Hospices Civils De Lyon

This study tests whether monitoring levels of a harmless virus called TTV can help doctors personalize immune-suppressing drugs for kidney transplant patients. The goal is to prevent long-term complications like infections, cancer, and organ rejection. About 600 adults who receiv…

This study is for women with advanced ovarian, fallopian tube, or peritoneal cancer whose tumors did not shrink enough with standard chemotherapy. Researchers are testing a new method called PIPAC, which delivers chemotherapy as a pressurized spray directly into the abdomen, comb…

This study tests whether a mechanical heart pump (LVAD) works better than standard medications for people with end-stage heart failure who are not yet bedridden. About 92 participants will either receive the pump or continue their current drug therapy. The goal is to see which ap…

This study tests whether starting a personalized home therapy program early (before age 2) can improve motor skills in babies at high risk for cerebral palsy. Researchers will compare children who receive this early program with those who get standard care. The goal is to see if …

This small study tests a device called MEX-CD1 that removes excess iron from the blood during a special type of dialysis. It is for people with myelodysplastic syndrome or myelofibrosis who have iron overload from blood transfusions but cannot take standard chelation therapy. Eac…

This study tests whether a special diet that promotes a diverse gut microbiome can help people lose more weight and keep it off after bariatric surgery. Sixty adults aged 25-65 who are scheduled for weight-loss surgery will be randomly assigned to receive either standard nutritio…

This pilot study will test laryngeal transplantation in 3 adults who have permanently lost the ability to speak, breathe, or swallow normally due to severe larynx damage. The goal is to restore these functions using a donor larynx, with a new nerve reconnection technique to impro…

This phase 2 trial tests whether spironolactone, a potassium-sparing diuretic, can slow the deterioration of the right ventricle and reduce arrhythmias in people with arrhythmogenic right ventricular dysplasia (ARVD). About 120 participants will receive either spironolactone or a…

This study is for people with a specific type of slow-growing brain tumor (oligodendroglioma) that needs treatment beyond surgery. The goal is to see if waiting to start radiation until the tumor grows back can help protect memory and thinking skills, without shortening how long …

This study compares two approaches to removing excess fluid in intensive care patients with acute kidney injury who are on dialysis. One group will have fluid removed at a moderate rate to actively reduce fluid buildup, while the other group will have fluid removed slowly to just…

This study is for men with a type of advanced prostate cancer that has stopped responding to hormone therapy. It tests whether giving a second course of a radioactive drug called Lu-PSMA can control the cancer again. Participants will receive the drug every six weeks until their …

This study tests a new approach where nurses, rather than doctors, adjust methadone doses for people starting treatment for opioid addiction. The goal is to see if this makes it easier for patients to stay in care for at least three months. The trial will enroll 182 adults in Fre…

This study tests a new treatment for people who have lost vision in both eyes due to severe burns or rare eye diseases. Doctors take a small sample of cells from the inside of the patient's cheek, grow them into a thin sheet in the lab, and then transplant that sheet onto the dam…

This study tests a program called PROADAPT for women aged 70 and older with advanced ovarian cancer who need surgery. The program includes exercise, nutrition advice, education, and medication management before and after surgery. The goal is to see if it reduces serious complicat…

This study tests whether a drug called interferon gamma can help intensive care patients recover more quickly from pneumonia they got while on a breathing machine. The drug aims to boost the immune system, which is often weakened after severe illness or injury. About 132 adults w…

This study tests whether extra support from a pharmacist—starting in the hospital and continuing after discharge—can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Two hundred participants will either receive this pharmaceutical …

This study looks at whether continuing a low dose of prednisone (5 mg/day) for an extra 12 months can help people with a type of blood vessel inflammation called ANCA-associated vasculitis stay in remission. About 146 adults who are already in remission and receiving rituximab wi…

This study tests if hydroxychloroquine, a drug used for malaria and autoimmune diseases, can help people with sarcoidosis reduce or stop taking steroids. Sarcoidosis causes inflammation, often in the lungs, but this trial focuses on cases affecting the skin, eyes, or bones. 140 a…

