Hospices Civils De Lyon

This study looks at whether a mechanical heart pump (LVAD) or standard heart failure medicines is better for people with advanced heart failure who are not yet in the hospital. About 92 adults with end-stage heart failure will be randomly assigned to get either an LVAD or continu…

This study looks at whether giving a second course of a targeted radiation drug (Lu-PSMA) can help control advanced prostate cancer that has stopped responding to hormone therapy. About 58 men who previously benefited from this treatment will receive it again. The goal is to see …

This study looks at whether continuing low-dose prednisone (a steroid) for 10 months helps prevent relapses better than stopping it after 1 month in people with ANCA-associated vasculitis. All participants are already on rituximab to maintain remission. The goal is to find the sa…

This study tests a new device that filters excess iron from the blood in people with myelodysplastic syndrome (MDS) or myelofibrosis who cannot take standard iron-removing medications. Participants will undergo three short dialysis-like sessions over one week. The goal is to see …

This study tests whether spironolactone, a medication that helps the body get rid of extra fluid, can slow down heart muscle damage and reduce dangerous heart rhythms in people with arrhythmogenic right ventricular dysplasia (ARVD). ARVD is a rare condition where heart muscle is …

This study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in 154 people with five types of rare advanced cancers that have stopped responding to standard treatments. The goal is to see if this treatment can control the cancer for at least 24 weeks.…

This study tests whether nurses in addiction centers can manage the start of methadone treatment for people with opioid use disorder. The goal is to see if this approach helps more patients stay in care for at least 3 months. The study will involve 182 adults starting methadone f…

This study tests a special program called PROADAPT for women aged 70 and older (or 60+ with health issues) who have advanced ovarian cancer and need surgery. The program includes nutrition advice, physical exercises, and education before surgery, plus extra support during the hos…

This study is for people with a specific type of slow-growing brain tumor (1p/19q codeleted low-grade oligodendroglioma) who need treatment beyond surgery. The goal is to see if delaying radiation therapy until the tumor progresses can reduce the risk of memory and thinking probl…

This study tests whether removing excess fluid more quickly (2 mL/kg/h) in ICU patients with acute kidney injury on dialysis improves recovery and reduces the need for breathing machines, blood pressure drugs, and dialysis. About 250 adults will be randomly assigned to either a f…

This study tests a new treatment for people who are blind due to a rare condition where both eyes lack stem cells needed to keep the cornea clear. Doctors take a small sample of cells from the inside of the cheek, grow them into a thin sheet in the lab, and then graft that sheet …

This study tests whether a drug called interferon gamma can help intensive care patients recover faster from pneumonia caused by a breathing machine. The drug aims to restore the immune system's ability to fight infection. About 132 adults on ventilators for over 5 days will rece…

This study tests whether hydroxychloroquine, a drug used for malaria and autoimmune diseases, can help people with sarcoidosis use less steroids while still controlling their disease. About 140 adults with sarcoidosis affecting areas outside the lungs (like skin, eyes, or bones) …

This study tests whether a collaborative approach between pharmacists and doctors can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Researchers will compare patients who receive this team-based care to those who get usual follow…

This study tests whether starting therapy before age 2 can lessen the effects of cerebral palsy in babies with certain brain injuries. About 66 infants will receive a home-based program with parent coaching and professional support. The goal is to improve motor skills and reduce …

This study tests laryngeal transplantation in 3 adults who have permanently lost the ability to speak, breathe, and swallow due to severe larynx damage. The goal is to restore these functions using a donor larynx, with a new nerve reconnection technique to improve outcomes. Parti…

This study checks if a combined test on a simple blotting paper (like a dried blood spot) can accurately detect type 1 diabetes in children. Researchers will compare results from the blotting paper test with standard blood tests in 106 children newly diagnosed with diabetes. If s…

This study is testing a new technology called optical biopsy that lets doctors see tissues in real-time during gynecological surgery without cutting them out. The goal is to see if it can quickly and accurately diagnose conditions and help surgeons remove tumors or endometriosis …

This study aims to develop a simple, non-invasive brain test using light (fNIRS) to measure brain function in people with Fragile X syndrome and Creatine Transporter Deficiency. Researchers will test 88 males aged 5 to 35 to see if this technique can detect unique brain activity …

This study aims to validate new blood markers that can quickly rule out serious infection in newborns, helping doctors avoid giving unnecessary antibiotics. About 358 babies in intensive care with signs of late-onset sepsis will be tested. If successful, these markers could reduc…

This study looks at whether a special PET scan using [18F]FET can better find tiny pituitary tumors that cause Cushing's disease, compared to standard MRI. About 20 adults with Cushing's disease will get the scan before surgery. If successful, it could help surgeons remove the ri…

This study aims to see if using a special risk score (the Lyon-VTE-score) helps doctors better prevent dangerous blood clots in pregnant women who are at high risk. About 600 pregnant women with a personal history of blood clots or a clotting disorder will be randomly assigned to…

This study tests a new treatment called EXL01, which contains a single type of beneficial gut bacteria (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two or three C.…

This study tests a new training program for general practitioners in France to help them talk with patients about improving diet, increasing physical activity, and reducing sitting time. The goal is to prevent chronic diseases like cancer and obesity. About 882 adults who are not…

This study tests whether a mobile van with a CT scanner and nurses can help more people, especially those with lower income or less access to healthcare, get screened for lung cancer. It compares this approach to the usual hospital-based screening. The goal is to see if the mobil…

This study follows 444 women who had Essure implants removed due to symptoms like pain or allergic reactions. Researchers will track how much symptoms improve over time and explore why some women feel better after removal. The goal is to better understand the body's response to t…

This study tests a virtual reality training program (KidTrain) designed to improve spatial hearing and speech understanding in noisy environments for children aged 7-17 with bilateral cochlear implants. The program uses immersive audio and visual cues to help children practice lo…

This study looks at whether hypnosis can reduce anxiety in adults recently diagnosed with certain blood cancers (like lymphoma). About 50 participants will receive hypnosis sessions, and their anxiety levels will be measured before and after. The goal is to see if this mind-body …

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke survivors improve motor function. The program adds 300 minutes of weekly active therapy to standard care, with remote monitoring by a therapist. Researchers will enro…

This study looks at whether a heart procedure called transcatheter ablation improves daily life for children aged 5 to 17 with arrhythmia. About 200 kids who need the procedure will fill out questionnaires about their physical, emotional, social, and school functioning before and…

This study tests a new tool called BougieCap™, a special cap attached to an endoscope, to widen short, non-cancerous narrowings in the esophagus. About 200 adults with trouble swallowing will be treated and followed for 6 months. The goal is to see if the device can safely and ef…

This study tests whether early, intensive breathing therapy can improve cough strength in ICU patients who have muscle weakness and struggle to come off a breathing machine. About 50 adults will be split into two groups: one gets standard care, the other gets extra breathing exer…

This study tests whether baclofen, a muscle relaxant, can help people dependent on benzodiazepines (like Valium or Xanax) safely reduce their dose. About 93 adults with moderate to severe dependence will receive either baclofen or a placebo for 28 days. The goal is to see if bacl…

This study tests a simple, drug-free technique called cutaneous resonance stimulation (RESC) to reduce anxiety in people waiting for heart surgery. About 62 participants will receive either the real RESC treatment or a sham touch. The goal is to see if RESC can calm the body's st…

This study tests a new, non-invasive way to treat nerve pain that hasn't responded to medication. The approach uses a mild electric current to stimulate the brain's motor cortex at a frequency matched to each person's own brain waves. Researchers will compare this personalized st…

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover muscle strength, mobility, and reduce pain after hip fracture surgery. About 25 participants will receive vibration sessions five times a week for four wee…

This study looks at two methods of removing a bladder catheter after urological surgery in men. One method is the usual way, where a nurse pulls it out. The other method lets the catheter fall out on its own due to gravity. The goal is to see which method makes patients more sati…

This study compares two advanced brain-mapping techniques—MEG and high-resolution EEG—to see which better locates the seizure-causing area in people with drug-resistant epilepsy who are candidates for surgery. One hundred participants will undergo both scans before surgery. The g…

This study watches how the body's natural daily rhythms (circadian cycles) change as people wake up from a coma after a severe brain injury. Researchers will monitor 90 intensive care patients using behavioral and brain tests to see if these rhythms signal recovery. The goal is t…

This study is creating a large collection of blood and DNA samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and stroke. Researchers will use these samples to investigate the genetic causes of these conditions and find better treatment targets. Participa…

