Can a second dose of this radioactive drug beat back prostate cancer again?
NCT ID NCT06866938
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for men with a type of advanced prostate cancer that has stopped responding to hormone therapy. It tests whether giving a second course of a radioactive drug called Lu-PSMA can control the cancer again. Participants will receive the drug every six weeks until their disease gets worse or side effects become too severe. The main goal is to see how many men are still alive without their cancer growing after 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[177Lu]Lu-PSMA-617 (Pluvicto), a radioactive drug that targets prostate cancer cells
What this could lead to
If successful, this could show that re-treatment with Lu-PSMA is a safe and effective option for men whose prostate cancer has progressed after an initial course of the same therapy.
What could go wrong
This is a small, early-phase (IIb) study with only 58 participants, so results may not apply to all patients. There is also a risk of side effects from the radiation, and the cancer may still progress despite re-treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de Nancy
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, 54511, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hôpital Louis Pradel, Hospices Civils de Lyon
NOT_YET_RECRUITINGBron, 69500, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Institut de cancérologie du Gard
NOT_YET_RECRUITINGNîmes, 30000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, CHU de Nantes Hôtel-Dieu
NOT_YET_RECRUITINGNantes, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, Centre Hospitalier de Grenoble Alpes
NOT_YET_RECRUITINGGrenoble, 38043, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, Centre Léon Berard
NOT_YET_RECRUITINGLyon, 69373, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, Institut Bergonié
NOT_YET_RECRUITINGBordeaux, 33000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, Institut Gustave Roussy
NOT_YET_RECRUITINGVillejuif, 94800, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Médecine Nucléaire, Institut de Cancérologie de Strasbourg
NOT_YET_RECRUITINGStrasbourg, 67200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, CHU Brest-Hôpital Morvan
NOT_YET_RECRUITINGBrest, 29200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, CHU Saint Etienne
NOT_YET_RECRUITINGSaint-Priest-en-Jarez, 42270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, 06189, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, Centre François Baclesse
NOT_YET_RECRUITINGCaen, 14076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, Centre Henri Becqueret
NOT_YET_RECRUITINGRouen, 76038, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, Centre Hospitalier Lyon Sud, HCL
RECRUITINGPierre-Bénite, 69310, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oncologie Médicale, Centre Jean Perrin
NOT_YET_RECRUITINGClermont-Ferrand, 63011, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact