Scientists probe immune system in severe COVID-19 to find new clues

NCT ID NCT04392401

Recruiting now Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 200 adults with COVID-19 in intensive care to see how their immune systems change over time. Researchers will collect blood samples at several points during the hospital stay and track health outcomes. The goal is to understand why some patients get worse and to find new ways to treat or prevent severe illness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify new treatments and biological markers to better manage COVID-19 in intensive care.
What could go wrong: This is an observational study, not testing a treatment. It may not directly lead to new therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTENSIVE CARE UNIT SARS-COV-2

Contacts and locations

Locations

CH de St Etienne
NOT_YET_RECRUITING

Saint-Etienne, 42055, France
Centre hospitalier universitaire de Grenoble Alpes
NOT_YET_RECRUITING

Grenoble, 38043, France
Hôpial de la Croix Rousse
RECRUITING

Lyon, 69004, France
Hôpital Edouard Herriot
RECRUITING

Lyon, 69003, France
Hôpital Edouard Herriot
RECRUITING

Lyon, 69003, France
Hôpital Gabriel Montpied
NOT_YET_RECRUITING

Clermont-Ferrand, 63000, France
Hôpital Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
Hôpital Pierre Wertheimer
RECRUITING

Bron, 69500, France

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