This study is a French registry that follows 1,500 pregnant women with multiple sclerosis (MS) or related conditions, along with their children. The goal is to learn how the disease and medications used during pregnancy affect both mother and child. Researchers will track relapse…

This study aims to create a simple tool to measure food preferences in people over 70 who are in geriatric hospital units. Swallowing problems can lead to poor nutrition, so understanding what foods patients like may help improve their diets. Researchers will test the tool with 2…

This study tests whether a special MRI technique can show where cranial nerves are located near skull base tumors before surgery. About 120 adults with such tumors will get a brain scan, and doctors will compare the nerve positions seen on the scan with what they find during the …

This study looks at how healthy adults use timing patterns in sounds and speech to predict what comes next. Researchers will use brain scans (EEG and MEG) and simple listening tasks to understand these processes. The goal is to learn more about language learning and comprehension…

This study looks at whether women who had more estrogen exposure (from birth control, hormone therapy, pregnancy, or early puberty) are more likely to develop large prolactin-secreting pituitary tumors instead of small ones. Researchers will compare the estrogen histories of 180 …

This study looks at why children and adults with Developmental Coordination Disorder (DCD) have trouble with motor skills like clumsiness and slowness. Researchers will test touch and body-position senses in 280 participants aged 9-11 and 18-40 to see if these sensory problems ar…

This study looks at whether sleep changes can warn of a flare-up in people with Crohn's disease or ulcerative colitis. Researchers will track sleep patterns and disease activity in 216 patients in remission for one year. The goal is to find early signs of relapse, which could hel…

This study looks at how common exocrine pancreatic insufficiency (EPI) is in people with active Crohn's disease who are starting a new biologic therapy. EPI means the pancreas doesn't make enough enzymes to digest food properly. Researchers will check 50 adults at the start of tr…

This study looks at how the help provided by family and friends to people with Alzheimer's disease changes as the disease gets worse. Researchers will track 312 patients and their caregivers to understand what factors—like memory loss, behavior changes, and other health issues—af…

This study looks at bone cells from children having surgery for craniosynostosis (early skull bone fusion). Researchers want to see how burosumab and vitamin D directly affect these cells, especially in children with a rare bone disease called hypophosphatemic rickets. The goal i…

This study follows 500 adults who had an ischemic stroke to identify biological and imaging markers that predict heart complications and recovery. Participants provide blood samples and imaging data, and their health is tracked for up to three months. The goal is to better unders…

This study looks at how the immune system changes over time in adults with severe COVID-19 who are in the intensive care unit. Researchers will collect blood samples from 200 patients to measure immune markers and see how they relate to organ failure, infections, or death. The go…

This study looks at how breathing and waking from sleep are connected in people with drug-resistant epilepsy. Researchers will measure carbon dioxide levels and breathing responses during deep sleep in 60 participants. The goal is to better understand why some patients face a hig…

This study looks at how often the blood pressure measured in the arm is lower than the true pressure in the body's core (aorta) in patients with shock. About 180 adults on strong blood-pressure-raising medicines will have two small tubes (catheters) placed in an arm and a leg art…

This study looks at whether a special diet that promotes a diverse gut microbiome can help people who have had bariatric surgery lose more weight and keep it off. Researchers will compare this diet to standard nutritional advice in 60 adults aged 25-65. The goal is to understand …

This study aims to understand why some patients struggle to use their penile prosthesis pump after implantation. Researchers will measure hand strength, touch sensitivity, and coordination in 60 adults who have had the device for over 3 months. The goal is to see how these factor…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study looks at how attention helps the brain stop unwanted actions, like looking at the wrong thing. Researchers will test 120 people, including healthy volunteers and patients with specific conditions, using eye-tracking tasks. The goal is to better understand these brain p…

This study is working on a lab test to measure how well a new type of hemophilia medicine (anti-TFPI antibodies) works. Researchers will take blood samples from 11 men with severe hemophilia who are already taking this medicine. The goal is to create a reliable test that doctors …

This study aims to collect blood and spinal fluid samples from 350 people with conditions like Parkinson's disease, ALS, glioblastoma, certain cancers, and rheumatoid arthritis. Researchers will analyze these samples to find new genetic markers that could help diagnose autoimmune…

This study looks at whether a simple ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. About 55 adults aged 18-74 with certain cancers will have an ultrasound and a standard body scan (DEXA) to compare results. The go…