This study aims to see if a French version of the OSA-18 questionnaire can accurately identify obstructive sleep apnea in children. Parents of children aged 4 to 17 who are already scheduled for a sleep test (polysomnography) will fill out the questionnaire. The results will be c…

This study tests a new method called IDBIORIV that can identify the germ causing a bloodstream infection and determine which antibiotics will work in just 90 minutes, compared to the usual 24-48 hours. Sepsis is a life-threatening condition that affects millions worldwide, and fa…

This study is testing whether measuring a natural immune marker called IFN-I in nasal swabs can help detect respiratory viral infections in older adults. Current PCR tests only look for a few viruses and can miss others or show old infections. The goal is to improve diagnosis, es…

This study is testing whether a non-invasive brain imaging technique called fNIRS can reliably measure brain function in people with Fragile X syndrome or Creatine Transporter Deficiency. Researchers will use a cartoon-based visual stimulus to record brain activity and compare it…

This study is testing whether a special PET scan using [18F]FET can better locate small pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in up to 30% of cases. Researchers will compare PET results with MRI and surgical findings in 20 adults to see i…

This study is testing whether a combined autoantibody test on a drop of blood from a finger prick (dried on special paper) can detect type 1 diabetes as accurately as the standard blood draw from a vein. The researchers will enroll 106 children newly diagnosed with type 1 diabete…

This study tests Cellvizio, a device that provides real-time, high-resolution views of tissues during gynecological surgery. Researchers want to see if it can help diagnose lesions and check surgical margins more accurately. The study will enroll 80 women undergoing laparoscopic …

This study is testing whether a set of blood markers can accurately rule out late-onset sepsis in newborns in intensive care. Researchers will enroll 358 babies with signs of infection and compare the markers against a panel of experts. If the markers work well, doctors could avo…

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This study tests whether a special scoring tool (the Lyon-VTE score) can better prevent dangerous blood clots in pregnant women at high risk compared to standard care. About 600 pregnant women with a personal history of blood clots or a clotting disorder will be randomly assigned…

This trial tests whether a mobile van with a CT scanner can help more people get screened for lung cancer, especially those who are socially disadvantaged. Over 4,300 heavy smokers aged 50-74 will be randomly assigned to either the mobile unit or a hospital. The goal is to see if…

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests if starting a personalized exercise program early can prevent or reduce joint and muscle pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 182 postmenopausal women with hormone-sensitive breast cancer will either receive the e…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to…

This study tests whether baclofen, a muscle relaxant, can help people dependent on benzodiazepines (like Valium or Xanax) safely reduce their dose. About 93 adults with moderate to severe dependence will receive either baclofen or a placebo for several weeks. The goal is to see i…

This study tests whether a non-invasive brain stimulation technique that matches a patient's own brain wave frequency can better relieve drug-resistant neuropathic pain. About 50 adults with long-term nerve pain that hasn't responded to standard treatments will receive three type…

This study is testing a new tool called BougieCap to treat short, non-cancerous narrowing of the esophagus. The device is a clear cap that fits on the end of a scope, allowing doctors to see and gently stretch the narrowed area. Researchers want to see if it helps people swallow …

This study follows 444 women who had Essure contraceptive implants removed due to symptoms like pain or other health issues. Researchers want to see how much symptoms improve after removal and understand why some women had problems. The goal is to help doctors choose the best rem…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke survivors improve motor function. 51 participants who had a stroke more than 30 days ago will use the device for 300 minutes of weekly therapy, guided remotely by a t…

This study tests a virtual reality training program (KidTrain) designed to help children aged 7-17 with bilateral cochlear implants improve their ability to locate sounds and understand speech in noisy environments. The training uses immersive VR with varying background noise and…

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover strength and mobility after a hip fracture. The vibration is applied to the leg muscles for 30 minutes, five times a week, for four weeks. The main goal is…

