Hospices Civils De Lyon

This study is testing whether a medication called spironolactone can slow the progression of a rare heart muscle disease called ARVD. It will involve 120 patients in France who will take either the drug or a placebo for three years. The goal is to see if the drug can reduce heart…

This study is testing a new treatment for people who are blind due to a complete loss of stem cells in both eyes, often from severe burns. Doctors take a small sample of tissue from inside a patient's cheek, grow it into a thin sheet in a lab, and then transplant it onto the dama…

This study is for adults with a specific, slow-growing brain tumor called a low-grade oligodendroglioma. It aims to find out if waiting to give radiation therapy until the tumor shows signs of growing again can help protect patients' memory and thinking skills, compared to starti…

This French study is testing whether a combination of two immunotherapy drugs can help control five types of advanced rare cancers that have progressed after standard treatment. It will enroll 154 adults whose cancers have specific rare origins, such as certain mesotheliomas, thy…

This study is testing which speed of fluid removal is better for ICU patients with sudden kidney failure who need dialysis. Researchers want to know if removing fluid more aggressively or more slowly helps patients get off life support machines faster and recover better. They are…

This study is testing whether a special, early, and intensive breathing exercise program can help ICU patients who are struggling to breathe on their own after being on a ventilator. The program uses a device to help patients cough more effectively, aiming to strengthen their bre…

This study aims to find the best way to connect kidney dialysis to a life support machine called ECMO, which helps patients with severe heart failure. Researchers will compare connecting the dialysis machine directly into the ECMO circuit versus using a separate connection. The g…

This study aims to find out which type of interdental brush (flossing tool) works better for daily gum care in young adults. Researchers are comparing specially sized brushes against regular ones to see which reduces gum bleeding and harmful bacteria more effectively over three m…

This study is tracking 3000 cancer patients who take their anticancer pills at home instead of receiving injections in the hospital. Researchers want to see if a special support program helps patients take the right dose safely and avoid problems. The goal is to improve how docto…

This study is testing larynx (voice box) transplants in three patients who have permanently lost their ability to speak, breathe normally, and swallow due to severe injury. The goal is to see if transplanting a donor larynx can restore these vital functions for people who have no…

This study is testing whether giving a second course of a targeted radiation drug called [177Lu]Lu-PSMA-617 can help men with advanced prostate cancer that has started growing again. The treatment specifically targets prostate cancer cells. The trial will enroll 58 men whose canc…

This study is testing a medical device called MEX-CD1 that works like dialysis to filter excess iron from the blood. It is for patients with myelodysplastic syndrome or myelofibrosis who need regular blood transfusions, which cause dangerous iron buildup, but who cannot tolerate …

This study is testing a special support program designed to help older women with advanced ovarian cancer better withstand and recover from major surgery. The program includes nutritional advice, physical exercise, and education before surgery, followed by coordinated care during…

This study is testing whether a home-based rehabilitation program using a special device called MindMotion GO can help stroke patients recover movement. Participants will use the device at home for 12 weeks while therapists monitor their progress remotely. The goal is to see if t…

This study is testing whether a new support program helps people with rheumatoid arthritis stick to their prescribed medications. The program involves pharmacists and doctors working together, starting support during a hospital stay and continuing it after the patient goes home. …

This study aims to improve safety for cancer patients receiving targeted radiation therapy by having pharmacists review all their medications. Researchers will enroll 600 adults with thyroid cancer, prostate cancer, or neuroendocrine tumors to test whether detailed medication rev…

This study aims to find the best length of time to keep patients with a serious autoimmune disease (ANCA-associated vasculitis) on a low dose of the steroid prednisone. Patients who are already in remission and receiving standard rituximab treatment will be randomly assigned to e…

This study is testing whether adding an immune-boosting drug called interferon gamma to standard antibiotics helps ICU patients on ventilators fight off pneumonia. It focuses on patients whose immune systems are weakened after severe illness or injury. The main goal is to see if …

This study is testing if a medication called baclofen can help people who are dependent on benzodiazepines (like Xanax or Valium) safely reduce their use. Researchers will compare baclofen to a placebo (inactive pill) in 93 adults who have tried and failed to quit these medicatio…

This study is testing a new system where specially trained nurses help manage the start of methadone treatment for people with opioid addiction, instead of relying only on doctors. The goal is to see if this nurse-led approach helps patients stay in treatment longer during the cr…

This study aims to understand how a powerful cystic fibrosis drug combination works in children's bodies. Researchers will measure drug levels in the blood of 150 kids aged 2-17 who are already taking the medicine. The goal is to find the best dose to control the disease while mi…

This study is testing a new type of PET scan to better find the tiny pituitary tumors that cause Cushing's disease. Current MRI scans can miss these small tumors about 30% of the time. Researchers will compare the new scan results to what surgeons actually find, hoping it will le…

This study aims to compare two advanced brain scanning techniques—magnetoencephalography (MEG) and high-resolution electroencephalography (EEG)—to see which is better at pinpointing the exact area of the brain causing seizures. It involves 100 people with drug-resistant epilepsy …

This study aims to improve the diagnosis of poor blood flow (chronic limb ischemia) in the arms. Researchers will first measure normal oxygen levels in the arms of 60 healthy volunteers using a simple, non-invasive skin sensor. They will then analyze past patient data to determin…

This study is testing a new, easier way to screen for early signs of type 1 diabetes in children. Researchers are comparing a simple finger-prick test done at home on blotting paper to the standard, more complex blood tests drawn from a vein. The goal is to validate this simpler …

This study aims to validate new blood tests to help doctors quickly determine if a hospitalized newborn has a serious bacterial infection. It involves 358 babies showing possible signs of infection. The goal is to create a faster, more accurate test to avoid giving antibiotics wh…

This study is testing a new imaging device called Cellvizio® that allows surgeons to see tissue at a cellular level in real-time during gynecological surgeries. The goal is to see if this 'optical biopsy' can accurately identify abnormal tissue—like tumors or endometriosis—withou…

This early-stage trial is testing a new probiotic pill called EXL01. It aims to prevent dangerous C. difficile infections from coming back in patients who are at high risk of recurrence. The study will compare the pill to a placebo in 56 patients to see if it's safe and if it can…

This study tests whether bringing lung cancer screening directly to people in mobile CT vans is more effective than asking them to visit a hospital. It aims to see if the mobile approach helps reach more people from disadvantaged backgrounds who are at high risk due to heavy smok…

This study is testing a new training program for family doctors in France. The goal is to help doctors have better, more supportive conversations with their patients about improving diet, increasing physical activity, and reducing sitting time. Researchers want to see if these im…

This study is testing whether giving parents practical training on avoiding everyday chemicals can lower the levels of those chemicals found in their babies' bodies. Researchers will enroll 90 healthy newborns and randomly assign their parents to either receive the training or no…

This study compares two methods for removing bladder catheters after urologic surgery. Researchers want to see if letting the catheter fall out naturally by gravity causes less discomfort than having a nurse pull it out. They will measure patient satisfaction, pain, and anxiety i…

This study is testing a virtual reality (VR) training program designed to help children aged 8-17 who use two cochlear implants. The goal is to improve their ability to figure out where sounds are coming from and understand speech when there is background noise, which are common …

This study is testing whether adding gentle, localized muscle vibration to standard rehabilitation can help elderly patients recover faster after hip fracture surgery. Researchers will enroll 25 patients aged 75+ to see if this vibration therapy is practical to use in hospital re…

This study is testing whether hypnosis can help reduce anxiety in people recently diagnosed with certain types of blood cancer (lymphoma). Researchers will measure anxiety levels in 50 patients before and after they receive 2-3 hypnosis sessions over 3 months. The goal is to see …

This study is testing whether a gentle skin stimulation technique can help reduce anxiety in patients scheduled for heart surgery. Researchers will compare the real technique to a sham (fake) treatment to see if it changes the body's stress response and lowers anxiety levels. The…

This study is collecting detailed information from 4,000 lung cancer patients over 10 years to help researchers better understand the disease. Participants will provide blood samples, tissue samples, and medical imaging data that will be stored in a research database. The goal is…

This study aims to develop new, at-home rehabilitation methods for people with a brain injury condition called 'unilateral neglect,' which affects spatial awareness. Researchers are testing whether virtual reality or mental imagery exercises can work as well as current hospital-b…

This study aims to understand the relationship between blood thickness (viscosity) and the risk of complications like blood clots in people with polycythemia, a condition where the body makes too many red blood cells. Researchers will measure blood thickness and clotting factors …

