Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a new pill keep High-Risk COVID-19 patients out of the hospital?

NCT ID NCT07743580

Not yet recruiting Disease control Sponsor: Shionogi Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether the oral antiviral secutrelvir can prevent severe COVID-19 in people who are at high risk for complications. Participants with mild symptoms and confirmed SARS-CoV-2 infection will receive either secutrelvir or a placebo. The study will measure how many experience medically attended visits, hospitalizations, or deaths due to worsening COVID-19, as well as how quickly symptoms resolve.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
secutrelvir (an antiviral drug taken as a pill)
What this could lead to
If successful, secutrelvir could offer a new oral treatment to prevent severe COVID-19 in people at high risk, potentially reducing hospitalizations and deaths.
What could go wrong
This is a phase 3 trial, but results are not guaranteed. The drug may not prove more effective than placebo, and safety concerns could emerge. Its benefit in the current COVID-19 landscape is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SARS-COV-2 are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS-COV-2

Contacts and locations

Locations

  • Abe Shun Naika Clinic

    Kasugai-Shi, Aiti, 815-0074, Japan

  • Chiba Aoba Municipal Hospital

    Chiba, Chiba, 206-0852, Japan

  • Continental Clinical Research, LLC

    Miami, Florida, 33144-4273, United States

  • Global Clinical Professionals

    St. Petersburg, Florida, 33705, United States

  • Hometown Urgent Care and Research

    Cincinnati, Ohio, 45215-1170, United States

  • Hope Clinical Trials - 3970 W Flagler St.

    Coral Gables, Florida, 33134-1642, United States

  • Japan Community Health Care Organization Nihonmatsu Hospital

    Nihommatsu, Fukushima, 964-8501, Japan

  • Kamezawa Clinic

    Tsuchiura-Shi, Ibaraki, 486-0817, Japan

  • Kendall South Medical Center Inc.

    Miami, Florida, 33185-5948, United States

  • MCpulmo-2018 Ltd

    Haskovo, 6300, Bulgaria

  • Medical Center Medconsult Pleven - Lovech Branch

    Lovech, 5500, Bulgaria

  • Medical Center Medconsult Pleven OOD

    Pleven, 5800, Bulgaria

  • Medical Center Unimed EOOD

    Sevlievo, Gabrovo, 5402, Bulgaria

  • Medical Corporation Shirayurikai Swing Nozaki Clinic

    Shinjuku-Ku, Tokyo, 180-0022, Japan

  • Medichi Sofia - Medical Center OOD

    Sofia, Sofia, 1113, Bulgaria

  • New Tampa Health

    Tampa, Florida, 33603-3402, United States

  • Reed Medical Research

    Miami, Florida, 33176-8709, United States

  • Research Bay, Inc.

    Tampa, Florida, 33607, United States

  • Sato Clinic

    Kawasaki-shi, Kanagawa, 150-0013, Japan

  • Shibasaki Internal Medicine and Pediatrics Clinic

    Sendai, Miyagi, 980-0871, Japan

  • Shizuka Medicine Clinic

    Musashino, Tokyo, 370-0071, Japan

  • Terada Clinic Respiratory Medicine and General Practice

    Himeji-shi, Hyôgo, 670-0849, Japan

  • Toda Internal Medicine & Neurology

    Akashi-Shi, Hyôgo, 674-0081, Japan

  • Tokyo Center Clinic

    Chuo-Ku, Tokyo, 103-0027, Japan

  • Tomita Internal Medicine Clinic

    Fukuoka, 810-0033, Japan

  • Tsuchiura Beryl Clinic

    Takasaki-shi, Gunma, 300-0062, Japan

  • Yotsuya Naika

    Shibuya-Ku, Tokyo, 160-0017, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.