This study tests whether early, intensive respiratory physiotherapy can improve cough strength in ICU patients with muscle weakness who are struggling to come off a ventilator. Fifty adults on breathing machines will receive either three daily sessions of specialized breathing ex…

This study tests a simple, drug-free technique called cutaneous resonance stimulation (RESC) to reduce anxiety in 62 people waiting for heart surgery. Researchers will measure how it affects the body's stress system and compare it to a fake version. The goal is to find a safe, no…

This study is testing whether hypnosis can reduce anxiety in adults recently diagnosed with certain blood cancers (lymphoma). Fifty participants will have their anxiety levels measured before starting hypnosis sessions and again after two and three sessions. The goal is to see if…

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study looks at how gut bacteria produce certain chemicals that might worsen fatty liver disease (MASLD). Researchers will collect stool, blood, and urine samples from 24 people with the condition and healthy volunteers. They aim to identify which bacteria are responsible for…

This study looks at how different mutations in the MORC2 gene lead to different symptoms, from Charcot-Marie-Tooth disease to a more complex condition called DIFGAN. Researchers will collect skin and blood samples from 45 participants to measure epigenetic and genetic markers. Th…

This study is looking at special markers in the blood (called biomarkers) to learn more about how to detect, diagnose, and track solid cancers. Researchers will collect blood samples from 6,000 adults with solid cancer and analyze them alongside standard tests. The goal is to see…

This study looks at why some people had severe COVID-19 while others had mild symptoms. Researchers will compare the immune system's early response (called interferon) in 134 adults who were sick during the first wave. They also want to see if gut bacteria play a role. The goal i…

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This study is testing a new, more comfortable brain scanner that uses special sensors to measure brain activity. Researchers will compare this new device to a standard scanner in 80 healthy volunteers and athletes who have had a mild concussion. The goal is to see if the new scan…

This study looks at how eating affects sleepiness and nighttime sleep in people with type 1 narcolepsy, idiopathic hypersomnia, and healthy volunteers. Over 4 days, participants will log their meals, wear a glucose monitor, and track sleep with a headband and watch. The goal is t…

This study is looking at 50 children and adults with rare autoinflammatory diseases—conditions where the immune system causes inflammation without a clear reason. Researchers want to find what leads to a faster diagnosis, what factors are linked to these diseases, and which treat…

This study looks at people with creatine transporter deficiency, a rare genetic condition that causes intellectual disability, seizures, and movement problems. Researchers want to find the best tests to measure symptoms, since many standard tests are too hard for these patients. …

This study is collecting blood samples and quality-of-life questionnaires from 125 people with aortic stenosis, a heart valve condition. Researchers want to find biological markers (biomarkers) that could signal inflammation or scarring in the heart before symptoms appear. The go…

This study looks at how gut microbes and environmental factors affect polyp development in people with familial adenomatous polyposis (FAP), a genetic condition that causes many colon polyps and often leads to cancer. Researchers will collect stool, blood, and duodenal fluid samp…

This study looks at how epileptic brain activity during sleep can cause awakenings and change dream recall or content. Researchers will use tiny electrical pulses in the brain during sleep to trigger mild epileptic activity and observe the effects. The goal is to better understan…

This study is creating a large collection of blood samples and health data from 3500 people with hepatitis B, including those who have already cleared the virus. Researchers will use these samples to look for viral RNA patterns that could signal a functional cure. No new treatmen…

This study tests a new, non-invasive method using calcium isotope ratios in blood to see if the drug cinacalcet improves bone calcium balance in children aged 3-17 who are on dialysis and have secondary hyperparathyroidism. Researchers will measure these ratios before and three m…

This study tests whether a special imaging technique called electrical impedance tomography (EIT) can safely measure blood flow and air distribution in the lungs of children with acute respiratory failure. Twenty children under 12 who are on breathing machines will receive a smal…

This study examines the clinical and socioeconomic factors linked to suicidal behavior in children and adolescents during the COVID-19 pandemic in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from 6,500 participants aged 8 to 17, including medical reco…