This study aims to understand how the brain makes decisions about putting in effort for a reward. Researchers will use safe, non-invasive brain scans and stimulation techniques on 204 healthy volunteers to see which brain circuits are involved. The goal is to build knowledge that…

This study aims to understand how the immune system changes over time in adults with severe COVID-19 who are in the intensive care unit (ICU). Researchers will observe 200 patients to see how their immune response relates to complications like organ failure or secondary infection…

This study aims to understand the differences in liver inflammation between two types of fatty liver disease: simple fatty liver (NAFL) and the more serious form (NASH). Researchers will collect liver cells from 60 patients already scheduled for a liver biopsy, using a fine needl…

This study aims to understand how patients feel and what medications they use after receiving CAR-T cell therapy for lymphoma. Researchers will follow 70 adults receiving this advanced treatment to track their quality of life and real-world experiences. The study focuses on gathe…

This study aims to understand if the body's natural daily rhythms are disrupted in people with Cryopyrin-Associated Periodic Syndrome (CAPS), a rare inflammatory condition. Researchers will compare 30 participants, including patients with CAPS and healthy household members, by me…

This study is investigating whether specific markers in the blood can help doctors better monitor colorectal cancer patients after surgery for peritoneal metastases. Researchers will track how quickly these markers clear from the blood after surgery in 58 participants, including …

This study aims to build a collection of blood and tissue samples from children with rare autoimmune and autoinflammatory diseases like lupus. Researchers will analyze these samples to identify genetic changes and immune system problems that cause these conditions. The goal is to…

This study aims to better understand how air moves in the lungs of children with severe breathing failure who are in intensive care. Researchers will use a special, non-invasive monitor to watch lung function in real time. They want to see how common ICU treatments, like changing…

This study aims to understand how iron deficiency and the iron supplements used to treat it affect the immune system in people with Hereditary Haemorrhagic Telangiectasia (HHT), a rare genetic disorder. Researchers will compare immune cell levels in three groups of adult HHT pati…

This research study aims to understand how our brains predict the timing of sounds and speech. Researchers will measure brain activity in healthy volunteers while they listen to different sounds and speech patterns. The goal is to learn how we use past patterns to anticipate what…

This study aims to build a collection of biological samples from adults diagnosed with brain tumors. The goal is to create a resource for future research to better understand these diseases. Participants will provide samples but will not receive any experimental treatment as part…

This study is testing whether a special type of MRI scan can detect and measure kidney damage in people with Fabry disease, a rare genetic disorder. Researchers will compare scan results from about 70 adults with Fabry disease to those from people without it. The goal is to see i…

This study aims to understand the link between specific gut bacteria, methane production, and irritable bowel syndrome (IBS) with constipation. Researchers will observe 40 adults with this condition, analyzing their stool and blood samples before and after their usual treatment. …

This study aims to measure the amount and cost of unpaid care provided by family members to people with Alzheimer's disease. Researchers will follow 312 patients and their caregivers to understand how care needs change as the disease progresses. The goal is to gather data to help…

This study aims to understand if a woman's lifetime exposure to estrogen influences whether she develops a larger or smaller type of prolactinoma, a common pituitary tumor. Researchers will compare the medical and reproductive histories of 180 women who have already been diagnose…

This study aims to understand how damage to a specific brain area affects vision and movement coordination in people with optic ataxia. Researchers will compare 160 participants—some with this condition and some healthy volunteers—using simple movement and perception tests. The g…

This study aims to gather detailed information from 500 people who have had an ischemic stroke. Researchers will collect blood samples and brain/heart scans to look for new markers that can predict how well someone recovers and their risk of future heart problems. The goal is to …

This study aims to understand how breathing and the brain's sleep-wake systems interact in people whose epilepsy doesn't respond well to medication. Researchers will monitor 60 participants overnight to measure their breathing responses and arousal thresholds during sleep. The go…

This study aims to understand why some people develop severe cases of flu, RSV, or COVID-19 requiring intensive care. Researchers are investigating whether certain antibodies that block a key part of the immune system (interferons) lead to higher virus levels and slower recovery.…

This study aims to create a detailed lab model using tissue donated by patients with and without endometriosis. The goal is to better understand the disease and see how this lab-grown tissue responds to different hormonal treatments. This could one day help doctors predict which …

This study aims to find better, non-invasive tests to predict which people with Type 2 diabetes are most likely to see their liver disease get worse. Researchers will follow 500 patients with both conditions to see if certain test results at the start can forecast future health p…