This study looks at how thick the blood is in 160 people with polycythemia, a condition where the body makes too many red blood cells. Researchers want to see if thicker blood causes more problems like blood clots. They are not testing any new treatments, just measuring blood vis…

This study looks at people with creatine transporter deficiency, a rare genetic condition that causes intellectual disability, seizures, and movement problems. Researchers want to find the best tests and tools to measure changes in patients' abilities, since many standard tests d…

This study is collecting blood and other biological samples from 400 children and their relatives who have rare autoimmune or autoinflammatory diseases like lupus. The goal is to find genetic mutations that cause these conditions. No treatments are tested; this is purely a resear…

This study looks at how children with epilepsy learn things without trying, like riding a bike or picking up social cues. Researchers will compare 40 children—some with epilepsy and some without—using a simple computer task. The goal is to see if this type of learning is affected…

This study looks at whether a shorter, 8-hour urine collection can give the same information as the standard 24-hour collection for people with Wilson disease. Wilson disease causes copper buildup in the body, and doctors monitor treatment by measuring copper in urine. The study …

This study aims to create a faster, simpler tool called the SBS Disk to measure quality of life in people with short bowel syndrome. Researchers will compare it to a longer existing questionnaire. About 100 adults who can read French and have short bowel syndrome will take part. …

This study looks at whether certain people have natural antibodies that block their immune system's first line of defense against viruses. Researchers will measure viral levels in nose samples from 360 adults and children in intensive care with severe flu, RSV, or COVID-19. The g…

This study looks at the long-term social and emotional well-being of people who had NMDA receptor encephalitis, a rare brain disease. Researchers will use questionnaires to measure fatigue, anxiety, depression, sleep, and quality of life in 30 adults who are at least 18 years old…

This study looks at how much adults with cystic fibrosis move and sit each day. Researchers want to understand activity patterns, especially in those on newer medications, to find who might need extra support. 270 adults from one hospital will fill out questionnaires and some wil…

This study is creating a national observatory to track early and advanced puberty in children seen in private healthcare. Researchers will collect data from about 3,360 children to understand why puberty is starting earlier and improve future care. The goal is to see if this appr…

This study looks at how iron supplements impact the immune system in people with Hereditary Haemorrhagic Telangiectasia (HHT), a rare genetic condition that causes frequent nosebleeds and iron deficiency. Researchers will compare immune cells in 155 adults who take no iron, oral …

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain circuits be…

This study explores whether a special MRI scan (T1 mapping) can detect kidney damage in people with Fabry disease. Researchers will compare MRI results from 70 adults—some with Fabry disease and some without—to see if the scan can measure fibrosis (scarring) in the kidneys. The g…

This study looks at 158 adults on a heart-lung machine (ECMO) who also need kidney dialysis. Doctors want to see if connecting the dialysis directly into the ECMO circuit works as well as using a separate tube. The main goal is to measure how long the dialysis filter lasts before…

This study compares different imaging techniques to see which best identifies dangerous carotid plaque that could cause a stroke. Researchers will study 77 people with at least 50% carotid narrowing—some who have had a stroke and some who haven't. The goal is to find the most acc…

This study tests whether virtual reality and mental imagery can replace traditional prism adaptation therapy for people with unilateral neglect after a brain injury. Researchers will first work with 480 healthy volunteers to see if these new methods work similarly to the standard…

This study looks at bacteria living in the liver, blood, and stool of people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this seri…

This study looks at 250 critically ill adults to see if a continuous finger sensor (perfusion index) can reliably replace the manual capillary refill time test, where doctors press on the skin and count seconds for color return. If the sensor matches the manual test, it could sav…

This study tests a program where trained mothers (peer supporters) help new mothers facing severe poverty or homelessness to breastfeed. About 50 mothers at a French hospital will receive support, and researchers will track how many complete the program. The goal is to see if thi…

This study looks at 30 infants with Down syndrome who are 6 months old. Researchers want to see if the way babies suck (non-nutritive sucking) is linked to how severe their sleep apnea is. The goal is to find a simple way to screen for sleep apnea early, so babies can get help so…

This study uses a non-invasive chest monitor (EIT) to see how air moves through the lungs of children with acute respiratory failure in the pediatric ICU. Researchers will observe how changes in ventilator settings, body position, and other treatments affect ventilation. The goal…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy people. …

