Could a common diuretic protect hearts in rare ARVD?

NCT ID NCT03593317

Recruiting now Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether spironolactone, a potassium-sparing diuretic, can slow the deterioration of the right ventricle and reduce arrhythmias in people with arrhythmogenic right ventricular dysplasia (ARVD). About 120 participants will receive either spironolactone or a placebo for 12 months, with follow-up over 3 years. The goal is to see if this drug can improve quality of life and reduce hospitalizations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: spironolactone
What this could lead to: If it works, this could point toward a treatment that slows heart muscle damage and reduces dangerous heart rhythms in people with ARVD.
What could go wrong: This is a phase 2 trial with only 120 participants, so results are preliminary. Spironolactone may not slow disease progression or reduce arrhythmias as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arrhythmogenic right ventricular cardiomyopathy heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA

Contacts and locations

Locations

CHU Amiens Picardie
NOT_YET_RECRUITING

Amiens, France
CHU Dijon
RECRUITING

Dijon, France
Groupe Hospitalo Universitaire Caremeau
NOT_YET_RECRUITING

Nîmes, France
Hôpital Arnaud de Villeneuve
RECRUITING

Montpellier, France
Hôpital Cardiologique Louis Pradel
RECRUITING

Bron, France
Hôpital Gabriel Montpied
NOT_YET_RECRUITING

Clermont-Ferrand, France
Hôpital Laennec
RECRUITING

Nantes, France
Hôpital Michallon
NOT_YET_RECRUITING

Grenoble, France
Hôpital Pitié Salpetrière
RECRUITING

Paris, France
Hôpital Rangueil
NOT_YET_RECRUITING

Toulouse, France
Hôpital de Haut-Lévêque
NOT_YET_RECRUITING

Pessac, France
Hôpital de la Timone
NOT_YET_RECRUITING

Marseille, France
Nouvel Hôpital Civil
NOT_YET_RECRUITING

Strasbourg, France

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