Newer Weight-Loss surgery may beat the gold standard

NCT ID NCT03610256

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compared two types of weight-loss surgery: the newer SADI-S and the standard RYGB. Researchers wanted to see which one leads to more weight loss after two years. The trial involved 382 adults with severe obesity and measured safety and nutritional effects as well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SADI-S (single-anastomosis duodeno-ileal bypass with sleeve gastrectomy) and RYGB (Roux-en-Y gastric bypass) surgical procedures

What this could lead to

If SADI-S proves superior, it could become a preferred surgical option for severe obesity, offering greater weight loss with fewer complications.

What could go wrong

This is a completed trial comparing two established surgeries, so results are reliable but may not apply to all patients. Both procedures carry risks like malnutrition and surgical complications.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

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Locations

Département de Chirurgie Digestive - CHU Grenoble

Grenoble, 38043, France
Département de Chirurgie Digestive - Institut Mutualiste Montsouris

Paris, 75014, France
Département de Chirurgie Digestive et Bariatrique, Clinique Mutualiste de l'Estuaire

Saint-Nazaire, 44600, France
Département de Chirurgie Digestive et Hépatobiliaire - Centre Hospitalier Privé Saint Grégoire

Saint-Grégoire, 35760, France
Département de Chirurgie Digestive et Hépatobiliaire - Hôpital Pitié Salpétrière

Paris, 75013, France
Département de Chirurgie Digestive et Thoracique, Hôpitaux Civils de Colmar

Colmar, 68024, France
Département de Chirurgie Digestive et Viscérale - Clinique de l'Anjou

Angers, 49000, France
Département de Chirurgie Digestive et Viscérale, Centre Hospitalier Jean Marcel

Brignoles, 83170, France
Département de Chirurgie Digestive, Centre Hospitalier René Dubos

Cergy-Pontoise, 95303, France
Service d'Endocrinologie, Diabète et Nutrition - Centre Hospitalier Lyon Sud - HCL

Pierre-Bénite, 69495, France
Service de Chirurgie Digestive - Centre Hospitalier Intercommunal de Créteil

Créteil, 94000, France
Service de Chirurgie Digestive - Hôpital Bichat

Paris, 75018, France
Service de Chirurgie Digestive et Bariatrique - Hôpital Edouard Herriot - HCL

Lyon, 69437, France
Service de Chirurgie Digestive et Endocrinienne - Groupe Hospitalier Pellegrin

Bordeaux, 33076, France
Service de Chirurgie Digestive et Endocrinienne - Hôtel Dieu

Nantes, 44000, France
Service de Chirurgie Digestive et Transplantation - Hôpital Archet II

Nice, 06202, France
Service de Chirurgie Digestive et Viscérale - Clinique La Parisière

Bourg-de-Péage, 26300, France
Service de Chirurgie Digestive, Générale et Cancérologique - HEGP

Paris, 75908, France
Service de Chirurgie Digestive, Hépatobiliaire et Endocrinienne - Hôpital Brabois adultes

Vandœuvre-lès-Nancy, 54511, France
Service de Chirurgie Digestive, Hôpital Rangueil

Toulouse, 31059, France
Service de Chirurgie Générale et Digestive - Hôpital Louis Mourier

Colombes, 92700, France
Service de Chirurgie Générale et Endocrinienne - Hôpital Huriez

Lille, 59037, France