This study aims to understand how patients aged 70 and older with advanced ovarian cancer tolerate PARP inhibitor medications in real-world settings. Researchers will follow 50 patients starting these drugs for the first time, tracking how much medication they can actually take v…

This study aims to understand how new, life-changing treatments for spinal muscular atrophy (SMA) are changing the course of the disease in children. Researchers will closely follow 60 children under 16 years old for two years to describe their health, development, and quality of…

This study is testing whether a special type of MRI scan can create a detailed map of nerves around skull base tumors. The goal is to see if this map accurately predicts where the nerves are located during surgery. If successful, it could help surgeons avoid damaging these import…

This study aims to better understand the brain signals produced when a person imagines moving their wrist. Researchers will use high-tech brain scanners (MEG and EEG) on healthy adults and a small group of stroke survivors with arm weakness. The goal is to gather detailed knowled…

This study aims to better understand how people wake up from a coma after a serious brain injury. Researchers will closely observe 90 patients in intensive care to see if the return of the body's natural daily rhythms is linked to regaining consciousness. The goal is to gather de…

This study aims to see if small wearable sensors can be used to safely measure how women walk during the early stages of labor. Researchers want to understand how walking patterns change with and without low-dose epidural pain relief. The goal is to gather information that could …

This study aims to create a reliable laboratory test to measure how well new hemophilia treatments called anti-TFPI antibodies are working. Researchers will test blood samples from 11 adult men with severe hemophilia who are taking these new medications. The goal is to develop a …

This study aims to understand how two medications—burosumab and active vitamin D—directly affect bone-forming cells. Researchers will collect bone cells from 20 children (aged 4 months to 18 years) who are already scheduled for surgery to correct premature skull bone fusion. The …

This study aims to create a simple questionnaire to understand the food likes and dislikes of older adults in the hospital. Researchers will adapt a tool used for children to make it suitable for patients over 70, including those with swallowing difficulties. The goal is to learn…

This study aims to find out if changes in sleep quality can serve as an early warning sign for flare-ups in people with Crohn's disease or ulcerative colitis. Researchers will monitor 216 patients who are currently in remission, tracking their sleep patterns with wrist-worn devic…

This study aims to better understand Long COVID by grouping patients based on their symptoms and then looking for matching patterns in their blood and immune systems. It will enroll 150 adults who have persistent symptoms after a COVID-19 infection and are in a specialized care p…

This study aims to understand why some men find it hard to use the pump for their penile prosthesis. Researchers will measure the hand strength, grip, and sensation of 60 patients with prostheses to see if these physical abilities are linked to how well the device works and how s…

This study aims to understand if and how bacteria from the gut travel to the liver in people with severe alcoholic hepatitis, a life-threatening liver condition. Researchers will analyze bacteria from liver tissue, blood, and stool samples of 50 patients. The goal is to see if sp…

This study aims to understand the long-term social and psychological challenges faced by young adults who have recovered from the acute phase of a rare autoimmune brain disease called NMDA receptor encephalitis. Researchers will survey 30 adult patients to measure their quality o…

This study aims to gather information about how pregnancy affects women with multiple sclerosis (MS) and related conditions. Researchers will follow 1,500 pregnant women and their children for up to six years to understand the safety of medications, the impact on disease progress…

This study aims to understand the memory, mood, and thinking problems that some patients experience while taking targeted oral drugs for a specific type of lung cancer. Researchers will work closely with 20 patients who have reported these side effects to describe their experienc…

This study aims to create a new, quicker questionnaire to measure quality of life for people with short bowel syndrome. Researchers will compare their new tool, which uses a simple disk format, to an existing, more complex questionnaire. The goal is to make it easier for doctors …

This study aims to see if a quick, non-invasive ultrasound scan of the thigh muscle can accurately detect muscle loss in people who have finished cancer treatment. Researchers will compare the ultrasound results to standard body scans and blood tests in 55 participants. The goal …

This study aims to understand how different glaucoma surgeries affect patients' quality of life and daily vision. Researchers will follow 132 adults undergoing standard glaucoma operations, asking them to complete questionnaires about their vision and life before and after surger…

This study aims to understand how much physical activity adults with cystic fibrosis get and how much time they spend sitting. Researchers will observe 270 patients to identify those with inactive lifestyles who might face greater health risks. The goal is to gather information t…