This study is following 300 people who have had a severe type of heart attack (STEMI). Researchers will collect blood, urine, and stool samples, and perform MRI scans to look for new biological and imaging markers that could help predict long-term outcomes. The goal is to better …

This study looks at how children with epilepsy learn things without trying, like picking up new skills or habits automatically. Researchers will compare 40 children—some with epilepsy and some without—using a simple computer task. The goal is to see if this type of hidden learnin…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study looks at two methods to check blood flow in critically ill patients: the traditional capillary refill time (pressing on skin and timing color return) and the perfusion index (a continuous reading from a finger clip). Researchers want to see if the perfusion index can r…

This study looks at how the autonomic nervous system (which controls automatic body functions) might be involved in liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goa…

This study looks at why the hepatitis B virus (HBV) stays in the liver for so long, even with treatment. Researchers will use a gentle needle technique to take small liver samples from 100 adults with chronic HBV. They want to see how the virus and the immune system interact insi…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study aims to find out how often a blood pressure difference between the arm and leg occurs in patients with shock. Researchers will measure blood pressure non-invasively in 180 adults receiving strong vasopressors. The goal is to understand this gap better, so doctors can a…

This study looks at how having one leg shorter than the other affects the hips and lower back in children aged 10 to 15. Researchers will use special X-rays and force measurements to calculate joint loads. The goal is to better understand the problem and help doctors decide on ea…

This study tests whether virtual reality or mental imagery can replace the standard prism adaptation therapy used for people with unilateral neglect after a brain injury. Researchers will compare these new methods to the traditional approach in 480 healthy volunteers. The goal is…

This study looks at bone cells from children having surgery for craniosynostosis (early skull bone fusion). Researchers want to see how burosumab and vitamin D directly affect these cells, especially in children with a rare bone disease called hypophosphatemic rickets. The goal i…

This study is measuring natural immune markers called interferons in healthy adults aged 80 and older. The goal is to establish normal reference values, which could help doctors better distinguish between active viral infections and past ones. Researchers will collect nasal swabs…

This study tests a new computer tool designed to help doctors and patients decide together which health screenings are right for each person. The tool asks patients health questions and then helps the doctor guide a conversation about screenings like cancer checks. The goal is to…

This study is testing several advanced imaging techniques to see if they can better predict which people with narrowed carotid arteries are at risk of a stroke. Researchers will compare 45 people who have already had a stroke with 105 who have not, using ultrasound and MRI to exa…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will measure sucking bursts and compare them to sleep study results. The goal is to find a simple way to scree…

This study compares robot-assisted bariatric surgery to standard laparoscopic surgery for obesity. About 482 adults aged 18-70 who qualify for weight-loss surgery will be randomly assigned to one of the two methods. The goal is to see if the robot's higher upfront cost is offset …

This study looks at whether a blood marker called mHLA-DR can help doctors predict severe complications after pancreatic surgery. About 100 people having this surgery will be followed. The goal is to find an early warning sign for problems like infection or pancreatic leaks.

This study is testing a program where trained volunteer mothers provide breastfeeding support to new mothers who are facing severe poverty, housing problems, or other major challenges. The goal is to see if this kind of peer support is acceptable and practical for these families.…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This study looks at how breathing and waking up from sleep are linked in people with drug-resistant epilepsy. About 60 adults with epilepsy and healthy volunteers will have their breathing tested during deep sleep. The goal is to understand why some people with epilepsy are at ri…

This study checks tongue strength in 78 children with suspected obstructive sleep apnea. Researchers use a device to measure tongue pressure during pushing and swallowing. They compare results to healthy kids to see if weak tongue muscles are linked to sleep problems.