This study aims to establish normal levels of immune markers called interferons in healthy adults aged 80 and older. By measuring these markers in the nose and blood of uninfected seniors, researchers hope to improve the accuracy of viral infection tests for older people. The stu…

This study looks at whether special brain wave patterns can predict if someone will have memory or thinking problems after surgery for epilepsy. About 50 adults with drug-resistant epilepsy who need brain electrode monitoring will do simple thinking tasks while their brain activi…

This study looks at how having one leg shorter than the other affects the hips and lower back in children aged 10 to 15. Researchers will use special X-rays and force measurements to calculate joint loads. The goal is to understand these effects better so doctors can decide on ea…

This study is building a large database of blood, tissue, and imaging samples from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to better understand the disease. The goal is to gather information, not to test a new treatment.

This study looks at how tiny communication points inside liver cells (called MAMs) might be linked to a serious liver condition called MASH. Researchers will study 20 adults having weight-loss surgery to see if these cell changes affect disease progression. The goal is to better …

This study follows 500 adults aged 40–80 with type 2 diabetes and fatty liver disease to see how well simple, non-invasive tests (like blood tests and ultrasound) can predict worsening liver damage. Researchers will track participants for several years to link these test results …

This study looks at whether the autonomic nervous system (which controls things like heart rate and digestion) can give clues about liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis. The goal is to find new ways to spot li…

This study aims to collect and store biological samples (like tumor tissue or blood) from 500 adults with confirmed brain tumors. The samples will be used for future research to better understand brain tumors. No treatment or experimental therapy is given—this is purely a sample …

This study is testing a computer program called Lianeli that helps doctors and patients decide together which health screenings (like cancer or diabetes checks) are needed. The goal is to see if the tool is easy to use in a busy doctor's office. About 210 adults in France will tr…

This study aims to find biological markers in the blood that could identify which patients with aortic stenosis (a narrowing of the heart's main valve) are at higher risk of heart problems, even before they feel symptoms. Researchers will collect blood samples and health informat…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes to learn a new motor skill, it might also boost other functions that use the same brain areas, like lang…

This study is looking at whether a blood test measuring mHLA-DR can help doctors predict severe complications after surgery for pancreatic cancer. The researchers will follow 100 patients who have pancreatic surgery to see if changes in this immune marker can warn of problems lik…

This study observes 150 adults with long-COVID symptoms lasting over 4 weeks. Researchers will collect clinical and lab data to group patients by symptom patterns and link these to immune markers. The goal is to find clues for better diagnosis and future treatments, but no direct…

This study looks at how blind people use a white cane to sense the world around them, like feeling for curbs or obstacles. Researchers will test touch perception on a rod and measure brain activity with EEG and MRI. The goal is to understand how the brain treats the cane as an ex…

This study looks at whether robot-assisted weight-loss surgery is worth its higher cost compared to standard laparoscopic surgery. About 482 adults with obesity will be randomly assigned to one of the two methods. Researchers will track complications, quality of life, and overall…

This study looks at tongue muscle function in children with suspected obstructive sleep apnea (OSA). Researchers will measure tongue pressure and movement in 78 children referred for sleep testing and compare them to healthy children. The goal is to find out if weak tongue muscle…

This study follows 60 children under 16 with spinal muscular atrophy who are already receiving SMN-restoring treatments. Researchers want to describe the new patterns of disease that emerge with these therapies and test which tools best measure progress. The goal is to improve mo…

This study is gathering detailed information from 45 adults with a rare nerve condition called IgM-anti-MAG peripheral neuropathy. Researchers want to describe the different types of the disease, how it changes over time, and how patients respond to treatments. The goal is to cre…

This study is looking at new blood tests to see if they can detect tiny bits of cancer left behind after surgery for colorectal cancer that has spread to the abdomen (peritoneal metastases). Currently, doctors rely on a visual check during surgery, but this may miss small amounts…

This study follows 70 adults with a type of blood cancer (diffuse large B-cell lymphoma) who are receiving CAR-T cell therapy. Researchers want to understand how the treatment affects patients' quality of life and what medications they actually use in everyday care. The goal is t…