This study aims to understand how critically ill patients' bodies respond to fluid removal during kidney filtration therapy. Researchers will measure pain and stress signals in 30 ICU patients receiving continuous kidney treatment. The goal is to learn if these signals correlate …

This study uses special MRI scans to better understand how kidneys from living donors work after being transplanted. Researchers will scan 60 people—both kidney donors and recipients—to measure blood flow, oxygen levels, and scarring in the kidneys. The goal is to gather informat…

This study aims to make monitoring easier for people with Wilson's Disease, a genetic condition where too much copper builds up in the body. Researchers are testing if collecting urine during a shorter, specific 8-hour window at night gives the same information as the current dif…

This research aims to understand how the brain's ability to focus attention interacts with its ability to stop or inhibit actions. The study will compare healthy adults to patients with specific brain conditions (like optic ataxia, hemispatial neglect, or ADHD) to see how these p…

This study aims to understand how often blood pressure readings from the wrist artery differ significantly from readings taken from the groin artery in patients with severe shock. Researchers will monitor 180 critically ill patients who already have both types of monitoring cathe…

This study aims to understand why some people have worse outcomes after a major heart attack. Researchers will follow 300 patients for five years, collecting blood samples and heart scans to identify new markers that predict future heart problems. The goal is to build a detailed …

This study aims to understand why more children are starting puberty earlier than expected. Researchers will collect health data from over 3,000 children, including those with early puberty, advanced puberty, and a comparison group without signs. The goal is to gather better info…

This study is testing a new idea: that training your brain with a physical skill, like a motor task, might make it easier to learn a new language. Researchers are recruiting over 1,100 healthy French-speaking adults to see if the brain changes from motor training can boost langua…

This study aims to learn more about how new treatments work for patients with a serious lung disease that also causes high blood pressure in the lungs. Researchers will look for changes in blood and urine chemicals before and during treatment. The goal is to understand the body's…

This study aims to identify blood markers that might predict which patients with aortic stenosis (a narrowing of the heart valve) are at higher risk for future heart problems, even before they feel symptoms. Researchers will collect blood samples and health information from 125 p…

This study aims to prepare for future treatment trials for Creatine Transporter Deficiency (CTD), a rare genetic disorder that causes severe intellectual disability, seizures, and movement problems. Researchers will test many different questionnaires, games, and activities on abo…

This national study follows 400 pregnant women with rare vascular conditions to understand pregnancy risks and complications. Researchers will track outcomes during pregnancy and for one year after birth through phone questionnaires. The goal is to gather scientific data to creat…

This study aims to collect blood and spinal fluid samples from people with various conditions like Parkinson's disease, ALS, cancer, and arthritis. Researchers will analyze these samples to discover new genetic markers that could help doctors better diagnose rare autoimmune brain…

This study aims to better predict whether epilepsy surgery might affect a patient's memory, attention, or other thinking skills. Researchers will map brain activity in 50 adults with drug-resistant epilepsy while they perform thinking tasks, using electrodes already implanted for…

This study aims to find out how common pancreas problems are in people with active Crohn's disease. Researchers will measure this in 50 adults before they start a new biologic drug and again 14 weeks later. The goal is to understand if these digestive issues are linked to Crohn's…

This study aims to understand how common muscle weakness and cognitive problems (often called 'chemobrain') are in people who have finished cancer treatment. Researchers will collect health data from 100 adult cancer survivors during a standard follow-up check-up day. The goal is…

This study aims to understand how communication between different parts of cells changes in people with fatty liver disease (MASH). Researchers will examine liver and blood samples from 20 patients undergoing weight-loss surgery to see if these cellular changes are linked to dise…

This study aims to understand the root causes of Developmental Coordination Disorder (DCD), a condition that causes clumsiness and affects daily activities in about 6% of children, often continuing into adulthood. Researchers will test children and adults with DCD to see if diffi…

This study aims to gather detailed information on a rare nerve disorder called IgM-MAG peripheral neuropathy. Researchers will follow 25 patients over time to understand how the disease progresses, how it responds to treatments, and how it affects daily life. The main goal is to …

This study is testing if adding hydroxychloroquine (an anti-malarial drug) to treatment helps people with sarcoidosis affecting areas outside the lungs (like skin, eyes, or joints) reduce or stop their steroid medication. About 140 participants will be randomly assigned to receiv…