This study looks at how blind people use a white cane to sense the world around them, not just to move. Researchers will test how well users can feel where a touch happens on the cane and measure brain activity during these tasks. The goal is to understand how the cane becomes an…

This study aims to create a reliable lab test to monitor how well anti-TFPI antibodies work in people with severe hemophilia. Researchers will take a single blood sample from 11 patients already on anti-TFPI therapy and test it in the lab. The goal is to better predict and manage…

This study investigates how brain activity changes when people imagine moving their wrist. Researchers will use advanced brain scans (MRI and MEG) to create personalized models of these signals, then test if they can decode imagined movements using simpler EEG recordings. The goa…

This study tests whether giving parents a short video and brochure about endocrine disruptors (chemicals in everyday products) can lower the levels of these chemicals in their babies' urine. About 90 newborns and their parents will be split into two groups: one gets the training,…

This study follows 132 adults having glaucoma surgery to see how their quality of life changes over six months. Patients fill out a questionnaire about vision-related daily activities before and after surgery. The goal is to compare different surgical techniques from the patient'…

This study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes to learn a new physical skill, it might also boost nearby brain areas used for language. The study will …

This study looks at whether people with CAPS (a rare genetic inflammatory condition) have disrupted circadian rhythms—the body's natural day-night cycle. Researchers will measure melatonin levels and track activity with a watch in 30 participants (patients and healthy household m…

This study is following 500 adults who had an ischemic stroke (a clot blocking blood flow in the brain). Researchers are collecting blood samples, brain scans, and health data to find new markers that can predict how well someone will recover and whether they will develop heart p…

This study follows 50 women aged 70 and older with advanced ovarian cancer who are starting PARP inhibitors for the first time. Researchers will track how much of the planned dose patients actually receive, and look at factors like age, genetics, and overall health that might aff…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) behaves in children aged 2 to 17. Researchers will measure drug levels in the blood and see how they relate to the drug's benefits and side effects, such as liver problems or mood …

This study looks at the long-term social and emotional challenges faced by people who have had NMDA receptor encephalitis, a rare brain inflammation. Researchers will ask 30 adults to complete questionnaires about fatigue, anxiety, depression, sleep, and quality of life. The goal…

This study looks at small molecules (metabolites) in the blood and urine of people with pulmonary hypertension caused by lung fibrosis. Researchers want to see how these metabolites change with treatment and whether they can tell who will respond well. The goal is to better under…

This study looks at how the help provided by family caregivers changes as Alzheimer's disease gets worse. Researchers will track 312 people with Alzheimer's and their caregivers to measure the time and cost of informal care. The goal is to understand what factors—like memory loss…

This study is creating a faster quality-of-life tool for people with short bowel syndrome, who often need long-term nutrition support. Researchers will compare a new simple 'disk' questionnaire to a longer existing one in 100 adults. The goal is to make regular check-ins easier f…

This study looks at new blood tests that might help doctors know if any cancer is left after surgery for colorectal cancer that has spread to the lining of the abdomen. Researchers will track certain substances in the blood before and after surgery in 58 adults. The goal is to un…

This study looks at bacteria found in the liver, blood, and stool of 50 people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this se…

This study looks at whether having a pharmacist review all medications (including those from other doctors) can improve safety for cancer patients receiving targeted radionuclide therapy. The study will include 600 adults with thyroid cancer, metastatic prostate cancer, or neuroe…

This study tests whether training general practitioners (GPs) in 'healthy conversation skills' can help patients improve their diet, physical activity, and reduce sedentary time. About 882 adults in France whose GPs receive the training will be compared to those whose GPs do not.…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study follows 60 children with spinal muscular atrophy (SMA) who are already receiving SMN-restoring therapies like nusinersen or gene therapy. Over two years, researchers will track their muscle function, fatigue, breathing, and thinking skills to describe new disease patte…

This study aims to create a complex lab-grown model of endometrial tissue using biopsies from women with and without endometriosis. Researchers will test how different hormone treatments affect the tissue, with the goal of predicting individual responses. The study involves 90 wo…

This study looks at how healthy people's brains predict the timing of sounds, especially in speech. Researchers will use EEG and MEG to record brain activity while participants listen to various sounds and press buttons. The goal is to understand how we process natural rhythms in…