This study looks at how the cystic fibrosis drug elexacaftor-tezacaftor-ivacaftor behaves in children aged 2 to 17. Researchers want to understand how drug levels in the blood relate to benefits and side effects. About 150 children with cystic fibrosis who already take this medic…

This study looks at how different types of glaucoma surgery affect patients' quality of life, not just eye pressure. About 132 adults having surgery will fill out questionnaires before and 6 months after their operation. The goal is to understand what matters most to patients, in…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can improve safety. TRT is a type of radiation treatment that targets cancer cells while sparing healthy tissue. Researchers will c…

This study tests whether teaching parents practical tips can reduce the amount of endocrine-disrupting chemicals found in babies' urine. About 90 healthy newborns and their families will take part. Half the parents get training on avoiding these chemicals; the other half follow u…

This study is not testing a new drug or treatment. Instead, it will collect information from 3000 adults taking oral anticancer drugs at home to understand how well the prescribed doses match what patients actually take, what side effects occur, and how care coordination between …

This study looks at how a brain region called the posterior parietal cortex (PPC) helps us combine vision and body awareness to guide hand movements. People with optic ataxia, caused by damage to this area, have trouble reaching for objects and may also have perception issues. Re…

This study follows 400 pregnant women with rare blood vessel diseases (like hereditary hemorrhagic telangiectasia, Marfan syndrome, or arteriovenous malformations) to track serious complications for mother and baby. Researchers will collect data via phone questionnaires during pr…

This study looks at whether people with CAPS (a rare genetic condition causing fever and inflammation) have disrupted daily body rhythms. Researchers will measure melatonin and other clock-related markers in 30 participants (15 with CAPS and 15 healthy household members). The goa…

This study looks at 30 ICU patients starting a type of kidney therapy (continuous renal replacement therapy) to remove extra fluid. Researchers want to see if a measure called the Analgesia Nociception Index (ANI), which tracks the balance between the 'fight or flight' and 'rest …

This study looks at how well patients aged 70 and older with advanced ovarian cancer tolerate PARP inhibitors, a type of targeted cancer drug. Researchers will track side effects and dose adjustments in 50 participants over time. The goal is to identify factors that help doctors …

This study aims to better understand how the brain controls movement, especially after a stroke. Researchers will use advanced brain imaging to decode signals related to imagined and real wrist movements. The goal is to improve brain-computer interfaces that could help stroke pat…

This study looks at muscle loss (sarcopenia) and cognitive problems (chemobrain) in people who have finished cancer treatment. Researchers will collect data from 100 adults aged 18-74 with certain cancers to understand how common these issues are. The goal is to improve support a…

This study aims to better understand why some people with fatty liver disease develop dangerous inflammation (NASH) while others do not. Researchers will collect liver cells from 60 adults using a special needle and analyze them with advanced techniques. The goal is to find new c…

This study tests whether small wearable sensors can safely track movement and walking in 30 pregnant women during early labor with a low-dose epidural. The goal is to see if these sensors can help monitor pain relief, predict falls, and understand labor progress. It is a first st…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to understand the bacteria's role and how they change with standard treatment. The goal is to fin…

This study aims to understand how treatments for pulmonary hypertension (PH) affect people with lung fibrosis. Researchers will analyze blood and urine samples from 80 participants before and during treatment to find chemical markers that show who responds well. The goal is to be…

This study looks at memory, mood, and thinking problems that can happen with certain targeted lung cancer pills (ALK/ROS1 inhibitors). Researchers will work with 20 patients to better understand these side effects and how they affect daily life. The goal is to create a better car…

This study aims to create a realistic model of the endometrium (the uterine lining) in the lab using tissue from patient biopsies. Researchers will test how different hormone treatments affect this model, with the goal of predicting which treatment works best for each person. The…

This study looks at why the hepatitis B virus (HBV) stays in the liver for so long, even with treatment. Researchers will use a thin needle to take small samples from the liver of 100 adults with chronic HBV. They want to see how the virus and the body's immune cells interact, wh…

This study follows 300 adults who had a severe type of heart attack (STEMI) to discover new biological and imaging markers that can predict how well they recover. Researchers will collect blood samples and perform MRI scans over one year, and track patients' health for up to five…

This study aims to better understand how donated kidneys perform after transplant and how a donor's remaining kidney adapts. Researchers will use special MRI scans to measure blood flow, oxygen levels, and tissue health in 60 participants (both donors and recipients). The goal is…