers used a special CT scan with gas to measure stomach volume at 3 and 12 months after surgery. The goal was to see if stomach enlargement is linked to weight regain, which coul…

This study followed 1100 adults with severe obesity who took WEGOVY (semaglutide) for 12 months. Researchers collected data on weight, eating habits, and blood markers to see how the drug worked in different groups. The goal is to use this information, along with artificial intel…