This study is testing whether simple blood tests and a liver scan can accurately track liver disease progression in 500 people with type 2 diabetes. Participants will be followed over time to see if these non-invasive tools can replace liver biopsies for detecting advanced scarri…

This study follows 70 adults with diffuse large B-cell lymphoma who are receiving CAR-T cell therapy outside of a clinical trial. Researchers will track patients' quality of life, medication use, and personal feedback over time using questionnaires. The goal is to understand the …

This study is for men who have had a penile prosthesis implanted for erectile dysfunction. It aims to understand how well they can manipulate the pump, including hand strength and sensation. Researchers will also look at how these abilities relate to erection rigidity and sexual …

This study uses a non-invasive imaging technique called electrical impedance tomography to watch how air moves through the lungs of children with acute respiratory failure in the pediatric ICU. Researchers will observe how changes in ventilator settings, body position, suctioning…

This study tests whether small wearable sensors can accurately track movement and walking patterns in 30 pregnant women during early labor, both with and without a low-dose epidural. The goal is to see if these sensors can help monitor pain relief effectiveness, predict fall risk…

This study looks at how a brain area called the posterior parietal cortex (PPC) helps us move and perceive the world. Researchers will compare people with optic ataxia, a condition caused by PPC damage, to healthy volunteers. Participants will perform simple tasks like pointing a…

This study looks at 150 adults with long-COVID to group them by their symptoms and link those groups to lab results. The goal is to find patterns that could help doctors predict outcomes and discover new treatments. Participants will have their health data and blood samples analy…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain networks be…

This study is gathering detailed information from 45 people with a rare nerve condition called IgM-anti-MAG peripheral neuropathy. The goal is to better understand the different types of the disease, how it changes over time, and how patients respond to treatments. Researchers wi…

This study uses a special MRI technique called diffusion tensor imaging to map cranial nerves before skull base tumor surgery. Researchers will compare the nerve positions seen on MRI with what surgeons actually find during the operation. The goal is to see if this imaging can he…

This study investigates whether higher lifetime exposure to estrogen—from sources like birth control, pregnancy, or hormone therapy—is linked to the development of larger prolactin-secreting pituitary tumors (macroprolactinomas) compared to smaller ones (microprolactinomas). Rese…

This study looks at whether a special brain imaging method called dynamic spectral imaging (ISD) can predict if someone will have memory or thinking problems after epilepsy surgery. Researchers will map brain activity during cognitive tasks in 50 adults with epilepsy who are alre…

This study looks at two methods for providing kidney dialysis to patients on ECMO (a heart-lung machine). One method uses a separate line for dialysis, while the other connects the dialysis machine directly into the ECMO circuit. The goal is to see if the direct connection works …

This study aims to collect and store biological samples (like tumor tissue and blood) from 500 adults with brain tumors. The samples will be used to build a research collection to help scientists better understand brain tumors. Participants do not receive any treatment as part of…

This study investigates how attention influences the brain's ability to inhibit or stop actions. Researchers will test 120 participants, including healthy volunteers and people with conditions like ADHD or stroke-related neglect, using computer-based tasks that measure eye and ha…

This study is an observatory that will track up to 3360 children in private healthcare who show signs of early or advanced puberty. Researchers will collect data like height, weight, and pubertal stage to better understand trends and possible causes, such as environmental factors…

This study looks at how children and adults with Developmental Coordination Disorder (DCD) sense touch and body position, and how they update their body image when using tools. Researchers will compare 280 participants with and without DCD to see if sensory deficits explain motor…

This study compares two advanced brain-mapping techniques—magnetoencephalography (MEG) and high-resolution EEG (EEG HR)—to see which better locates the seizure-causing area in people with drug-resistant epilepsy who are candidates for surgery. Researchers will enroll 100 particip…

This study looks at how tiny communication points inside liver cells (called MAMs) change in people with a fatty liver disease called MASH. Researchers will collect liver and blood samples from 20 adults having weight-loss surgery. The goal is to understand what goes wrong in the…

This study collects blood and optional spinal fluid samples from 350 people with Parkinson's, ALS, glioblastoma, certain cancers, or rheumatoid arthritis. The goal is to find new genetic markers that could lead to better diagnostic tests for autoimmune encephalitis and paraneopla…

This study looks at how copper levels in urine change throughout the day in people with Wilson disease, a genetic condition that causes copper buildup. Currently, patients must collect all urine over 24 hours to monitor treatment, which is inconvenient. Researchers want to see if…

This study looks at a special heart monitor called the Analgesia Nociception Index (ANI) in 30 intensive care patients receiving continuous kidney dialysis. The goal is to see if changes in ANI are linked to blood pressure changes during fluid removal. Researchers hope to better …

This registry follows 1,500 women with multiple sclerosis (MS) or related conditions through pregnancy and after childbirth. Researchers will track relapses, use of disease-modifying drugs, and outcomes for both mothers and children. The goal is to better understand how MS and it…

This study looks at how common exocrine pancreatic insufficiency (EPI) is in people with active Crohn's disease who are starting a biologic therapy. EPI means the pancreas doesn't make enough enzymes to digest food properly. Researchers will check for EPI at the start of treatmen…

This study looks at memory, thinking, and mood problems that can happen with certain targeted lung cancer drugs (ALK/ROS1 inhibitors). About 20 patients who have these side effects will undergo detailed brain and psychiatric tests. The goal is to better understand these issues an…

This study is not a treatment trial. It aims to collect blood samples from 400 children and their relatives who have rare autoimmune or autoinflammatory diseases (like lupus or juvenile arthritis). Researchers will analyze the samples to find genetic mutations that cause these co…

This study is creating a simple tool to measure food preferences in patients over 70 in geriatric wards. Researchers will show patients photos of foods to see which ones they recognize and like. The goal is to better understand how swallowing problems affect food choices and help…

This study follows 200 adults with COVID-19 in intensive care to see how their immune systems change over time. Researchers will collect blood samples at several points during the hospital stay and track health outcomes. The goal is to understand why some patients get worse and t…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to see which bacteria are present and how they change with standard treatment. The goal is to bet…

This study follows 216 adults with inflammatory bowel disease (IBD) who are in remission. They wear a wrist monitor and fill out sleep questionnaires for one year to see if changes in sleep quality can predict when a flare-up will happen. The goal is to find early warning signs o…

This study looks at how thick the blood is in 160 people with polycythemia (a condition with too many red blood cells). Researchers want to see if thicker blood causes more symptoms like headaches or dizziness, and how it differs between types of polycythemia. No new treatments a…

This study is building a large database of blood samples, tumor samples, and scans from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can help future studies. The goal is to better understand lung cancer and imp…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study looks at how much physical activity and sitting time adults with cystic fibrosis have, especially those on the latest triple-combination drug. Researchers will ask 270 participants about their activity and use activity monitors on a smaller group. The goal is to unders…

This study looks at how iron supplements, often given for anemia, affect the immune system in people with Hereditary Haemorrhagic Telangiectasia (HHT), a rare genetic disorder that causes frequent nosebleeds and abnormal blood vessels. About 155 adults with HHT will be divided in…

This study investigates whether certain autoantibodies that block the body's natural antiviral defenses lead to higher viral levels and slower recovery in severe respiratory infections like flu, RSV, and COVID-19. Researchers will measure viral load changes over a week in 360 ICU…

This study looks at the immune cells inside the liver of people with non-alcoholic fatty liver disease (NAFLD). The goal is to find differences between those with simple fatty liver and those with the more serious form, NASH, which can lead to cirrhosis and liver cancer. Research…

This study looks at whether a quick ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. Researchers will compare the ultrasound results with a standard whole-body scan (DEXA) in 55 adults aged 18-74 with certain cancers…

This study tracks 3,000 cancer patients taking oral anticancer drugs at home. Researchers want to see how well the drugs work in real life and what problems arise. The goal is to improve monitoring and coordination between hospitals and local doctors.